Biomechanical and biochemical compatibility in innovative biomaterials

2012 ◽  
pp. 37-61 ◽  
Author(s):  
J. Huang ◽  
Z.X. Guo
Keyword(s):  
Innovative Biomaterials

scholarly journals Bacterial Biopolymer: Its Role in Pathogenesis to Effective Biomaterials

Polymers ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1242
Author(s):  
Sreejita Ghosh ◽  
Dibyajit Lahiri ◽  
Moupriya Nag ◽  
Ankita Dey ◽  
Tanmay Sarkar ◽  
...  
Keyword(s):  
Pathogenic Bacteria ◽  
Carbon Sources ◽  
Chemical Properties ◽  
Interdisciplinary Studies ◽  
Extracellular Dna ◽  
Antimicrobial Drugs ◽  
Cell Factories ◽  
Food Components ◽  
Innovative Biomaterials ◽  
And Chemical Properties

Bacteria are considered as the major cell factories, which can effectively convert nitrogen and carbon sources to a wide variety of extracellular and intracellular biopolymers like polyamides, polysaccharides, polyphosphates, polyesters, proteinaceous compounds, and extracellular DNA. Bacterial biopolymers find applications in pathogenicity, and their diverse materialistic and chemical properties make them suitable to be used in medicinal industries. When these biopolymer compounds are obtained from pathogenic bacteria, they serve as important virulence factors, but when they are produced by non-pathogenic bacteria, they act as food components or biomaterials. There have been interdisciplinary studies going on to focus on the molecular mechanism of synthesis of bacterial biopolymers and identification of new targets for antimicrobial drugs, utilizing synthetic biology for designing and production of innovative biomaterials. This review sheds light on the mechanism of synthesis of bacterial biopolymers and its necessary modifications to be used as cell based micro-factories for the production of tailor-made biomaterials for high-end applications and their role in pathogenesis.

scholarly journals Mesenchymal stromal cells encapsulation in innovative biomaterials: application to osteoarthritis treatment

2014 ◽  
Vol 22 ◽  
pp. S444
Author(s):  
F. Hached ◽  
P-G. Pinta ◽  
G. Rethore ◽  
C. Vinatier ◽  
N. Maillard ◽  
...  
Keyword(s):  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Osteoarthritis Treatment ◽  
Innovative Biomaterials

Mineralization of Eroded Dental Enamel Seeded with Fluoride and a Tricalcium Phosphate Ternary Biomaterial

2010 ◽  
Vol 76 ◽  
pp. 42-47 ◽  
Author(s):  
Robert L. Karlinsey ◽  
Allen C. Mackey ◽  
Emily R. Walker ◽  
Trenton J. Walker ◽  
Christabel X. Fowler
Keyword(s):  
Ir Spectroscopy ◽  
Dose Response ◽  
Tricalcium Phosphate ◽  
Phosphate Uptake ◽  
Dental Enamel ◽  
Enamel Microstructure ◽  
Fluoride Uptake ◽  
Therapeutic Applications ◽  
Innovative Biomaterials ◽  
Bovine Enamel

The inability to sufficiently prevent and/or repair chemically-etched dental enamel serves as one example that underlines the importance and need for the development of innovative biomaterials for therapeutic applications. In this work we explored the seeding capability of 225 ppm and 1100 ppm fluoride with and without a novel β-tricalcium phosphate-silica-urea (TCP-Si-Ur) biomaterial (concentrations of 20, 40, 80, and 200 ppm) to mineralize into acid-etched bovine enamel. The nature of the mineralization was evaluated by measuring the fluoride and phosphate uptake into the eroded enamel, as well as the orthophosphate microstructure using infrared (IR) spectroscopy. These enamel fluoride uptake and IR experiments revealed a fluoride dose response exists for eroded enamel treated with 225 and 1100 ppm F. The inclusion of 20, 40, and 80 ppm TCP-Si-Ur with 225 ppm F was similar to 225 ppm F alone and did not produce a fluoride uptake dose response; however, 200 ppm TCP-Si-Ur combined with 1100 ppm F improved raw fluoride uptake relative to 1100 ppm F. Furthermore, we found the combination of either 225 ppm or 1100 ppm fluoride plus TCP-Si-Ur at different loading levels leads to unique and significant mineral integration into the PO4 enamel network, including the formation of P-F bonds. The observations reported herein demonstrate the combination of fluoride plus a novel TCP-Si-Ur biomaterial produces synergistic mineralization and bears significantly on eroded enamel microstructure.

scholarly journals Recent Advances in Implant Biomaterials - A Review

2020 ◽  
Vol 11 (4) ◽  
pp. 6962-6965
Author(s):  
Miloni Suresh Shah ◽  
Revathi Duraisamy ◽  
Sindhuja Devi S ◽  
Santhosh Kumar M P
Keyword(s):  
Dental Implants ◽  
Dental Implant ◽  
Dental Materials ◽  
Glass Ceramics ◽  
Recent Period ◽  
Recent Advances ◽  
Dental Practitioners ◽  
Innovative Biomaterials ◽  
Implant Dentistry ◽  
Missing Tooth

