Proceedings: Hormonal changes occurring in cattle following the administration of prostaglandin F 2alpha

Reproduction ◽  
1974 ◽  
Vol 36 (2) ◽  
pp. 484-485 ◽  
Author(s):  
C. Nancarrow ◽  
H Hearnshaw ◽  
P. Mattner ◽  
P. Connell ◽  
B. Restall
Keyword(s):  
Hormonal Changes ◽  
Prostaglandin F

THE SEQUENCE OF HORMONAL CHANGES DURING PROSTAGLANDIN INDUCED LUTEOLYSIS OF THE SUPERLUTEINIZED RAT OVARY

1978 ◽  
Vol 87 (3) ◽  
pp. 617-624 ◽  
Author(s):  
P. A. Torjesen ◽  
R. Dahlin ◽  
E. Haug ◽  
A. Aakvaag
Keyword(s):  
Binding Sites ◽  
Limit Of Detection ◽  
Serum Levels ◽  
Female Rats ◽  
Serum Prolactin ◽  
Hormonal Changes ◽  
Subsequent Increase ◽  
Serum Progesterone ◽  
Serum Lh ◽  
Prostaglandin F

ABSTRACT Immature female rats were pre-treated with pregnant mare's serum gonadotrophin (PMSG) and human chorionic gonadotrophin (HCG) to achieve superluteinization. Eight days after the HCG administration luteolysis was induced by sc injection of 5 μg of the prostaglandin F2α (PGF2α) analogue cloprostenol (Estrumate®). The serum levels of progesterone, 20α-dihydroprogesterone (20α-DHP), prolactin (PRL) and luteinizing hormone (LH) as well as the number of ovarian LH binding sites were measured during the first 23 h after cloprostenol injection. The serum levels of progesterone decreased from 500 to 200 ng/ml within 25 min after cloprostenol administration. A further decrease to 20 ng/ml occurred during the next 4 h, and serum progesterone remained low for the rest of the period. An increase in serum prolactin (PRL) to values between 28 and 44 ng/ml was observed after 3 h and the values remained elevated for the next 7 h. Although the serum levels of progesterone declined immediately, the serum 20α-dihydroprogesterone (20α-DHP) levels remained at 60 to 140 ng/ml for the first 5 h and then gradually increased to values corresponding to the initial progesterone levels 14 to 23 h after treatment. The number of ovarian LH binding sites was between 1.2 and 1.4 × 10−12 mol/mg protein during the first 9 h after prostaglandin (PG) injection, and then decrreased to 0.8 and 0.5 × 10−12 mol/mg protein at 14 and 23 h, respectively. The serum LH levels remained below the limit of detection for the assay (10 ng/ml) throughout the observation period. PGF2α injection induced the same basic changes in the serum levels of progesterone and 20α-DHP as cloprostenol treatment. Thus, the first effect of PG treatment measured was an immediate decline in the serum levels of progesterone, and this decline probably initiated the subsequent increase in pituitay PRL and ovarian 20α-DHP secretion. Therefore, the decrease in the number of ovarian LH binding sites appeared to be a consequence rather than a mediator of luteolytic effects of the prostaglandins.

Hormonal changes at oestrus, parturition and post-partum oestrus in the tammar wallaby (Macropus eugenii)

1983 ◽  
Vol 96 (1) ◽  
pp. 155-161 ◽  
Author(s):  
C. H. Tyndale-Biscoe ◽  
L. A. Hinds ◽  
C. A. Horn ◽  
G. Jenkin
Keyword(s):  
Post Partum ◽  
Tammar Wallaby ◽  
Oestrous Cycle ◽  
High Peak ◽  
Rapid Decline ◽  
Hormonal Changes ◽  
Progesterone Concentration ◽  
Macropus Eugenii ◽  
Slow Decline ◽  
Prostaglandin F

