Controlling the degradation of natural polymers for biomedical applications

2008 ◽  
pp. 106-128 ◽  
Author(s):  
H.S. AZEVEDO ◽  
T.C. SANTOS ◽  
R.L. REIS
Keyword(s):  
Biomedical Applications ◽  
Natural Polymers

Biomedical Applications of Natural Polymers for Drug Delivery

2014 ◽  
Vol 18 (2) ◽  
pp. 152-164 ◽  
Author(s):  
Mariana Chifiriuc ◽  
Alexandru Grumezescu ◽  
Valentina Grumezescu ◽  
Eugenia Bezirtzoglou ◽  
Veronica Lazar ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Natural Polymers

scholarly journals Topographical and Biomechanical Guidance of Electrospun Fibers for Biomedical Applications

Polymers ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 2896
Author(s):  
Sara Ferraris ◽  
Silvia Spriano ◽  
Alessandro Calogero Scalia ◽  
Andrea Cochis ◽  
Lia Rimondini ◽  
...  
Keyword(s):  
Surface Modification ◽  
Biomedical Applications ◽  
Biomedical Application ◽  
Electrospun Fibers ◽  
Natural Polymers ◽  
Polymeric Fibers ◽  
Biological Phenomena ◽  
Proper Design ◽  
Synthetic And Natural Polymers ◽  
Selection Of

Electrospinning is gaining increasing interest in the biomedical field as an eco-friendly and economic technique for production of random and oriented polymeric fibers. The aim of this review was to give an overview of electrospinning potentialities in the production of fibers for biomedical applications with a focus on the possibility to combine biomechanical and topographical stimuli. In fact, selection of the polymer and the eventual surface modification of the fibers allow selection of the proper chemical/biological signal to be administered to the cells. Moreover, a proper design of fiber orientation, dimension, and topography can give the opportunity to drive cell growth also from a spatial standpoint. At this purpose, the review contains a first introduction on potentialities of electrospinning for the obtainment of random and oriented fibers both with synthetic and natural polymers. The biological phenomena which can be guided and promoted by fibers composition and topography are in depth investigated and discussed in the second section of the paper. Finally, the recent strategies developed in the scientific community for the realization of electrospun fibers and for their surface modification for biomedical application are presented and discussed in the last section.

scholarly journals Modeling of the Behavior of Natural Polysaccharides Hydrogels for Bio-pharma Applications

2017 ◽  
Vol 12 (6) ◽  
pp. 1934578X1701200
Author(s):  
Diego Caccavo ◽  
Sara Cascone ◽  
Gaetano Lamberti ◽  
Annalisa Dalmoro ◽  
Anna Angela Barba
Keyword(s):  
Biomedical Applications ◽  
Release Kinetics ◽  
A Priori ◽  
Trial And Error ◽  
Solidification Behavior ◽  
Natural Polymers ◽  
Case Histories ◽  
Micro Particles ◽  
Natural Polysaccharide ◽  
Synthetic And Natural Polymers

Hydrogels, even if not exclusively obtained from natural sources, are widely used for pharmaceuticals and for biomedical applications. The reasons for their uses are their biocompatibility and the possibility to obtain systems and devices with different properties, due to variable characteristics of the materials. In order to effectively design and produce these systems and devices, two main ways are available: i) trial-and-error process, at least guided by experience, during which the composition of the system and the production steps are changed in order to get the desired behavior; ii) production process guided by the a-priori simulation of the systems’ behavior, thanks to proper tuned mathematical models of the reality. Of course the second approach, when applicable, allows tremendous savings in term of human and instrumental resources. In this mini-review, several modeling approaches useful to describe the behavior of natural polysaccharide-based hydrogels in bio-pharma applications are reported. In particular, reported case histories are: i) the size calculation of micro-particles obtained by ultrasound assisted atomization; ii) the release kinetics from core-shell micro-particles, iii) the solidification behavior of blends of synthetic and natural polymers for gel paving of blood vessels, iv) the drug release from hydrogel-based tablets. This material can be seen as a guide toward the use of mathematical modeling in bio-pharma applications.

