scholarly journals In utero exposure to persistent organochlorine pollutants and reproductive health in the human male

Reproduction ◽  
2014 ◽  
Vol 148 (6) ◽  
pp. 635-646 ◽  
Author(s):  
Anne Vested ◽  
Cecilia H Ramlau-Hansen ◽  
Sjurdur F Olsen ◽  
Jens Peter Bonde ◽  
Henrik Støvring ◽  
...  
Keyword(s):  
Reproductive Health ◽  
Semen Quality ◽  
Sperm Concentration ◽  
In Utero ◽  
Reproductive Hormone ◽  
Blood Samples ◽  
Persistent Organochlorine ◽  
Hormone Levels ◽  
Organochlorine Pollutants ◽  
Exposure Levels

Persistent organochlorine pollutants (POPs) are ubiquitous, bioaccumulative compounds with potential endocrine-disrupting effects. They cross the placental barrier thereby resulting inin uteroexposure of the developing fetus. The objective of this study was to investigate whether maternal serum concentrations of polychlorinated biphenyls (PCBs) andp,p′-dichlorodiphenyldichloroethylene (p,p′-DDE) during pregnancy are associated with son's semen quality and reproductive hormone levels. During 2008–2009, we recruited 176 male offspring from a Danish cohort of pregnant women who participated in a study in 1988–1989. Each provided semen and blood samples that were analyzed for sperm concentration, total sperm count, motility, and morphology, and reproductive hormone levels, respectively. The maternal blood samples were collected in pregnancy week 30 and were analyzed for the concentrations of six PCBs (PCB-118, -138, -153, -156, -170, and -180) andp,p′-DDE. The potential associations betweenin uteroexposure to ΣPCBs (pmol/ml), Σdioxin like-(DL) PCBs (PCB-118 and -156) (pmol/ml), andp,p′-DDE and semen quality and reproductive hormone levels were investigated using multiple regression. Maternal median (range) exposure levels of ΣPCB, ΣDL-PCB, andp,p′-DDE were 10.0 (2.1–35.0) pmol/ml, 0.8 (0.2–2.7) pmol/ml, and 8.0 (0.7–55.3) pmol/ml, respectively, reflecting typical background exposure levels in the late 1980s in Denmark. Results suggested thatin uteroexposure to ΣPCB, ΣDL-PCB, andp,p′-DDE was not statistically significantly associated with semen quality measures or reproductive hormone levels. Thus, results based on maternal PCB andp,p′-DDE concentrations alone are not indicative of long-term consequences for male reproductive health; however, we cannot exclude that these POPs in concert with other endocrine-modulating compounds may have adverse effects.

scholarly journals Study of Semen Quality, Reproductive Hormone Levels, and Lipid Levels in Men From Arkhangelsk, a City in North of European Russia

2020 ◽  
Vol 14 (4) ◽  
pp. 155798832093971
Author(s):  
Ludmila Osadchuk ◽  
Elena Tipisova ◽  
Maxim Kleshchev ◽  
Irina Gorenko ◽  
Alexander Osadchuk
Keyword(s):  
Luteinizing Hormone ◽  
Semen Quality ◽  
Sperm Quality ◽  
Sperm Concentration ◽  
Semen Parameters ◽  
Reproductive Hormone ◽  
Lipid Levels ◽  
Hormone Levels ◽  
Progressive Motility ◽  
European North

Male populations in the European North of Russia have not previously been investigated for semen quality. The aim of this study was to evaluate semen parameters, reproductive hormone levels, and lipid levels in volunteers from the general urban population of the European North of Russia, to compare the data published for men from the neighboring Northern or Eastern European countries, and to evaluate associations between sperm quality and serum hormonal and lipid levels. Ninety-nine volunteers aged 23–63 years residing in the city of Archangelsk were enrolled in the study. All men had blood samples drawn and completed a questionnaire concerning their health status and lifestyle; 90 men delivered semen samples. The medians for semen volume, sperm concentration, progressive motility, and normal morphology were 3.0 ml, 42.12 million/ml, 43.8%, and 6.5%, respectively. Sperm parameters below normal threshold values were found in 38.9% of participants. It seems that the sperm quality in our study group was slightly worse than in men from Finland, Norway, Sweden, or Estonia, but very similar to that in men from Denmark or Poland. The significant negative correlations of luteinizing hormone levels and positive correlations of inhibin B levels with sperm concentration and progressive motility were revealed. Higher levels of luteinizing hormone and lower levels of inhibin B were found in participants with impaired compared to normal sperm quality. No reliable links were found between serum total cholesterol, triglyceride, high and low-density lipoprotein cholesterol, and semen parameters.

scholarly journals Pornography Use Could Lead to Addiction and Was Associated With Reproductive Hormone Levels and Semen Quality: A Report From the MARHCS Study in China

2021 ◽  
Vol 12 ◽  
Author(s):  
Zhihong Cui ◽  
Min Mo ◽  
Qing Chen ◽  
Xiaogang Wang ◽  
Huan Yang ◽  
...  
Keyword(s):  
College Students ◽  
Semen Quality ◽  
Sperm Concentration ◽  
Serum Prolactin ◽  
Reproductive Hormone ◽  
Lower Serum ◽  
Hormone Levels ◽  
Male College ◽  
Pornography Use ◽  
Male College Students

