Adherence to levothyroxine treatment and factors related with adherence in hypothyroid patients

2021 ◽  
Author(s):  
Ahmet Dirikoc ◽  
Birgul Genc ◽  
Didem Ozdemir ◽  
Abbas Ali Tam ◽  
Oya Topaloglu ◽  
...  
Keyword(s):  
Hypothyroid Patients ◽  
Levothyroxine Treatment

scholarly journals Probiotics Ingestion Does Not Directly Affect Thyroid Hormonal Parameters in Hypothyroid Patients on Levothyroxine Treatment

2017 ◽  
Vol 8 ◽  
Author(s):  
Giorgia Spaggiari ◽  
Giulia Brigante ◽  
Sara De Vincentis ◽  
Umberto Cattini ◽  
Laura Roli ◽  
...  
Keyword(s):  
Hypothyroid Patients ◽  
Levothyroxine Treatment

scholarly journals The relationship between the TSH values and the Tpeak – Tend interval duration in hypothyroid patients receiving Levothyroxine treatment

2019 ◽  
Vol 57 (2) ◽  
pp. 175-180
Author(s):  
Hüseyin Avni Findikli ◽  
Ayşe Şahin Tutak ◽  
Hakan Aydin
Keyword(s):  
Hormone Level ◽  
Cross Sectional Study ◽  
Healthy Individuals ◽  
Sectional Study ◽  
Control Groups ◽  
Cross Sectional ◽  
And Control ◽  
The Relationship ◽  
Hypothyroid Patients ◽  
Levothyroxine Treatment

Abstract Introduction. Changes in thyroid hormone level can affect the cardiovascular system. The aim of this study was to show how the Tpeak -Tend (Tpe) interval, which is a new marker of ventricular arrythmia, is affected in patients who have become euthyroid following Levothyroxine treatment for hypothyroidism, as this has not been examined previously in literature. Materials and Methods. This, cross-sectional study included a total of 119 females aged 18-45 years, separated into 3 groups as hypothyroid, euthyroid and control groups. For evaluation of the QTc and Tpe intervals, examination on precordial V5 lead was made of all the ECGs taken routinely on presentation of the patients. Results. The Tpe and QTc intervals of the hypothyroid group were determined to be significantly prolonged compared to those of the euthyroid and control groups (p < 0.001) and the values of the euthyroid and control groups were similar. A positive correlation was determined between TSH levels and Tpe and QTc intervals. Tpe interval AUC = 0.801 (%95 CI: 0.719 – 0.884) was higher than that of QTc AUC = 0.689 (%95 CI: 0.591 – 0.786). Conclusions. The Tpe duration was evaluated in respect of the risk of arrythmia in hypothyroid patients. In patients who had become euthyroid, the Tpe interval was found to be similar to that of healthy individuals and was more predictive than QTc. In the light of these findings it can be recommended that measurement of the Tpe interval should be preferred to QTc as a marker of the arrythmogenic effect in hypothyroid patients.

Profiling of Carnitine and Acylcarnitines of Late-Diagnosed Hypothyroid Patients with Fatigue Under Levothyroxine Treatment

2021 ◽  
Author(s):  
Mst. Noorjahan Begum ◽  
Suprovath Kumar Sarker ◽  
Golam Sarower Bhuyan ◽  
Md Tarikul Islam ◽  
Shahinur Haque ◽  
...  
Keyword(s):  
Hypothyroid Patients ◽  
Levothyroxine Treatment

Adherence of levothyroxine treatment in primary hypothyroid patients in Turkey: a multicenter study

2014 ◽  
Author(s):  
Dilek Gogas Yavuz ◽  
Lezzan Keskin ◽  
Aysegul Atmaca ◽  
Oguz Dikbas ◽  
Zeliha Hekimsoy ◽  
...  
Keyword(s):  
Multicenter Study ◽  
Hypothyroid Patients ◽  
Levothyroxine Treatment

scholarly journals Headache in recent onset hypothyroidism: Prevalence, characteristics and outcome after treatment with levothyroxine