scholarly journals Biomedical applications of natural-based polymers combined with bioactive glass nanoparticles

2017 ◽  
Vol 5 (24) ◽  
pp. 4555-4568 ◽  
Author(s):  
Á. J. Leite ◽  
J. F. Mano
Keyword(s):  
Bioactive Glass ◽  
Biomedical Applications ◽  
Natural Polymers ◽  
Composition Design

The combination of natural polymers with nanoparticles allowed the development of functional bioinspired constructs. This review discusses the composition, design, and applications of bioinspired nanocomposite constructs based on bioactive glass nanoparticles (BGNPs).

scholarly journals Trends in the Development of Tailored Elastin-Like Recombinamer–Based Porous Biomaterials for Soft and Hard Tissue Applications

2021 ◽  
Vol 7 ◽  
Author(s):  
Lubinda Mbundi ◽  
Miguel González-Pérez ◽  
Fernando González-Pérez ◽  
Diana Juanes-Gusano ◽  
José Carlos Rodríguez-Cabello
Keyword(s):  
Extracellular Matrix ◽  
Biomedical Applications ◽  
Physicochemical Characteristics ◽  
Matrix Composition ◽  
Natural Polymers ◽  
Hard Tissue ◽  
Modular Assembly ◽  
Cell Compartmentalization ◽  
Porous Biomaterials ◽  
Synthetic And Natural Polymers

Porous biomaterials are of significant interest in a variety of biomedical applications as they enable the diffusion of nutrients and gases as well as the removal of metabolic waste from implants. Pores also provide 3D spaces for cell compartmentalization and the development of complex structures such as vasculature and the extracellular matrix. Given the variation in the extracellular matrix composition across and within different tissues, it is necessary to tailor the physicochemical characteristics of biomaterials and or surfaces thereof for optimal bespoke applications. In this regard, different synthetic and natural polymers have seen increased usage in the development of biomaterials and surface coatings; among them, elastin-like polypeptides and their recombinant derivatives have received increased advocacy. The modular assembly of these molecules, which can be controlled at a molecular level, presents a flexible platform for the endowment of bespoke biomaterial properties. In this review, various elastin-like recombinamer–based porous biomaterials for both soft and hard tissue applications are discussed and their current and future applications evaluated.

scholarly journals PLGA – THE SMART POLYMER FOR DRUG DELIVERY

2021 ◽  
Vol 9 (5) ◽  
pp. 334-345
Author(s):  
N. Surya ◽  
S. Bhattacharyya
Keyword(s):  
Drug Delivery ◽  
Biodegradable Polymers ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Glycolic Acid ◽  
Delivery Systems ◽  
Nano Particles ◽  
Natural Polymers ◽  
Smart Polymer ◽  
Novel Drug

Polymers have become an integral part of novel drug delivery system. One such successful biodegradable polymer is poly lactic-co-glycolic acid (PLGA) which consists of polyesters of lactic acid and glycolic acid. It is one of the FDA-approved biodegradable polymers which is extensively used for therapeutic purposes in recent times.The aim. To illuminate researchers on the chemistry, novel properties and applications of PLGA in pharmaceutical fields.Materials and methods. Various internet sources like Science Direct, Scopus, Web of Science, PubMed and google scholar were used as the data source. The key words search was carried out for the following words and combinations: PLGA, Novel drug delivery, PLGA Nano particles, biomedical applications of PLGA.Results. Pharmaceutical and biomedical industries are flooded with the use of synthetic and natural polymers. The mechanical and viscoelastic properties of the polymers make them suitable for the temporal and spatial delivery of therapeutic agents for an extended period. Employment of copolymerization techniques lead to the modification of water solubility of the polymers and make them suitable for various applications of drug delivery systems. Biodegradable polymers due to their biocompatibility and biodegradable property have attracted their use in novel drug delivery systems. PLGA is one of them. PLGA is versatile as it can be fabricated into any size, shape, and can be used to encapsulate small molecules, tissue engineering, and bone repair, etc.Conclusion. The sensitivity and biodegradability of PLGA makes it a smart polymer for targeted and sustained delivery of drugs and in various biomedical applications.

