scholarly journals The impact of harmful occupational risk factors on the markers of bone metabolism in industrial workers

2021 ◽  
Vol 100 (9) ◽  
pp. 964-968
Author(s):  
Kristina V. Klimkina ◽  
Inna V. Lapko
Keyword(s):  
Bone Metabolism ◽  
Bone Tissue ◽  
Cathepsin K ◽  
Phosphorus Metabolism ◽  
Industrial Workers ◽  
Mineral Density ◽  
Occupational Risk Factors ◽  
Industrial Enterprises ◽  
Calcium Phosphorus ◽  
The Impact

Introduction. Unfavourable factors of the working environment affect bone tissue, increasing the risk of developing osteoporosis in workers of harmful industries, which is an urgent social and hygienic problem due to the high prevalence and severity of medical and social consequences. The aim of the study was to investigate the impact of industrial vibration and physical overload on the markers of bone metabolism in industrial workers. Materials and methods. One hundred fifty-two employees of mining and mechanical engineering enterprises in contact with industrial vibration and physical overload were examined. The assessment of bone tissue metabolism in the workers was carried out by the method of solid-phase enzyme immunoassay to determine biochemical markers of bone metabolism: bone alkaline phosphatase, osteocalcin, C-terminal serum telopeptide, cathepsin K, as well as indicators of calcium-phosphorus metabolism. X-ray densitometry was used to assess bone mineral density. Results. There was a significant decrease in the markers of osteogenesis: the concentration of CSF (14.26 ± 4.13 and 18.69±5.28, respectively, p< 0.05) and osteocalcin (12.23±4.15 and 17.84±5.17, respectively, p < 0.05) and an increase in the markers of bone resorption: the level of beta-CrossLaps (0.629±0.162 and 0.361±0.095, respectively, p = 0.002) and the level of cathepsin K (12.49±5.28 and 0.59±0.02, respectively, p < 0.001) in workers of industrial enterprises exposed to physical factors of production. The correlation between the markers of bone metabolism and the experience of exposure to adverse working conditions was established. Conclusion. Combined exposure to physical labour factors is a predictor of calcium-phosphorus metabolism and bone metabolism disorders, increasing the risk of metabolic osteopathy in industrial workers.

scholarly journals DYNAMICS OF CHANGES IN THE SERUM MINERAL METABOLISM OF YOUNG PEOPLE WITH GENERALIZED PERIODONTITIS ON THE BACKGROUND OF PRIMARY HYPOTHYROIDISM

2021 ◽  
Vol 21 (1) ◽  
pp. 81-84
Author(s):  
O.M. Repetska ◽  
M.M. Rozhko ◽  
T.M. Dmytryshyn ◽  
A.B. Kostyshyn
Keyword(s):  
Young People ◽  
Thyroid Hormones ◽  
Bone Metabolism ◽  
Bone Tissue ◽  
Primary Hypothyroidism ◽  
The Body ◽  
Phosphorus Metabolism ◽  
Mineral Density ◽  
Periodontal Tissues ◽  
Calcium Phosphorus

At present, there is no definitive opinion on the effect of thyroid hormones on bone metabolism, as the dualism of their effects has been proven. Various studies show mixed data on metabolic changes in periodontal tissues on the background of thyroid dysfunction. Bone tissue plays a key role in the complex system of mechanisms of regulation of calcium and phosphorus homeostasis in the body. The processes of modeling and remodeling of bone and its mineralization are closely related to calcium metabolism. The biochemical manifestation of osteoporotic processes in the cell bone in generalized periodontitis is a violation of calcium-phosphorus homeostasis on the background of altered markers of bone metabolism. According to the literature, it is known that the main indicator of calcium-phosphorus metabolism is the content of calcium in the serum. However, for the metabolic characteristics of the inflammatory-dystrophic process in the cell bone, it is necessary to study the level of inorganic phosphorus and calculate the molar ratio of calcium / phosphorus. The calcium / phosphorus ratio in the blood is important for the study of calcium deposits in bone tissue. Maintenance of normal bone structure depends on the exchange of phosphates between blood and bone tissue. Magnesium along with calcium is needed to achieve optimal bone mineral density. Magnesium helps maintain normal levels of calcium in bone tissue, its constant renewal in bone, prevents calcium loss. With limited intake of magnesium, the formation of calcium phosphate is inhibited. In order to establish indicators that would reflect the peculiarities of metabolic disorders in the organic matrix of the cell process, which is the main component of the periodontium, we conducted biochemical studies, which included the study of calcium-phosphorus metabolism and serum magnesium in patients with primary hypothyroidism and persons without endocrine pathology. According to the results of studies, in young people with generalized periodontitis on the background of reduced thyroid function, there were violations of calcium-phosphorus metabolism in the serum, which consisted of hypocalcemia and decreased calcium-phosphorus ratio. This may indicate abnormalities in calcium intake and absorption in patients with hypothyroidism. We attribute this fact to the fact that for the normal absorption and metabolism of calcium, thyroid hormones are needed, the production of which is reduced in this endocrine pathology. Data on the negative changes of calcium-phosphorus homeostasis, and especially the violation of calcium absorption by patients with generalized periodontitis in young people with primary hypothyroidism, should be considered when developing schemes for the treatment and prevention of periodontal disease in this category of patients.

