Antiandrogenic therapy with ciproterone acetate in female patients who suffer from both androgenetic alopecia and acne vulgaris

Background. Androgenetic Alopecia in Women (AGA) occurs due to an underlying susceptibility of hair follicles to androgenic miniaturization, caused by androgens. Clinically, AGA is characterized by progressive hair loss, with a marked hair thinning in the fronto-parietal area so that the scalp can be easily seen. Acne vulgaris is androgen-dependent and often affects the skin that has an increased number of oil glands: face, back and chest. Although the sebaceous glands are present on the scalp too, it is very rare to get acne at this site, as the hair acts as a wig and allows the sebum to drain and does not block the pores. Both AGA and Acne Vulgaris are signs of hyperandrogenism. Cyproterone acetate/ethinyl estradiol (2mg/0.035mg) products are authorized for the treatment of androgenetic symptoms in women, such as acne, seborrhea, mild forms of hirsutism and androgenetic alopecia. Our study had a double purpose: - To evaluate the result of the study regimen Melleva 35 (one pill per day, for 3 consecutive months) in patients with moderate to severe acne, suffering also from Androgenetic Alopecia; - To establish the efficacy of the drug on acne and alopecia improvement, both from the doctor’s and patient’s point of view. Patients and methods. After being informed of the aims and procedures of the study, participants provided a written informed consent. A number of 35 female subjects with moderate to severe acne vulgaris remained in the study. The subjects had also been diagnosed as suffering from AGA, on the basis of clinical criteria, including the pattern of hair loss and trichoscopy assessment. Results. 83% of study subjects reported that their hair did not continue to fall after 3 months of antiandrogen therapy. The females were evaluated using trichoscopy and the doctor noticed hair regrowth in 77% of the cases. Regarding the improvement of acne lesions after the treatment, 40% of study subjects recorded good improvement and 26% recorded excellent results with Melleva 35. The acceptance of the treatment was very high, 86% patients were compliant with the study therapy. The rate of adverse events (5 cases) was within the limits of the treatment tested by the study. Almost a third of the total number of subjects (28.5%) reached a good satisfaction level after the treatment, while 37.1% claimed moderate satisfaction. Conclusion. There was no correlation between the age of the subjects and the treatment for acne therefore our first hypothesis was rejected. As a conclusion, antiandrogenic therapy with Melleva 35, 1 pill per day, for 3 consecutive months, shows good results for patients who suffer from both Androgenetic Alopecia and Acne Vulgaris.

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Disorders of Hair

10.2310/fm.1107 ◽

2013 ◽

Author(s):

James Q Del Rosso

Keyword(s):

Hair Loss ◽

Alopecia Areata ◽

Hair Growth ◽

Growth Cycle ◽

Hair Follicles ◽

Common Type ◽

Diagnosis And Treatment ◽

Basic Knowledge ◽

Androgenetic Alopecia ◽

Broad Overview

A basic knowledge of the hair growth cycle is needed to evaluate disorders of hair growth. This chapter presents a broad overview of the physiology and evaluation of hair growth, as well as discussions of specific types of alopecia. The epidemiology, pathogenesis, diagnosis, and treatment of androgenetic alopecia, the most common type of nonscarring hair loss, are covered. Diffuse hair shedding is generalized hair loss over the entire scalp. Diagnosis and treatment of telogen effluvium, anagen arrest (anagen effluvium), and other causes of diffuse hair shedding are covered in detail. Alopecia areata, typically characterized by patchy hair loss; cicatricial alopecia, which results from permanent scarring of the hair follicles; and miscellaneous causes of hair loss are also discussed. Tables list the causes of diffuse and cicatricial alopecia, telogen effluvium, and miscellaneous chemicals and categories of drugs that can cause alopecia, as well as miscellaneous causes of hair loss. Included is an algorithm outlining the approach to diagnosing nonscarring alopecia, as well as a variety of clinical photographs. This review contains 9 highly rendered figures, 6 tables, and 42 references.