Cephalalgia ◽  
2016 ◽  
Vol 37 (10) ◽  
pp. 938-946 ◽  
Author(s):  
Marise de Farias Lima Carvalho ◽  
Josian Silva de Medeiros ◽  
Marcelo Moraes Valença
Keyword(s):  
Subclinical Hypothyroidism ◽  
Posterior Part ◽  
Cross Sectional Study ◽  
Overt Hypothyroidism ◽  
Sectional Study ◽  
Cross Sectional ◽  
Recent Onset ◽  
Severe Intensity ◽  
Hypothyroid Patients ◽  
Levothyroxine Treatment

Objective The objective of this article is to analyze the features of headache attributed to hypothyroidism (HAH), evaluate the differences between groups with and without HAH, between “overt” and “subclinical” hypothyroidism groups, and evaluate outcomes after levothyroxine treatment. Methods Patients with hypothyroidism were selected in a cross-sectional study, followed prospectively for 12 months, and classified as subclinical or overt hypothyroidism. The patients were divided into two groups: with and without HAH. Results HAH was reported by 73/213 (34%) patients, involving the following areas: fronto-orbital (49%), temporal (37%), and posterior part of the head (15%). The HAH features were as follows: pulsatile (63%), four to 72 hours’ duration (78%), unilateral (47%), nausea/vomiting (60%), and moderate-severe intensity (72%). Hypothyroidism symptomatology was similar in both groups, except for a greater frequency of hoarseness in the group with HAH. Migraine history was more frequent in the patients with HAH (53% vs 38%, p < 0.05). The frequency of HAH was similar both in overt and subclinical hypothyroidism. After levothyroxine treatment 78% reported a decrease in HAH frequency. Subclinical and overt hypothyroid patients reported a similar alleviation of their headaches. Conclusion Patients with HAH may present with unilateral, pulsatile, episodic pattern, and nausea/vomiting, which is at odds with the criteria for HAH established by ICHD 3 beta. Not all individuals responded to levothyroxine, and patients with the subclinical form of hypothyroidism benefit from this treatment.

scholarly journals SAT-425 Characteristics of Hypothyroid Patients Achieving Long Term Euthyroidism on Levothyroxine Treatment

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Howard Tandeter ◽  
JaYanah Murad ◽  
Liad Alfandari ◽  
Victor Novack ◽  
Merav Fraenkel
Keyword(s):  
Subclinical Hypothyroidism ◽  
Thyroid Autoantibodies ◽  
Iron Supplements ◽  
Levothyroxine Replacement ◽  
Clalit Health Service ◽  
Study Population ◽  
Pre Treatment ◽  
Hypothyroid Patients ◽  
Levothyroxine Treatment

Abstract Background Studies have shown that hypothyroid patients treated with Levothyroxine replacement therapy often experience fluctuations in TSH levels, while others remain well controlled over time. Aim To assess the association between pre-treatment TSH and other biochemical and clinical characteristics and long-term maintenance of normal TSH under Levothyroxine treatment. Methods This is a retrospective nested case-control study. Study population included patients above age 18 insured by Clalit Health Service (CHS) in the South of Israel between the years 2002-2017, diagnosed with hypothyroidism (ICD 9 code 244.9) and who had at least one TSH measurement before initiating levothyroxine therapy, purchased this medication for at least 5 consecutive years with one annual TSH measurement while on treatment. Patients with surgical, post iodine ablation or congenital hypothyroidism were excluded. Patients with a TSH level within the normal range for 5 consecutive years were defined as cases while the others served as controls. Demographic, laboratory, pregnancy status and pharmacy purchase were extracted from the computerized medical records of CHS and compared between the groups. Results Out of 5472 patients included in the study, 644 had a normal TSH for 5 consecutive years (11.8%, cases). Mean age at first levothyroxine purchase was 55.8±13.7 in cases and 54.10±16.2 in controls (p=0.003) and females comprised 84.8% and 81.4% respectively (p=0.035). Mean pretreatment TSH was 5.15±9.6 in cases and 10.02±29 in controls (p&lt;0.001). Thyroid autoantibodies (anti TPO or anti thyroglobulin) were available in 40.8% and 44.8% of cases and controls respectively (P=0.63) and were positive in 36.5% and 56.7% (p&lt;0.01). Subclinical hypothyroidism was diagnosed in 44.4% of cases and 54.6% of controls with prior to treatment. The odds ratio (OR) for having normal TSH for at least 5 consecutive years, using multivariable logistic regression was 0.99 for pretreatment mean TSH (p=0.89), 0.48 for positive thyroid antibodies (p&lt;0.001), 0.72 for pretreatment diagnosis of subclinical hypothyroidism (p=0.032), 0.69 for use of iron supplements and 1.01 for age at first levothyroxine purchase (per year, p=0.02). Conclusions In our study population of adults with hypothyroidism treated with levothyroxine, only 11.8% were controlled for at least 5 consecutive years. Positive thyroid autoantibodies, pretreatment subclinical hypothyroidism and use of iron supplements lowered probability of long term TSH normalization, while age was associated with the increased rate. Further research should test whether TSH control for 5 consecutive years signals simply “good contol”, or perhaps the possibility of transient forms of hypothyroidism for which treatment discontinuation is recommended.

