Biomedical Applications of Natural Polymers for Drug Delivery

2014 ◽  
Vol 18 (2) ◽  
pp. 152-164 ◽  
Author(s):  
Mariana Chifiriuc ◽  
Alexandru Grumezescu ◽  
Valentina Grumezescu ◽  
Eugenia Bezirtzoglou ◽  
Veronica Lazar ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Natural Polymers

scholarly journals PLGA – THE SMART POLYMER FOR DRUG DELIVERY

2021 ◽  
Vol 9 (5) ◽  
pp. 334-345
Author(s):  
N. Surya ◽  
S. Bhattacharyya
Keyword(s):  
Drug Delivery ◽  
Biodegradable Polymers ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Glycolic Acid ◽  
Delivery Systems ◽  
Nano Particles ◽  
Natural Polymers ◽  
Smart Polymer ◽  
Novel Drug

Polymers have become an integral part of novel drug delivery system. One such successful biodegradable polymer is poly lactic-co-glycolic acid (PLGA) which consists of polyesters of lactic acid and glycolic acid. It is one of the FDA-approved biodegradable polymers which is extensively used for therapeutic purposes in recent times.The aim. To illuminate researchers on the chemistry, novel properties and applications of PLGA in pharmaceutical fields.Materials and methods. Various internet sources like Science Direct, Scopus, Web of Science, PubMed and google scholar were used as the data source. The key words search was carried out for the following words and combinations: PLGA, Novel drug delivery, PLGA Nano particles, biomedical applications of PLGA.Results. Pharmaceutical and biomedical industries are flooded with the use of synthetic and natural polymers. The mechanical and viscoelastic properties of the polymers make them suitable for the temporal and spatial delivery of therapeutic agents for an extended period. Employment of copolymerization techniques lead to the modification of water solubility of the polymers and make them suitable for various applications of drug delivery systems. Biodegradable polymers due to their biocompatibility and biodegradable property have attracted their use in novel drug delivery systems. PLGA is one of them. PLGA is versatile as it can be fabricated into any size, shape, and can be used to encapsulate small molecules, tissue engineering, and bone repair, etc.Conclusion. The sensitivity and biodegradability of PLGA makes it a smart polymer for targeted and sustained delivery of drugs and in various biomedical applications.

scholarly journals Biocompatible Polymers Combined with Cyclodextrins: Fascinating Materials for Drug Delivery Applications

Molecules ◽  
2020 ◽  
Vol 25 (15) ◽  
pp. 3404 ◽  
Author(s):  
Bartłomiej Kost ◽  
Marek Brzeziński ◽  
Marta Socka ◽  
Małgorzata Baśko ◽  
Tadeusz Biela
Keyword(s):  
Drug Delivery ◽  
Polyethylene Oxide ◽  
Biomedical Applications ◽  
Controlled Drug Delivery ◽  
Natural Polymers ◽  
Supramolecular Systems ◽  
Aliphatic Polyesters ◽  
Different Types ◽  
Functional Biomaterials ◽  
Synthetic And Natural Polymers

Cyclodextrins (CD) are a group of cyclic oligosaccharides with a cavity/specific structure that enables to form inclusion complexes (IC) with a variety of molecules through non-covalent host-guest interactions. By an elegant combination of CD with biocompatible, synthetic and natural polymers, different types of universal drug delivery systems with dynamic/reversible properties have been generated. This review presents the design of nano- and micro-carriers, hydrogels, and fibres based on the polymer/CD supramolecular systems highlighting their possible biomedical applications. Application of the most prominent hydrophobic aliphatic polyesters that exhibit biodegradability, represented by polylactide and polycaprolactone, is described first. Subsequently, particular attention is focused on materials obtained from hydrophilic polyethylene oxide. Moreover, examples are also presented for grafting of CD on polysaccharides. In summary, we show the application of host-guest interactions in multi-component functional biomaterials for controlled drug delivery.

scholarly journals A Review of Gum Hydrocolloid Polyelectrolyte Complexes (PEC) for Biomedical Applications: Their Properties and Drug Delivery Studies

Processes ◽  
2021 ◽  
Vol 9 (10) ◽  
pp. 1796
Author(s):  
Jindrayani Nyoo Putro ◽  
Valentino Bervia Lunardi ◽  
Felycia Edi Soetaredjo ◽  
Maria Yuliana ◽  
Shella Permatasari Santoso ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Order Equation ◽  
Zero Order ◽  
Natural Polymers ◽  
Polyelectrolyte Complexes ◽  
First Order ◽  
Natural Gum

