Changes in body composition following 12 months randomized treatment with metformin vs oral contraceptives vs combined treatment in polycystic ovary syndrome

2014 ◽  
Author(s):  
Dorte Glintborg ◽  
Magda Altinok ◽  
Hanne Mumm ◽  
Anne Pernille Hermann ◽  
Pernille Ravn ◽  
...  
Keyword(s):  
Body Composition ◽  
Polycystic Ovary Syndrome ◽  
Oral Contraceptives ◽  
Polycystic Ovary ◽  
Combined Treatment ◽  
Ovary Syndrome

scholarly journals Lean Women on Metformin and Oral Contraceptives for Polycystic Ovary Syndrome Demonstrate a Dehydrated Osteosarcopenic Phenotype: A Pilot Study

Nutrients ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 2055 ◽  
Author(s):  
Charikleia Stefanaki ◽  
Flora Bacopoulou ◽  
Eleni Kandaraki ◽  
Dario Boschiero ◽  
Evanthia Diamandi-Kandarakis
Keyword(s):  
Body Composition ◽  
Polycystic Ovary Syndrome ◽  
Oral Contraceptives ◽  
Muscle Glycogen ◽  
Polycystic Ovary ◽  
Body Water ◽  
The Body ◽  
Low Grade ◽  
Ovary Syndrome ◽  
Cellular Dehydration

Scarce data exist on the body composition of lean women with polycystic ovary syndrome (PCOS) on treatment with metformin and oral contraceptives (OCs). Thirty-four lean (body mass index 18.5–24.9 kg/m2) women (17 with PCOS on metformin and OCs treatment for six months and 17 controls) aged 18–40 years were assessed for body composition parameters (fat, muscle, glycogen, protein masses, bone masses, and body water compartments) and phase angles. PCOS patients demonstrated lower muscle, glycogen and protein masses (U = 60, p = 0.003), along with a lower bone mineral content and mass (U = 78, p = 0.021; U = 74, p = 0.014) than their healthy counterparts, while total and abdominal fat masses were similar between the two groups. PCOS patients also exhibited increased extracellular body water (U = 10, p < 0.001) and decreased intracellular water, compatible with low-grade inflammation and cellular dehydration. Key differences in body composition between women with PCOS and controls demonstrated an osteosarcopenic body composition phenotype in PCOS patients. A confirmation of these findings in larger studies may render osteosarcopenia management a targeted adjunct therapy in women with PCOS.

Characteristics of body composition in different phenotypes of women with polycystic ovary syndrome

2015 ◽  
Author(s):  
Dusan Ilic ◽  
Djuro Macut ◽  
Ivana Bozic Antic ◽  
Jelica Bjekic Macut ◽  
Danijela Vojnovic Milutinovic ◽  
...  
Keyword(s):  
Body Composition ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Ovary Syndrome

Influence of oral contraceptives on anthropomorphometric, endocrine, and metabolic profiles of anovulatory polycystic ovary syndrome patients

2014 ◽  
Vol 101 (6) ◽  
pp. 1757-1765.e1 ◽  
Author(s):  
Miranda G. Mes-Krowinkel ◽  
Yvonne V. Louwers ◽  
Annemarie G.M.G.J. Mulders ◽  
Frank H. de Jong ◽  
Bart C.J.M. Fauser ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Oral Contraceptives ◽  
Polycystic Ovary ◽  
Metabolic Profiles ◽  
Ovary Syndrome

scholarly journals Anthropometric and body composition analysis of infertile women with polycystic ovary syndrome

2017 ◽  
Vol 12 (2) ◽  
pp. 139-145 ◽  
Author(s):  
Havagiray R. Chitme ◽  
Eman A.K. Al Azawi ◽  
Anfal M. Al Abri ◽  
Buthina M. Al Busaidi ◽  
Zamzam K.A. Salam ◽  
...  
Keyword(s):  
Body Composition ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Composition Analysis ◽  
Ovary Syndrome ◽  
Body Composition Analysis ◽  
Infertile Women

scholarly journals SUN-010 Efficacy of High Intensity Intermittent Training for Improving Cardio-Metabolic Health in Women with Polycystic Ovary Syndrome: A Pilot Study

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Rhiannon Kate Patten ◽  
Luke McIlvenna ◽  
Alba Moreno-Asso ◽  
Nigel Nigel Stepto ◽  
Danielle Hiam
Keyword(s):  
Body Composition ◽  
Insulin Sensitivity ◽  
Polycystic Ovary Syndrome ◽  
High Intensity ◽  
Polycystic Ovary ◽  
Metabolic Health ◽  
Moderate Intensity ◽  
Sensitivity Index ◽  
Maximal Heart Rate ◽  
Ovary Syndrome

Abstract Polycystic ovary syndrome (PCOS) is a common and complex endocrinopathy with reproductive and metabolic manifestations, carrying a major health and economic burden. Exercise training has consistently been found improve clinical outcomes in women with PCOS, but shortfalls with exercise prescription are evident. Research suggests that high intensity intermittent exercise (HIIT) is feasible, well tolerated and enjoyable for people with or at risk of chronic disease and can address many of the shortfalls and barriers to exercise participation. To investigate the effects of high intensity exercise, twenty-four reproductive aged, overweight and obese, previously sedentary women with PCOS were recruited from the community and randomised to complete either 12 weeks of moderate intensity continuous cycling exercise (MOD; 50-60% of maximal heart rate [HRmax]; n=11) or HIIT (90-95% HRmax; n=13). All exercise was supervised by an exercise physiologist and completed 3 times per week on a cycle ergometer. Baseline and post testing measures consisted of peak oxygen consumption (VO2peak) determine by a graded maximal exercise test, insulin sensitivity determined by hyperinsulinaemic-euglycaemic clamp, body composition outcomes and anti-mullerian hormone (AMH). Enjoyment was also measured throughout the intervention using feeling scales. Significant improvements were seen for VO2peak after HIIT with an average increase of 5.6 ± 2.5 mL.kg-1.min-1 (P=0.013) and non-significant increases in the MOD group (3.4 ± 2.1 mL/kg/min; P=0.20). Body composition, fasting insulin and AMH values remained unchanged in both groups. Non-significant improvements in glucose infusion rate (3.3 ± 2.8 mg.lbmkg-1.min-1; P=0.06) and insulin sensitivity index (M-to-I ratio; 3.0 ± 3.8 mg.lbmkg-1.min-1[mU/I]-1 x 100; P=0.17) were found as a result of HIIT compared to no changes after moderate intensity exercise. Importantly, HIIT was also found to be more enjoyable than moderate intensity continuous exercise. The present study is the first to compare current exercise recommendations of moderate and vigorous intensities in women with PCOS. The results of this study provide preliminary validation of HIIT and should be considered for improving cardio-metabolic health in women with PCOS.

Sign in / Sign up

Export Citation Format

Share Document