Efficacy of Double Pedicle Graft with and without PRGF in Treating Cl I and Cl II Gingival Recessions

Background and aims. The aim of this study was to evaluate the effect of double pedicle graft (DPG) with and without plasma rich in growth factor (PRGF) in the treatment of Miller's Cl I and II gingival recessions. Materials and methods. Thirty-two bilateral buccal gingival Miller’s Cl I and II recessions were selected. Sixteen of the recessions were treated with DPG and PRGF (test group). The remaining sixteen recessions were treated with DPG (control group). The clinical parameters, including clinical probing depth (CPD), clinical attachment level (CAL), recession depth (RD), recession width (RW) and keratinized gingiva width (KGW), were measured at baseline and 1, 3 and 6 months later. Data were analyzed with paired t-test. Results. After 6 months, both groups exhibited a significant improvement in all the criteria mentioned above. However, none of the groups showed significant differences in pocket depths after 6 months. At the end of the study there were significant improvements in recession depths and widths and clinical attachment levels and keratinized gingiva width between test and control groups Conclusion. The method using DPG+PRGF resulted in more favorable clinical outcomes than only DPG.

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Evaluation of PRF Efficiency in the Treatment of Infrabony Defects

PRILOZI ◽

10.2478/prilozi-2020-0025 ◽

2020 ◽

Vol 41 (1) ◽

pp. 79-86

Author(s):

Jana Milutinovic ◽

Mirjana Popovska ◽

Biljana Rusevska ◽

Milan Nacevski ◽

Stefan Anastasovski ◽

...

Keyword(s):

Test Group ◽

Control Group ◽

Clinical Parameters ◽

Flap Surgery ◽

Clinical Attachment Level ◽

Positive Effects ◽

Probing Depth ◽

Infrabony Defects ◽

Open Flap Debridement ◽

Attachment Level

AbstractAim: The present study aimed to investigate the effectiveness of PRF in the treatment of infrabony defects in patients with chronic periodontitis by evaluating the clinical outcome through periodontal depth, clinical attachment level at the baseline, 6 and 9 months post operatively.Material and Methods: Sixty infrabony defects with probing depth ≥ 5 mm were treated. The inclusion criterion was the necessity for surgical bilateral maxillary treatment. By using split-mouth study design, each patient had one side treated with conventional flap surgery and the other side with conventional flap surgery and PRF. Clinical parameters, such as probing depth (PD) and clinical attachment lost (CAL), were recorded in both groups at baseline, 6 and 9 months post operatively.Results: Positive effects for all clinical and radiographic parameters were evident in the group with PRF. Mean PD reduction demonstrated statistically significant greater results in the test group (4.00±1.07 mm) compared to the control one (4.83±0.99 mm), p = 0.003 after 9 months postoperatively. After 9 months, there were better results in the test group compared to the control group for CAL (5.60±1.61 mm, 6.20±1.58 mm), but statistically not significant.Conclusion: Additional use of PRF in the conventional surgical treatment of infrabony defects demonstrated better parameters than the open flap debridement alone.

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The treatment of gingival recession with coronally advanced flap with platelet-rich fibrin

Dental Journal (Majalah Kedokteran Gigi) ◽

10.20473/j.djmkg.v52.i1.p8-12 ◽

2019 ◽

Vol 52 (1) ◽

pp. 8

Author(s):

Asti Rosmala Dewi ◽

Agus Susanto ◽

Yanti Rusyanti

Keyword(s):