STUDY OF SERUM ELECTROLYTES IMBALANCES IN FEMALE THYROID PATIENTS AT AIIMS, PATNA: A HOSPITAL BASED COMPARATIVE STUDY.

2019 ◽  
Vol 3 (6) ◽  
Author(s):  
Dr. Jyoti Kumari ◽  
Dr. Dev Kant ◽  
Dr. Mala Mahto
Keyword(s):  
Standard Deviation ◽  
Early Detection ◽  
P Value ◽  
Selective Electrode ◽  
Serum Electrolytes ◽  
Sodium Potassium ◽  
Paired Samples ◽  
Electrode Method ◽  
Hypothyroid Patients ◽  
Key Words Hypothyroidism

Objectives: This present study was to compare the serum electrolytes (Na, K and Cl) imbalances in hypothyroidism, hyperthyroidism with euthyroidism female cases. Methods: A detail history, clinical examinations and relevant investigations were performed to all female thyroid cases. Thyroid hormones were estimated by chemiluminiscence method using Siemens Advia Centaur XP instrument. Electrolyte levels (Na+, k+ & Cl-) were measured by ion selective electrode method using Eschweiler combi. Results: Data was analyzed with the help of SPSS (version 26) software. Paired samples statistics was used. Mean ± standard deviation and t value were calculated. P value was taken less than or equal to 0.05 (p ≤ 0.05) for significant differences. Conclusions: This present study concluded that electrolytes sodium, potassium and chloride levels were significantly reduced in hypothyroidism female cases compared to euthyroids female (controls). This suggests that hypothyroid patients should be regularly checked for serum electrolytes. Early detection and treatment can prevent the further complications related to the disorder and will be helpful during the management of thyroid patients. Key words: Hypothyroidism, hyperthyroidism, euthyroidism, electrolytes.

EVALUATION OF A SIMPLIFIED METHOD FOR DETERMINING SERUM THYROXINE BY COMPETITIVE PROTEIN BINDING ANALYSIS

1970 ◽  
Vol 64 (4) ◽  
pp. 630-636 ◽  
Author(s):  
Stephen C. Thorson ◽  
Ronald Tsujikawa ◽  
James L. Brown ◽  
Robert T. Morrison ◽  
Hamish W. McIntosh
Keyword(s):  
Protein Binding ◽  
Clinical Application ◽  
Thyroid Status ◽  
Serum Thyroxine ◽  
Binding Analysis ◽  
Simplified Method ◽  
Competitive Protein Binding ◽  
Hypothyroid Patients

ABSTRACT Serum thyroxine concentrations were determined in 66 euthyroid, 30 hyperthyroid and 13 hypothyroid patients using both the established Murphy method and a simplified method of competitive protein binding analysis. A diagnosis compatibility of 96% was found with both methods indicating that the simplified method has comparable clinical application as an initial screen of thyroid status.

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