Correlation of ulcer size and serum cortisol in subjects with Aphthous Ulcers

2012 ◽  
Vol 2 (11) ◽  
pp. 381-382
Author(s):  
Dr. Arun Kumar M Dr. Arun Kumar M ◽  
◽  
Dr. Vasanthi Ananthakrishnan ◽  
Dr. Jaisri Goturu
Keyword(s):  
Serum Cortisol ◽  
Ulcer Size ◽  
Aphthous Ulcers

scholarly journals Effectivity of Guava leaves (Psidium guajava) as Mouthwash for Patients with Aphthous Ulcers

2013 ◽  
Vol 28 (2) ◽  
pp. 8-13 ◽  
Author(s):  
Ferdinand Z. Guintu ◽  
Antonio H. Chua
Keyword(s):  
Treatment Group ◽  
Chloride Solution ◽  
Psidium Guajava ◽  
Control Group ◽  
Control Groups ◽  
Ulcer Size ◽  
Aphthous Ulcers ◽  
Isotonic Sodium Chloride ◽  
Vas Scores ◽  
Guava Leaves

Objective: To determine whether Psidium guajava leaves mouthwash is effective in the management of patients with aphthous ulcers Methods: Study Design: Randomized prospective open label clinical study Setting:           Tertiary Government Training Hospital Subjects:         Thirty two patients diagnosed with aphthous ulcers were randomly divided into two groups, a treatment group using prepared guava leaves mouthwash, and a control group using isotonic sodium chloride solution mouthwash, given thrice a day for seven days. Patients were evaluated using a 10 point Visual Analog Scale. The sizes of the aphthous ulcers were measured using a caliper, and compared on day 1 and day 7 for both treatment and control groups. Results were subjected to statistical analysis using T-test, Mann-Whitney U test, and Fisher Exact test. Results: Comparison of VAS scores of guava treatment and NSS control groups showed that there were no differences in pain experienced on days 1 and 2. However, the VAS scores from day 3 to 7 had p values ranging from 0.02 - 0.0001 which showed significant differences in resolution of pain. There was statistically significant marked improvement of pain symptoms as early as three days post-treatment among patients who were administered guava leaves mouthwash. Complete resolution of aphthous ulcers in 75% of the study group was observed on day 7. Mean ulcer size post-treatment with guava gargle was 0.25mm compared to 0.75mm for NSS gargle. The mean size difference at day 7 was 1.44mm for the guava treatment group and 0.88mm for the NSS control group. There was a statistically significant faster resolution of ulcer size on day 7 in 16/16 or 100 % of patients in the treatment group compared with only 10/16 or 62.5% of patients in the control group. Patients who were administered guava leaves mouthwash generally fared better than those administered isotonic sodium chloride solution. Conclusion: Guava leaves mouthwash was effective for aphthous ulcers in terms of reduction of symptoms of pain and faster reduction of ulcer size. Further clinical trials comparing this mouthwash against other treatment options are recommended. Keywords: Guava leaves (Psidium guajava), aphthous ulcers, mouthwash  

Comparison of Virgin Coconut Oil with 5% Amlexanox in Management of Minor Recurrent Aphthous Ulcers - A Randomized Control Trial

2021 ◽  
Vol 13 (2) ◽  
pp. 16-22
Author(s):  
Dr. Kavitha Ravindran Nambiar ◽  
Dr. Krupashankar R ◽  
Dr. Veena S N ◽  
Dr. Neha Vijay ◽  
Dr. Kavitha A P
Keyword(s):  
Adverse Effects ◽  
Coconut Oil ◽  
Signs And Symptoms ◽  
Virgin Coconut Oil ◽  
Ulcer Size ◽  
Aphthous Ulcers ◽  
Wide Range ◽  
Recurrent Aphthous Ulcers ◽  
Group A ◽  
Anti Inflammatory

Objective: Recurrent Aphthous Ulcer (RAU) is a common (75-80%) painful inflammatory ulcerative disorder of the non-keratinized oral mucosa. Wide range of antiseptics, anti-inflammatory, antibiotics and corticosteroids are available for treatment. Amlexanox is a topical anti-inflammatory and anti-allergic drug used to treat RAS. Recently, there has been increase in interest in use of essential oil and herbal medicine in managing RAU, one such natural product is virgin coconut oil. This study is aimed to determine the efficacy of VCO in management of signs and symptoms of minor recurrent aphthous ulcers. Methodology: 40 patients were included for the study who were randomly divided into two groups. 20 patients in Group A (VCO) and 20 patients in Group B (5%Amlexanox). Primary outcome measured were reduction in ulcer size (in mm) and pain (VAS 1-10). Results: There is high statistical significant difference within the groups in ulcer healing and pain reduction (p=0.00) on 3rd and 5th day. In group A significant reduction in pain was present on the 5th day (p=0.02) and no significant reduction in ulcer size (p=0.083). No adverse effects were reported in either group. Conclusion: VCO could be used as an effective and safe drug in managing the signs and symptoms of RAS. It is edible oil with no known adverse effects and could be a safe therapeutic alternative in children and pregnant women.

