Plasma concentrations of vitamin D metabolites in pubertal girls with anorexia nervosa

ABSTRACT Plasma concentrations of 25-hydroxyvitamin D (25-OHD), 1,25-dihydroxyvitamin D (1,25-(OH)2D), 24,25-dihydroxyvitamin D (24,25-(OH)2D) and vitamin D-binding protein (DBP) were measured in 12 pubertal girls (aged 10-18 yr) with anorexia nervosa in relapse. The results were compared with similar data obtained in 81 healthy girls representing all stages of puberty. The patients with anorexia nervosa had significantly lower 1,25-(OH)2D levels (71 vs. 124 pmol/l; p<0.0005), and significantly higher 24,25-(OH)2D levels (6.0 vs. 3.2 nmol/l; p<0.0005), whereas the 25-OHD concentrations were similar in the two groups (85.7 vs. 86.7 nmol/l). The molar ratios of 24,25-(OH)2D to 25-OHD, which reflects the relative activity of the 24-hydroxylation, were significantly higher in the anorectics (6.6 % vs. 3.6 %; p<0.0005). The mean level of DBP did not differ between the two groups, and accordingly the calculated "free-fraction of 1,25-(OH)2 D" was significantly lower in the anorectic patients (p<0.0005). It appears that the regulatory mechanisms of the vitamin D endocrine system are altered in the patients with anorexia nervosa at puberty resulting in a relative decrease of the plasma concentration of 1,25-(OH)2D and increase of the 24,25-(OH)2D concentration. Key words: Anorexia nervosa, vitamin D metabolism, 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, 24,25-dihydroxyvitamin D, vitamin D binding protein

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Vitamin D Binding Protein and Monocyte Response to 25-Hydroxyvitamin D and 1,25-Dihydroxyvitamin D: Analysis by Mathematical Modeling

PLoS ONE ◽

10.1371/journal.pone.0030773 ◽

2012 ◽

Vol 7 (1) ◽

pp. e30773 ◽

Cited By ~ 68

Author(s):

Rene F. Chun ◽

Bradford E. Peercy ◽

John S. Adams ◽

Martin Hewison

Keyword(s):

Mathematical Modeling ◽

Vitamin D ◽

Binding Protein ◽

Vitamin D Binding Protein ◽

Hydroxyvitamin D ◽

Dihydroxyvitamin D ◽

1,25 Dihydroxyvitamin D ◽

25 Hydroxyvitamin D

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Calcium-Regulating Hormones and Minerals From Birth to 18 Months of Age: A Cross-Sectional Study. I. Effects of Sex, Race, Age, Season, and Diet on Vitamin D Status

PEDIATRICS ◽

10.1542/peds.77.6.883 ◽

1986 ◽

Vol 77 (6) ◽

pp. 883-890

Author(s):

P. Lichtenstein ◽

B. L. Specker ◽

R. C. Tsang ◽

F. Mimouni ◽

C. Gormley

Keyword(s):

Vitamin D ◽

Human Milk ◽

Binding Protein ◽

Vitamin D Metabolites ◽

Vitamin D Status ◽

Vitamin D Binding Protein ◽

Hydroxyvitamin D ◽

Dihydroxyvitamin D ◽

1,25 Dihydroxyvitamin D ◽

25 Hydroxyvitamin D

The influence of sex, race, age, season, and diet (cow's milk formula v human milk) on the vitamin D and vitamin D-binding protein status in infants less than 18 months of age was investigated in this crosssectional, prospective study of 198 infants. No differences by sex were observed in serum 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, 24,25-dihydroxyvitamin D, or vitamin D-binding protein concentrations. By race, black infants had significantly elevated serum 1,25-dihydroxyvitamin D levels relative to white infants. By age, vitamin D-binding protein concentrations increased with increasing age. By season, serum 25-hydroxyvitamin D concentrations were low in winter, whereas 1,25-dihydroxyvitamin D and vitamin D-binding protein were high in winter compared with summer. By diet, formula-fed infants had higher serum concentrations of all measured vitamin D metabolites and vitamin D-binding protein than human milk-fed infants. Thus, race, age, season, and diet exert, individually or in combination, different and significant effects on vitamin D metabolites; these should be considered in assessing infant vitamin D status.

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Genetic polymorphisms of the vitamin D binding protein and plasma concentrations of 25-hydroxyvitamin D in premenopausal women

American Journal of Clinical Nutrition ◽

10.3945/ajcn.2008.26445 ◽

2008 ◽

Vol 89 (2) ◽

pp. 634-640 ◽

Cited By ~ 167

Author(s):

Marc Sinotte ◽

Caroline Diorio ◽

Sylvie Bérubé ◽

Michael Pollak ◽

Jacques Brisson

Keyword(s):

Vitamin D ◽

Genetic Polymorphisms ◽

Binding Protein ◽

Plasma Concentrations ◽

Premenopausal Women ◽

Vitamin D Binding Protein ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D

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Vitamin D Metabolites and Binding Protein Predict Preeclampsia in Women with Type 1 Diabetes

Nutrients ◽

10.3390/nu12072048 ◽

2020 ◽

Vol 12 (7) ◽

pp. 2048

Author(s):

Clare B. Kelly ◽

Carol L. Wagner ◽

Judith R. Shary ◽

Misti J. Leyva ◽

Jeremy Y. Yu ◽

...

Keyword(s):

Vitamin D ◽

Type 1 Diabetes ◽

Binding Protein ◽

Vitamin D Metabolites ◽

Vitamin D Binding Protein ◽

Hydroxyvitamin D ◽

Dihydroxyvitamin D ◽

Healthy Pregnancy ◽

25 Hydroxyvitamin D

The risk for preeclampsia (PE) is enhanced ~4-fold by the presence of maternal type 1 diabetes (T1DM). Vitamin D is essential for healthy pregnancy. We assessed the total, bioavailable, and free concentrations of plasma 25-hydroxyvitamin D (25(OH)D), 1,25-dihydroxyvitamin D (1,25(OH)2D), and vitamin D binding protein (VDBP) at ~12, ~22, and ~32 weeks’ gestation (“Visits” (V) 1, 2, and 3, respectively) in 23 T1DM women who developed PE, 24 who remained normotensive, and 19 non-diabetic, normotensive women (reference controls). 25(OH)D deficiency was more frequent in diabetic than non-diabetic women (69% vs. 22%, p < 0.05), but no measure of 25(OH)D predicted PE. By contrast, higher 1,25(OH)2D concentrations at V2 (total, bioavailable, and free: p < 0.01) and V3 (bioavailable: p < 0.05; free: p < 0.01), lower concentrations of VDBP at V3 (p < 0.05), and elevated ratios of 1,25(OH)2D/VDBP (V2, V3: p < 0.01) and 1,25(OH)2D/25(OH)D (V3, p < 0.05) were all associated with PE, and significance persisted in multivariate analyses. In summary, in women with T1DM, concentrations of 1,25(OH)2D were higher, and VDBP lower, in the second and third trimesters in women who later developed PE than in those who did not. 1,25(OH)2D may serve as a new marker for PE risk and could be implicated in pathogenesis.

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