Acceptability of a Dapivirine Gel Administered Rectally to HIV-1 Seronegative Adults (MTN-033 Study)

2021 ◽  
Vol 33 (5) ◽  
pp. 361-376
Author(s):  
José A. Bauermeister ◽  
Ryan C. Tingler ◽  
Sherri Johnson ◽  
Nicole Macagna ◽  
Jonathan Lucas ◽  
...  
Keyword(s):  
Hiv Prevention ◽  
Phase I ◽  
Phase I Trial ◽  
Prevention Strategies ◽  
Delivery Methods ◽  
Biomedical Hiv Prevention ◽  
Hiv Prevention Strategies ◽  
Sex With Men ◽  
Rectal Microbicide ◽  
Hiv 1

We triangulated quantitative and qualitative assessments to evaluate participants’ acceptability of 0.05% dapivirine rectal microbicide (RM) gel administered via two separate modalities (a rectal applicator and an artificial phallus for use as a coital simulation device) as part of a Phase I trial (N = 14) among men who have sex with men (MSM) randomized using a 1:1 ratio. Overall, participants reported favorable acceptability of the gel (n = 11; 78.6%), the same or more at the end of the study compared to when they started the study. Additionally, when discussing their preferred administration modality, they noted that both methods had positive qualities but also potential areas of improvement. Our findings underscore the need to create multiple delivery methods for a future microbicide gel (i.e., with and without the need for an applicator) and highlight the importance of offering MSM choices in how biomedical HIV prevention strategies are delivered.

scholarly journals Birth Cohort Variations Across Functional Knowledge of HIV Prevention Strategies, Perceived Risk, and HIV-Associated Behaviors Among Gay, Bisexual, and Other Men Who Have Sex With Men in the United States

2018 ◽  
Vol 12 (6) ◽  
pp. 1824-1834 ◽  
Author(s):  
Akshay Sharma ◽  
Erin M. Kahle ◽  
Stephen P. Sullivan ◽  
Rob Stephenson
Keyword(s):  
Hiv Prevention ◽  
Birth Cohort ◽  
Perceived Risk ◽  
The United States ◽  
Prevention Strategies ◽  
The Past ◽  
Hiv Prevention Strategies ◽  
Functional Knowledge ◽  
Sex With Men ◽  
Exposure Prophylaxis

Gay, bisexual, and other men who have sex with men (GBMSM) in the United States remain heavily impacted by HIV. The purpose of this study was to describe intergenerational differences in functional knowledge of HIV prevention strategies, perceived risk, recent condomless anal sex (CAS), and HIV testing behavior. Eight hundred sexually active GBMSM were recruited via Facebook from August to September 2015, and administered a Web-based survey which included 12 multiple-choice questions to elicit data regarding functional knowledge of different HIV prevention approaches (e.g., condom use, pre-exposure prophylaxis post-exposure prophylaxis, treatment as prevention, circumcision). Cumulative logit and multivariable logistic models were formulated to examine birth cohort variations across four analytic outcomes. Younger generations were significantly more knowledgeable, as were GBMSM with higher education. Non-Hispanic non-White GBMSM and those reporting a bisexual/other sexual orientation had lower functional knowledge. Younger generations were equally concerned about contracting HIV as their older counterparts. Perceived risk was significantly higher among non-Hispanic non-White and Hispanic GBMSM, but lower among those with higher education and those in a relationship. Finally, birth cohort variations with respect to engaging in CAS with ≥2 men in the past 3 months and testing for HIV in the past year were not markedly pronounced. Younger GBMSM might be more knowledgeable about HIV prevention strategies compared to their predecessors, but are equally concerned about contracting HIV. Researchers and practitioners should consider intergenerational and other demographic differences while designing multifaceted HIV prevention programs for GBMSM.

Substance use patterns and awareness of biomedical HIV prevention strategies among sexual and gender minority men in Canada

AIDS Care ◽  
2020 ◽  
Vol 32 (12) ◽  
pp. 1506-1514 ◽  
Author(s):  
Kiffer G. Card ◽  
Anabelle Bernard Fournier ◽  
Justin T. Sorge ◽  
Jeffrey Morgan ◽  
Daniel Grace ◽  
...  
Keyword(s):  
Substance Use ◽  
Hiv Prevention ◽  
Prevention Strategies ◽  
Gender Minority ◽  
Use Patterns ◽  
Biomedical Hiv Prevention ◽  
Hiv Prevention Strategies ◽  
Sexual And Gender Minority ◽  
Minority Men ◽  
And Gender

scholarly journals Patterns of a Rectal Microbicide Placebo Gel Use in a Preparatory Stage for a Phase I Trial Among Young Men Who Have Sex with Men