Platelet Rich Plasma ◽

Test Group ◽

Gingival Recession ◽

Control Group ◽

Clinical Parameters ◽

Clinical Attachment Level ◽

Platelet Rich Fibrin ◽

Coronally Advanced Flap ◽

And Control ◽

Attachment Level

Background: Of the various techniques developed for the treatment of gum recession, the current innovation in the use of platelet rich plasma (PRF) has been applied to the treatment of root-end closure procedures. Purpose: This study analyzed the effect of the coronally advanced flap (CAF) in combination with platelet-rich fibrin (PRF) during treatment of gingival recession. Methods: This research constituted an experimental study incorporating a split-mouth design which was conducted on eight participants (with 16 recession defects) who were divided into two groups consisting of the CAF group with PRF and another CAF group without PRF. Clinical parameters consisting of gingival recession (GR), keratinized gingival width (KGW), recession width (RW) and clinical attachment level (CAL) were measured both before and 21 days after surgery). Results: The average differences between clinical parameters in the test group were as follows: GR (2.25 ± 0.27), KGW (1.81 ± 0.75), RW (3.44 ± 1.35), and CAL (2.56 ± 0.50); while in the control group they were as follows: GR (2.00 ± 0.71), KGW (1.94 ± 0.78), RW (3.50 ± 1.91) and CAL (2.00 ± 0.76). There were significant differences in the GR and CAL between the test and control groups (p ≤ 0.05). Conclusion: A combination of the CAF procedure and PRF was proven to be more effective in covering the GR and increasing the CAL.

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Clinical Evaluation of Intrabony Defects in Localized Aggressive Periodontitis Patients with and without Bioglass- An In-vivo Study

Kathmandu University Medical Journal ◽

10.3126/kumj.v10i1.6906 ◽

2012 ◽

Vol 10 (1) ◽

pp. 7-10

Author(s):

KV Satyanarayana ◽

BR Anuradha ◽

G Srikanth ◽

P Mohan Chandra ◽

T Anupama ◽

...

Keyword(s):

Bioactive Glass ◽

Test Group ◽

Gingival Recession ◽

Aggressive Periodontitis ◽

Control Group ◽

Defect Depth ◽

Clinical Attachment Level ◽

Probing Depth ◽

Localized Aggressive Periodontitis ◽

Attachment Level

Background Aggressive periodontitis is a specific type of periodontitis with clearly identifiable clinical characteristics such as “rapid attachment loss, bone destruction” and “familial aggregation”. Regeneration of mineralized tissues affected by aggressive periodontitis comprises a major scientific and clinical challenge. In recent years some evidence has been provided that bioactive glass is also capable of supporting the regenerative healing of periodontal lesions. Objective The aim of this clinical and radiological prospective study was to evaluate the efficacy of bioactive glass in the treatment of intra-bony defects in patients with localized aggressive periodontitis. Methods Twelve localized aggressive periodontitis patients with bilaterally located three-walled intra-bony defect depth ? 2 mm, preoperative probing depths ? 5 mm were randomly treated either with the bioactive glass or without the bioactive glass. The clinical parameters plaque index, gingival index, probing depth, gingival recession, clinical attachment level, and mobility were recorded prior to surgery as well as 12 months after surgery. Intraoral radiographs were digitized to evaluate the bone defect depth at baseline and 12 months after the surgery. Results After 12 months, a reduction in probing depth of 3.92 + 0.313 mm (P <0.001) and a gain in clinical attachment level of 4.42+0358mm (P <0.001) were registered in the test group. In the control group, a reduction in probing depth of 2.5 +0.230mm (P <0.001) and a gain in clinical attachment level of 2.58 + 0.149 mm (P<0.001) was recorded. Radiographically, the defects were found to be filled by 2.587 + 0.218 mm (P <0.001) in the test group and by 0.1792 + 0.031mm (P <0.001) in the control group. Changes in gingival recession showed no significant differences. . Conclusion Highly significant improvements in the parameters Probing depth, Clinical attachment level, and Bone defect depth were recorded after 12 months, with regenerative material. KATHMANDU UNIVERSITY MEDICAL JOURNAL VOL.10 | NO. 1 | ISSUE 37 | JAN - MAR 2012 | 11-15 DOI: http://dx.doi.org/10.3126/kumj.v10i1.6906

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Clinical and radiographic evaluation of applying 1% metformin biofilm with plasma rich in growth factor (PRGF) for treatment of two-wall intrabony periodontal defects: A randomized clinical trial

Journal of Dental Research Dental Clinics Dental Prospects ◽

10.15171/joddd.2019.008 ◽

2019 ◽

Vol 13 (1) ◽

pp. 51-56

Author(s):

Shabnam Khalifehzadeh ◽

Sina Haghanifar ◽

Niloofar Jenabian ◽

Sohrab Kazemi ◽

Mahmoud Hajiahmadi

Keyword(s):

