scholarly journals Vitamin D in relation to metabolic risk factors, insulin sensitivity and adiponectin in a young Middle-Eastern population

2009 ◽  
Vol 160 (6) ◽  
pp. 965-971 ◽  
Author(s):  
Marie-Hélène Gannagé-Yared ◽  
Rima Chedid ◽  
Simon Khalife ◽  
Emmanuel Azzi ◽  
Fernand Zoghbi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Ldl Cholesterol ◽  
Middle Eastern ◽  
Density Lipoprotein ◽  
Multivariate Regression Analysis ◽  
Metabolic Risk Factors ◽  
Metabolic Risk ◽  
Model Assessment ◽  
Homa Index

ObjectivesSeveral studies suggest a link between circulating 25-hydroxyvitamin D (25(OH)D) and metabolic risk factors. However, this relation has been mainly studied in elderly and/or obese subjects. In addition, the relation between 25(OH)D and adiponectin is unclear. The purpose of this study is to look at these relations in non-obese young individuals.DesignWe investigated the relation between serum 25(OH)D and adiposity, blood pressure, glucose metabolism, lipid profile, and adiponectin in 381 randomly selected university students (201 males and 180 females, mean age 23.9±3.9).ResultsIn the overall population, 25(OH)D is significantly inversely correlated with body mass index (BMI), systolic blood pressure (SBP), waist circumference (WC), fasting plasma glucose (FPG), insulin levels, and homeostasis model assessment of insulin resistance (HOMA index) and positively correlated with adiponectin and high density lipoprotein-cholesterol (P<0.01 for all variables). In males, these correlations are still significant for BMI, SBP, WC, and adiponectin (P=0.02,P=0.01,P=0.04 andP=0.01 respectively); also, 25(OH)D is inversely correlated with low density lipoprotein (LDL)-cholesterol (P=0.007). In females, 25(OH)D is only inversely correlated with FPG and HOMA index (P<0.001 andP=0.03 respectively). In multivariate regression analysis models, after adjustment for sex and BMI, 25(OH)D is an independent predictor of FPG and SBP (P=0.032 andP=0.05 respectively) in the overall population, while in males 25(OH)D is a predictor of LDL-cholesterol and SBP independently of BMI (P=0.007 andP=0.035 respectively).ConclusionIn non-obese young subjects, we observe new relationships between 25(OH)D and several metabolic risk factors and adiponectin. Further research is needed to elucidate the gender differences and to look at the relation between 25(OH)D and adiponectin.

scholarly journals Higher level of faecal SCFA in women correlates with metabolic syndrome risk factors

2012 ◽  
Vol 109 (5) ◽  
pp. 914-919 ◽  
Author(s):  
Tatiana F. S. Teixeira ◽  
Łukasz Grześkowiak ◽  
Sylvia C. C. Franceschini ◽  
Josefina Bressan ◽  
Célia L. L. F. Ferreira ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Metabolic Risk Factors ◽  
Metabolic Risk ◽  
Model Assessment ◽  
Homa Index ◽  
Normal Limits ◽  
Faecal Concentration ◽  
Lean Group

SCFA provide energy to the host and influence lipid and glucose metabolism, suggesting that they may have an impact on the occurrence of metabolic risk factors. The aim of the present study was to determine the concentration of SCFA in faeces of lean and obese individuals and to analyse whether associations between faecal SCFA and metabolic syndrome parameters are present. Lean (n20) and obese (n20) women of similar age (28·5 (sd7·6)v.30·7 (sd6·5) years,P= 0·33) participated in the study. Anthropometric measurements, body composition, blood pressure and biochemical parameters were assessed. SCFA were extracted from faeces and quantified by GC. Blood pressure and blood glucose, although within the normal limits, were higher in the obese group compared to lean subjects (P< 0·05). Lower HDL concentration and higher insulin and homeostasis model assessment (HOMA) index were observed in the obese than in the lean group (P< 0·05). The median values of SCFA (% w/w) from the lean and obese groups were butyric (0·021v.0·044,P= 0·024), propionic (0·021v.0·051,P= 0·007) and acetic (0·03v.0·061,P= 0·01). SCFA correlated positively with metabolic syndrome risk factors such as adiposity, waist circumference and HOMA index (P< 0·05), and inversely with HDL (P< 0·05). Our results suggest that the higher faecal concentration of SCFA is associated with metabolic risk factors and thus may influence metabolic homeostasis.

scholarly journals Associations of eating frequency with adiposity measures, blood lipid profiles and blood pressure in British children and adolescents

