scholarly journals Mapping the journey of transition: a single center study of 170 childhood onset GH deficiency patients

2021 ◽  
Author(s):  
Mirjana Doknic ◽  
Marko Stojanovic ◽  
Ivan Soldatovic ◽  
Tanjana Milenkovic ◽  
Vera Zdravkovic ◽  
...  
Keyword(s):  
Body Composition ◽  
Transition To Adulthood ◽  
Transition Period ◽  
Gh Deficiency ◽  
Metabolic Parameters ◽  
Single Center ◽  
Mineral Density ◽  
Childhood Onset ◽  
Cross Sectional ◽  
Sectional Analysis

Objective: To analyze metabolic parameters, body composition (BC) and bone mineral density (BMD) in childhood onset GH deficiency (COGHD) patients during transition period (TP). Design: Single center, retrospective study was performed on 170 consecutive COGHD patients (age 19.2±2.0 years, range 16-25) transferred after growth completion from two pediatric clinics to adult endocrine unit. Two separate analyses were performed: 1) cross-sectional analysis of hormonal status, metabolic parameters, BC and BMD at first evaluation after transfer from pediatrics to adult department; 2) longitudinal analysis of BC and BMD dynamics after 3 years of GH replacement therapy (rhGH) in TP. Results: COGHD was of a congenital cause (CONG) in 50.6% subjects, tumor related (TUMC) in 23.5% and idiopathic (IDOP) in 25.9%. TUMC patients had increased insulin and lipids levels (p<0.01) and lower Z score at L-spine (p<0.05) compared to CONG and IDOP groups. Patients treated with rhGH in childhood demonstrated lower fat mass and increased BMD compared to rhGH-untreated group (p<0.01). Three years of rhGH after growth completion resulted in significant increase in lean body mass (12.1%) and BMD at L-spine (6.9%), parallel with decrease in FM (5.2%). Conclusion: The effect of rhGH in childhood is invaluable for metabolic status, BC and BMD in transition to adulthood. Tumor related COGHD subjects are at higher risk for metabolic abnormalities, alteration of body composition and decreased BMD, compared to those with COGHD of other causes. Continuation of rhGH in transition is important for improving BD and BMD in patients with persistent COGHD.

scholarly journals Approach to the Growth Hormone-Deficient Child during Transition to Adulthood

2007 ◽  
Vol 92 (4) ◽  
pp. 1195-1200 ◽  
Author(s):  
Sally Radovick ◽  
Sara DiVall
Keyword(s):  
Transition To Adulthood ◽  
Adult Height ◽  
Gh Deficiency ◽  
Mineral Density ◽  
Childhood Onset ◽  
Metabolic Complications ◽  
Final Adult Height ◽  
Deficient Child ◽  
Impaired Cardiac Function

Abstract The observation that some adults with childhood-onset GH deficiency have low bone mineral density, low lean body mass, diminished quality of life, abnormal lipids, and impaired cardiac function, all of which may improve after treatment with GH, has prompted pediatric endocrinologists to reevaluate the practice of discontinuing GH in all patients after attainment of final adult height. The treatment of adolescents to prevent the metabolic complications of GH deficiency is an emerging practice. Studies addressing the evaluation and care of adolescents during this period and the benefits of GH in this setting are conflicting. Our approach in determining which adolescents to retest, when and how to test for persistent GH deficiency, and which subjects to treat is discussed in the context of available clinical data.

scholarly journals Resistance training versus weight-bearing aquatic exercise: a cross-sectional analysis of bone mineral density in postmenopausal women

2013 ◽  
Vol 53 (2) ◽  
pp. 193-198 ◽  
Author(s):  
Sandor Balsamo ◽  
Licia Maria Henrique da Mota ◽  
Frederico Santos de Santana ◽  
Dahan da Cunha Nascimento ◽  
Lídia Mara Aguiar Bezerra ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Resistance Training ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Weight Bearing ◽  
Aquatic Exercise ◽  
Mineral Density ◽  
Cross Sectional ◽  
Cross Sectional Analysis ◽  
Sectional Analysis

scholarly journals The association of circulating irisin with metabolic risk factors in Chinese adults: a cross-sectional community-based study

2019 ◽  
Author(s):  
Lizhi Tang ◽  
Yuzhen Tong ◽  
Fang Zhang ◽  
Guilin Chen ◽  
Yun Cong Zhang ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Linear Regression ◽  
Pearson Correlation ◽  
Metabolic Parameters ◽  
Enzyme Linked Immunosorbent Assay ◽  
Model Assessment ◽  
Fasting Insulin ◽  
Cross Sectional ◽  
Sectional Analysis ◽  
Overweight Subjects

Abstract Background Irisin is a myokine that leads to increased energy expenditure by stimulating the browning of white adipose tissue. We aimed to investigate the association of serum irisin levels with metabolic parameters in middle aged Chinese population. Methods The study was based on a cross-sectional analysis of data from 524 nondiabetic subjects aged 40~65. All participants were recruited from a screening survey for Metabolic Syndrome in a community in Southwest China, including 294 subjects categorized as overweight (defined as BMI≧25 kg/m2 ) and 230 subjects as normal control (defined as 18.5≦BMI<25 kg/m2). Serum irisin concentration was quantified by enzyme linked immunosorbent assay (ELISA). The relationship of irisin with metabolic factors was determined by Pearson correlation. Multivariate linear regression was used to analyze the association of irisin with insulin resistance. Logistic regression was performed to assess the association of irisin with odds of overweight. Results Serum irisin levels were significantly lower in nondiabetic overweight subjects compared with control (11.46 ± 4.11vs14.78 ± 7.03µg/mL, p = 0.02). Circulating irisin was positively correlated with quantitative insulin sensitivity check index (QUICKI, r = 0.178, p = 0.045) and triglycerides (r = 0.149, p = 0.022); while irisin was negatively correlated with waist circumference (WC, r = -0.185, p = 0.037), waist-to-hip ratio (WHR, r = -0.176, p = 0.047), fasting insulin (r = -0.2, p = 0.024), serum creatinine (r = -0.243, p = 0.006), homeostasis model assessment for insulin resistance (HOMA-IR, r = -0.189, p = 0.033). Multiple linear regression showed that irisin was inversely associated with HOMA-IR (β = -0.342 ± 0.154, p = 0.029). Higher irisin was associated with decreased odds of being overweight (OR = 0.281, β = -1.271, p = 0.024). Conclusions We found that serum irisin levels were lower in overweight subjects. Moreover, serum irisin levels were inversely correlated with adverse metabolic parameters including WC, WHR, creatinine, HOMA-IR and fasting insulin, suggesting that irisin may play a role in obesity related insulin resistance.

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