Clinical Trial ◽

Repeated Measurements ◽

Radiographic Evaluation ◽

Clinical Parameters ◽

Test Results ◽

Clinical Attachment Level ◽

Probing Depth ◽

Digital Subtraction Radiography ◽

Attachment Level ◽

Radiographic Changes

Background. The ultimate aim of periodontal treatment is to regenerate periodontium and regenerative treatment after that. The aim of this study was to evaluate the effect of PRGF with 1% metformin biofilm in the treatment of two-wall intrabony periodontal defects. Methods. In this clinical trial, 8 patients with moderate chronic periodontitis and two-wall intrabony defect were selected. The defects were assigned to 4 groups: debridement, 1% metformin, PRGF, PRGF and metformin. The parameters of vertical probing depth, vertical clinical attachment level and gingival index were measured at baseline, immediately before surgery, and 3 and 6 months after surgery. In addition, the radiographic changes were evaluated with digital subtraction radiography before and 6 months after surgery. Analysis of the results was performed with repeated measurements, Friedman test and chisquared test. Results. All the groups exhibited improvements in all the clinical parameters after 6 months. Inter-group comparison of GI, CAL and PPD parameters revealed no statistically significant differences. Radiographic changes in the group of 1% metformin with PRGF revealed statistically significant differences compared with other groups; however, there were no statistically significant differences in other groups. Conclusion. Application of PRGF with 1% metformin in intrabony two-wall periodontal defects was effective in improving the clinical parameters but this effect revealed no difference compared with other groups; however, in terms of radiographic changes significant improvements were noted.

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Periodontal Outcomes in Liver Transplantation Individuals: A Systematic Review and Meta-analysis

Journal of Gastrointestinal and Liver Diseases ◽

10.15403/jgld-3142 ◽

2021 ◽

Vol 30 (1) ◽

pp. 122-131

Author(s):

Tuélita Marques Galdino ◽

Carla Souza Oliveira ◽

Allyson Nogueira Moreira ◽

Francisco Ivison Rodrigues Limeira ◽

Cláudia Silami Magalhães ◽

...

Keyword(s):

Alveolar Bone ◽

Meta Analysis ◽

Grey Literature ◽

Mean Difference ◽

Control Group ◽

Clinical Attachment Level ◽

Probing Depth ◽

Meta Analyses ◽

And Control ◽

Attachment Level

Aim: To systematically review the literature for observational studies evaluating periodontal outcomes in pre- and post-liver transplant (LT) individuals compared to a control group. Methods: Specific strategies were designed to search five databases and the grey literature. Hand-searches were also performed. The following periodontal outcomes were analyzed in pre-LT, post-LT and control groups: plaque index (PI), gingival index (GI), gingival growth (GO), alveolar bone loss (ABL) probing depth (PD) and clinical attachment level (CAL). Meta-analyses and subgroup analyses were conducted. Results: Among the 257 studies retrieved, 11 studies were included. Four studies were incorporated into the meta-analysis and showed that PI (mean difference=0.15, 95%CI: 0.12-0.18) and GI (mean difference=0.31, 95%CI: 0.06-0.56) were significantly higher in post-LT individuals compared to the control group. There was no significant mean difference of PD (mean difference=0.49, 95%CI: -0.26-1.25) but CAL (mean differ- ence=1.47, 95%CI: 0.19-2.75) were significantly higher in pre-LT individuals compared to the control group. Conclusion: The higher means of PI and GI in post-LT and CAL in pre-LT compared to healthy individuals suggest a relationship between the periodontal condition and the transplantation status.

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Oral application of probiotics in the treatment of peri-implant mucositis

Periodontology ◽

10.33925/1683-3759-2019-24-3-233-235 ◽

2019 ◽

Vol 24 (3) ◽

pp. 233-235

Author(s):

C. R. Ahmedbeyli

Keyword(s):

