Comparison of the Serum Gamma-Glutamyl Transferase and Serum Uric Acid Levels according to the Obesity Types Based upon on the Body Mass Index in Korean Men

Abstract Background Conflicting evidence exists on the relationship between body mass index (BMI) and serum uric acid (SUA). Therefore, we aimed to evaluate the SUA–BMI relationship in a large-scale epidemiological survey in coastal China. Methods This survey was conducted among the general population in the coastal region of China from September 2014 to January 2015. SUA Levels were measured by the automatic Sysmex Chemix-180 biochemical analyzer. Results A total of 6098 men (BMI: 24.58 ± 3.74 kg/m2) and 7941 women (24.56 ± 3.64 kg/m2) were included in this study. A stronger positive BMI-SUA association was found for men than women (all P-values < 0.05). The piecewise linear spline models indicated a U-shaped relationship of SUA-BMI association for both men and women; and the lowest turning points were at 19.12 kg/m2 for men and 21.3 kg/m2 for women. When BMIs were lower than the nadir point, each 1 kg/m2 increase in BMI related to a 7.74-fold (95% CI − 14.73, − 0.75) reduction for men and 2.70-fold reduction (− 4.47, − 0.94) for women in SUA levels. Once the BMI was higher than the nadir point, each 1 kg/m2 increase in BMI was related to a 5.10-fold (4.44, 5.77) increment for men and 3.93-fold increment (3.42, 4.43) for women in SUA levels. The regression coefficient differences between the two stages were 12.84 (5.66, 20.03) for men and 6.63 (4.65, 8.61) for women. Conclusions A U-shaped relationship between BMI and SUA was found for both men and women; the association was stronger for men than women.

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Relation of serum uric acid and body mass index to mortality in high-risk patients with established coronary artery disease: A report from the ET-CHD registry, 1997–2006

Journal of Cardiology ◽

10.1016/j.jjcc.2013.06.002 ◽

2013 ◽

Vol 62 (6) ◽

pp. 354-360 ◽

Cited By ~ 10

Author(s):

Yi-Hwei Li ◽

Gen-Min Lin ◽

Chin-Lon Lin ◽

Ji-Hung Wang ◽

Yu-Jung Chen ◽

...

Keyword(s):

Coronary Artery Disease ◽

Body Mass Index ◽

Uric Acid ◽

Coronary Artery ◽

High Risk ◽

Serum Uric Acid ◽

Body Mass ◽

Established Coronary Artery Disease ◽

Risk Patients ◽

Artery Disease

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The predictive value of serum uric acid, roll-over test, and body mass index in pre-eclampsia

International Journal of Gynecology & Obstetrics ◽

10.1016/j.ijgo.2005.10.017 ◽

2005 ◽

Vol 92 (2) ◽

pp. 133-134 ◽

Cited By ~ 4

Author(s):

F. Kaypour ◽

H. Masomi Rad ◽

N. Ranjbar Novin

Keyword(s):

Body Mass Index ◽

Uric Acid ◽

Serum Uric Acid ◽

Body Mass ◽

Predictive Value

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Association between Sex Hormone and Blood Uric Acid in Male Patients with Type 2 Diabetes

International Journal of Endocrinology ◽

10.1155/2017/4375253 ◽

2017 ◽

Vol 2017 ◽

pp. 1-8 ◽

Cited By ~ 5

Author(s):

Wen Cao ◽

Ren-Dong Zheng ◽

Shu-Hang Xu ◽

Yao-Fu Fan ◽

Hong-Ping Sun ◽

...

Keyword(s):

Type 2 Diabetes ◽

Body Mass Index ◽

Uric Acid ◽

Waist Circumference ◽

Serum Uric Acid ◽

Body Mass ◽

Sex Hormone ◽

Gonadal Dysfunction ◽

Male Patients

The association between serum uric acid (SUA) level and sexual dysfunction in patients with diabetes is not well characterized. Type 2 diabetes mellitus (T2DM) causes metabolic disorders, including abnormal serum uric acid (SUA) levels. In this study, we enrolled 205 male patients with T2DM and investigated the relationship between sex hormone levels and SUA. Patients were divided into four groups based on SUA quartiles. On the other hand, based on the total testosterone (TT) level, patients were divided into three groups; SUA and other laboratory indices were determined. Increase in SUA level was significantly associated with decreased levels of TT, luteinizing hormone, follicle-stimulating hormone, sex hormone-binding globulin, and increased levels of dehydroepiandrosterone, age, body mass index (BMI), waist circumference, glycated hemoglobin, serum creatinine, and HOMA-IR levels. SUA, waist circumference, BMI, and HOMA-IR showed a negative correlation with TT level, while age showed a positive correlation with TT level. SUA and body mass index were found to be risk factors for gonadal dysfunction. Therefore, we conclude that hypogonadism of male patients with T2DM is related to SUA level.

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