The Synergy Effect of Weight-Bearing Circuit Training and Aloe QDM Complex on Obese Middle Aged Women: a Randomized Double-Blind Controlled Trial

BackgroundDepression is common and the efficacy of antidepressants is suboptimal. High plasma homocysteine has been consistently associated with depression, and treatment with certain B vitamins demonstrably reduces its concentration.AimsTo determine whether vitamins B6, B12and folic acid enhance response to antidepressant treatment over 52 weeks.MethodRandomised, double-blind, placebo-controlled trial of citalopram (20–40 g) together with 0.5mg of vitamin B12, 2mg of folic acid and 25mg of vitamin B6 for 52 weeks (Australian and New Zealand Clinical Trials Registry: 12609000256279). Participants were community-dwelling adults aged 50 years or over with DSM-IV-TR major depression. We measured severity of symptoms with the Montgomery–åsberg Depression Rating Scale (MADRS). The primary outcome was remission of the depressive episode after 12, 26 and 52 weeks. Secondary outcomes included reduction of MADRS scores over time and relapse of major depression after recovery by week 12.ResultsIn total, 153 people were randomised (76 placebo, 77 vitamins). Remission of symptoms was achieved by 78.1 and 79.4% of participants treated with placebo and vitamins by week 12 (P= 0.840), by 76.5 and 85.3% at week 26 and 75.8 and 85.5% at week 52 (effect of intervention over 52 weeks: odds ratio (OR) = 2.49, 95% CI 1.12–5.51). Group differences in MADRS scores over time were not significant (P= 0.739). The risk of subsequent relapse among those who had achieved remission of symptoms at week 12 was lower in the vitamins than placebo group (OR = 0.33, 95% CI 0.12–0.94).ConclusionsB vitamins did not increase the 12-week efficacy of antidepressant treatment, but enhanced and sustained antidepressant response over 1 year. Replication of these findings would mandate that treatment guidelines adopt the adjunctive use of B vitamins as a safe and inexpensive strategy to manage major depression in middle-aged and older adults.

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Effects of N-acetyl glucosamine and chondroitin sulfate supplementation on knee pain and self-reported knee function in middle-aged and older Japanese adults: a randomized, double-blind, placebo-controlled trial

Aging Clinical and Experimental Research ◽

10.1007/s40520-015-0412-6 ◽

2015 ◽

Vol 28 (2) ◽

pp. 197-205 ◽

Cited By ~ 7

Author(s):

Taishi Tsuji ◽

Jieun Yoon ◽

Naruki Kitano ◽

Tomohiro Okura ◽

Kiyoji Tanaka

Keyword(s):

Chondroitin Sulfate ◽

Knee Pain ◽

Controlled Trial ◽

Knee Function ◽

Middle Aged ◽

Double Blind ◽

Double Blind Placebo ◽

Japanese Adults

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Dose-dependent effects of fish oil on cardio-metabolic biomarkers in healthy middle-aged and elderly Chinese people: a double-blind randomized controlled trial

Food & Function ◽

10.1039/c7fo01566f ◽

2018 ◽

Vol 9 (6) ◽

pp. 3235-3243 ◽

Cited By ~ 4

Author(s):

Jia Song ◽

Manjiang Hu ◽

Cheng Li ◽

Bo Yang ◽

Qing Ding ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Fish Oil ◽

Controlled Trial ◽

Chinese People ◽

Middle Aged ◽

Double Blind ◽

Randomized Controlled ◽

Elderly Chinese ◽

Metabolic Biomarkers ◽

Dose Dependent

Fish oil dose-dependently regulated serum PUFA and cardio-metabolic biomarkers in healthy middle-aged and elderly Chinese people who consumed insufficient n-3PUFA.

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Effects of prismatic adaptation on balance and postural disorders in patients with chronic right stroke: protocol for a multicentre double-blind randomised sham-controlled trial

BMJ Open ◽

10.1136/bmjopen-2021-052086 ◽

2021 ◽

Vol 11 (11) ◽

pp. e052086

Author(s):

Aurélien Hugues ◽

Amandine Guinet-Lacoste ◽

Sylvie Bin ◽

Laurent Villeneuve ◽

Marine Lunven ◽

...

