scholarly journals BMP2, 4 and 6 and BMPR1B are altered from early stages of bovine cystic ovarian disease development

Reproduction ◽  
2016 ◽  
Vol 152 (4) ◽  
pp. 333-350 ◽  
Author(s):  
Pablo U Díaz ◽  
Gustavo J Hein ◽  
Eduardo M Belotti ◽  
Fernanda M Rodríguez ◽  
Florencia Rey ◽  
...  
Keyword(s):  
Dairy Cattle ◽  
Bone Morphogenetic Proteins ◽  
Control Group ◽  
Disease Development ◽  
Low Doses ◽  
Spanish Translation ◽  
Antral Follicles ◽  
Ovarian Disease ◽  
Theca Cells ◽  
Cystic Ovarian Disease

Cystic ovarian disease (COD) is an important cause of subfertility in dairy cattle. Bone morphogenetic proteins (BMPs), mainly BMP2, BMP4 and BMP6, play a key role in female fertility. In this study, we hypothesized that an altered BMP system is associated with ovarian alterations contributing to COD pathogenesis. Therefore, we examined the expression of BMP2, BMP4 and BMP6 and BMP receptor 1B (BMPR1B) in the ovaries of animals with spontaneous or ACTH-induced COD, as well as during the development of the disease, in a model of follicular persistence induced by low doses of progesterone (at 5, 10 and 15 days of follicular persistence). Results showed changes in BMP2, BMP4 and BMP6 expression during folliculogenesis, in granulosa and theca cells in the COD groups, as well as at different stages of follicular persistence. Results also showed changes in BMPR1B expression in developing follicles in animals with COD, and at the initial stages of follicular persistence (P5). Comparison between groups showed significant differences, mainly in BMP4 and BMP6 expression, in granulosa and theca cells of different follicular categories. The expression of these BMPs also increased in cystic and persistent follicles, in relation to antral follicles of the control group. BMPR1B showed high expression in cystic follicles. Together, these results may indicate an alteration in BMPs, especially in BMP4 and BMP6, as well as in BMPR1B, which occurs early in folliculogenesis and incipiently during the development of COD, which could be a major cause of recurrence of this disease in cattle. Free Spanish abstract: A Spanish translation of this abstract is freely available at http://www.reproduction-online.org/content/152/4/333.abstract.

scholarly journals Genetic Parameters for Cystic Ovarian Disease in Dutch Black and White Dairy Cattle

2001 ◽  
Vol 84 (1) ◽  
pp. 286-291 ◽  
Author(s):  
G.A. Hooijer ◽  
R.B.F. Lubbers ◽  
B.J. Ducro ◽  
J.A.M. van Arendonk ◽  
L.M.T.E. Kaal-Lansbergen ◽  
...  
Keyword(s):  
Dairy Cattle ◽  
Genetic Parameters ◽  
Ovarian Disease ◽  
Black And White ◽  
Cystic Ovarian Disease

scholarly journals Risk Factors of Cystic Ovarian Disease in Dairy Cattle.

1998 ◽  
Vol 44 (2) ◽  
pp. 191-195 ◽  
Author(s):  
Victor Chisha ZULU ◽  
Colin PENNY
Keyword(s):  
Risk Factors ◽  
Dairy Cattle ◽  
Ovarian Disease ◽  
Cystic Ovarian Disease

101 Effects of Active Immunization Against GnRH in Oocyte Donors with Cystic Ovarian Disease

2018 ◽  
Vol 30 (1) ◽  
pp. 190
Author(s):  
O. A. C. Faria ◽  
L. R. O. Dias ◽  
L. Leme ◽  
G. Fernandes ◽  
A. A. G. Fidelis ◽  
...  
Keyword(s):  
Repeated Measures ◽  
Endometrial Thickness ◽  
Active Immunization ◽  
Response To Treatment ◽  
Control Group ◽  
Individual Response ◽  
Embryo Production ◽  
Ovarian Disease ◽  
Oocyte Donors ◽  
Cystic Ovarian Disease