2017 ◽  
Vol 22 (2) ◽  
pp. 412-420 ◽  
Author(s):  
José A. Bauermeister ◽  
R. Giguere ◽  
C. S. Leu ◽  
C. Dolezal ◽  
I. Febo ◽  
...  
Keyword(s):  
Phase I ◽  
Phase I Trial ◽  
Young Men ◽  
Preparatory Stage ◽  
Sex With Men ◽  
Rectal Microbicide

scholarly journals Quality of HIV Websites With Information About Pre-Exposure Prophylaxis or Treatment as Prevention for Men Who Have Sex With Men: Systematic Evaluation (Preprint)

2018 ◽  
Author(s):  
Taylor Silverman ◽  
Nicole Asante ◽  
Jacob J van den Berg
Keyword(s):  
Hiv Prevention ◽  
Hiv Infection ◽  
Rating Scale ◽  
The United States ◽  
Treatment As Prevention ◽  
Key Words And Phrases ◽  
Prevention Strategies ◽  
Hiv Prevention Strategies ◽  
Sex With Men ◽  
Exposure Prophylaxis

BACKGROUND Knowledge and uptake of high-efficacy HIV prevention strategies such as pre-exposure prophylaxis (PrEP) and treatment as prevention (TasP) remain low among men who have sex with men (MSM) who are at the highest risk for HIV infection in the United States. Electronic health (eHealth) interventions are promising tools for disseminating information about these critical yet underutilized strategies and addressing key barriers to uptake among target populations. However, existing HIV prevention websites are understudied and unevaluated. OBJECTIVE This study aimed to systematically review and evaluate existing HIV websites that include information about PrEP or TasP for MSM. METHODS From March 2018 to May 2018, 2 trained research assistants (RAs) entered relevant key words and phrases into 3 commonly used search engines and applied exclusion criteria to all returned results to identify 31 websites included in this review. RAs independently scored each website for authority, usability, interactivity, and PrEP/TasP-related content based on a standardized rating scale and then averaged the results. RESULTS No website received a perfect score in any of the 4 categories, and the average website score was 62% (37/60). Less than a quarter of the websites (23%, 7/31) received a score of more than 75% (7.5/10) for content. Approximately two-thirds of the websites (65%, 20/31) received a score of 50% (5/10) or lower for interactivity. The average score in usability was 68% (6.8/10) and in authority was 69% (6.9/10). Other deficiencies observed included difficulty locating relevant content and lack of information targeting audiences with the highest likelihood of HIV infection. CONCLUSIONS Existing HIV prevention websites with information about PrEP or TasP for MSM fail to provide adequate content as well as present that content to users in an interactive and audience-conscious way. Future eHealth interventions should attempt to rectify these deficiencies to successfully engage and educate MSM at high risk for HIV regarding prevention strategies.

scholarly journals Using population attributable risk to choose HIV prevention strategies in men who have sex with men

2011 ◽  
Vol 11 (1) ◽  
Author(s):  
Rebecca J Guy ◽  
Handan Wand ◽  
David P Wilson ◽  
Garrett Prestage ◽  
Fengyi Jin ◽  
...  
Keyword(s):  
Hiv Prevention ◽  
Population Attributable Risk ◽  
Attributable Risk ◽  
Prevention Strategies ◽  
Hiv Prevention Strategies ◽  
Sex With Men

scholarly journals Awareness, Utilization, and Preferences for Traditional and Contemporary HIV Prevention Strategies Among Facebook and Instagram-Using MSM in the United States

2021 ◽  
Vol 20 ◽  
pp. 232595822110247
Author(s):  
Akshay Sharma ◽  
Ariana Paredes-Vincent ◽  
Erin M. Kahle
Keyword(s):  
Hiv Prevention ◽  
The United States ◽  
Easy Access ◽  
Individual Risk ◽  
Post Exposure Prophylaxis ◽  
Prevention Strategies ◽  
Hiv Prevention Strategies ◽  
And Bisexual ◽  
Sex With Men ◽  
Exposure Prophylaxis

HIV prevention research among men who have sex with men (MSM) has traditionally focused on individual risk reduction strategies. Our study evaluated awareness, utilization, and preferences for 10 complementary HIV prevention strategies among 1,286 MSM recruited via Facebook and Instagram from June-August 2018. Ages ranged from 18-85 years, and the majority were non-Hispanic white (n = 1,019, 79.24%), college-educated (n = 819, 63.69%), gay-identifying (n = 1,074, 83.51%), and partnered (n = 808, 62.83%). Post-exposure prophylaxis was the least familiar option, and engaging in sexual activities other than anal sex was the most utilized option. Progressively older and bisexual-identifying MSM were less likely, but those with higher educational levels and easy access to local HIV resources were more likely to be aware of and to be utilizing a greater number of strategies. Additionally, Hispanic MSM were less likely to be aware of, and those in a “closed” relationship were less likely to be utilizing a greater number of strategies. In a subset of 775 multiple strategy users, pre-exposure prophylaxis, regularly testing for HIV, and limiting the number of sex partners emerged as the most preferred options. Combination intervention packages for MSM should be tailored to personal circumstances, including sexual orientation, relationship characteristics and access to local HIV resources.

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