Results of study of biochemical markers of bone metabolism in men with coronary heart disease

2020 ◽  
pp. 39-43
Author(s):  
A. V. Voronkina ◽  
T. A. Raskina ◽  
M. V. Letaeva ◽  
Yu. V. Averkieva ◽  
O. S. Malyshenko ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Bone Formation ◽  
Bone Metabolism ◽  
Biochemical Markers ◽  
Coronary Atherosclerosis ◽  
Cathepsin K ◽  
Arterial Calcification ◽  
Mineral Density ◽  
Bone Remodeling Markers

The development of atherosclerosis is closely related to the calcification of the vessel intima and fibrous plaques, being a complex and multifactorial process, in which the markers of bone formation and resorption play an important role. Objective. To study the biochemical markers of bone metabolism in men with stable coronary heart disease (CHD). Material and methods. The study included 102 men with verified CHD. Data were evaluated by densitometry, coronary angiography, multispiral computed tomography, color duplex scanning of brachiocephalic arteries, serum lipids (total cholesterol, triglycerides [TG], high-density [LHD] and low-density lipoprotein cholesterol), concentrationsin the blood of osteocalcin (OC), bone alkaline phosphatase (BAP), cathepsin K and C-telopeptides (CTx). Results. Concentrations of BAP, cathepsin K and CTx in patients with CHD were significantly higher than in men without CHD. The concentration of OC in men with normal bone mineral density was significantly lower than in patients with osteopenic syndrome. There was a direct correlation between OC and antiatherogenic HDL cholesterol and the inverse correlation between OC and TG, CTx and TG. There was no correlation between the level of bone remodeling markers and coronary artery (CA) lesion variant and the severity of coronary atherosclerosis on SYNTAX scale. The correlation analysis did not reveal the connection of biochemical markers of bone metabolism with the severity of coronary atherosclerosis and calcification and thickness of intima-media complex of carotid arteries. Absolute values of bone formation indices (BAP, OC) were significantly higher in patients with severe СA calcification than in patients without signs of calcification. Summary. Increased rates of osteogenesis and osteoresorption characterize the accelerated process of bone metabolism and indicate in favor of high rates of bone loss in men with CHD, which confirms the likelihood of common pathophysiological mechanisms of bone resorption and arterial calcification.

scholarly journals Impact of Monthly 120 Mg Denosumab on Bone Metabolism in Bone-metastatic Prostate Cancer Undergoing Androgen Deprivation Therapy

2017 ◽  
Vol 2 (3) ◽  
pp. 41-46
Author(s):  
Jimpei Miyakawa ◽  
Satoru Taguchi ◽  
Motofumi Suzuki ◽  
Kaori Endo ◽  
Yorito Nose ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Lumbar Spine ◽  
Femoral Neck ◽  
Bone Metabolism ◽  
Androgen Deprivation Therapy ◽  
Metastatic Prostate Cancer ◽  
Androgen Deprivation ◽  
Mineral Density ◽  
Bone Metabolism Markers ◽  
The Impact

Background: While semiannual 60 mg denosumab is a common treatment for osteoporosis, impact of monthly 120 mg denosumab, the common treatment protocol for bone metastases from solid tumors, on bone metabolism is unclear.Materials and Methods: We reviewed 15 patients with bone-metastatic prostate cancer who initiated monthly 120 mg denosumab in conjunction with androgen deprivation therapy between 2013 and 2014. Bone mineral density (BMD) was measured at lumbar spine and femoral neck using dual energy X-ray absorptiometry (DXA), before treatment and annually thereafter. Bone metabolism markers, including urine N-terminal telopeptide (uNTx) and bone type alkaline phosphatase (BAP), were monitored monthly.Results: Twelve of 15 (80%) patients had evaluable DXA before treatment, and of them, eight underwent DXA after a year of initiation without discontinuation of denosumab. Percent changes in BMD from baseline were +6.2% at lumbar spine and +7.6% at femoral neck, both of which were significant increases (both P<0.01). Bone metabolism markers were evaluable in 11 (73%) patients: uNTx decreased rapidly, while BAP declined gradually after initiating denosumab. These effects were similar to those seen by the standardized dose for osteoporosis in previous literature. There were no denosumab-related severe adverse events during the follow-up period. Conclusions: The impact of monthly 120 mg denosumab on bone metabolism was significant, but almost equivalent to that of the standard dose for osteoporosis (60mg semiannually) in bone-metastatic prostate cancer undergoing androgen deprivation therapy. Whereas the higher dose has reportedly reduced skeleton-related events, the effect on bone metabolism seemed plateaued or showed no dose-dependency.