Cows intensively used as oocyte donors for in vitro embryo production (IVEP) are usually kept nonpregnant for prolonged intervals, exposed to successive hormonal treatments, and frequently become overweight. These are all risk factors for the development of endocrine unbalance and, consequently, cystic ovarian disease (COD). The aim of this study was to evaluate the effect of active immunization against gonadotropin-releasing hormone (GnRH) on (1) ovarian follicular population, and (2) development potential of oocytes used for IVEP. Nelore (Bos indicus) cows (n = 14), previously diagnosed with chronic COD (Faria et al. 2017 Anim. Reprod., in press), weighing 620.0 ± 12.8 kg and with body condition score of 4.1 ± 0.2, were assigned to control (n = 6) or treatment (n = 8) group. Cows in the treatment group received 2 SC injections of 1.0 mL of anti-GnRH vaccine (Bopriva, Zoetis, Brazil), 28 days apart (weeks 0 and 4), whereas cows in the control group received placebo on the same schedule. Transrectal ultrasonography was performed weekly from week 0 to evaluate the number and distribution of follicles among size classes, endometrial thickness, and clinical presence of mucometra. Immunization was considered effective (E-IM) when no follicles ≥5.0 mm were observed on the ovaries during a given examination. Cows having E-IM were then used as oocyte donors for IVEP. Cumulus-oocyte complexes (COC) were collected in 5 consecutive ovum pick-up weekly sessions. As a control for IVEP, oocytes from a slaughterhouse were used, with similar procedures performed on the same days and using the same semen batch. The MIXED procedure of SAS (SAS Institute Inc., Cary, NC, USA) with repeated-measures statement was used to evaluate the effects of treatment, time, and interactions on ovarian endpoints; and the GLM procedure was used to analyse embryo production data. Results are shown as mean ± SEM. There were time and time × treatment effects on ovarian parameters. Treated cows had a decrease (P < 0.05) in the average diameter of the largest follicle and in the number of follicles ≥8 mm, and an increase (P < 0.05) in follicular population after week 6. Nonetheless, individual response to treatment was variable: only 50% of the cows (4 of 8) were E-IM at week 8, whereas 25% (2 of 8) still had COD (largest follicle ≥18.0 mm) at this timepoint. Overall, a negative correlation was detected between follicular population and the diameter of the largest follicle (r = –0.60, P < 0.0001) or the number of follicles ≥8 mm (r = –0.47, P < 0.0001). There was no effect (P > 0.05) of treatment on endometrial thickness or mucometra score. Cows with E-IM produced 22.2 ± 3.6 total and 12.9 ± 2.3 viable COC. Cleavage rate did not differ between E-IM and control (slaughterhouse) oocytes (70.8 ± 7.0 v. 75.1 ± 3.0%, respectively; P > 0.05); however, blastocyst rate was greater in the E-IM group compared with controls (39.7 ± 5.5 v. 20.5 ± 4.7%, respectively; P < 0.02). In summary, our results suggest that active immunization against GnRH leads to variable results in the distribution of the follicular population in cows with COD, but it does not negatively affect IVEP efficiency. This research was supported by Zoetis, CNPq, and CAPES.

Treatment and control of cystic ovarian disease in dairy cattle: A review

1987 ◽  
Vol 143 (3) ◽  
pp. 226-237 ◽  
Author(s):  
Ahmad Ijaz ◽  
M.L. Fahning ◽  
Raimunds Zemjanis
Keyword(s):  
Dairy Cattle ◽  
Ovarian Disease ◽  
Cystic Ovarian Disease ◽  
And Control

Cystic ovarian disease in Dutch dairy cattle, I. Incidence, risk factors and consequences

1994 ◽  
Vol 38 (3) ◽  
pp. 191-197 ◽  
Author(s):  
H.M Laporte ◽  
H Hogeveen ◽  
Y.H Schukken ◽  
J.P.T.M Noordhuizen
Keyword(s):  
Risk Factors ◽  
Dairy Cattle ◽  
Ovarian Disease ◽  
Incidence Risk ◽  
Cystic Ovarian Disease
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