2014 ◽  
Vol 111 (12) ◽  
pp. 2176-2183 ◽  
Author(s):  
Kentaro Murakami ◽  
M. Barbara E. Livingstone
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Total Cholesterol ◽  
Ldl Cholesterol ◽  
Blood Lipid ◽  
Lipid Profiles ◽  
Metabolic Risk Factors ◽  
Metabolic Risk ◽  
Eating Frequency ◽  
British Children

Several epidemiological studies in adults have suggested a favourable effect of frequent eating on blood lipid profiles, but evidence in younger populations is lacking. In the present cross-sectional study, we examined the associations of eating frequency (EF) with metabolic risk factors in British children aged 4–10 years (n818) and adolescents aged 11–18 years (n818). Dietary intake was assessed using a 7 d weighed dietary record. EF was calculated based on all eating occasions, except for those providing < 210 kJ of energy. Metabolic risk factors examined were total, HDL-cholesterol and LDL-cholesterol concentrations, TAG concentration, BMIz-score, waist:height ratio (WHtR; only adolescents), and systolic and diastolic blood pressures. Adjustment was made for age, sex, social class, physical activity levels, intakes of protein, fat, total sugar and dietary fibre, ratio of reported energy intake to estimated energy requirement (EI:EER) and BMIz-score (except for BMIz-score and WHtR). In children, EF was inversely associated with total cholesterol and LDL-cholesterol concentrations (n324,P= 0·01 and 0·04, respectively). Conversely, EF was positively associated with BMIz-score in adolescents (P= 0·004). There were no associations between EF and other metabolic risk factors. In analyses in which only plausible energy reporters (EI:EER: 0·72–1·28) were included, similar results were obtained, except for an inverse association between EF and diastolic blood pressure in children. In conclusion, a higher EF is associated with lower total cholesterol and LDL-cholesterol concentrations in children but with a higher BMIz-score in adolescents.

scholarly journals Evaluation of Anthropometric Indices for Metabolic Syndrome and their Association with Metabolic Risk Factors among Healthy Individuals in New Belgrade

2013 ◽  
Vol 30 (1) ◽  
pp. 21-30
Author(s):  
Veroslava Stanković ◽  
Svetlana Stojanović ◽  
Nađa Vasiljević
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Blood Glucose ◽  
Health Risk ◽  
Density Lipoprotein ◽  
Metabolic Risk Factors ◽  
Lipoprotein Cholesterol ◽  
Metabolic Risk ◽  
Anthropometric Indices

Summary People with metabolic syndrome (MetSy) are about twice as likely to develop cardiovascular disease and over four times as likely to develop type 2 diabetes compared to subjects without metabolic syndrome. Waist circumferences (WC) and body mass index (BMI) are useful screening tools for making the diagnosis. MetSy has increased the health risk in primary care. The aim of the study was to evaluate the anthropometric indices for MetSy and determine which of simple anthropometric measurements is most closely associated with metabolic risk factors. The research included 264 individuals, of which 132 men with mean age (±SD) of 44.73 ±9.37 years and 132 women with mean age (±SD) of 46.67±8.44 years. Antropometric indicators were measured using standard protocols, without shoes and outerwear. BMI was calculated as weight/height2(kg/m2) ratio, as recommended by the World Health Organization (WHO). Blood pressure measurements were obtained with the subject in a seated position by using a standard mercury sphygmomanometer. Blood samples were obtained after a minimum of 12-h fast; the metabolic parameters (high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol, triglycerides, blood glucose) were analyzed by standard procedures. Analysis of the examinees’ medical records was also performed. Metabolic syndrome was diagnosed using the International Diabetes Federation (IDF) criteria. The analysis of the research results were performed using the Statistical Package for Social Science version 10.0 (SPSS 10.0 for Windows). The prevalence of the metabolic syndrome was 44.7% in men and 43.2% in women. Normal-weight subjects of both sexes were significantly younger and had significantly lower blood glucose, total cholesterol, LDL and triglycerides than overweight and obese subjects. Systolic and diastolic blood pressure values were significantly increased in parallel with increasing of BMI. For the whole sample, both anthropometric indices had significant associations with the other five components of MetSy. Waist circumference is a simple measure of adiposity most strongly associated with metabolic abnormalities. The results obtained in this study indicate that WC is a good indicator of health risk in women but not in men. Measurement of WC by BMI categories may indicate a person with an increased risk of development of chronic diseases.

scholarly journals Association between Inflammatory Markers and Clinical and Metabolic Risk Factors for Cardiovascular Diseases