This study aimed to investigate the situations of pornography use among male college students of China, to explore the addiction possibility for pornography use, and to study the associations between pornography use and reproductive hormone levels and semen quality. Five hundred sixty-eight participants met the inclusion criteria and finished all of the questionnaires and hormone level and semen parameter examinations. A majority of participants (except one) had pornography use experience, 94.2% participants started pornography use before college, and 95.9% participants reported they had masturbation experience when using pornography. Early contact to pornography, frequent pornography use, high amount of time spending on pornography use, and frequent masturbation during pornography use were correlated with addiction trends. Earlier pornography use was found to be associated with lower serum prolactin (PRL), follicle-stimulating hormone (FSH), and progesterone (Prog), as well as lower sperm concentration and total sperm count. Higher frequency of pornography use was associated with lower serum estrogen (E2). In conclusion, pornography use was common among male college students in China. Early contact, high frequent use, and high frequency of masturbation during pornography use could lead to addiction trends and aberrant reproductive hormone levels and semen quality.

scholarly journals Persistent Organochlorine Pollutants with Endocrine Activity and Blood Steroid Hormone Levels in Middle-Aged Men

PLoS ONE ◽  
2013 ◽  
Vol 8 (6) ◽  
pp. e66460 ◽  
Author(s):  
Elise Emeville ◽  
Frank Giton ◽  
Arnaud Giusti ◽  
Alejandro Oliva ◽  
Jean Fiet ◽  
...  
Keyword(s):  
Steroid Hormone ◽  
Middle Aged ◽  
Endocrine Activity ◽  
Persistent Organochlorine ◽  
Hormone Levels ◽  
Organochlorine Pollutants

scholarly journals Exercise improved semen quality and reproductive hormone levels in sedentary obese adults

2017 ◽  
Vol 34 (3) ◽  
pp. 603 ◽  
Author(s):  
Miguel Ángel Rosety ◽  
Antonio Jesus Díaz ◽  
Jesús María Rosety ◽  
María Teresa Pery ◽  
Francisco Brenes-Martín ◽  
...  
Keyword(s):  
Semen Quality ◽  
Reproductive Hormone ◽  
Obese Adults ◽  
Hormone Levels

scholarly journals In Utero and Peripubertal Metals Exposure in Relation to Reproductive Hormones and Sexual Maturation and Progression among Boys in Mexico City

2020 ◽  
Author(s):  
Pahriya Ashrap ◽  
John D. Meeker ◽  
Brisa N. Sánchez ◽  
Niladri Basu ◽  
Marcela Tamayo-Ortiz ◽  
...  
Keyword(s):  
Sexual Maturation ◽  
Pubic Hair ◽  
In Utero ◽  
Reproductive Hormones ◽  
Testicular Volume ◽  
Metal Exposure ◽  
Reproductive Hormone ◽  
Essential Metal ◽  
Hormone Levels ◽  
Metal Levels

Abstract Background: Endocrine disrupting chemicals (EDCs) such as metals have been reported to alter circulating reproductive hormone concentrations and pubertal development in animals. However, the relationship has rarely been investigated among humans, with the exception of heavy metals, such as Pb and Cd. Our aim was to investigate measures of in utero and peripubertal metal exposure in relation to reproductive hormone levels and sexual maturation and progression among boys from the Early Life Exposure in Mexico to Environmental Toxicants (ELEMENT) cohorts.Methods: Our analysis included 118 pregnant women and their male children from the ELEMENT study. Essential and non-essential metals were measured in urine collected from the mothers during the third trimester of pregnancy and their male children at 8-14 years. Reproductive hormone levels [serum testosterone, estradiol, dehydroepiandrosterone sulfate (DHEA-S), inhibin B, and sex hormone-binding globulin (SHBG)] were measured in blood samples from the children at 8-14 years. We also assessed Tanner stages for sexual maturation (genital, pubic hair development, and testicular volume), at two time points (8–14, 10-18 years). We used linear regression to independently examine urinary metal levels in relation to each peripubertal reproductive hormones adjusting for child age and BMI. Generalized estimation equations (GEEs) were used to evaluate the association of in utero and peripubertal metal exposures with sexual maturation and progression during follow-up based on Tanner staging and testicular volume.Results: In utero and prepubertal concentrations of some urinary metals were associated with increased levels of peripubertal reproductive hormones, especially non-essential metal(loid)s As and Cd (in utero), and Ba (peripubertal) as well as essential metal Mo (in utero) in association with testosterone. More advanced pubic hair developmental stage and higher testicular volume at the early teen visit was observed for boys with higher non-essential metal concentrations, including in utero Al and peripubertal Ba, and essential metal Zn concentration (peripubertal). These metals were also associated with slower pubertal progression between the two visits.Conclusion: These findings suggest that male reproductive development may be associated with both essential and non-essential metal exposure during in utero and peripubertal windows.

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