scholarly journals Adiponectin: serum levels, promoter polymorphism, and associations with birth size and cardiometabolic outcome in young adults born large for gestational age

2010 ◽  
Vol 162 (1) ◽  
pp. 53-60 ◽  
Author(s):  
Ana Carolina Bueno ◽  
Aniette R Espiñeira ◽  
Fábio L Fernandes-Rosa ◽  
Roberto Molina de Souza ◽  
Margaret de Castro ◽  
...  
Keyword(s):  
Gestational Age ◽  
Regulatory Region ◽  
Adult Life ◽  
Serum Levels ◽  
Postnatal Growth ◽  
Assessment Model ◽  
Variant Allele ◽  
Abdominal Circumference ◽  
Large For Gestational Age ◽  
Birth Size

ObjectiveTo assess whether the −11391G>A polymorphism in the regulatory region of the adiponectin gene (ADIPOQ) is associated with birth size, postnatal growth, adiponectinemia, and cardiometabolic risk in adult life.DesignCase–control study nested within a prospective cohort of 2063 community subjects born in 1978/1979 and followed since birth to date.MethodsADIPOQ −11391G>A genotype–phenotype associations were evaluated in 116 subjects born large for gestational age (LGA) and 392 gender-matched controls at birth (birth size), at 8–10 years (catch-down growth), and at 23–25 years of age (cardiometabolic profile).ResultsThe −11391A variant allele frequency was higher in LGA subjects (P=0.04). AA genotype was associated with augmented probability of being born LGA (odds ratio=4.14; 95% confidence interval: 1.16–16.7; P=0.03). This polymorphism was associated neither with body composition nor with postnatal growth pattern. At the age of 23–25 years, the −11391A variant allele was associated with higher serum adiponectin levels (GG: 10.7±6.2 versus GA: 12.2±6.5 versus AA: 14.2±6.8 μg/ml; P<0.01). Subjects born LGA presented higher body mass index (BMI; P=0.01), abdominal circumference (P=0.04), blood pressure (P=0.04), and homeostasis assessment model for insulin resistance (P=0.01) than adequate for gestational age. Symmetry at birth did not influence these variables. The occurrence of catch-down of weight was associated with lower BMI and abdominal circumference (P<0.001) at 23–25 years.ConclusionsThe −11391A ADIPOQ gene variant was associated with increased chance of being born LGA and with higher adiponectin levels in early adult life.

Leptin, Insulin, and Glucose Serum Levels in Large-for-Gestational-Age Infants of Diabetic and Non-Diabetic Mothers

2008 ◽  
Vol 21 (1) ◽  
Author(s):  
M.M. Vela-Huerta ◽  
E.U. San Vicente-Santoscoy ◽  
J.M. Guizar-Mendoza ◽  
N. Amador-Lieona ◽  
C. Aldana-Valenzuela ◽  
...  
Keyword(s):  
Gestational Age ◽  
Serum Levels ◽  
Large For Gestational Age ◽  
Diabetic Mothers

scholarly journals Plasma IL-1 Receptor Antagonist Concentration Has an Inverse Association With Birth Weight in Prepubertal Children

2018 ◽  
Vol 2 (3) ◽  
pp. 232-239 ◽  
Author(s):  
Henrikki Nordman ◽  
Raimo Voutilainen ◽  
Leena Antikainen ◽  
Jarmo Jääskeläinen
Keyword(s):  
Receptor Antagonist ◽  
Gestational Age ◽  
Standard Deviation Score ◽  
Large For Gestational Age ◽  
Birth Size ◽  
Study Cohort ◽  
Low Grade ◽  
Inverse Association ◽  
Prepubertal Children ◽  
Hs Crp

Abstract Context Birth size has an impact on later cardiometabolic risk that is strongly related to low-grade inflammation. Objective To evaluate plasma interleukin-1 receptor antagonist (IL-1ra) concentrations in relation to birth size and cardiometabolic and inflammatory markers in prepubertal children. Design A cohort study. Anthropometric data were recorded. Fasting blood samples were collected for plasma analyses of IL-1ra, alanine transaminase, total cholesterol, high- and low-density lipoprotein cholesterols, triglyceride, glucose, and serum analyses of 25-hydroxyvitamin D [25(OH)D] and high-sensitivity C-reactive protein (hs-CRP) concentrations. Participants Forty-nine large for gestational age (LGA), 56 appropriate for gestational age, and 23 small for gestational age (SGA) children at 5 to 8 years of age were examined. Main Outcome Measures Differences in IL-1ra concentrations among the birth-size groups and associations between IL-1ra and other metabolic markers were assessed. Results Body mass index (BMI) standard deviation score (SDS)-adjusted plasma IL-1ra concentrations were highest in the SGA- and lowest in the LGA-born children (P = 0.015). Age- and sex-adjusted IL-1ra concentrations had strongest associations with BMI SDS (P &lt; 0.001) and hs-CRP (P &lt; 0.001, also when further adjusted for BMI SDS). Conclusions Prepubertal children born SGA had the highest and those born LGA the lowest IL-1ra concentrations in this study cohort. Most associations found between IL-1ra and the studied metabolic parameters were weight related, but the association with hs-CRP remained strong after adjustment for BMI. It seems that at prepuberty, SGA children have a stronger inflammatory state than LGA children and may thus be at a greater risk for later metabolic disturbances.