2009 ◽  
Vol 63 (4-5) ◽  
pp. 204-209
Author(s):  
Inga Stuķēna ◽  
Andrejs Kalvelis ◽  
Guntis Bahs ◽  
Uldis Teibe ◽  
Pēteris Tretjakovs ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Diseases ◽  
Carbohydrate Metabolism ◽  
Inflammatory Markers ◽  
Density Lipoprotein ◽  
Metabolic Risk Factors ◽  
Lipoprotein Cholesterol ◽  
Metabolic Risk ◽  
Model Assessment ◽  
Tnf Α

Association between Inflammatory Markers and Clinical and Metabolic Risk Factors for Cardiovascular Diseases The inflammatory reaction plays an important role in the development of atherosclerosis. The clinical significance of the main inflammatory markers — C-reactive protein (CRP), interleukin 6 (IL6), tumour necrosis factor alpha (TNF-α), plasminogen activator inhibitor 1 (PAI1), etc. — has not been fully established. CRP, IL6, TNF-α, and PAI1 were assessed in 100 patients in terms of certain clinical indicators (sex, obesity indicators, blood pressure, and heart rate), total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein-cholesterol (HDL-C), triglycerides (TG), glucose, insulin, homeostasis model assessment of insulin resistance (HOMA-IR), adiponectin, and leptin levels. CRP and PAI1 levels were elevated in subjects with increased body mass index (BMI) and waist circumference. CRP correlated positively with indicators of carbohydrate metabolism and negatively with TC, HDL-C, and adiponectin. PAI1 correlated positively with insulin levels, HOMA-IR, leptin, and TG, but negatively with HDL-C. IL6 correlated negatively with TC, but TNF-α correlated negatively with HDL-C. Both IL6 and TNF-α correlated positively with leptin levels. TNF-α correlated with TG levels and the indicators of carbohydrate metabolism only in women. CRP and PAI1 are the most sensitive inflammatory markers; their levels were higher in adipose subjects.

scholarly journals High-dose vitamin D supplementation is associated with an improvement in several cardio-metabolic risk factors in adolescent girls: a nine-week follow-up study

2017 ◽  
Vol 55 (2) ◽  
pp. 227-235 ◽  
Author(s):  
Sayyed Saeed Khayyatzadeh ◽  
Seyed Jamal Mirmoosavi ◽  
Mostafa Fazeli ◽  
Zahra Abasalti ◽  
Amir Avan ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Vitamin D ◽  
Adolescent Girls ◽  
Density Lipoprotein ◽  
Vitamin D Supplementation ◽  
Metabolic Risk Factors ◽  
High Dose ◽  
Metabolic Risk ◽  
High Dose Vitamin

Background Vitamin D deficiency is a prevalent and important global health problem. Because of its role in growth and development, vitamin D status is likely to be particularly important in adolescent girls. Here, we explored the effects of high-dose vitamin D supplementation on cardio-metabolic risk factors. Methods We have examined the effects of vitamin D supplementation on cardio-metabolic risk factors in 988 healthy adolescent girls in Iran. Fasting blood samples and anthropometric measurements were obtained at baseline and after supplementation with high-dose vitamin D. All individuals took a capsule of 50,000 IU vitamin D/week for nine weeks. The study was completed by 940 participants. Results The prevalence of vitamin D deficiency was 90% at baseline, reducing to 16.3% after vitamin D supplementation. Vitamin supplementation was associated with a significant increase in serum concentrations of 25 (OH) vitamin D and calcium. There were significant reductions in diastolic blood pressure, heart rate, waist circumference and serum fasting blood glucose, total- and low-density lipoprotein-cholesterol after the nine-week period on vitamin D treatment, but no significant effects were observed on body mass index, systolic blood pressure or serum high-density lipoprotein cholesterol and triglyceride. Conclusion Vitamin D supplementation had beneficial effects on cardio-metabolic profile in adolescent girls.

scholarly journals Radial Pulse Wave Signals Combined with Ba-PWV for the Risk Prediction of Hypertension and the Monitoring of Its Accompanying Metabolic Risk Factors

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Zhen Qi ◽  
Zhi-Yue Zhao ◽  
Jia-Tuo Xu ◽  
Li-Ping Zhu ◽  
Yu Zhang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Risk Prediction ◽  
Radial Artery ◽  
Pulse Wave ◽  
Density Lipoprotein ◽  
Metabolic Risk Factors ◽  
Metabolic Risk ◽  
Radial Pulse ◽  
New Model