Concentrations of progesterone, prolactin, LH and 13,14 dihydro-15-keto-prostaglandin F2α (PGFM) were measured in plasma of eight tammar wallabies at 8-hourly intervals during the end of pregnancy and post-partum oestrus initiated by removing the pouch young, and during the end of the oestrous cycle, similarly initiated. In the non-pregnant cycle oestrus occurred 29·7 ± 0·7 (mean ±s.e.m.) days after initiation of the cycle, was preceded by a slow decline in progesterone concentration from 1·6 nmol/l to less than 0·64nmol/l and was followed by a preovulatory peak of LH 5·3± 3·9 h later. In the pregnant cycle birth occurred 26·1±0·2 days after removing the pouch young and was followed 8·0 ± 2·1 h later by oestrus and 16·0± 2·5 h by an LH peak. The latter events thus occurred 3·2 days earlier in the pregnant than in the non-pregnant cycle. Parturition coincided with a very rapid decline in progesterone and a transient high peak of prolactin. In two females sampled less than 25 min after parturition there was a transient peak of PGFM but in all others the concentrations of PGFM remained basal throughout. It is suggested that the fetus and/or placenta is involved in both the premature decline in progesterone and the initiation of parturition and that onset of oestrus and ovulation, being a consequence of a decline in progesterone, are therefore also determined by the fetus.

Influence of prostaglandins E2 and F2α on passage pressure across the uterotubal junction and isthmus in the rat

1995 ◽  
Vol 29 (3) ◽  
pp. 327-334 ◽  
Author(s):  
J. Ortega-Moreno
Keyword(s):  
Uterine Horn ◽  
Prostaglandin E ◽  
Hormonal Changes ◽  
Before And After ◽  
Treatment Measures ◽  
Prostaglandin F ◽  
Regulation Of Transport ◽  
Pre Treatment ◽  
The Right ◽  
Prostaglandins E2 And F2α

The influence of prostaglandins E2 and F2α on passage pressure across the uterotubal junction (UTJ) and isthmus were studied in rats that were either in the pro-oestrus, oestrus, metoestrus or dioestrus phases. Effects of these prostaglandins were also investigated in rats that had been either ovariectomized and treated with oestradiol or medroxiprogesterone acetate, or only ovariectomized. In each rat, the left UTJ was surgically resected and the isthmus anastomosed to the uterine horn, whereas the right UTJ was left untouched. The passage pressures across the left isthmus and the right UTJ were measured before and after prostaglandin treatment. The pressures obtained in the UTJ in the oestrus phase and oestrogen-treated ovariectomized animals were lower than those registered in the remaining groups. Prostaglandin E2 decreased the pressures when compared with pre-treatment measures in all groups. Significantly higher pressures were registered across the UTJ in prostaglandin F2α than in E2 treatment, with these higher pressures being similar to pre-treatment pressures. Both hormonal changes throughout the oestrous cycle and prostaglandin E2 treatment had a similar influence on the passage pressure across the isthmus, as that described for UTT, but with lower values. The results indicate that prostaglandin E2 decreases the passage pressure across both UTJ and isthmus and can have an influence on the regulation of transport across these 2 areas.

scholarly journals Estrus Responses and Hormonal Profiles of Gilts Following Treatments with Prostaglandin F2α

2017 ◽  
Vol 40 (1) ◽  
pp. 13-20
Author(s):  
Yusuf Abdulrasheed Alimi ◽  
Oluwafisayo Oluwadamilare Leigh ◽  
Oluwatoyin Oluwasola Ajala ◽  
John Olusoji Abiola
Keyword(s):  
Prostaglandin F2α ◽  
Hormonal Changes ◽  
Serum Samples ◽  
Intramuscular Injections ◽  
Hormonal Profiles ◽  
Prostaglandin F ◽  
Injection Control ◽  
Group A ◽  
Group B ◽  
Group D

