Randomized clinical trial to compare the effects of glargine multidosis versus CSII therapy on metabolic and oxidative stress parameters in people with type 1 diabetes

Abstract Background Type 1 diabetes is a main health burden with several related comorbidities. It has been shown that endothelial function, vascular structure, and metabolic parameters are considerably disrupted in patients with type 1 diabetes. Omega-3 as an adjuvant therapy may exert profitable effects on type 1 diabetes and its complications by improving inflammation, oxidative stress, immune responses, and metabolic status. Because no randomized clinical trial has examined the effects of omega-3 consumption in children and adolescents with type 1 diabetes; the present study aims to close this gap. Methods This investigation is a randomized clinical trial, in which sixty adolescents with type 1 diabetes will be randomly assigned to receive either omega-3 (600 mg/day) or placebo capsules for 12 weeks. Evaluation of anthropometric parameters, flow-mediated dilation (FMD) as an endothelial function marker, carotid intima-media thickness (CIMT) as a vascular structure marker, proteinuria, biochemical factors including glycemic and lipid profile, blood urea nitrogen (BUN), creatinine, high-sensitivity C-reactive protein (hs-CRP), and erythrocyte sedimentation rate (ESR), as well as blood pressure will be done at the baseline and end of the trial. Also, dietary intake and physical activity will be assessed throughout the study. Statistical analysis will be performed using the SPSS software (Version 24), and P < 0.05 will be considered statistically meaningful. Discussion It is hypothesized that omega-3 supplementation may be beneficial for the management of type 1 diabetes and its complications by reducing inflammation and oxidative stress and also modulating immune responses and glucose and lipid metabolism through various mechanisms. The present study aims to investigate any effect of omega-3 on patients with type 1 diabetes. Ethical aspects This trial received approval from Medical Ethics Committee of Iran University of Medical Sciences, Tehran, Iran (IR.IUMS.REC.1400.070). Trial registration Iranian Registry of Clinical Trials IRCT20210419051010N1. Registered on 29 April 2021

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Faculty Opinions recommendation of Effect of continuous glucose monitoring on glycemic control in adolescents and young adults with type 1 diabetes: A randomized clinical trial.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.738151941.793576584 ◽

2020 ◽

Author(s):

Helmy Siragy

Keyword(s):

Clinical Trial ◽

Type 1 Diabetes ◽

Young Adults ◽

Glycemic Control ◽

Randomized Clinical Trial ◽

Continuous Glucose Monitoring ◽

Glucose Monitoring ◽

Adolescents And Young Adults

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Omega-3 fatty acids and mood stabilizers alter behavioral and oxidative stress parameters in animals subjected to fenproporex administration

Metabolic Brain Disease ◽

10.1007/s11011-016-9942-7 ◽

2016 ◽

Vol 32 (2) ◽

pp. 519-528 ◽

Cited By ~ 2

Author(s):

Lara M. Gomes ◽

Milena Carvalho-Silva ◽

Letícia J. Teixeira ◽

Joyce Rebelo ◽

Isabella T. Mota ◽

...

Keyword(s):

Oxidative Stress ◽

Fatty Acids ◽

Mood Stabilizers ◽

Omega 3 Fatty Acids ◽

Omega 3 ◽

Oxidative Stress Parameters ◽

And Oxidative Stress ◽

Stress Parameters

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Behavior and oxidative stress parameters in rats subjected to the animal's models induced by chronic mild stress and 6-hydroxydopamine

Behavioural Brain Research ◽

10.1016/j.bbr.2021.113226 ◽

2021 ◽

Vol 406 ◽

pp. 113226

Author(s):

Talita Tuon ◽

Sandra S. Meirelles ◽

Airam B. de Moura ◽

Thayse Rosa ◽

Laura A. Borba ◽

...

Keyword(s):

Oxidative Stress ◽

Chronic Mild Stress ◽

Mild Stress ◽

Oxidative Stress Parameters ◽

6 Hydroxydopamine ◽

And Oxidative Stress ◽

Stress Parameters

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Conjugated Linoleic Acid-Curcumin Attenuates Cognitive Deficits and Oxidative Stress Parameters in the Ethidium Bromide–Induced Model of Demyelination

Neurotoxicity Research ◽

10.1007/s12640-020-00310-0 ◽

2021 ◽

Author(s):

Behnaz Barzegarzadeh ◽

Homeira Hatami ◽

Gholamreza Dehghan ◽

Nazli Khajehnasiri ◽

Mehdi Khoobi ◽

...

Keyword(s):

Oxidative Stress ◽

Linoleic Acid ◽

Conjugated Linoleic Acid ◽

Ethidium Bromide ◽

Cognitive Deficits ◽

Oxidative Stress Parameters ◽

And Oxidative Stress ◽

Stress Parameters

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Protective role of Sterculia tragacantha aqueous extract on pancreatic gene expression and oxidative stress parameters in streptozotocin-induced diabetic rats

Journal of Complementary and Integrative Medicine ◽

10.1515/jcim-2021-0020 ◽

2021 ◽

Vol 0 (0) ◽

Author(s):

Basiru Olaitan Ajiboye ◽

Babatunji Emmanuel Oyinloye ◽

Jennifer Chidera Awurum ◽

Sunday Amos Onikanni ◽

Adedotun Adefolalu ◽

...

Keyword(s):

Oxidative Stress ◽

Body Weight ◽

Protective Role ◽

Diabetic Rats ◽

Gene Expressions ◽

Ki 67 ◽

Oxidative Stress Parameters ◽

And Oxidative Stress ◽

Stress Parameters

Abstract Objectives The current study evaluates the protective role of aqueous extract of Sterculia tragacantha leaf (AESTL) on pancreatic gene expressions (insulin, PCNA, PDX-1, KI-67 and GLP-1R) and oxidative stress parameters in streptozotocin-induced diabetic rats. Methods Diabetes mellitus was induced into the experimental Wistar animals via intraperitoneal (IP) injection of streptozotocin (35 mg/kg body weight) and 5% glucose water was given to the rats for 24 h after induction. The animals were categorized into five groups of 10 rats each as follows normal control, diabetic control, diabetic rats administered AESTL (150 and 300 mg/kg body weight) and diabetic rats administered metformin (200 mg/kg) orally for two weeks. Thereafter, the animals were euthanized, blood sample collected, pancreas harvested and some pancreatic gene expressions (such as insulin, PCNA, PDX-1, KI-67, and GLP-1R)s as well as oxidative stress parameters were analyzed. Results The results revealed that AESTL significantly (p<0.05) reduced fasting blood glucose level, food and water intake, and lipid peroxidation in diabetic rats. Diabetic rats administered different doses of AESTL showed a substantial upsurge in body weight, antioxidant enzyme activities, and pancreatic gene expressions (insulin, PCNA, PDX-1, KI-67, and GLP-1R). Conclusions It can therefore be concluded that AESTL has the ability to protect the pancreas during diabetes mellitus conditions.

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