Management of Aphthous Ulceration with Topical Quercetin: A Randomized Clinical Trial

2010 ◽  
Vol 11 (4) ◽  
pp. 9-16 ◽  
Author(s):  
Ahmed Abd El-Meguid Mostafa Hamdy ◽  
Mohamed Abd El-Moneam Ibrahem
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Topical Application ◽  
Size Difference ◽  
Control Group ◽  
Ulcer Size ◽  
Aphthous Ulcers ◽  
Aphthous Ulceration ◽  
Group 2 ◽  
Group 1

Abstract Aim Recurrent aphthous ulceration is the most commonly known oral mucosal disease. Quercetin is a useful therapeutic agent for the treatment of colitis and gastric ulcer. The objective of this study was to determine the effect of topical application of quercetin in the treatment of minor aphthous ulcers. Methods and Materials Forty male patients with no known pathology of the oral mucosa other than minor aphthous ulcers were enrolled in this study. Patients were randomly divided into two groups, each consisting of 20 patients. Group 1 (control group) patients used a benzydamine hydrochloride mouthwash three times daily. Group 2 patients placed two to three dabs of quercetin three times daily directly on their ulcers. Clinical evaluation of patients included assessment of ulcer size, pain measure, and interviews regarding the topical application of quercetin in terms of consistency, taste, local tolerability, and ease of application. Results The topical application of quercetin cream to minor mouth ulcers relieved pain and produced complete healing in seven of the Group 2 patients (35 percent) in 2–4 days, 18 patients (90 percent) in 4–7 days, and 20 patients (100 percent) in 7–10 days. When comparing the mean ulcer size after 10 days, lesions in the Group 2 patients were smaller than those in Group 1, and the size difference between the two groups was significantly different (p<0.004). Also, 90 percent of patients responded that they appreciated the ease of application when using the topical quercetin, and they did not object to its consistency or taste. Conclusion Quercetin is a safe, well-tolerated, and highly effective promising new, adjunctive treatment for healing common aphthous ulcers. Clinical Significance Although aphthous ulcers typically resolve on their own in one to two weeks, the daily topical application of quercetin may be useful in accelerating the healing process of minor aphthous ulcers. Citation Hamdy AAEM, Ibrahem MAE. Management of Aphthous Ulceration with Topical Quercetin: A Randomized Clinical Trial. J Contemp Dent Pract [Internet]. 2010 July; 11(4):009-016. Available from: http://www.thejcdp. com/journal/view/volume11-issue4-hamdy

scholarly journals Relative Efficacy of Quercetin Compared with Benzydamine Hydrochloride in Minor Aphthae: A Prospective, Parallel, Double Blind, Active Control, Preliminary Study

2017 ◽  
Vol 2017 ◽  
pp. 1-6
Author(s):  
Maitreyi Pandya ◽  
Anupama N. Kalappanavar ◽  
Rajeshwari G. Annigeri ◽  
Dhanya S. Rao
Keyword(s):  
Ulcer Healing ◽  
Treatment Modalities ◽  
Double Blind ◽  
Ulcer Size ◽  
Aphthous Ulcers ◽  
Group A ◽  
The Mean ◽  
Preliminary Study ◽  
Group B ◽  
Mouth Wash

Background and Objectives. Recurrent aphthous stomatitis is an inflammatory condition present since ancient era wherein numerous treatment modalities have been tried. But complete eradication of the disease has not been possible and hence newer agents are being introduced. One such agent is a flavonoid named quercetin with proven antioxidant, anti-inflammatory, and ulcer healing properties. Methods. 40 patients with minor aphthous ulcers were divided equally into two groups: A and B. Group A patients were advised to apply quercetin gel and Group B patients were advised to take benzydamine hydrochloride mouth wash. Clinical evaluation including assessment of ulcer size and pain score and questionnaire about the acceptability of both the drugs in terms of taste and ease of application was carried out. Each criterion was compared and statistically analyzed. Results. There was statistically significant reduction in the mean score of pain sensation and ulcer area in both the groups. Quercetin showed statistically highly significant ulcer size reduction as compared to benzydamine hydrochloride. Conclusion. From the present study, it is evident that quercetin is safe, well tolerated, and effective therapy which promotes complete ulcer healing in a short duration of time.

