Comparison of Virgin Coconut Oil with 5% Amlexanox in Management of Minor Recurrent Aphthous Ulcers - A Randomized Control Trial

Objective: Recurrent Aphthous Ulcer (RAU) is a common (75-80%) painful inflammatory ulcerative disorder of the non-keratinized oral mucosa. Wide range of antiseptics, anti-inflammatory, antibiotics and corticosteroids are available for treatment. Amlexanox is a topical anti-inflammatory and anti-allergic drug used to treat RAS. Recently, there has been increase in interest in use of essential oil and herbal medicine in managing RAU, one such natural product is virgin coconut oil. This study is aimed to determine the efficacy of VCO in management of signs and symptoms of minor recurrent aphthous ulcers. Methodology: 40 patients were included for the study who were randomly divided into two groups. 20 patients in Group A (VCO) and 20 patients in Group B (5%Amlexanox). Primary outcome measured were reduction in ulcer size (in mm) and pain (VAS 1-10). Results: There is high statistical significant difference within the groups in ulcer healing and pain reduction (p=0.00) on 3rd and 5th day. In group A significant reduction in pain was present on the 5th day (p=0.02) and no significant reduction in ulcer size (p=0.083). No adverse effects were reported in either group. Conclusion: VCO could be used as an effective and safe drug in managing the signs and symptoms of RAS. It is edible oil with no known adverse effects and could be a safe therapeutic alternative in children and pregnant women.

Download Full-text

FORMULASI NANOEMULSI ASPIRIN MENGGUNAKAN ETANOL 96 % SEBAGAI KO-SURFAKTAN

WARTA FARMASI ◽

10.46356/wfarmasi.v6i1.66 ◽

2017 ◽

Vol 6 (1) ◽

pp. 1-11

Author(s):

Nur Saadah Daud ◽

Musdalipah Musdalipah ◽

Asriyanti Lamadari

Keyword(s):

Oral Administration ◽

Pain Therapy ◽

Coconut Oil ◽

Tween 80 ◽

Moderate Pain ◽

Virgin Coconut Oil ◽

Cycling Test ◽

Inflammatory Drugs ◽

Anti Inflammatory ◽

20 Nm

ABSTRAK Aspirin termasuk dalam golongan Non Steroidal Anti Inflammatory Drugs (NSAIDs) yang banyak digunakan pada pengobatan nyeri ringan sampai sedang, antipiretik, anti inflamasi, serta anti koagulan. Pada penggunaan secara oral dapat menurunkan efektifitas obat akibat metabolisme lintas pertama. Alternatif untuk mengatasi masalah tersebut yaitu membuat sediaan topikal nanoemulsi aspirin. Nanoemulsi yaitu sistem emulsi yang transparan, tembus cahaya dan merupakan d ispersi minyak air yang distabilkan oleh lapisan film dari surfaktan dan ko-surfaktan, yang memiliki ukuran droplet 20 nm-500 nm. Penelitian ini bertujuan untuk membuat nanoemulsi aspirin dengan variasi konsentrasi etanol 96 % sebagai ko-surfaktan. Nanoemulsi aspirin dibuat dengan Virgin Coconut Oil (VCO) sebagai fase minyak, tween 80 sebagai surfaktan,dan etanol 96 % sebagai ko-surfaktan. Hasil penelitian mendapatkan 5 formula nanoemulsi jernih beraroma khas dengan nilai pH berkisar pada range 4,0-4,5 yang telah memenuhi pH normal kulit. dengan konsentrasi etanol 96 % yaitu 10 %, 15 %, 20 %, 25 % dan 30 %, dan dibuat 3 replikasi. Hasil uji stabilitas fisik menunjukkan bahwa kelima formula menghasilkan nanoemulsi yang stabil dan tidak terjadi pemisahan fase sesudah uji sentrifugasi dan cycling test dilakukan. Kata Kunci : Nanoemulsi, Aspirin, Etanol 96%, Ko-surfaktan ABSTRACT Acetosal known to be a part of the group medications called Non Steroidal Anti Inflammatory Drugs (NSAIDs) that was used for mild to moderate pain therapy, antipyretic, anti inflamation and anti coagulan. Oral administration of acetosal may decrease its effectiveness because of the first past metabolism problem. The purpose of this study was to formulate acetosal into nanoemulsion form for topical preparation as an alternative to avoid those problem with ethanol 96% as co-surfactant. Nanoemulsion was an emultion system which transparent, glasslike, and comes from dispertion of water and oil stabilized by film-coated that made from surfactant and co-surfactant combination, which has droplet size around 20 nm-500 nm. Acetosal nanoemulsions were prepared with Virgin Coconut Oil (VCO) as oil phase, tween 80 as surfactant and ethanol 96 % as co-surfactant. There were 5 formulas of transparent acetosal nanoemultion. Their yield of pH were about 4,0-4,5 were met the normal skin’s pH. They were acetosal nanoemulsions with ethanol 96 % of 10%, 15%, 20%, 25%, and 30%. These five were stable and did not show the separation of phase after both centrifugation and cycling test. Keyword : Nanoemulsion, Acetosal, Ethanol 96%, Co-Surfactan