Test Group ◽

Clinical Effectiveness ◽

Group Differences ◽

Control Group ◽

Gingival Index ◽

Control Groups ◽

Oral Application ◽

Probing Depth ◽

Time Periods ◽

And Control

Relevance: to evaluate the clinical eﬀectiveness of probiotic as an adjunct to professionally administered plaque removal (PAPR) in the treatment of peri-implant mucositis.Materials and methods: 42 patients with at least 2 implants with peri-implant mucositis and probing depth (PD) of 3-4 mm were selected and randomly divided into two groups. Test group received PAPR plus probiotic powder (Enteﬂavin® 4 g), whereas control group received PAPR only. Plaque index (PI), Gingival Index (GI), Bleeding on Probing (BoP), PD were measured at baseline and at days 21, 90, 180 and 360 after treatment.Results: TEST and control groups involved 21 patients with 61 implants and 21 patients with 59 implants, respectively. All clinical parameters were improved in both groups. Inter-group diﬀerences for PI, GI, BoP & PD were found to be statistically signiﬁcant at all time periods after the treatment in favor of test group (p < 0.05).Conclusion: PAPR alone or in combination with probiotic powder revealed clinical improvements in peri-implant mucositis patients. Better results were obtained with the adjunctive administration of probiotic. Probiotic therapy may be useful for the prevention and treatment of peri-implant mucositis.

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Influence of abutment material on peri-implant clinical parameters: a prospective study

Brazilian Dental Science ◽

10.14295/bds.2014.v17i3.972 ◽

2014 ◽

Vol 17 (3) ◽

pp. 19 ◽

Cited By ~ 1

Author(s):

Fabiano Cortez Zanardo ◽

José Della Pasqua Neto ◽

Luiz Henrique Alves Madeira ◽

Jamil Awad Shibli ◽

Keize Távora Barbosa ◽

...

Keyword(s):

Test Group ◽

Control Group ◽

Clinical Parameters ◽

Probing Depth ◽

Single Tooth ◽

Custom Made ◽

A Prospective Study ◽

Clinical Measures ◽

Short Time ◽

And Control

Objective: This study evaluated the peri-implant clinical parameters of zirconia versus metallic abutments for standardized custom-made implantsupported single-tooth restorations. Material and Methods: Sixteen subjects received 30 dental implants on esthetic region of upper jaws. Test group had 14 implant-supported single-tooth restorations with ceramic abutment and control group had 16 restorations with metallic abutment. Peri-implant clinical parameters were recorded after 110 ± 10 days in function at six sites by each implant, in each subject. The means of clinical measures: probing depth (PD) and clinical attachment level (CAL); mean of percentages of sites with visible plaque (VP), bleeding on probing (BOP) and suppuration (SU) were recorded to each subject. To verify differences between groups Mann Whitney U-test was selected PD and CAL and k-light test VP, BOP and SU. Results: One zirconia implant-supported single-tooth restoration fractured at insertion time. The mean of PD, CAL, and BOP of the samples sites were lower to test group than control (p < 0.05). There were no differences of mean levels of VP and S between test and control group (p > 0.05). Conclusion: Clinical parameters around implant-supported restorations were influenced by abutment type with better results to zirconia abutments, at least, after short time period evaluation.

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Effects of Virgin Coconut Oil as Adjunct Therapy in the Treatment of Allergic Rhinitis

Journal of Clinical and Health Sciences ◽

10.24191/jchs.v1i1.5850 ◽

2016 ◽

Vol 1 (1) ◽

pp. 22

Author(s):

Nazli Zainuddin ◽

Nurul Azira Mohd Shah ◽

Rosdan Salim

Keyword(s):

Allergic Rhinitis ◽

Side Effects ◽

Coconut Oil ◽

Test Group ◽

Nasal Symptom ◽

Control Group ◽

Virgin Coconut Oil ◽

Control Groups ◽

Significant Difference ◽

And Control

Introduction: The role of virgin coconut oil in the treatment of allergic rhinitis is controversial. Thus, the aim of the present study is to determine the effects of virgin coconut oil ingestion, in addition to standard medications, on allergic rhinitis. We also studied the side effects of consumption of virgin coconut oil. Methods: Fifty two subjects were equally divided into test and control groups. All subjects received a daily dose of 10mg of loratadine for 28 days. The test group was given 10ml of virgin coconut oil three times a day in addition to loratadine. The symptoms of allergic rhinitis were scored at the beginning and end of the study. Results:, the symptom score were divided into nasal and non-nasal symptom scores. Sneezing score showed a significant difference, however the score was more in control group than test group, indicating that improvement in symptom was more in control group. The rest of the nasal symptom and non-nasal symptom score showed no significant difference between test and control groups. Approximately 58% of the test subjects developed side effects from consumption of virgin coconut oil, mainly gastrointestinal side effects. Conclusion: In the present study, ingestion of virgin coconut oil does not improve the overall and individual symptoms of allergic rhinitis, furthermore it has side effects.

