Features of the physical development, calcium-phosphorus metabolism and mineral density of the bones in children with chronic lung diseases

Introduction. Unfavourable factors of the working environment affect bone tissue, increasing the risk of developing osteoporosis in workers of harmful industries, which is an urgent social and hygienic problem due to the high prevalence and severity of medical and social consequences. The aim of the study was to investigate the impact of industrial vibration and physical overload on the markers of bone metabolism in industrial workers. Materials and methods. One hundred fifty-two employees of mining and mechanical engineering enterprises in contact with industrial vibration and physical overload were examined. The assessment of bone tissue metabolism in the workers was carried out by the method of solid-phase enzyme immunoassay to determine biochemical markers of bone metabolism: bone alkaline phosphatase, osteocalcin, C-terminal serum telopeptide, cathepsin K, as well as indicators of calcium-phosphorus metabolism. X-ray densitometry was used to assess bone mineral density. Results. There was a significant decrease in the markers of osteogenesis: the concentration of CSF (14.26 ± 4.13 and 18.69±5.28, respectively, p< 0.05) and osteocalcin (12.23±4.15 and 17.84±5.17, respectively, p < 0.05) and an increase in the markers of bone resorption: the level of beta-CrossLaps (0.629±0.162 and 0.361±0.095, respectively, p = 0.002) and the level of cathepsin K (12.49±5.28 and 0.59±0.02, respectively, p < 0.001) in workers of industrial enterprises exposed to physical factors of production. The correlation between the markers of bone metabolism and the experience of exposure to adverse working conditions was established. Conclusion. Combined exposure to physical labour factors is a predictor of calcium-phosphorus metabolism and bone metabolism disorders, increasing the risk of metabolic osteopathy in industrial workers.

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The investigation of changes of indexes of calcium metabolism in rats with decreased function of thyroid gland under the influence of physical loading

Bukovinian Medical Herald ◽

10.24061/2413-0737.xviii.3.71.2014.148 ◽

2014 ◽

Vol 18 (3 (71)) ◽

Author(s):

N. G. Pobigun

Keyword(s):

Bone Mineral Density ◽

Thyroid Gland ◽

Calcium Metabolism ◽

Inorganic Phosphorus ◽

Phosphorus Metabolism ◽

Mineral Density ◽

Thyroid Status ◽

Greater Trochanter ◽

Physical Loading ◽

Calcium Phosphorus

The changes of indexes of calcium-phosphorus metabolism and data of densitometry of bone tissue in experimental hypofunction of thyroid gland in conditions of action of physical loading have been revealed. In these conditions worsening of thyroid status was accompanied by the increase of content of inorganic phosphorus and albumins in blood serum on the background of increase of bone mineral density in the area of greater trochanter of femurs in comparison with the similar indexes in animals with hypothyroid dysfunction.

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DYNAMICS OF CHANGES IN THE SERUM MINERAL METABOLISM OF YOUNG PEOPLE WITH GENERALIZED PERIODONTITIS ON THE BACKGROUND OF PRIMARY HYPOTHYROIDISM

Актуальні проблеми сучасної медицини Вісник Української медичної стоматологічної академії ◽

10.31718/2077-1096.21.1.81 ◽

2021 ◽

Vol 21 (1) ◽

pp. 81-84

Author(s):

O.M. Repetska ◽

M.M. Rozhko ◽

T.M. Dmytryshyn ◽

A.B. Kostyshyn

Keyword(s):

Young People ◽

Thyroid Hormones ◽

Bone Metabolism ◽

Bone Tissue ◽

Primary Hypothyroidism ◽

The Body ◽

Phosphorus Metabolism ◽

Mineral Density ◽

Periodontal Tissues ◽

Calcium Phosphorus

At present, there is no definitive opinion on the effect of thyroid hormones on bone metabolism, as the dualism of their effects has been proven. Various studies show mixed data on metabolic changes in periodontal tissues on the background of thyroid dysfunction. Bone tissue plays a key role in the complex system of mechanisms of regulation of calcium and phosphorus homeostasis in the body. The processes of modeling and remodeling of bone and its mineralization are closely related to calcium metabolism. The biochemical manifestation of osteoporotic processes in the cell bone in generalized periodontitis is a violation of calcium-phosphorus homeostasis on the background of altered markers of bone metabolism. According to the literature, it is known that the main indicator of calcium-phosphorus metabolism is the content of calcium in the serum. However, for the metabolic characteristics of the inflammatory-dystrophic process in the cell bone, it is necessary to study the level of inorganic phosphorus and calculate the molar ratio of calcium / phosphorus. The calcium / phosphorus ratio in the blood is important for the study of calcium deposits in bone tissue. Maintenance of normal bone structure depends on the exchange of phosphates between blood and bone tissue. Magnesium along with calcium is needed to achieve optimal bone mineral density. Magnesium helps maintain normal levels of calcium in bone tissue, its constant renewal in bone, prevents calcium loss. With limited intake of magnesium, the formation of calcium phosphate is inhibited. In order to establish indicators that would reflect the peculiarities of metabolic disorders in the organic matrix of the cell process, which is the main component of the periodontium, we conducted biochemical studies, which included the study of calcium-phosphorus metabolism and serum magnesium in patients with primary hypothyroidism and persons without endocrine pathology. According to the results of studies, in young people with generalized periodontitis on the background of reduced thyroid function, there were violations of calcium-phosphorus metabolism in the serum, which consisted of hypocalcemia and decreased calcium-phosphorus ratio. This may indicate abnormalities in calcium intake and absorption in patients with hypothyroidism. We attribute this fact to the fact that for the normal absorption and metabolism of calcium, thyroid hormones are needed, the production of which is reduced in this endocrine pathology. Data on the negative changes of calcium-phosphorus homeostasis, and especially the violation of calcium absorption by patients with generalized periodontitis in young people with primary hypothyroidism, should be considered when developing schemes for the treatment and prevention of periodontal disease in this category of patients.

