Therapeutic doses of phosphoramide mustard cause germ cell death in the prepubertal mouse testis

2016 ◽  
Author(s):  
Siobhan Rice ◽  
Ellie Smart ◽  
Federica Lopes ◽  
Rod Mitchell ◽  
Norah Spears
Keyword(s):  
Cell Death ◽  
Germ Cell ◽  
Mouse Testis ◽  
Phosphoramide Mustard ◽  
Therapeutic Doses

scholarly journals Spontaneous Germ Cell Apoptosis in Humans: Evidence for Ethnic Differences in the Susceptibility of Germ Cells to Programmed Cell Death

1998 ◽  
Vol 83 (1) ◽  
pp. 152-156 ◽  
Author(s):  
Amiya P. Sinha Hikim ◽  
Christina Wang ◽  
Yanhe Lue ◽  
Larry Johnson ◽  
X.-H Wang ◽  
...  
Keyword(s):  
Cell Death ◽  
Programmed Cell Death ◽  
Germ Cell ◽  
Ethnic Differences ◽  
Germ Cells ◽  
Cell Apoptosis ◽  
Germ Cell Apoptosis

scholarly journals Fluoxetine-induced androgenic failure impairs the seminiferous tubules integrity and increases ubiquitin carboxyl-terminal hydrolase L1 (UCHL1): Possible androgenic control of UCHL1 in germ cell death?

2019 ◽  
Vol 109 ◽  
pp. 1126-1139 ◽  
Author(s):  
Marina L. Câmara ◽  
Talita B. Almeida ◽  
Fabiane de Santi ◽  
Beatriz M. Rodrigues ◽  
Paulo S. Cerri ◽  
...  
Keyword(s):  
Cell Death ◽  
Germ Cell ◽  
Seminiferous Tubules ◽  
Carboxyl Terminal

scholarly journals Genetic control of programmed cell death in the Caenorhabditis elegans hermaphrodite germline

Development ◽  
1999 ◽  
Vol 126 (5) ◽  
pp. 1011-1022 ◽  
Author(s):  
T.L. Gumienny ◽  
E. Lambie ◽  
E. Hartwieg ◽  
H.R. Horvitz ◽  
M.O. Hengartner
Keyword(s):  
Cell Death ◽  
Caenorhabditis Elegans ◽  
Germ Cell ◽  
Somatic Cell ◽  
Cell Fate ◽  
Germ Cells ◽  
Mapk Pathway ◽  
Apoptotic Cell ◽  
C Elegans ◽  
Pathway Activation

Development of the nematode Caenorhabditis elegans is highly reproducible and the fate of every somatic cell has been reported. We describe here a previously uncharacterized cell fate in C. elegans: we show that germ cells, which in hermaphrodites can differentiate into sperm and oocytes, also undergo apoptotic cell death. In adult hermaphrodites, over 300 germ cells die, using the same apoptotic execution machinery (ced-3, ced-4 and ced-9) as the previously described 131 somatic cell deaths. However, this machinery is activated by a distinct pathway, as loss of egl-1 function, which inhibits somatic cell death, does not affect germ cell apoptosis. Germ cell death requires ras/MAPK pathway activation and is used to maintain germline homeostasis. We suggest that apoptosis eliminates excess germ cells that acted as nurse cells to provide cytoplasmic components to maturing oocytes.

scholarly journals Germ cell connectivity enhances cell death in response to DNA damage in the Drosophila testis

eLife ◽  
2017 ◽  
Vol 6 ◽  
Author(s):  
Kevin L Lu ◽  
Yukiko M Yamashita
Keyword(s):  
Dna Damage ◽  
Cell Death ◽  
Germ Cell ◽  
Germ Cells ◽  
High Sensitivity ◽  
Next Generation ◽  
Drosophila Testis

Two broadly known characteristics of germ cells in many organisms are their development as a ‘cyst’ of interconnected cells and their high sensitivity to DNA damage. Here we provide evidence that in the Drosophila testis, connectivity serves as a mechanism that confers to spermatogonia a high sensitivity to DNA damage. We show that all spermatogonia within a cyst die synchronously even when only a subset of them exhibit detectable DNA damage. Mutants of the fusome, an organelle that is known to facilitate intracyst communication, compromise synchronous spermatogonial death and reduces overall germ cell death. Our data indicate that a death-promoting signal is shared within the cyst, leading to death of the entire cyst. Taken together, we propose that intercellular connectivity supported by the fusome uniquely increases the sensitivity of the germline to DNA damage, thereby protecting the integrity of gamete genomes that are passed on to the next generation.

407 REGULATION OF HUMAN MALE GERM CELL DEATH BY MODULATORS OF ATP PRODUCTION

2005 ◽  
Vol 53 (1) ◽  
pp. S149.5-S149
Author(s):  
K. Erkkila ◽  
L. Dunkel ◽  
S. Kyttanen ◽  
R. S. Swerdloff
Keyword(s):  
Cell Death ◽  
Germ Cell ◽  
Male Germ Cell ◽  
Atp Production ◽  
Human Male
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