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Stem cells from human hair follicles: first mechanical isolation for immediate autologous clinical use in androgenetic alopecia and hair loss

Stem Cell Investigation ◽

10.21037/sci.2017.06.04 ◽

2017 ◽

Vol 4 (7) ◽

pp. 58-58 ◽

Cited By ~ 41

Author(s):

Pietro Gentile ◽

Maria G. Scioli ◽

Alessandra Bielli ◽

Augusto Orlandi ◽

Valerio Cervelli

Keyword(s):

Stem Cells ◽

Hair Loss ◽

Human Hair ◽

Hair Follicles ◽

Androgenetic Alopecia ◽

Clinical Use ◽

Mechanical Isolation

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Acne Vulgaris Mimicking Cutaneous Lupus Erythematosus in an Adolescent: Report of a Rare Case

Case Reports in Dermatology ◽

10.1159/000511530 ◽

2021 ◽

pp. 69-74

Author(s):

Irma Bernadette S. Sitohang ◽

Agung Mohamad Rheza ◽

Sondang P. Sirait ◽

Eyleny Meisyah Fitri ◽

Lis Surachmiati Suseno

Keyword(s):

Lupus Erythematosus ◽

Acne Vulgaris ◽

Cutaneous Lupus Erythematosus ◽

Systemic Lupus ◽

Malar Rash ◽

Clinical Criteria ◽

Severe Acne ◽

American College Of Rheumatology ◽

Adolescent Report ◽

Cutaneous Lupus

Acne vulgaris is a chronic and self-limiting disorder of the pilosebaceous unit which is primarily seen in adolescents. Acne vulgaris presents as polymorphic lesions, consisting of comedones, papules, pustules, cysts, nodules, scarring, and dyspigmentation. Acneiform presentation of cutaneous lupus erythematosus (CLE) is extremely rare. The presentation of CLE is notoriously diverse and often mimics a broad range of unrelated skin disorders. We present a case by referring to American College of Rheumatology (ACR) criteria for systemic lupus erythematosus (SLE); our patient’s conditions did not meet any of the clinical criteria of the Systemic Lupus International Collaborating Clinics (SLICC) for SLE. Subsequent to thorough history-taking, physical examination, and laboratory evaluations, the diagnosis of acne vulgaris was established, and a diagnosis of CLE was excluded. As acneiform presentation of CLE is rare, we here present a case which resembled both acne vulgaris and CLE. We describe our experience in establishing the diagnosis of severe acne vulgaris accompanied by scars in a 12-year-old boy with a malar rash and scars on his frontal and malar area who had initially been misdiagnosed as having CLE. This unusual case highlights the broad spectrum of adolescent acne and the importance of clinical identification of the disease so that unnecessary workups might be avoided.

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The Use of Finasteride in Treating Androgenetic Alopecia in Adult Men

Journal of Pharmacy Technology ◽

10.1177/875512250001600205 ◽

2000 ◽

Vol 16 (2) ◽

pp. 50-53

Author(s):

Karen C Hobdy-Henderson ◽

Chad LeClair ◽

Tam Huynh ◽

Kiet Huynh

Keyword(s):

Hair Loss ◽

English Language ◽

Data Extraction ◽

Package Insert ◽

Hair Follicles ◽

Androgenetic Alopecia ◽

Oral Drug ◽

Adult Men ◽

English Language Journal ◽

Study Selection

Objective: To review the medical literature discussing the use of finasteride in the treatment of androgenetic alopecia in adult men. Data Sources: English-language journal articles, the Internet, and the manufacturer's package insert. Study Selection: Clinical trials evaluating the efficacy and safety of finasteride in the treatment of men with mild to moderate androgenetic alopecia were selected. Of these trials, those evaluating the efficacy of finasteride were blinded, randomized, placebo-controlled studies of 12-months' duration conducted in men between 18 and 41 years of age; those evaluating the safety of finasteride were conducted in rats, mice, and rabbits. Data Extraction: Data were extracted and analyzed if the information was relevant and consistent. Study selection was based on study design and clinical end points. Data Synthesis: Male pattern hair loss is a common condition in which men experience thinning of the hair on the scalp. This often results in a receding hairline or balding on the top of the head. This type of hair loss is known as androgenetic alopecia. In men with androgenetic alopecia, the balding scalp contains miniaturized hair follicles and increased amounts of dihydrotestosterone (DHT) compared with a hairy scalp. Administration of finasteride decreases scalp and serum DHT concentrations in these men, causing an increase in the number of scalp hairs for most men and helping to fill in thin or balding areas of the scalp. Conclusions: Finasteride is the first oral drug in its class to be used in treating alopecia in men only. It maintains and regrows hair on top of the head and anterior midscalp area. Finasteride begins to block the formation of DHT almost immediately; however, because hair grows slowly, visible results from the daily use of finasteride are not seen for at least three months. This drug is not recommended for use in women and children. Finasteride demonstrates an excellent profile in treating men with hair loss.