Download Full-text

Virgin coconut oil enhances neuroprotective and anti‐inflammatory factors in the thymus and mesenteric lymph nodes of rats

Clinical and Experimental Neuroimmunology ◽

10.1111/cen3.12540 ◽

2019 ◽

Vol 11 (1) ◽

pp. 65-72

Author(s):

Sunil Karrunanithi ◽

Kishore A. Ravichandran ◽

Lalgi Hima ◽

Uday P. Pratap ◽

Ramasamy Vasantharekha ◽

...

Keyword(s):

Lymph Nodes ◽

Coconut Oil ◽

Inflammatory Factors ◽

Virgin Coconut Oil ◽

Mesenteric Lymph Nodes ◽

Mesenteric Lymph ◽

Anti Inflammatory

Download Full-text

In vitro anti-inflammatory and skin protective properties of Virgin coconut oil

Journal of Traditional and Complementary Medicine ◽

10.1016/j.jtcme.2017.06.012 ◽

2019 ◽

Vol 9 (1) ◽

pp. 5-14 ◽

Cited By ~ 20

Author(s):

Sandeep R. Varma ◽

Thiyagarajan O. Sivaprakasam ◽

Ilavarasu Arumugam ◽

N. Dilip ◽

M. Raghuraman ◽

...

Keyword(s):

Coconut Oil ◽

Virgin Coconut Oil ◽

Protective Properties ◽

Anti Inflammatory

Download Full-text

Antioxidant, anti‐inflammatory, and antiapoptotic effects of virgin coconut oil against antibiotic drug gentamicin‐induced nephrotoxicity via the suppression of oxidative stress and modulation of iNOS/NF‐ĸB/caspase‐3 signaling pathway in Wistar rats

Journal of Food Biochemistry ◽

10.1111/jfbc.13100 ◽

2019 ◽

Vol 44 (1) ◽

Cited By ~ 1

Author(s):

Ademola C. Famurewa ◽

Ekenechukwu K. Maduagwuna ◽

Abiola M. Folawiyo ◽

Elizabeth E. Besong ◽

Albert N. Eteudo ◽

...

Keyword(s):

Oxidative Stress ◽

Signaling Pathway ◽

Wistar Rats ◽

Caspase 3 ◽

Coconut Oil ◽

Virgin Coconut Oil ◽

Antibiotic Drug ◽

Anti Inflammatory

Download Full-text

Saussurea lappa: A Comprehensive Review on its Pharmacological Activity and Phytochemistry

Current Traditional Medicine ◽

10.2174/2215083805666190626144909 ◽

2020 ◽

Vol 6 (1) ◽

pp. 13-23

Author(s):

Reyaz Hassan ◽

Mubashir Hussain Masoodi

Keyword(s):