The utilization of natural gum polysaccharides as the vehicle for drug delivery systems and other biomedical applications has increased in recent decades. Their biocompatibility, biodegradability, and price are much cheaper than other materials. It is also renewable and available in massive amounts, which are the main reasons for its use in pharmaceutical applications. Gum can be easily functionalized with other natural polymers to enhance their applications. Various aspects of the utilization of natural gums in the forms of polyelectrolyte complexes (PECs) for drug delivery systems are discussed in this review. The application of different mathematical models were used to represent the drug release mechanisms from PECs; these models include a zero-order equation, first-order equation, Higuchi, simplified Higuchi, Korsmeyer–Peppas, and Peppas–Sahlin.

scholarly journals Biodegradable Natural Polymers for Biomedical Applications

2019 ◽  
pp. 67-80
Author(s):  
Israt Parveen ◽  
Md. Iqbal Mahmud ◽  
Ruhul A. Khan
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Wound Healing ◽  
Biodegradable Polymers ◽  
Biomedical Applications ◽  
Modern Medicine ◽  
Natural Polymers ◽  
Present Contribution ◽  
Pharmaceutical Applications ◽  
Physical Chemical

Biodegradable polymers as biomaterial are hotcake nowadays especially in medical and pharmaceutical applications. The present contribution comprises an overview of the biodegradable polymers for various biomedical applications. To meet the need of modern medicine, their physical, chemical, functional, biomechanical are highlighted as well as biodegradation properties like non-toxicity, low antigenicity, high bio-activity etc. This review summarizes the emerging and innovative field of biopolymer with the focus on tissue engineering, temporary implants, wound healing, and drug delivery applications etc.

Hydrogel: Polymeric Smart Material in Drug Delivery

2016 ◽  
Vol 875 ◽  
pp. 45-62 ◽  
Author(s):  
Ranjana Das ◽  
Himadri Sekhar Samanta ◽  
Chiranjib Bhattacharjee
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Cell Encapsulation ◽  
Skin Grafting ◽  
Living System ◽  
Temperature Modulation ◽  
Self Healing ◽  
Natural Polymers ◽  
Ph Change

A ‘biomaterial’, recognizes some materials for biomedical applications like replacement of living system and wound stressing. ‘Biomaterials’ includes different compounds from diverse origins, like polymers, metals, ceramics and composites. Along with conventional natural polymers (polysaccharides, proteins), synthetic and biodegradable polymers like Polyvinyl alcohol, Polyvinylpyrrolidone, Polyetheleneglycol, Polylactic acid, Polyhydroxy acid are promisingly used in drug delivery, tissue engineering, biomedical sensing, skin grafting and medical adhesives. ‘Hydrogel’ a new generation biodegradable polymer typically used for pharmaceutical and medical purposes. Hydrogels are coined as super absorbent with significant function in health care, especially in wound treatment and protection. Unique characteristics features like enhanced hydrophilicity, biocompatibility, zero-toxicity and biodegradability along with soft and rubbery consistency, low interfacial tension and ‘self-healing’ properties make them compatible with living tissues. Hydrogels have been widely investigated as the carrier for drug delivery systems owing to their unusual characteristics like swelling in aqueous medium, pH and temperature sensitivity, or sensitivity towards other stimuli. Hydrogels being biocompatible materials have been recognized to function as drug protectors, especially for peptides and proteins, from in-vivo environment. In present context, development of ‘in situ’ forming systems for various biomedical applications, including drug delivery, cell encapsulation, and tissue repair are emerging. Among several typical hydrogel synthesis approaches like, solvent exchange, UV-irradiation, ionic cross-linkage, pH change, and temperature modulation, the ‘thermosensitive’ approach is advantageous since it does not require use of any organic solvents, co-polymerization agents and externally applied trigger for gelation. This review presents an overview to the advances in hydrogel based drug delivery system with some reconstructive features in the biomedical applications.

scholarly journals Gelatin Based Hydrogels for Tissue Engineering and Drug Delivery Applications

2021 ◽  
pp. 244-270
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Stem Cell ◽  
Biomedical Applications ◽  
Natural Polymers ◽  
Comprehensive Overview ◽  
Alkali Extraction ◽  
Extraction Processes ◽  
Different Sources ◽  
Physical Crosslinking

Gelatin is one of the most popular natural polymers which is widely used in food, pharmaceutical, biomedical and cosmetic industries. The gelatin has been prepared from different sources such as porcine skin, cattle bone, and fish, etc. Depending on the type of acidic and alkali extraction processes the type of gelatin A and B were obtained. This chapter provides a comprehensive overview of preparation of gelatin base hydrogel. Furthermore, we evaluate their method of crosslinking through Schift-base, Mischeal-addition-based, light, UV, chemical, and physical crosslinking. Moreover, due to the unique properties of gelatin they have the ability to immobilize cells and can be applied for stem cell and drug delivery in biomedical applications.