Birth Size, Postnatal Growth and Growth during Growth Hormone Treatment in Small-for-Gestational-Age Children: Associations with IGF1 Gene Polymorphisms and Haplotypes?

2009 ◽  
Vol 72 (1) ◽  
pp. 15-24 ◽  
Author(s):  
Wietske A. Ester ◽  
Joyce B. van Meurs ◽  
Nicolette J. Arends ◽  
Andr&eacute; G. Uitterlinden ◽  
Maria A. de Ridder ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Gene Polymorphisms ◽  
Growth Hormone Treatment ◽  
Hormone Treatment ◽  
Postnatal Growth ◽  
Birth Size ◽  
I Gene

Abdominal Circumference Alone versus Estimated Fetal Weight after 24 Weeks to Predict Small or Large for Gestational Age at Birth: A Meta-Analysis

2017 ◽  
Vol 34 (11) ◽  
pp. 1115-1124 ◽  
Author(s):  
José Yordan ◽  
Bradley Holbrook ◽  
Pranita Nirgudkar ◽  
Ellen Mozurkewich ◽  
Nathan Blue
Keyword(s):  
Gestational Age ◽  
Meta Analysis ◽  
Screening Method ◽  
Case Series ◽  
Fetal Weight ◽  
Abdominal Circumference ◽  
Large For Gestational Age ◽  
Predictive Values ◽  
Sensitivity Specificity ◽  
Estimated Fetal Weight

Objective We compared the sensitivity and specificity of abdominal circumference (AC) alone versus estimated fetal weight (EFW) to predict small for gestational age (SGA) or large for gestational age (LGA) at birth. Study Design We searched the literature for studies assessing an ultrasonographic AC or EFW after 24 weeks to predict SGA or LGA at birth. Case series or studies including anomalous fetuses or multiple gestations were excluded. We computed the sensitivity, specificity, and positive and negative predictive values of any AC or EFW cutoff analyzed by at least two studies. Results We identified 2,460 studies, of which 40 met inclusion criteria (n = 36,519). Four studies assessed AC alone to predict SGA (n = 5,119), and six assessed AC to predict LGA (n = 6,110). Sixteen assessed EFW to predict SGA (n = 13,825), and 22 evaluated EFW to predict LGA (n = 18,896). To predict SGA, AC and EFW < 10th percentile have similar ability to predict SGA. To predict LGA, AC cutoffs were comparable to all EFW cutoffs, except that AC > 35 cm had better sensitivity. Conclusion After 24 weeks, AC is comparable to EFW to predict both SGA and LGA. In settings where serial EFWs are inaccessible, a simpler screening method with AC alone may suffice.

Predictive Value of Fetal Abdominal Circumference in Diagnosing Large for Gestational Age Infants [9D]

2019 ◽  
Vol 133 (1) ◽  
pp. 44S-44S
Author(s):  
Rohini Kopparam ◽  
Kathy Matthews ◽  
Rana Khan ◽  
Tracy B. Grossman ◽  
Shari Ellen Gelber
Keyword(s):  
Gestational Age ◽  
Predictive Value ◽  
Abdominal Circumference ◽  
Large For Gestational Age

IGF-II expression and methylation in small for gestational age infants

2015 ◽  
Vol 28 (5-6) ◽  
Author(s):  
Shulian Zhang ◽  
Guanpeng Zhai ◽  
Jin Wang ◽  
Wenjing Shi ◽  
Rong Zhang ◽  
...  
Keyword(s):  
Birth Weight ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Newborn Infants ◽  
Adult Life ◽  
Adverse Outcomes ◽  
Large For Gestational Age ◽  
Increased Risk ◽  
The Status ◽  
Appropriate For Gestational Age

AbstractLow birth weight is associated with an increased risk of adverse outcomes in many diseases in adult life. We investigated the expression of IGF-II and the status of differentially methylated regions (DMR) in small for gestational age (SGA) infants after birth.Plasma IGF-II, IGF-II receptor (IGF2R), IGF-I, and IGF-binding protein 3 (IGFBP3) levels were measured after birth in 150 newborn infants. These included 30 term appropriate for gestational age (AGA), 30 term SGA, 30 term large for gestational age (LGA), 30 preterm AGA, and 30 preterm SGA infants.Plasma IGF-II levels after birth were lower in both term SGA (435.1±33.82 vs. 620.4±44.79, p=0.002) and LGA infants (483.7±33.8 vs. 620.42±44.79, p=0.018) than in term AGA infants. The expression ofIGF-II was associated with birth weight and expressed at high levels, which suggests that IGF-II may continue to play an important role after birth.

scholarly journals Childhood Health Outcomes in Term, Large-for-Gestational-Age Babies With Different Postnatal Growth Patterns

2017 ◽  
Vol 187 (3) ◽  
pp. 507-514 ◽  
Author(s):  
Xiaoping Lei ◽  
Dongying Zhao ◽  
Lisu Huang ◽  
Zhongcheng Luo ◽  
Jun Zhang ◽  
...  
Keyword(s):  
Health Outcomes ◽  
Gestational Age ◽  
Postnatal Growth ◽  
Growth Patterns ◽  
Large For Gestational Age ◽  
Childhood Health
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