Our aim was to study whether radial pulse wave signals can improve the risk prediction of incident hypertension and are associated with its concomitant metabolic risk factors beyond the traditional cardiovascular risk factor Ba-PWV. By enrolling 523 Chinese subjects in this study, linear and stepwise regression analysis was performed to assess the association of radial artery pulse wave signals and Ba-PWV with blood pressure and its related metabolic risk factors such as fasting plasma glucose (FPG), total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and uric acid (UA). The area under the receiver-operating characteristic curve (AUC), net reclassification improvement (NRI), and integrated discrimination improvement (IDI) were calculated by risk assessment plot to compare the discriminative ability among models with and without radial artery pulse wave signals. After adjusting related confounding factors, radial artery pulse wave variable h3/h1 was selected as the sensitive influential factor for blood pressure. Moreover, a new model with h3/h1 had a higher AUC than the reference model without it (0.86 vs 0.84; P=0.030). And the NRI and IDI for the new model was 50.0% (P=0.017) and 3.16% (P=0.044), respectively. In addition to Ba-PWV, we found that the decrease of t4, t5, and h5 might be associated with higher FPG, TC, LDL-C, and UA and lower HDL-C. This research might provide a valuable additional tool for remote wearable monitoring of radial artery pulse wave signals in hypertension risk evaluation and management.

Predictive Nomogram of RAGE Genetic Polymorphisms and Metabolic Risk Factors for Myocardial Infarction Risk in a Han Chinese Population

Angiology ◽  
2017 ◽  
Vol 68 (10) ◽  
pp. 877-883 ◽  
Author(s):  
Weiming Li ◽  
Yingxue Li ◽  
Zhiyong Zhang ◽  
Kun Xia ◽  
Xiaoming Shang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Blood Pressure ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Recessive Model ◽  
Metabolic Risk Factors ◽  
Metabolic Risk ◽  
Predictive Capability ◽  
Low Density Lipoprotein Cholesterol

We investigated the association of 4 well-characterized polymorphisms in receptor for the advanced glycation end-product ( RAGE) gene with myocardial infarction (MI) risk and the changes in metabolic risk factors among 717/612 patients/controls, with the aim of constructing a predictive nomogram. The genotype/allele distributions differed significantly between the 2 groups for T-429C ( Pgenotype/allele = .004/.001) and G1704T ( P < .001/.001). T-429C was significantly associated with MI risk, especially under a recessive model (adjusted odds ratio: 2.24, 95% confidence interval: 1.33-3.79, P = .003). For G1704T, significance was detected under additive (1.37; 1.12-1.67; P = .002) and recessive (3.86; 2.27-6.57; P < .001) models. There were significant differences in blood pressure and low-density lipoprotein cholesterol (LDL-C) across T-429C genotypes and in total cholesterol and LDL-C across G1704T genotypes. The overall best multifactor dimensionality reduction model included dyslipidemia, G1704T, and T-429C. Further predictive nomogram on 2 significant polymorphisms, blood pressure and lipids, showed a better predictive capability (concordance index = 0.716, P < .001). Altogether, we identified 2 polymorphisms of RAGE, T-429C and G1704T, which interacted with metabolic risk factors associated with the occurrence of MI. We also constructed a genetic–metabolic nomogram that can better predict MI risk.

Risk factors for cardiovascular diseases and development of prehypertension

2018 ◽  
pp. 37-43
Author(s):  
В.В. Шерстнев ◽  
М.А. Грудень ◽  
В.П. Карлина ◽  
В.М. Рыжов ◽  
А.В. Кузнецова ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Ldl Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Serum Levels ◽  
Left Ventricular ◽  
Optimal Blood Pressure