Think Behçet's When Aphthous Ulcers Recur

2008 ◽  
Vol 38 (23) ◽  
pp. 27
Author(s):  
NANCY WALSH
Keyword(s):  
Aphthous Ulcers

Healing venous ulcers with different modalities of leg compression

Phlebologie ◽  
2006 ◽  
Vol 35 (05) ◽  
pp. 349-355 ◽  
Author(s):  
E. O. Brizzio ◽  
G. Rossi ◽  
A. Chirinos ◽  
I. Cantero ◽  
G. Idiazabal ◽  
...  
Keyword(s):  
Wound Care ◽  
Univariate Analysis ◽  
Compression Therapy ◽  
Healing Time ◽  
Clinical Parameters ◽  
Compression Stockings ◽  
Local Pressure ◽  
Ulcer Size ◽  
Venous Ulcers ◽  
Unexpected Findings

Summary Background: Compression therapy (CT) is the stronghold of treatment of venous leg ulcers. We evaluated 5 modalities of CT in a prospective open pilot study using a unique trial design. Patients and methods: A group of experienced phlebologists assigned 31 consecutive patients with 35 venous ulcers (present for 2 to 24 months with no prior CT) to 5 different modalities of leg compression, 7 ulcers to each group. The challenge was to match the modality of CT with the features of the ulcer in order to achieve as many healings as possible. Wound care used standard techniques and specifically tailored foam pads to increase local pressure. CT modalities were either stockings Sigvaris® 15-20, 20-30, 30-40 mmHg, multi-layer bandages, or CircAid® bandaging. Compression was maintained day and night in all groups and changed at weekly visits. Study endpoints were time to healing and the clinical parameters predicting the outcome. Results: The cumulative healing rates were 71%, 77%, and 83% after 3, 6, and 9 months, respectively. Univariate analysis of variables associated with nonhealing were: previous surgery, presence of insufficient perforating and/or deep veins, older age, recurrence, amount of oedema, time of presence of CVI and the actual ulcer, and ulcer size (p <0.05-<0.001). The initial ulcer size was the best predictor of the healing-time (Pearson r=0.55, p=0.002). The modality of CT played an important role also, as 19 of 21 ulcers (90%) healed with stockings but only 8 of 14 with bandages (57%; p=0.021). Regression analysis allowed to calculate a model to predict the healing time. It compensated for the fact that patients treated with low or moderate compression stockings were at lower risk of non-healing. and revealed that healing with stockings was about twice as rapid as healing with bandages. Conclusion: Three fourths of venous ulcers can be brought to healing within 3 to 6 months. Healing time can be predicted using easy to assess clinical parameters. Irrespective of the initial presentation ulcer healing appeared more rapid with the application of stockings than with bandaging. These unexpected findings contradict current believes and require confirmation in randomised trials.

Platelet Function in Surgical Stress

1985 ◽  
Vol 54 (04) ◽  
pp. 849-852 ◽  
Author(s):  
O Naesh ◽  
J T Friis ◽  
I Hindberg ◽  
K Winther
Keyword(s):  
Stress Response ◽  
Negative Correlation ◽  
Surgical Stress ◽  
Plasma Concentrations ◽  
Serum Cortisol ◽  
Cortisol Concentration ◽  
Pulmonary Dysfunction ◽  
Arterial Po2 ◽  
Elective Cholecystectomy ◽  
Serum Cortisol Concentration

SummaryTen patients for elective cholecystectomy were studied pre-, per- and postoperatively. All had neurolept anesthesia. Plasma concentrations of β-TG, TXB2 and 5-HT and intraplatelet 5-HT were measured. Aggregation to ADP was recorded.Serum cortisol concentration was used as index of the stress response, showing peroperative increase and postoperative decrease. Closely related to this we observed a significant increase in P-β-TG and P-TXB2 with postoperative normalization in 6 patients without complications. P-5-HT had a peak peropera-tively and remained elevated postoperatively. A negative correlation between P--5-HT and decreasing intraplatelet 5-HT postoperatively was observed.High postoperative levels of P--5-HT seem to be related to low arterial Po2 and pulmonary dysfunction. In 3 patients with complications a second increase in P-β-TG, P-TXB2 and partly in P--5-HT was found. Platelets were temporarily refractory to ADP immediately following surgery and showed increased aggregabil-ity postoperatively. We conclude that platelets are activated in surgical stress.

ADRENOCORTICAL RESPONSE TO NON-EXHAUSTIVE MUSCULAR EXERCISE

1972 ◽  
Vol 70 (1) ◽  
pp. 73-80 ◽  
Author(s):  
L. W. Raymond ◽  
J. Sode ◽  
J. R. Tucci
Keyword(s):  
Treadmill Exercise ◽  
Serum Cortisol ◽  
Treadmill Walking ◽  
Exhaustive Exercise ◽  
Muscular Exercise ◽  
Adrenocortical Response ◽  
Exercise Tachycardia ◽  
Before And After

ABSTRACT Treadmill walking produced a prompt reduction in serum cortisol in 10 of 12 healthy military men. In contrast, two subjects, with pre-exercise tachycardia and apprehension, showed an increase in serum cortisol with treadmill exercise. In each group, the changes produced by exercise were still evident 30 and 60 minutes after the 30-minute treadmill walk. Urine collected before and after exercise contained similar amounts of 11-hydroxy- and 17-hydroxycorticosteroid material. These results may be explained by an increase in cortisol utilization during exercise and/or by a change in its distribution. The data indicate that in the absence of psychic factors, non-exhaustive exercise is not associated with pituitary adrenocortical activation.

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