Biological Activity ◽

Adverse Effects ◽

Chemical Constituents ◽

Literature Survey ◽

Perennial Herb ◽

Comprehensive Review ◽

Saussurea Lappa ◽

Therapeutic Uses ◽

Wide Range ◽

Anti Inflammatory

Around 3000 species of Saussurea are known, however Saussurea lappa Clarke which is perennial herb and has been traditionally used as anticancer, anti-inflammatory, antiviral, medicine without many adverse effects. Phytochemistry of Saussurea lappa after thorough literature survey revealed various varied and copious metabolites such as sesquiterpenes, flavonoids, phytosterols, lignans, terpenes. Many of these compounds have been found to possess a wide range of biological activity such as anticancer, anti-inflammatory, anti-hepatotoxic, anti-viral, etc. Among sesquiterpenes particularly Dehydrocostuslactone, dihydrocostunolide, costunolide Lappadilactone, have been isolated as the main chemical constituents. This review aims to cover published work from public databases (e.g. PubMed, Google Scholar, ResearchGate) and Non-English, Ph.D./MS thesis databases (e.g. CKNIChina, Jairo-Japan, Myto-Malaysia, Shodhganga-India) with a particular focus on phytochemistry and therapeutic uses of different fractions as well as isolated compounds from Saussurea lappa.

Download Full-text

Anti-inflammatory, analgesic, and antipyretic activities of virgin coconut oil

Pharmaceutical Biology ◽

10.3109/13880200903062614 ◽

2009 ◽

Vol 48 (2) ◽

pp. 151-157 ◽

Cited By ~ 62

Author(s):

S. Intahphuak ◽

P. Khonsung ◽

A. Panthong

Keyword(s):

Coconut Oil ◽

Virgin Coconut Oil ◽

Anti Inflammatory

Download Full-text

In vivo Antinociceptive and Anti-inflammatory Activities of Dried and Fermented Processed Virgin Coconut Oil

Medical Principles and Practice ◽

10.1159/000323756 ◽

2011 ◽

Vol 20 (3) ◽

pp. 231-236 ◽

Cited By ~ 33

Author(s):

Z.A. Zakaria ◽

M.N. Somchit ◽

A.M. Mat Jais ◽

L.K. Teh ◽

M.Z. Salleh ◽

...

Keyword(s):

Coconut Oil ◽

Virgin Coconut Oil ◽

Anti Inflammatory

Download Full-text

Effect of Virgin Coconut Oil Application on the Skin of Preterm Newborns: A Randomized Controlled Trial

Journal of Tropical Pediatrics ◽

10.1093/tropej/fmz041 ◽

2019 ◽

Vol 66 (2) ◽

pp. 129-135

Author(s):

Mithun Chandra Konar ◽

Kamirul Islam ◽

Atanu Roy ◽

Taraknath Ghosh

Keyword(s):

Adverse Effect ◽

Randomized Controlled Trial ◽

Controlled Trial ◽

Neurodevelopmental Outcome ◽

Coconut Oil ◽

Preterm Neonates ◽

Virgin Coconut Oil ◽

Randomized Controlled ◽

Group A ◽

Group B

Abstract Background Preterm constitutes a major part of neonatal mortality, particularly in India. Due to dermal immaturity, preterm neonates are susceptible to various complications like infection, hypothermia, etc. Emollient application is a traditional practice in our subcontinent. Aims To find out the efficacy of coconut oil application for skin maturity, prevention of sepsis, hypothermia and apnea, its effect on long-term neurodevelopment and adverse effect of it, if any. Material and methods A randomized controlled trial was conducted in the rural field practice area of Department of Community Medicine, Burdwan Medical College from March 2014 to August 2018. Preterm born in the study period was divided into Group A (received virgin coconut oil application) and Group B (received body massage without any application). Neonatal skin condition was assessed on 7th, 14th, 21st and 28th day of life. Neurodevelopmental status was assessed on 3rd, 6th and 12th months. Results A total of 2294 preterm were included in the study. Groups A and B consisted of 1146 and 1148 preterm infants, consecutively. Mean gestational age of the study population was 31.9 ± 3.4 weeks and 50.4% were male. Mean weight loss in first few days was less in group A but mean weight gain per day was higher in group B. Lesser incidences of hypothermia and apnea, and better skin maturity and neurodevelopmental outcome were noted in group A. No significant adverse effect was noted with coconut oil application. Conclusion Use of coconut oil helps in dermal maturity and better neurodevelopmental outcome. Further studies are warranted for universal recommendation.

Download Full-text