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Clinical and Immunological Efficacy of Mangosteen and Propolis Extracted Complex in Patients with Gingivitis: A Multi-Centered Randomized Controlled Clinical Trial

Nutrients ◽

10.3390/nu13082604 ◽

2021 ◽

Vol 13 (8) ◽

pp. 2604

Author(s):

Jin-Young Park ◽

Kyung-A Ko ◽

Ji-Yeong Lee ◽

Jae-Woon Oh ◽

Hyun-Chang Lim ◽

...

Keyword(s):

Patient Reported Outcomes ◽

Daily Intake ◽

Test Group ◽

Control Group ◽

Controlled Clinical Trial ◽

Control Groups ◽

Immunological Parameters ◽

Significant Difference ◽

Patient Reported ◽

And Control

Background: Mangosteen and propolis extracts (MAEC) have been potential therapeutic agents known to exhibit powerful antioxidant and anti-inflammatory properties. The aim of the current study was to evaluate the clinical and immunological efficacy of MAEC as well as safety and patient-reported outcomes (PROMs) on gingivitis and incipient periodontitis. Methods: This study was performed on 104 patients diagnosed with gingivitis or incipient periodontitis. At baseline, the participants were randomly allocated to either the test group, with daily intake of a single capsule containing 194 mg of MAEC for eight weeks, or control group, with placebo. Clinical periodontal evaluation and immunological parameters from saliva and gingival sulcular fluid were assessed at baseline, four, and eight weeks. Individual PROMs were assessed by OHIP-14 questionnaires. Results: There was a significant difference of modified gingival index at four and eight weeks between the test and control groups. In the test group, crevicular interleukin (IL)-6 was reduced, and the salivary matrix metalloproteinase (MMP)-9 was increased after eight weeks. PROMs were improved up to four weeks compared to placebo. Conclusion: Oral administration of MAEC would have a potential to reduce gingival inflammation clinically and immunologically in the patients with gingivitis and incipient periodontitis.

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Adjunctive air-polishing with erythritol in nonsurgical periodontal therapy: a randomized clinical trial

BMC Oral Health ◽

10.1186/s12903-020-01363-5 ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

Holger F. R. Jentsch ◽

Christian Flechsig ◽

Benjamin Kette ◽

Sigrun Eick

Keyword(s):

Test Group ◽

Nonparametric Tests ◽

Periodontal Therapy ◽

Periodontal Pocket ◽

Control Group ◽

Clinical Variables ◽

Air Polishing ◽

Probing Depth ◽

Nonsurgical Periodontal Therapy ◽

Attachment Level

Abstract Background This study was aimed to investigate if the adjunctive use of erythritol air-polishing powder applied with the nozzle-system during subgingival instrumentation (SI) has an effect on the outcome of non-surgical periodontal treatment in patients with moderate to severe periodontitis. Methods Fourty-two individuals with periodontitis received nonsurgical periodontal therapy by SI without (controls, n = 21) and with adjunctive air-polishing using nozzle + erythritol powder (test, n = 21). They were analyzed for the clinical variables BOP (primary outcome at six months), probing depth (PD), attachment level, four selected microorganisms and two biomarkers at baseline, before SI as well as three and six months after SI. Statistical analysis included nonparametric tests for intra- and intergroup comparisons. Results In both groups, the clinical variables PD, attachment level and BOP significantly improved three and six months after SI. The number of sites with PD ≥ 5 mm was significantly lower in the test group than in the control group after six months. At six months versus baseline, there were significant reductions of Tannerella forsythia and Treponema denticola counts as well as lower levels of MMP-8 in the test group. Conclusions Subgingival instrumentation with adjunctive erythritol air-polishing powder does not reduce BOP. But it may add beneficial effects like reducing the probing depth measured as number of residual periodontal pocket with PD ≥ 5 mm when compared with subgingival instrumentation only. Clinical relevance The adjunctive use of erythritol air-polishing powder applied with the nozzle-system during SI may improve the clinical outcome of SI and may reduce the need for periodontal surgery. Trial registration The study was retrospectively registered in the German register of clinical trials, DRKS00015239 on 6th August 2018, https://www.drks.de/drks_web/navigate.do?navigationId=trial.HTML&TRIAL.

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