scholarly journals Relationships Between Thyroid Hormones, Insulin-Like Growth Factor-1 and Antioxidant Levels in Hypothalamic Amenorrhea and Impact on Bone Metabolism

2019 ◽  
Vol 51 (05) ◽  
pp. 302-308
Author(s):  
Antonio Mancini ◽  
Edoardo Vergani ◽  
Carmine Bruno ◽  
Angelina Barini ◽  
Andrea Silvestrini ◽  
...  
Keyword(s):  
Bone Turnover ◽  
Bone Metabolism ◽  
Bone Alkaline Phosphatase ◽  
Antioxidant Systems ◽  
Special Focus ◽  
Mineral Density ◽  
Hypothalamic Amenorrhea ◽  
Low T3 ◽  
Group A ◽  
The Impact

AbstractReduced bone mineral density (BMD) in Functional Hypothalamic Amenorrhea (FHA) is mainly related to hypoestrogenism, but other hormonal derangement (reduced conversion of T4–T3 and GH resistance) can play a role. These hormones are involved in antioxidant systems regulation. We evaluated the impact of hormonal alterations, with special focus on low T3 and IGF-1 levels, on antioxidant systems as a link with osteoporosis in FHA. Forty-three FHA patients, 15–34 years, with BMI range 17.3–23.4 kg/m2, were divided in 2 groups according to fT3 levels; group A (n=22), low fT3 (<2.4 pg/ml) and group B (n=21), normal fT3 (≥ 2.4 pg/ml). We evaluated hormonal parameters (fT3, fT4, TSH, IGF-1, FSH, LH, estradiol, DHEAS, testosterone, cortisol), bone metabolism (calcium, phosphorus, 25-OH Vitamin D, PTH, β-crosslaps, bone alkaline phosphatase) and total antioxidant capacity (TAC), expressed as LAG (latency time in radical species appearance using spectrophotometric method). BMD was assessed by DEXA. Group A patients exhibited significantly lower levels of IGF-1 (159.76±14.79 vs. 220.05±15.25 ng/ml) and osteocalcin (17.51±1.14 vs. 21.49±1.56 ng/ml); LAG values were significantly higher in A (66.33±1.74 s) vs. B (54.62±1.74 s). A significant direct correlation was found between both IGF-1 and fT3 with osteocalcin (r²=0.22, p=0.0049 and r²=0.34, p=0.0001, respectively). No difference in LAG between groups according to IGF-1 were found. These data show a correlation between altered bone turnover and low fT3, which is highly prevalent in FHA. Low fT3 levels may contribute to reduced BMD. Oxidative stress could be the link underlying different bone turnover pattern and endocrine dysfunction in FHA.

scholarly journals Well-being, mood and calcium homeostasis in patients with hypoparathyroidism receiving standard treatment with calcium and vitamin D

2002 ◽  
pp. 215-222 ◽  
Author(s):  
W Arlt ◽  
C Fremerey ◽  
F Callies ◽  
M Reincke ◽  
P Schneider ◽  
...  
Keyword(s):  
Vitamin D ◽  
Standard Treatment ◽  
Treatment Options ◽  
Well Being ◽  
Controlled Study ◽  
Mineral Density ◽  
Current Standard ◽  
Cross Sectional ◽  
Calcium Phosphorus ◽  
The Impact

OBJECTIVE: Standard treatment in hypoparathyroidism consists of calcium and vitamin D (or vitamin D analogs) but does not employ replacement of the actual missing hormone. Only few studies have evaluated the efficacy of calcium/vitamin D treatment in hypoparathyroidism; the impact of chronic hypoparathyroid disease on well-being has not been investigated previously. DESIGN: Cross-sectional, controlled study in 25 unselected women with postsurgical hypoparathyroidism since 6.4plus minus8.0 years (s.d.) on stable treatment with calcium and vitamin D (or analogs) and in 25 controls with a history of thyroid surgery but intact parathyroid function, who were matched for sex, age and time since surgery. METHODS: Assessment of well-being and mood using validated questionnaires (the revised version Symptom Checklist 90 (SCL-90-R); the Giessen Complaint List (GBB-24); and the von Zerssen Symptom List (B-L Zerssen)), serum and urinary calcium/phosphorus homeostasis, and in the hypoparathyroid patients also screening for secondary disease by kidney ultrasound, ophthalmological split lamp examination, and measurement of bone mineral density. RESULTS: Serum calcium was in the accepted therapeutic range in the majority of hypoparathyroid patients. However, calcium/phosphorus homeostasis as a whole was clearly non-physiological. Nephrolithiasis was detected in 2 and cataracts in 11 of 25 hypoparathyroid patients. As compared with controls, hypoparathyroid patients had significantly higher global complaint scores in GBB-24 (P=0.036), B-L Zerssen (P=0.002) and SCL-90-R (P=0.020) with predominant increases in the subscale scores for anxiety, phobic anxiety and their physical equivalents. CONCLUSIONS: Current standard treatment in hypoparathyroidism is not only associated with an altered calcium/phosphorus homeostasis but also fails to restore well-being in these patients. Future studies need to address the impact of more physiological treatment options like parathyroid hormone(1-34) or parathyroid transplantation on well-being and mood in these patients.