Usage of Implants in dentistry is tremendously increasing in recent times. This has led to the invention of new biomaterials for dental implants by the researchers. Continuous evolution has occurred in the field of dental implant biomaterials in the last two decades leading to the emergence of innovative biomaterials. This article summarizes the different implant biomaterials and the recent advances in this field. The material science and they are various biological and physical properties affecting their treatment outcome are discussed. Throughout the years, myriads of dental materials have been tried for replacement of missing tooth. Now titanium remains the gold standard as a dental implant material. Over the recent period, many Implant biomaterials have evolved. It includes composites, glass-ceramics, metal alloys, ceramics, glasses, and polymers. Nanotechnology is an emerging application in the branch of implant dentistry. Nanotechnology can improve the properties of dental implants for achieving good osseointegration. It is imperative for dental practitioners to have a good idea about the various biomaterials used for dental implants. 

Current trends and future perspectives of bone substitute materials – From space holders to innovative biomaterials

2012 ◽  
Vol 40 (8) ◽  
pp. 706-718 ◽  
Author(s):  
Andreas Kolk ◽  
Jörg Handschel ◽  
Wolf Drescher ◽  
Daniel Rothamel ◽  
Frank Kloss ◽  
...  
Keyword(s):  
Bone Substitute ◽  
Future Perspectives ◽  
Current Trends ◽  
Bone Substitute Materials ◽  
Innovative Biomaterials ◽  
Substitute Materials

Nonlinear Dynamics of Human Aortas for Viscoelastic Mechanical Characterization

2020 ◽  
Author(s):  
Marco Amabili ◽  
Prabakaran Balasubramanian ◽  
Isabella Bozzo ◽  
Ivan D. Breslavsky ◽  
Giovanni Ferrari ◽  
...  
Keyword(s):  
Mechanical Characterization ◽  
Synergistic Effects ◽  
Dynamic Stiffness ◽  
Advanced Materials ◽  
Resting Heart Rate ◽  
Flow Conditions ◽  
Cardiovascular Devices ◽  
Structure Interaction ◽  
Innovative Biomaterials

Abstract The results of this work present eleven human thoracic aortas tested on a mock circulatory loop (MCL) that was developed to simulate physiological pulsatile flow conditions. Results showed cyclic axisymmetric diameter changes, which were compatible with in-vivo cyclic diameter changes at resting heart rate. The dynamic stiffness increased with age, but the cyclic axisymmetric diameter variation decreased with age when at a resting pulse rate. The energy dissipation was also noted to decrease with increased age. The synergistic effects of the fluid-structure interaction and the viscoelasticity led to larger damping at higher pulse rates. The projected outcome of this work is creating innovative biomaterials that better reproduce the aortic dynamic behavior. The findings complement expanding avenues in advanced materials, with the aim of creating improved and mechanically compatible cardiovascular devices, like grafts and stents.

scholarly journals Plant Products for Innovative Biomaterials in Dentistry

Coatings ◽  
2012 ◽  
Vol 2 (3) ◽  
pp. 179-194 ◽  
Author(s):  
Elena M. Varoni ◽  
Marcello Iriti ◽  
Lia Rimondini
Keyword(s):  
Plant Products ◽  
Innovative Biomaterials

scholarly journals Innovative Biomaterials for Bone Regrowth

2019 ◽  
Vol 20 (3) ◽  
pp. 618 ◽  
Author(s):  
Maria Iaquinta ◽  
Elisa Mazzoni ◽  
Marco Manfrini ◽  
Antonio D’Agostino ◽  
Lorenzo Trevisiol ◽  
...  
Keyword(s):  
Biological Sciences ◽  
Stem Cells ◽  
Regenerative Medicine ◽  
High Performance ◽  
Cellular Biology ◽  
Innovative Biomaterials ◽  
Bioactive Agents ◽  
Bone Regrowth ◽  
Short Time

The regenerative medicine, a new discipline that merges biological sciences and the fundamental of engineering to develop biological substitutes, has greatly benefited from recent advances in the material engineering and the role of stem cells in tissue regeneration. Regenerative medicine strategies, involving the combination of biomaterials/scaffolds, cells, and bioactive agents, have been of great interest especially for the repair of damaged bone and bone regrowth. In the last few years, the life expectancy of our population has progressively increased. Aging has highlighted the need for intervention on human bone with biocompatible materials that show high performance for the regeneration of the bone, efficiently and in a short time. In this review, the different aspects of tissue engineering applied to bone engineering were taken into consideration. The first part of this review introduces the bone cellular biology/molecular genetics. Data on biomaterials, stem cells, and specific growth factors for the bone regrowth are reported in this review.

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