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“Yuvanpidika : A modern and Ayurvedic perspective.”

National Journal of Research in Ayurved Science ◽

10.52482/ayurlog.v8i04.638 ◽

2020 ◽

Vol 8 (04) ◽

Author(s):

Tanvi Sanjay Pawar ◽

Archana Gharge

Keyword(s):

Acne Vulgaris ◽

Self Esteem ◽

Hair Follicles ◽

Oil Glands ◽

Cutibacterium Acnes ◽

The Face ◽

Sebum Production ◽

Chronic Skin ◽

Local Release ◽

Chronic Skin Disease

Acne vulgaris is a chronic skin disease of the pilo-sebaceous unit and develops due to blockages in the skin's hair follicles. It is characterized by blackheads or whiteheads, pimples, oily skin, and possible scarring It primarily affects areas of the skin with a relatively high number of oil glands, including the face, upper part of the chest, and back. These blockages are thought to occur as a result of the following four abnormal processes: a higher than normal amount of oily sebum production (influenced by androgens), excessive deposition of keratin protein leading to comedo formation, colonization of the follicle by Cutibacterium acnes (C. acnes) bacteria, and the local release of pro-inflammatory chemicals in the skin. The resulting appearance can lead to anxiety, reduced self-esteem and, in extreme cases, depression or suicidal thoughts. In Ayurveda, it is termed as Mukhadushika. In Ayurveda, Mukhadushika is described under the heading of Kshudra rogas. These diseases are called as Kshudra because of their lesser severity. According to Sushruta Samhita Nidan Sthana, these are Shalmali thorn like eruption found on the face of adolescents are called as Mukhadushika or Yuvan Pidika. These are impregnated with Meda. Vitiated Vata Dosha, Kapha Dosha and Rakta Dosha are considered to be the main Samprapti Ghatak of Mukhadushika. In Ayurveda treatment of diseases is mainly of two types of Chikitsa are described i.e. Shodhana Chikitsa and Shamana Chikitsa. Similarly in Mukhadushika also Shodhana and Shamana Chikitsa is done.

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ОБҐРУНТУВАННЯ ВИБОРУ ДОПОМІЖНИХ РЕЧОВИН У СКЛАДІ ЛІКАРСЬКОГО КОСМЕТИЧНОГО ЗАСОБУ ПРОТИ АКНЕ З ЕФІРНОЮ ОЛІЄЮ ЧЕБРЕЦЮ

World Science ◽

10.31435/rsglobal_ws/30112019/6777 ◽

2019 ◽

Vol 2 (11(51)) ◽

pp. 52-55

Author(s):

Лисянська Г. П. ◽

Ал Зедан Фаді

Keyword(s):

Equilibrium Dialysis ◽

Acne Vulgaris ◽

Hair Follicles ◽

Oil Glands ◽

Thyme Oil ◽

Carbopol 940 ◽

Oil Concentration ◽

Dialysis Method ◽

Gel Composition

Acne (acne vulgaris) is a long-term skin disease involving the hair follicles and oil glands. Nowadays the phytomedicines are preferable for acne treatment. The aim of this work is choosing of excipients for antiacne cosmetics with thyme oil. Thyme oil concentration was 0,25% for all compositions. Carbopol 940, Sodium carboxymethylcellulose, Hydroxyethylcellulose and PEG were chosen as the bases for gels with thyme oil. All formulations were examined by uniformity and pH tests. Franz diffusion dells were used for investigation of thyme oil releasing by the equilibrium dialysis method. It was established that Carbopol 940 had the highest value of thyme oil releasing from the gel composition.

