8. Honey: Th e Thyme Honey of Aphrodite

2019 ◽  
pp. 193-220
Keyword(s):  
Thyme Honey

scholarly journals Response Surface Methodology to Optimize the Isolation of Dominant Volatile Compounds from Monofloral Greek Thyme Honey Using SPME-GC-MS

Molecules ◽  
2021 ◽  
Vol 26 (12) ◽  
pp. 3612
Author(s):  
Marinos Xagoraris ◽  
Alexandra Skouria ◽  
Panagiota-Kyriaki Revelou ◽  
Eleftherios Alissandrakis ◽  
Petros A. Tarantilis ◽  
...  
Keyword(s):  
Response Surface Methodology ◽  
Volatile Compounds ◽  
Response Surface ◽  
Solid Phase ◽  
Gas Chromatography Mass Spectrometry ◽  
Volatile Fraction ◽  
Equilibration Time ◽  
Stirrer Speed ◽  
Magnetic Stirrer ◽  
Thyme Honey

This study aimed at an experimental design of response surface methodology (RSM) in the optimization of the dominant volatile fraction of Greek thyme honey using solid-phase microextraction (SPME) and analyzed by gas chromatography-mass spectrometry (GC-MS). For this purpose, a multiple response optimization was employed using desirability functions, which demand a search for optimal conditions for a set of responses simultaneously. A test set of eighty thyme honey samples were analyzed under the optimum conditions for validation of the proposed model. The optimized combination of isolation conditions was the temperature (60 °C), equilibration time (15 min), extraction time (30 min), magnetic stirrer speed (700 rpm), sample volume (6 mL), water: honey ratio (1:3 v/w) with total desirability over 0.50. It was found that the magnetic stirrer speed, which has not been evaluated before, had a positive effect, especially in combination with other factors. The above-developed methodology proved to be effective in the optimization of isolation of specific volatile compounds from a difficult matrix, like honey. This study could be a good basis for the development of novel RSM for other monofloral honey samples.

scholarly journals A scientific note on the characteristics of thyme honey from the Greek island of Kithira

Apidologie ◽  
2000 ◽  
Vol 31 (3) ◽  
pp. 457-458 ◽  
Author(s):  
Angeliki Tsigouri ◽  
Maria Passaloglou-Katrali
Keyword(s):  
Scientific Note ◽  
Thyme Honey ◽  
Greek Island

scholarly journals Investigation of Volatile Compounds in Combination with Multivariate Analysis for the Characterization of Monofloral Honeys

2021 ◽  
Vol 12 (1) ◽  
pp. 264
Author(s):  
Chrysoula Tananaki ◽  
Vasilios Liolios ◽  
Dimitrios Kanelis ◽  
Maria Anna Rodopoulou
Keyword(s):  
Volatile Compounds ◽  
Volatile Profile ◽  
Gas Chromatograph ◽  
Aroma Profile ◽  
Extraction Separation ◽  
Mass Spectrometer System ◽  
Chemometric Approach ◽  
Spectrometer System ◽  
Thyme Honey

Lately there has been a growing demand for monofloral honeys with distinctive properties. Considering the limitations of pollen analysis, the volatile profile of honey has been proposed as a helpful supplementary tool for the confirmation of monoflorality; however, research remains regarding the volatile markers that may characterize the monofloral honey types. Therefore, in this study, we tried to expand the research by investigating the aroma profiles of five monofloral honey types (fir, pine, erica, thyme, cotton) and discriminate them through chemometric approach. A purge and trap–gas chromatograph–mass spectrometer system was used for the extraction, separation, and identification of volatile and semi-volatile compounds. Thyme honey had the richest quantitatively aroma profile, with 97 volatile compounds, whereas fir and cotton honeys had 65 and 60 volatile compounds, respectively. From a total of 124 compounds, the 38 were detected in all the studied honey types. Thyme honey was distinguished by the presence (or percentage participation) of benzeneacetaldehyde, benzealdehyde, and benzyl nitrile; erica honey of isophorone and furfural; cotton honey of 1-butanol, 2-methyl, 1-pentanol, and 4-methyl-; and honeydew honeys of α-pinene, octane, and nonanal. The discriminant analysis confirmed that the percentage participation of volatile compounds may lead to the discrimination of the studied monofloral honey types.

scholarly journals Protective Effect of Thyme Honey against Valproic Acid Hepatotoxicity in Wistar Rats

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Rezvan Omidipour ◽  
Leila Zarei ◽  
Mandana Beigi Boroujeni ◽  
Asghar Rajabzadeh
Keyword(s):  
Valproic Acid ◽  
Liver Enzymes ◽  
Hepatic Necrosis ◽  
Male Rats ◽  
Enzyme Analysis ◽  
Antioxidant Compounds ◽  
Tissue Samples ◽  
Biochemical Evaluation ◽  
Hematoxylin Eosin ◽  
Thyme Honey