scholarly journals Injectable Cryogels in Biomedicine

Gels ◽  
2021 ◽  
Vol 7 (2) ◽  
pp. 38
Author(s):  
Duygu Çimen ◽  
Merve Asena Özbek ◽  
Nilay Bereli ◽  
Bo Mattiasson ◽  
Adil Denizli
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Biomedical Applications ◽  
Natural Polymers ◽  
Research Areas ◽  
Macroporous Materials ◽  
Monomer Solution ◽  
Recent Developments ◽  
Physical Resistance ◽  
Synthetic And Natural Polymers

Cryogels are interconnected macroporous materials that are synthesized from a monomer solution at sub-zero temperatures. Cryogels, which are used in various applications in many research areas, are frequently used in biomedicine applications due to their excellent properties, such as biocompatibility, physical resistance and sensitivity. Cryogels can also be prepared in powder, column, bead, sphere, membrane, monolithic, and injectable forms. In this review, various examples of recent developments in biomedical applications of injectable cryogels, which are currently scarce in the literature, made from synthetic and natural polymers are discussed. In the present review, several biomedical applications of injectable cryogels, such as tissue engineering, drug delivery, therapeutic, therapy, cell transplantation, and immunotherapy, are emphasized. Moreover, it aims to provide a different perspective on the studies to be conducted on injectable cryogels, which are newly emerging trend.

Applications of natural polymers in mucoadhesive drug delivery: An overview

2018 ◽  
Vol 3 (2) ◽  
pp. 38-42 ◽  
Author(s):  
Ashish Garg ◽  
Sweta Garg ◽  
Manish Kumar ◽  
Suresh Kumar ◽  
Ajay Kumar Shukla ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Natural Polymers

Self-Assembled Nanocarriers Based on Amphiphilic Natural Polymers for Anti- Cancer Drug Delivery Applications

2018 ◽  
Vol 23 (35) ◽  
Author(s):  
Sally Sabra ◽  
Mona Abdelmoneem ◽  
Mahmoud Abdelwakil ◽  
Moustafa Taha Mabrouk ◽  
Doaa Anwar ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Drug ◽  
Natural Polymers ◽  
Anti Cancer ◽  
Drug Delivery Applications ◽  
Self Assembled ◽  
Cancer Drug Delivery

Biocompatible Polymers and their Potential Biomedical Applications: A Review

2019 ◽  
Vol 25 (34) ◽  
pp. 3608-3619 ◽  
Author(s):  
Uzma Arif ◽  
Sajjad Haider ◽  
Adnan Haider ◽  
Naeem Khan ◽  
Abdulaziz A. Alghyamah ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Biomedical Applications ◽  
Living System ◽  
Health Condition ◽  
The Body ◽  
Biocompatible Polymers ◽  
Nano Technology ◽  
Artificial Grafts ◽  
Immunological Reactions

Background: Biocompatible polymers are gaining great interest in the field of biomedical applications. The term biocompatibility refers to the suitability of a polymer to body and body fluids exposure. Biocompatible polymers are both synthetic (man-made) and natural and aid in the close vicinity of a living system or work in intimacy with living cells. These are used to gauge, treat, boost, or substitute any tissue, organ or function of the body. A biocompatible polymer improves body functions without altering its normal functioning and triggering allergies or other side effects. It encompasses advances in tissue culture, tissue scaffolds, implantation, artificial grafts, wound fabrication, controlled drug delivery, bone filler material, etc. Objectives: This review provides an insight into the remarkable contribution made by some well-known biopolymers such as polylactic-co-glycolic acid, poly(ε-caprolactone) (PCL), polyLactic Acid, poly(3- hydroxybutyrate-co-3-hydroxyvalerate) (PHBV), Chitosan and Cellulose in the therapeutic measure for many biomedical applications. Methods: : Various techniques and methods have made biopolymers more significant in the biomedical fields such as augmentation (replaced petroleum based polymers), film processing, injection modeling, blow molding techniques, controlled / implantable drug delivery devices, biological grafting, nano technology, tissue engineering etc. Results: The fore mentioned techniques and other advanced techniques have resulted in improved biocompatibility, nontoxicity, renewability, mild processing conditions, health condition, reduced immunological reactions and minimized side effects that would occur if synthetic polymers are used in a host cell. Conclusion: Biopolymers have brought effective and attainable targets in pharmaceutics and therapeutics. There are huge numbers of biopolymers reported in the literature that has been used effectively and extensively.

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