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Disorders of Hair

10.2310/im.1107 ◽

2013 ◽

Author(s):

James Q Del Rosso

Keyword(s):

Hair Loss ◽

Alopecia Areata ◽

Hair Growth ◽

Growth Cycle ◽

Hair Follicles ◽

Common Type ◽

Diagnosis And Treatment ◽

Basic Knowledge ◽

Androgenetic Alopecia ◽

Broad Overview

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THE EFFICACY OF PLATELET RICH PLASMA IN TREATMENT OF ANDROGENETIC ALOPECIA

International Journal of Advanced Research ◽

10.21474/ijar01/13360 ◽

2021 ◽

Vol 9 (08) ◽

pp. 1087-1098

Author(s):

Omar Yousif Dhannoon Alalaf ◽

Keyword(s):

Medical Treatment ◽

Hair Loss ◽

Imaging System ◽

Hair Follicles ◽

Androgenetic Alopecia ◽

Long Term Results ◽

Pull Test ◽

Plasma Fraction ◽

Over The Top ◽

Male Pattern

Dermoscopy is a non-invasive diagnostic technique for the observation of pigmented skin lesions, permitting the recognition of morphologic structures not visible by the naked eye. The technique consists of placing mineral oil, alcohol or even water on the skin lesion that is subsequently inspected using a hand-held lens, a hand-held dermatoscope, a stereomicroscope, a camera, or a digital imaging system. The magnifications of these various instruments range from 6x even up to 100x.The fluid placed on the lesion eliminates surface reflection and renders the cornified layer translucent, thus allowing a better visualization of pigmented structures within the epidermis, the dermoepidermal junction and the superficial dermis. Male-pattern hair loss (MPHL), also known as androgenic alopecia and male pattern baldness, is hair loss that occurs due to an underlying susceptibility of hair follicles toshrinkage due to the influence of androgenic hormones. Male-pattern hair loss is the most common cause of hair loss and will affect up to 70% of men and 40% of women at some point in their lifetimes.Men typically present with progressive hair loss at the temples and vertex balding, whereas women typically present with diffuse hair loss over the top of their scalps.Platelet-rich plasma is defined as a volume of the plasma fraction of autologus blood with an above baseline platelet concentration usually more than 1,000,000 platelets/ÃŽÂ¼L.PRPs regenerative potential depends on the levels of released GFs.Alpha granules of platelets contain GFs, which upon activation, are responsible for the initiation and maintenance of the healing response. PRP is known to carry more than 20 GFs and other protein molecules, such as adhesion molecules, chemokines, which interact to promote inflammation, cell proliferation, differentiation, and regeneration.In this study, the aim was to objectively assess the proposed therapeutic effect of PRP in treatment of AGA through measuring hair density using dermoscopic evaluation, hair pull test, gross pictures and patients satisfaction scale.The study included 30 patients of different grades of androgenetic alopecia, our patients were 15 males and 15 females ranging from grade ÃŽÂ™ to ÃŽÂ™ÃŽÂ™ÃŽÂ™ by Ludwig classification for FPHL and from grade 3 to grade 6 for Norwood and Hamilton classification for male androgenetic alopecia of a total 6 sessions, 4 successive ones with 3 weeks apart of a total 12 weeks and 2 separate sessions, 24wk and the last evaluation was done 1 year later to the 1st session.The results were classified depending on the lasting effect of the PRP into short term results lasting up to 4 months from the start of the sessions which gave statistically positive values regarding the hair pull test results and hair follicles counted by dermoscope and the long term results starting from the 5th month up to 1 year duration from the start of the sessions which showed decline in both numbers of hair pull test and Which indicatesthe needfo retreatment or addition of another line o medical treatment e.g., minoxidil or finasteride. Also PRP can be considered ahumble tool in the treatment of AGA, as it is sufficient alone without the medical treatment.

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