Цель - исследование взаимосвязи факторов риска сердечно-сосудистых заболеваний и развития предгипертонии. Методика. Проведен сравнительный и корреляционный анализы показателей модифицируемых и немодифицируемых факторов риска сердечно-сосудистых заболеваний у обследованных лиц в возрасте 30-60 лет с «оптимальным» артериальным давлением, (n = 63, АД <120/80 мм рт.ст.) и лиц с предгипертонией (n = 52, АД = 120-139/80-89 мм рт.ст.). Результаты. Показано, что лица с предгипертонией по сравнению с группой лиц, имеющих «оптимальное» артериальное давление характеризуются статистически значимо повышенным содержанием холестерина и холестерина липопротеидов низкой плотности, интеллектуальным характером трудовой деятельности, а также значимыми сочетаниями факторов риска: повышенный уровень холестерина липопротеидов низкой плотности с интеллектуальным характером трудовой деятельности; повышенное содержание креатинина с уровнем триглициридов; наследственная отягощенность по заболеваниям почек и интеллектуальным характером трудовой деятельности; наследственная отягощенность по сахарному диабету и гипертрофия левого желудочка сердца. У лиц с предгипертонией документированы перестройки структуры взаимосвязи (количество, направленность и сила корреляций) между показателями факторов риска в сравнении с лицами, имеющими «оптимальное» артериальное давление. Заключение. Выявленные особенности взаимосвязей факторов риска сердечно-сосудистых заболеваний при предгипертонии рассматриваются как проявление начальной стадии дизрегуляционной патологии и нарушения регуляции физиологических систем поддержания оптимального уровня артериального давления. The aim of the study was to investigate the relationship between risk factors for cardiovascular disease and development of prehypertension. Methods. Comparative and correlation analyses of modifiable and non-modifiable risk factors for cardiovascular disease were performed in subjects aged 30-60 with «optimal» blood pressure (n = 63, BP <120/80 mm Hg) and prehypertension (n = 52, BP = 120-139 / 80-89 mm Hg). Results. The group with prehypertension compared with the «optimal» blood pressure group had significantly increased serum levels of low-density lipoprotein (LDL) cholesterol and high-density lipoprotein (HDL) cholesterol, sedentary/intellectual type of occupation, and significant combinations of risk factors. The risk factor combinations included an increased level of LDL cholesterol and a sedentary/intellectual occupation; increased serum levels of creatinine and triglycerides; hereditary burden of kidney disease and a sedentary/intellectual occupation; hereditary burden of diabetes mellitus and cardiac left ventricular hypotrophy. In subjects with prehypertension compared to subjects with «optimal» blood pressure, changes in correlations (correlation number, direction, and strength) between parameters of risk factors were documented. Conclusion. The features of interrelationships between risk factors for cardiovascular disease observed in prehypertension are considered a manifestation of early dysregulation pathology and disordered regulation of physiological systems, which maintain optimal blood pressure.

FGF23, metabolic risk factors, and blood pressure in patients with primary hyperparathyroidism undergoing parathyroid adenomectomy

Surgery ◽  
2016 ◽  
Vol 159 (1) ◽  
pp. 211-217 ◽  
Author(s):  
Inga-Lena Nilsson ◽  
Sophie Norenstedt ◽  
Fredrik Granath ◽  
Jan Zedenius ◽  
Ylva Pernow ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Primary Hyperparathyroidism ◽  
Metabolic Risk Factors ◽  
Metabolic Risk

Association between serum zinc concentrations and metabolic risk factors among Chinese children and adolescents

2021 ◽  
pp. 1-31
Author(s):  
Qianrang Zhu ◽  
Yue Dai ◽  
Jingxian Zhang ◽  
Wei Xie ◽  
Hui Zuo ◽  
...  
Keyword(s):  
Risk Factors ◽  
Children And Adolescents ◽  
Density Lipoprotein ◽  
Serum Zinc ◽  
Negative Association ◽  
Metabolic Risk Factors ◽  
Chinese Children ◽  
Metabolic Risk ◽  
Zinc Concentrations ◽  
Chinese Children And Adolescents

Abstract Purpose Zinc plays an important role in metabolic processes in human organisms and is indispensable in many enzymatic processes. To date, few studies have assessed the association between serum zinc and metabolic risk factors in children and adolescents. The aim of the present study was to examine whether serum zinc concentrations was associated with metabolic risk factors in Chinese children and adolescents. Methods This study was a cross-sectional analysis of data from the 2016-2017 China National Nutrition and Health Surveillance for Children and Nursing in Jiangsu Province. A total of 3241 participants aged 6 -17years were included. Metabolic risk factors included fasting glucose (FG), total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL-C), low-density lipoprotein (LDL-C), systolic blood pressure and diastolic blood pressure. Data were analyzed using multivariable linear regression and generalized additive models, which were adjusted for age, gender, high sensitive C-reactive protein, estimated glomerular filtration rate, body mass index and region of residence, to assess the associations of serum zinc concentrations with metabolic risk factors. Results We observed a negative association between serum zinc concentrations and FG (coefficient = -0.532; 95% CI: -0.569, -0.495; p< 0.001). Moreover, TC (coefficient = 0.175 ; 95% CI 0.127, 0.222; p< 0.001), HDL-C (coefficient = 0.137 ; 95% CI 0.082, 0.193; p< 0.001) and LDL-C (coefficient = 0.195 ; 95% CI 0.128, 0.263; p< 0.001) were found to be positively associated with zinc levels. A generalized additive model showed that the negative association between serum zinc and FG was weak at lower serum zinc concentrations, and was stronger with the increase in serum zinc concentrations. Additionally, a U-shaped association between serum zinc and TG was observed. Conclusions Serum zinc concentrations were associated with FG, TC, TG, HDL-C and LDL-C levels in Chinese children and adolescents. Lower levels of serum zinc were more likely related to a poor metabolic status.

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