Keyword(s):

Controlled Trial ◽

Weight Bearing ◽

Body Axis ◽

Double Blind ◽

Longitudinal Body Axis ◽

Stroke Lesion ◽

The Right ◽

Prismatic Adaptation ◽

Straight Ahead ◽

Postural Disorders

IntroductionPatients with right stroke lesion have postural and balance disorders, including weight-bearing asymmetry, more pronounced than patients with left stroke lesion. Spatial cognition disorders post-stroke, such as misperceptions of subjective straight-ahead and subjective longitudinal body axis, are suspected to be involved in these postural and balance disorders. Prismatic adaptation has showed beneficial effects to reduce visuomotor disorders but also an expansion of effects on cognitive functions, including spatial cognition. Preliminary studies with a low level of evidence have suggested positive effects of prismatic adaptation on weight-bearing asymmetry and balance after stroke. The objective is to investigate the effects of this intervention on balance but also on postural disorders, subjective straight-ahead, longitudinal body axis and autonomy in patients with chronic right stroke lesion.Methods and analysisIn this multicentre randomised double-blind sham-controlled trial, we will include 28 patients aged from 18 to 80 years, with a first right supratentorial stroke lesion at chronic stage (≥12 months) and having a bearing ≥60% of body weight on the right lower limb. Participants will be randomly assigned to the experimental group (performing pointing tasks while wearing glasses shifting optical axis of 10 degrees towards the right side) or to the control group (performing the same procedure while wearing neutral glasses without optical deviation). All participants will receive a 20 min daily session for 2 weeks in addition to conventional rehabilitation. The primary outcome will be the balance measured using the Berg Balance Scale. Secondary outcomes will include weight-bearing asymmetry and parameters of body sway during static posturographic assessments, as well as lateropulsion (measured using the Scale for Contraversive Pushing), subjective straight-ahead, longitudinal body axis and autonomy (measured using the Barthel Index).Ethics and disseminationThe study has been approved by the ethical review board in France. Findings will be submitted to peer-reviewed journals relative to rehabilitation or stroke.Trial registration numberNCT03154138.

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Improvement of gastrointestinal discomfort and inflammatory status by a synbiotic in middle-aged adults: a double-blind randomized placebo-controlled trial

Scientific Reports ◽

10.1038/s41598-020-80947-1 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Audrey M. Neyrinck ◽

Julie Rodriguez ◽

Bernard Taminiau ◽

Camille Amadieu ◽

Florent Herpin ◽

...

Keyword(s):

Controlled Trial ◽

16S Rrna Gene Sequencing ◽

Rrna Gene ◽

Middle Aged ◽

Double Blind ◽

Aged People ◽

Gut Barrier Function ◽

Inflammatory Status ◽

Synbiotic Supplementation ◽

Aged Subjects

AbstractSeveral studies suggest that microbial alterations (dysbiosis) are intimately linked to chronic inflammation occurring upon aging. The aim of this study was to investigate the potential interest of a synbiotic approach (co-administration of a probiotic bacteria and a prebiotic dietary fibre) to improve gastrointestinal wellness and inflammatory markers in middle-aged people. Middle-aged subjects were randomized to take synbiotic (Bifidobacterium animalis lactis and fructo-oligosaccharides (FOS)) or placebo for 30 days. Stool frequency and consistency were improved in both placebo and synbiotic-treated volunteers while the synbiotic treatment significantly decreased the number of days with abdominal discomfort. Synbiotic treatment had no impact on mood dimensions, quality of life scores or the overall composition of the gut microbiota (16S rRNA gene sequencing of DNA extracted from stool). Importantly, plasma proinflammatory cytokines (interleukin (IL)-6, IL-8, IL-17a and interferon-gamma (IFNγ)) were significantly lower after 30 days of synbiotic supplementation. This effect appears to be independent of the gut barrier function. This study demonstrates that a combination of B. animalis lactis and the well-known prebiotic FOS could be a promising synbiotic strategy to decrease inflammatory status with improvement of gut disorders in middle-aged people.

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