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PROGRAMMING OF SKELETAL DEVELOPMENT IN CHILDREN: THE ROLE OF VITAMIN D

Osteoporosis and Bone Diseases ◽

10.14341/osteo2014331-33 ◽

2014 ◽

Vol 17 (3) ◽

pp. 31-33

Author(s):

L A Scheplyagina

Keyword(s):

Bone Mineral Density ◽

Vitamin D ◽

Vitamin D Deficiency ◽

Bone Mineral ◽

Skeletal Development ◽

Phosphorus Metabolism ◽

Mineral Density ◽

Working Age ◽

Calcium Phosphorus

Well known that the lack of vitamin D in mother leads to its deficiency in the fetus. Vitamin D deficiency in the fetus significantly increases the risk of disorders of calcium/phosphorus metabolism, decreases of size of ante - and postnatal skeleton of the child, and affects the child ’s growth, bone mineral density and increases the risk of fractures in working age.

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Abstract #1017 Parathyroid Function in Hyperthyroidism in Relation to Calcium-Phosphorus Metabolism

Endocrine Practice ◽

10.1016/s1530-891x(20)47384-7 ◽

2018 ◽

Vol 24 ◽

pp. 226-227

Author(s):

Ayotunde Ale ◽

Olatunbosum Olawale ◽

Onyido Okwuchi ◽

Sunday Ogundele ◽

Anthonia Ogbera

Keyword(s):

Phosphorus Metabolism ◽

Parathyroid Function ◽

Calcium Phosphorus

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Lung Function and Quality of Life in Workers with Chemical and Dust Exposure

Revista de Chimie ◽

10.37358/rc.18.2.6104 ◽

2018 ◽

Vol 69 (2) ◽

pp. 346-349 ◽

Cited By ~ 1

Author(s):

Marina Ruxandra Otelea ◽

Oana Cristina Arghir ◽

Corina Zugravu ◽

Eugenia Naghi ◽

Sabina Antoniu ◽

...

Keyword(s):

Quality Of Life ◽

Occupational Exposure ◽

Lung Function ◽

Lung Diseases ◽

Dust Exposure ◽

Chronic Lung Diseases ◽

Respiratory Exposure ◽

Increased Risk ◽

Occupational Settings

Regarding the widely distribution of respiratory exposure hazards in occupational settings, workers have an increased risk for chronic lung diseases. For assessing the quality of life and lung function in workers exposed to chemicals and dust, St George�s Respiratory Questionnaire (SGRQ) and spirometry were performed among 40 patients, admitted in Occupational Clinic Department of Colentina Hospital, Bucharest, Romania, during February, 2017. SGRQ showed different predictors for patients according to their occupational exposure and total symptoms score correlated better with decreased spirometric parameters in defining lung function deterioration. Quality of life is earlier affected than lung function deterioration and emphasises the need of more sensitive methods for an earlier identification and better evaluation of respiratory hazards in different workplaces.

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Low serum vitamin B12 levels are associated with degenerative rotator cuff tear

BMC Musculoskeletal Disorders ◽

10.1186/s12891-021-04231-7 ◽

2021 ◽

Vol 22 (1) ◽

Author(s):

Jae Hwa Kim ◽

Go-Tak Kim ◽

Siyeoung Yoon ◽

Hyun Il Lee ◽

Kyung Rae Ko ◽

...

Keyword(s):

Logistic Regression ◽

Rotator Cuff ◽

Univariate Analysis ◽

Serum Vitamin ◽

Serum Levels ◽

Control Group ◽

Mineral Density ◽

Calcium Phosphorus ◽

Healthy Control ◽

Low Serum

Abstract Background Vitamin B12 (Vit B12) deficiency results in elevated homocysteine levels and interference with collagen cross-linking, which may affect tendon integrity. The purpose of this study was to investigate whether serum Vit B12 levels were correlated with degenerative rotator cuff (RC) tear. Methods Eighty-seven consecutive patients with or without degenerative RC tear were enrolled as study participants. Possible risk factors (age, sex, medical history, bone mineral density, and serum chemistries including glucose, magnesium, calcium, phosphorus, zinc, homocysteine, Vitamin D, Vit B12, homocysteine, and folate) were assessed. Significant variables were selected based on the results of univariate analyses, and a logistic regression model (backward elimination) was constructed to predict the presence of degenerative RC tear. Results In the univariate analysis, the group of patients with degenerative RC tear had a mean concentration of 528.4 pg/mL Vit B12, which was significantly lower than the healthy control group (627.1 pg/mL). Logistic regression analysis using Vit B12 as an independent variable revealed that Vit B12 concentrations were significantly correlated with degenerative RC tear (p = 0.044). However, Vit B12 levels were not associated with tear size. Conclusion Low serum levels of Vit B12 were independently related to degenerative RC tear. Further investigations are warranted to determine if Vit B12 supplementation can decrease the risk of this condition.

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