Abstract This study investigated the effect of three intramuscular injections of Prostaglandin F2α (PGF2α) administered seven days apart on estrus responses and some reproductive hormonal profiles in post-pubertal gilts.Sixteen gilts were divided into groups A, B, C, and D, with four animals in each group. Group A, B and C gilts were treated with PGF2α injections intramuscularly at doses 5mg,7.5mg and 10mg per gilt respectively on Days 0, 6 and 13 of the experiment. Group D (Control) were treated with intramuscular injections of 2ml phosphate-buffered saline (PBS) instead. Serum samples were collected every 24 hours for four days after each PGF2α injection and estrus detection was conducted daily. Results showed that 100% of Group A came into estrus 96 hours after the second PGF2α injection,while 50% of Group B came into estrus after the first injection; with the other 50% exhibiting estrus following the 2nd injection. Only 50% of Group C displayed estrus signs and this was observed following the second PGF2α injection. Control gilts did not express behavioral estrus during this study, suggesting that PGF2α may have induced estrus in the treated animals. LH and estradiol concentrations were significantly different in Group A and B when compared to the control following the 2nd PGF2α injection. In all, it was observed that serum concentrations of LH, FSH and oestradiol-17β reached maximal levels just prior to expression of estrus, thus suggesting that the pattern of reproductive hormonal changes in PGF2α-synchronized gilts may be quite similar to those of naturally cycling in-estrus gilts.

FOETAL AND MATERNAL HORMONAL CHANGES PRECEDING NORMAL BOVINE PARTURITION

1977 ◽  
Vol 84 (3) ◽  
pp. 653-662 ◽  
Author(s):  
J. T. Hunter ◽  
R. J. Fairclough ◽  
A. J. Peterson ◽  
R. A. S. Welch
Keyword(s):  
Vena Cava ◽  
Rapid Decrease ◽  
Hormonal Changes ◽  
Jugular Veins ◽  
Dramatic Rise ◽  
Prostaglandin F ◽  
Competitive Protein Binding ◽  
Plasma Hormone ◽  
Jersey Cows ◽  
Chronic Cannulation

ABSTRACT Successful chronic cannulation of the foetal posterior vena cava and maternal utero-ovarian and jugular veins in five Jersey cows between days 240 and 260 of gestation enabled changes in plasma hormone levels preceding calving to be monitored. All cows delivered live calves within the expected range of gestation for the breed. Corticosteroids were assayed by competitive protein-binding, and prostaglandin F, progesterone, oestrone and oestradiol-17β by radioimmunoassay. Foetal corticosteroids rose slowly from 5.0 ± 0.7 ng/ml at 20 days to 9.3 ± 3.0 ng/ml at 10 days before term, then progressively increased to a mean of 74 ng/ml at calving. Maternal levels remained relatively constant at 5 to 15 ng/ml, though higher concentrations occurred following surgery. Foetal oestrone and oestradiol-17β concentrations were both less than 50 pg/ml and showed little change toward term. The maternal uteroovarian oestrogens increased slowly from 20 to 10 days pre-partum and then rose more rapidly reaching peak levels (2.9 ± 0.6 ng/ml for oestrone and 1.4 ± 0.3 ng/ml for oestradiol-17β) 1 to 4 days before delivery. Maternal progesterone concentrations fell towards term, with a rapid decrease over the last 36–48 h. Prostaglandin F levels showed little change until 36–48 h before calving when they gradually increased until the last 24 h where was a dramatic rise, reaching peak levels (5.7 ± 0.6 ng/ml) during labour.

Parathyroid gland before and after cisplatin treatment

1987 ◽  
Vol 45 ◽  
pp. 860-861
Author(s):  
S.K. Aggarwal ◽  
J.M. Fadool
Keyword(s):  
Parathyroid Gland ◽  
Wistar Rats ◽  
Antitumor Agent ◽  
The Body ◽  
Cross Linking ◽  
Limiting Factor ◽  
Hormonal Changes ◽  
Primary Mechanism ◽  
Before And After ◽  
Dna Strands

Cisplatin (CDDP) a potent antitumor agent suffers from severe toxic side effects with nephrotoxicity being the major dose-limiting factor, The primary mechanism of its action has been proposed to be through its cross-linking DNA strands. It has also been shown to inactivate various transport enzymes and induce hypocalcemia and hypomagnesemia that may be the underlying cause for some of its toxicities. The present is an effort to study its influence on the parathyroid gland for any hormonal changes that control calcium levels in the body.Male Swiss Wistar rats (Crl: (WI) BR) weighing 200-300 g and of 60 days in age were injected (ip) with cisplatin (7mg/kg in normal saline). The controls received saline injections only. The animals were injected (iv) with calcium (0.5 ml of 10% calcium gluconate/day) and were killed by decapitation on day 1 through 5. Trunk blood was collected in heparinized tubes.