scholarly journals RECENT ADVANCES IN HYDROGELS FOR BIOMEDICAL APPLICATIONS

2018 ◽  
Vol 11 (11) ◽  
pp. 62
Author(s):  
Surojeet Das ◽  
Vivek Kumar ◽  
Rini Tiwari ◽  
Leena Singh ◽  
Sachidanand Singh
Keyword(s):  
Biomedical Applications ◽  
Three Dimensional ◽  
Primary Objective ◽  
Cellular Interactions ◽  
Natural Polymers ◽  
Synthetic Materials ◽  
Physical And Chemical ◽  
Modern Era ◽  
Synthetic And Natural Polymers

Hydrogels are three-dimensional polymeric network, capable of entrapping substantial amounts of fluids. Hydrogels are formed due to physical or chemical cross-linking in different synthetic and natural polymers. Recently, hydrogels have been receiving much attention for biomedical applications due to their innate structure and compositional similarities to the extracellular matrix. Hydrogels fabricated from naturally derived materials provide an advantage for biomedical applications due to their innate cellular interactions and cellular-mediated biodegradation. Synthetic materials have the advantage of greater tunability when it comes to the properties of hydrogels. There has been considerable progress in recent years in addressing the clinical and pharmacological limitations of hydrogels for biomedical applications. The primary objective of this article is to review the classification of hydrogels based on their physical and chemical characteristics. It also reviews the technologies adopted for hydrogel fabrication and the different applications of hydrogels in the modern era.

scholarly journals Biocompatible Polymers Combined with Cyclodextrins: Fascinating Materials for Drug Delivery Applications

Molecules ◽  
2020 ◽  
Vol 25 (15) ◽  
pp. 3404 ◽  
Author(s):  
Bartłomiej Kost ◽  
Marek Brzeziński ◽  
Marta Socka ◽  
Małgorzata Baśko ◽  
Tadeusz Biela
Keyword(s):  
Drug Delivery ◽  
Polyethylene Oxide ◽  
Biomedical Applications ◽  
Controlled Drug Delivery ◽  
Natural Polymers ◽  
Supramolecular Systems ◽  
Aliphatic Polyesters ◽  
Different Types ◽  
Functional Biomaterials ◽  
Synthetic And Natural Polymers

Cyclodextrins (CD) are a group of cyclic oligosaccharides with a cavity/specific structure that enables to form inclusion complexes (IC) with a variety of molecules through non-covalent host-guest interactions. By an elegant combination of CD with biocompatible, synthetic and natural polymers, different types of universal drug delivery systems with dynamic/reversible properties have been generated. This review presents the design of nano- and micro-carriers, hydrogels, and fibres based on the polymer/CD supramolecular systems highlighting their possible biomedical applications. Application of the most prominent hydrophobic aliphatic polyesters that exhibit biodegradability, represented by polylactide and polycaprolactone, is described first. Subsequently, particular attention is focused on materials obtained from hydrophilic polyethylene oxide. Moreover, examples are also presented for grafting of CD on polysaccharides. In summary, we show the application of host-guest interactions in multi-component functional biomaterials for controlled drug delivery.

Hybrid Biodegradable Films from Collagenous Wastes and Natural Polymers for Biomedical Applications

2011 ◽  
Vol 2 (3) ◽  
pp. 323-335 ◽  
Author(s):  
R. Murali ◽  
A. Anumary ◽  
M. Ashokkumar ◽  
P. Thanikaivelan ◽  
B. Chandrasekaran
Keyword(s):  
Biomedical Applications ◽  
Biodegradable Films ◽  
Natural Polymers
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