DETERMINING PROBABILITY OF CANCER CELL TRANSFOMATION AT HUMAN PAPILLOMAVIRUS INFECTION

Aim. The purpose of the work was to assess the probability of cancerous transformation of cells for viruses of high and low oncogenic risk. Aim. The purpose of the work was to assess the probability of cancerous transformation of cells for viruses of high and low oncogenic risk. Results. Using normalized squared error (NSE) for viruses of high (20 strains) and low (153 strains) oncogenic risk, rank statistic of 2-exponential type was build. For productive papillomavirus infection, NSE function was determined as the growing accurate 2-exponent of a cell layer basal to the epithelial surface. Logarithm of NSE numerical values is proportional to the cell entropy that is connected with the availability of virus DNA. To calculate entropy, generalized Hartley formula was used with the informational cell of dimension d: H = NdLOG(NSE), where N is the generalized cell coordinate. Conclusions. Using a statistical ensemble of E6 proteins separately for viruses of high and low oncogenic risk made it possible to assess the probability of cancerous transformation of cells, which was proportional to the ratio of the area of entropy of cancer transformation to the area of the productive entropy region papillomavirus infection.

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Epidemiology of Human Papillomavirus Infection

CrossRef Listing of Deleted DOIs ◽

10.1080/00365590050509922 ◽

2000 ◽

Vol 34 (6) ◽

pp. 194-200 ◽

Cited By ~ 21

Author(s):

Joakim Dillner ◽

Chris J. L. M. Meijer ◽

Geo von Krogh ◽

Simon Horenblas

Keyword(s):

Human Papillomavirus ◽

Human Papillomavirus Infection ◽

Papillomavirus Infection

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The Usability of p16 Immunohistochemical Staining as a Screening Test of Human Papillomavirus Infection in Head and Neck Squamous Cell Carcinoma

Korean Journal of Otorhinolaryngology - Head and Neck Surgery ◽

10.3342/kjorl-hns.2010.53.10.620 ◽

2010 ◽

Vol 53 (10) ◽

pp. 620

Author(s):

Moon Oh Kwon ◽

Se-Heon Kim ◽

Jun Yeon Hwang ◽

Sei Young Lee

Keyword(s):

Squamous Cell Carcinoma ◽

Human Papillomavirus ◽

Cell Carcinoma ◽

Head And Neck ◽

Squamous Cell ◽

Screening Test ◽

Immunohistochemical Staining ◽

Neck Squamous Cell Carcinoma ◽

Human Papillomavirus Infection ◽

Papillomavirus Infection

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Management of patients in conditions of female consultation at persistent course of papillomavirus infection of the cervix

HEALTH OF WOMAN ◽

10.15574/hw.2017.117.34 ◽

2017 ◽

pp. 34-36

Author(s):

N.A. Shcherbina ◽

◽

D.I. Demidenko ◽

A.D. Demidenko ◽

N.V. Kapustnik ◽

...

Keyword(s):

Human Papillomavirus ◽

Key Words ◽

Maximum Effect ◽

Cervical Epithelium ◽

Results Of Treatment ◽

Human Papillomavirus Infection ◽

Papillomavirus Infection ◽

Complex Therapy ◽

Effect Of Treatment

Under our supervision there were 66 women with a diagnosis of "dysplasia of cervical epithelium mild" on the background of persistent human papillomavirus infection (PVI). With the aim of improving the treatment of dysplasia of the 1st degree in rehabilitation activities after cryoablation there were applied drugs Distreptaza and inducer of interferon. The results of treatment were evaluated after 3 months. For patients of the 1st group (18 women) who underwent only cryoablation, the efficacy of therapy was 77.8%. In the 2nd group (22 women) after cryoablation was used inducer of interferon, the effectiveness made up of 90.9%. The maximum effect of treatment - 100% recorded in 3rd group (26 patients), where after cryoablation was carried out treatment with Distreptaza and inducer of interferon. The results of treatment obtained in this group allow to recommend the complex therapy of PVI in conditions of female consultation. Key words: dysplasia, HPV, cryosurgery, Distreptaza, inducer of interferon.

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