Introduction. Valproic acid is a medication most commonly used in the treatment of emotional and neurological depression, psychological imbalances, epilepsy, and bipolar disorder. Dark honey, like thyme honey, contains more antioxidant compounds than other samples. The purpose of this study was to evaluate the effect of thyme honey on the potential hepatic effects of valproic acid. Methods. In this study, 48 male rats were randomly divided into 8 groups ( n = 6 ): G1 (control): healthy rats (normal saline 0.9%), G2: thyme honey (1 g/kg), G3: thyme honey (2 g/kg dose), G4: thyme honey (3 g/kg dose), G5: VPA (500 mg/kg), G6: VPA (500 mg/kg) and thyme honey (1 g/kg), G7: VPA (500 mg/kg) and thyme honey (2 g/kg dose), and G8: VPA (500 mg/kg) and thyme honey (3 g/kg dose). Groups G1 to G5 received the drug for 28 days. On day 14, administration of thyme honey for G6 to G8 groups was carried out using gavage until day 28. VPA was administered one hour after honey. To carry out the biochemical evaluation, blood samples were collected from all the groups and their serums were used for MDA, TAC, and liver enzymes (AST, ALT, and GGT). Tissue samples of each rat were also removed for histological studies with hematoxylin-eosin and Masson’s trichrome staining. Results. The use of thyme honey significantly improved the histopathological parameters of the liver tissue, including hypertrophic degeneration and nucleus alteration, expansion of sinusoids, fibrosis and hepatic necrosis, and inflammation as well as hypertrophy of Kupffer cells. In the groups receiving VPA, the rate of lipid peroxidation increased, which indicates the destruction of the liver cell membrane due to drug consumption. TAC levels also increased following increase in thyme honey dosage ( p ≤ 0.05 ). The results of liver enzyme analysis showed a decrease in AST and ALT levels in the G6 group and a decrease in GGT level in the G8 group ( p ≤ 0.05 ). Conclusion. Based on the results of this study, it seems that high percentage of antioxidants in thyme honey enabled it to improve hepatic complications and reduce the rate of hepatocellular destruction.

Determination of eucalyptol camphor menthol and thymol in Greek thyme honey by GC-FID

2008 ◽  
Vol 37 (2) ◽  
pp. 181-189 ◽  
Author(s):  
A. Tsigouri ◽  
M. Passaloglou-Katrali ◽  
O. Sabatakou
Keyword(s):  
Thyme Honey

The effect of thyme honey nasal spray on chronic rhinosinusitis: a double-blind randomized controlled clinical trial

2014 ◽  
Vol 272 (6) ◽  
pp. 1429-1435 ◽  
Author(s):  
Farnaz Hashemian ◽  
Neda Baghbanian ◽  
Zahra Majd ◽  
Mohammad-Reza Rouini ◽  
Javaneh Jahanshahi ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Chronic Rhinosinusitis ◽  
Nasal Spray ◽  
Controlled Clinical Trial ◽  
Randomized Controlled Clinical Trial ◽  
Double Blind ◽  
Randomized Controlled ◽  
Thyme Honey

The application of Taguchi method to determine the optimum blend of unifloral honeys to most closely match thyme honey quality

2009 ◽  
Vol 44 (10) ◽  
pp. 1877-1886 ◽  
Author(s):  
Maria Dimou ◽  
Simos Marnasidis ◽  
Ioanna Antoniadou ◽  
Maria Pliatsika ◽  
George J. Besseris
Keyword(s):  
Taguchi Method ◽  
Thyme Honey

scholarly journals The Synergistic Beneficial Effect of Thyme Honey and Olive Oil against Diabetes and Its Complications Induced by Alloxan in Wistar Rats

2021 ◽  
Vol 2021 ◽  
pp. 1-20
Author(s):  
Hajar Lafraxo ◽  
Meryem Bakour ◽  
Hassan Laaroussi ◽  
Asmae El Ghouizi ◽  
Driss Ousaaid ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Olive Oil ◽  
Wistar Rats ◽  
Low Density Lipoprotein ◽  
Physicochemical Characterization ◽  
Density Lipoprotein ◽  
Modern Medicine ◽  
Phytochemical Analysis ◽  
Thyme Honey

Diabetes is a metabolic disorder characterized by a chronic increase in blood glucose. Owing to the limitations observed with antidiabetics in modern medicine, medicinal plants and bee products are known as good matrices for the search for new antidiabetic molecules. The present study focused on the evaluation of the hypoglycemic and the protective properties of two natural products widely used in complementary and alternative medicine (thyme honey and olive oil). To achieve this, the study was carried out on Wistar rats rendered diabetic by the injection of a single dose of alloxan monohydrate (65 mg/kg body weight (BW)). First, the physicochemical characterization and the phytochemical analysis of thyme honey and olive oil were carried out, and then in vivo study was conducted on 42 Wistar rats divided into seven groups: three groups were normal, one group was untreated diabetic, and three groups were diabetic rats treated with thyme honey (2 g/kg BW) or olive oil (10 mL/kg BW) or their combination ((1 g/kg BW of thyme honey) and (5 mL/kg BW of olive oil)). During the experiment, the glycemia was measured regularly every 10 days. After 30 days of treatment, the rats were sacrificed. The serum and urine were analyzed to determine hepatic enzymes levels (AST, ALT, ALP, and LDH), lipidic profile (total cholesterol, triglycerides, high-density lipoprotein, low-density lipoprotein), and kidney parameters (urea, uric acid, creatinine, total protein, sodium, potassium, and chloride). The liver, pancreas, and kidneys were analyzed to evaluate their histological changes and to determine their enzymatic antioxidant content (catalase, GSH, and GPx) and the levels of MDA. The results obtained showed that thyme honey or olive oil, and especially their combination, improved significantly the blood glucose levels and they protect against metabolic changes and the complications induced by diabetes.

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