scholarly journals Osteoporosis and antithrombotic therapy

2021 ◽  
Vol 26 (5) ◽  
pp. 4173
Author(s):  
N. V. Brailova ◽  
E. N. Dudinskaya ◽  
V. A. Kuznesova ◽  
O. N. Tkacheva
Keyword(s):  
Bone Mineral Density ◽  
Bone Metabolism ◽  
Bone Tissue ◽  
Bone Mineral ◽  
Vitamin K Antagonists ◽  
Oral Anticoagulants ◽  
Direct Oral Anticoagulants ◽  
Antiplatelet Agents ◽  
Mineral Density ◽  
Negative Effect

Anticoagulant and antiplatelet agents are used to prevent stroke and thromboembolic events. There is insufficient data on the effect of these drugs on bone tissue. In addition, the available data are ambiguous, which increases suspicion when used in individuals at high risk of osteoporosis. The article provides data on the effect of anticoagulant and antiplatelet agents on bone metabolism, bone mineral density and the fracture risk. Literature data indicate a negative effect of heparin on bone tissue, which is increase the risk of fractures. Low molecular weight heparins has lower effect on bone tissue than heparin. It is known that vitamin K antagonists significantly affect bone metabolism and markers of bone formation, however, data on the effect on bone mineral density and the risk of fractures are contradictory. Direct oral anticoagulants are relatively safe in relation to bone tissue. Data on the effects of antiplatelet drugs on bone are ambiguous.

Features of the structural and functional state of bone tissue in patients with generalized periodontitis who live in different anthropogenically loaded areas

2020 ◽  
Vol 33 (2) ◽  
Author(s):  
Khrystyna Kovalyshyn ◽  
Mykola Rozhko
Keyword(s):  
Rheumatoid Arthritis ◽  
Bone Metabolism ◽  
Bone Tissue ◽  
Functional State ◽  
Mineral Density ◽  
Tissue Mineral Density ◽  
Degree Of Severity

Introduction. A research was conducted of the features of the structural and functional state of bone tissue in patients with generalized periodontitis with rheumatoid arthritis who live in different anthropogenically loaded areas. Aim. The aim of the research is to assess the bone tissue mineral density according to the indicators of densitometric researches and the level of a marker of bone metabolism in generalized periodontitis of I and II degree of severity. Material and methods. We examined 105 patients with GP of the I and II degree of severity, among whom were patients with rheumatoid arthritis who live in environmentally favorable and unfavorable areas. Peculiarities of the structural and functional state of bone tissue were assessed using an ultrasonic densitometer Sunlight Mini Omni TM and the level of a marker of bone tissue resorption of deoxypyridinoline in urine. Results. Patients with generalized periodontitis with rheumatoid arthritis who live in environmentally unfavorable areas, found the largest number of people with signs of osteopenia, osteoporosis and elevated levels of deoxypyridinoline. In particular, in generalized periodontitis of the II degree of severity with osteopenia – 14 people (48.27%), with osteoporosis – 9 people (31%), the level of deoxypyridinoline determined in women was 12.03 ± 0.16 n/mol, which in 2.2 times significantly higher than the group of healthy (p < 0.001). Conclusions. According to densitometric parameters and the level of deoxypyridinoline in the urine, the acceleration of bone tissue resorption in patients with generalized periodontitis of the II degree of severity with rheumatoid arthritis who live in environmentally unfavorable areas was established.

Hormonal and metabolic peculiarities of occupational lumbosacral radiculopathy

2019 ◽  
pp. 15-18
Author(s):  
I. V. Lapko ◽  
V. A. Kiryakov
Keyword(s):  
Bone Metabolism ◽  
Bone Tissue ◽  
Mineral Density ◽  
Lumbosacral Radiculopathy

The study presented describes formation of osteopenic syndrome in workers exposed to physical overexertion and general vibration that is associated with changes in bone metabolism and in mineral density of bone tissue. The data obtained prove bone metabolism to be influenced by pituitary and thyroid system hormones in patients with occupational lumbosacral radiculopathy.

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