Pengembangan perangkat pembelajaran dengan menggunakan pendekatan keterampilan proses untuk meningkatkan hasil belajar mata pelajaran التربية الجسمية bagi siswa kelas XI IPA MAN I Kota Mojokerto

2017 ◽  
Vol 1 (1) ◽  
pp. 115
Author(s):  
Sudar Kajin
Keyword(s):  
Learning Outcomes ◽  
Learning Strategy ◽  
Bone Structure ◽  
The Body ◽  
Process Skills ◽  
Hormonal Changes ◽  
Learning Tools ◽  
Body Structure ◽  
Use Of Resources ◽  
The Look

Growth and development of the child have the nature of a thorough and intertwined relationships between components (health, nutrition, and environment). In general, child development can be grouped into three areas, namely cognitive, affective, and psychomotor, whereas biological growth which includes a change in the body structure. Body structure regarding the changes in bone structure, especially the long bones that have an impact on changes in body size, whereas changes in bodily functions is a result of hormonal changes that affect the physiological function .. The purpose of this development are: 1) Describe the product feasibility study التربية الجسمية for grade XI IPA at MAN I Mojokerto 2) Describe the development of learning tools using process skills can improve learning outcomes subjects التربية الجسمية class XI IPA at MAN I Mojokerto From the results of this development can be concluded: 1) results of expert validation and testing, the model approach process skills is fit for use for subjects of Physical Education, Sport and Health, because the products developed are not revised by experts but from the results of questionnaire of students stated that require revision are: (a) Improve the look model or change the learning strategy, and (b) improve the use of resources in implementing the model. 2) Product development learning tools using process skills can improve learning outcomes subjects التربية الجسمية class XI IPA at MAN I Mojokerto. From the class of the test increased learning completeness of Pre and Post Tests Tests are respectively 77.78% increase to 91.67%.

Pituitary responses to a dopamine antagonist at different times of the day in normal women

1982 ◽  
Vol 100 (4) ◽  
pp. 481-485 ◽  
Author(s):  
F. R. Pérez-López ◽  
C. M. González-Moreno ◽  
M. D. Abós ◽  
J. A. Andonegui ◽  
R. H. Corvo
Keyword(s):  
Serum Prolactin ◽  
Dopamine Antagonist ◽  
Hormonal Changes ◽  
Healthy Women ◽  
Serum Lh ◽  
Normal Women ◽  
The Times ◽  
Serum Tsh

Abstract. In order to determine whether or not pituitary responsiveness to the dopaminergic antagonist clebopride changes during the nyctohemeral cycle, 10 healthy women with regular cycles were given 1 mg of clebopride orally at 09.00 h and 24.00 h with at least a 5 day interval between each test. In addition, 5 of the women were given a placebo instead of clebopride at midnight to evaluate the spontaneous hormonal changes. During the 24.00 h test the women had significantly higher P < 0.05) mean TSH basal levels. Serum prolactin (Prl) increased significantly (P < 0.001) after clebopride administration while these changes did not occur when placebo was used instead of clebopride at midnight. The Prl response to clebopride was qualitatively similar at 09.00 h and at 24.00 h. Clebopride given at midnight induced a significant increase (P < 0.05) in serum TSH while this change did not occur when the drug was given at 09.00 h or when placebo was given at midnight. The administration of clebopride resulted in no discernible alterations in serum LH, FSH or GH in either the 09.00 h or the 24.00 h tests. Thus, Prl responses to clebopride were similar in the morning and at midnight, TSH significantly increased after clebopride at midnight whereas this did not occur when the drug was given in the morning, and no significant changes were induced in LH, FSH or GH at the times studied.

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