scholarly journals Effectiveness of Highly Active Anti-retroviral Therapy (HAART) in the Adult Population in the Ashanti Region of Ghana

2021 ◽  
Vol 6 (2) ◽  
pp. 53
Author(s):  
Kwaku G. Oppong ◽  
Eric Boakye-Gyasi ◽  
Kwesi B. Mensah ◽  
Ralph Obeng ◽  
Akua A. Abruquah ◽  
...  
Keyword(s):  
Medical Record ◽  
Highly Active Antiretroviral Therapy ◽  
Adult Population ◽  
Haemoglobin Concentration ◽  
Significant Rise ◽  
Cross Sectional ◽  
Strict Adherence ◽  
Cd4 Counts ◽  
Ashanti Region ◽  
Highly Active

  AIDS is the late stage of infection with the Human Immunodeficiency Virus (HIV). Even though the Highly Active Antiretroviral Therapy (HAART) for the management of HIV/ AIDS has been in existence in Ghana since 2003, there is still limited data on their effectiveness. This study therefore sort to ascertain the effectiveness of HAART used at Anti-retroviral therapy (ART) Centres in the Ashanti region of Ghana by assessing its effects on immunological and haematological markers as well as some significant indicators such as body temperature and blood pressure changes. The study was a retrospective cross sectional study which reviewed medical record folders of 156 HIV infected patients who had attended the selected ART centres in the Ashanti region of Ghana between 2010 and 2014. About 49% of the study population had a significant rise in their CD4 counts after six months strict adherence to specific HAART regimen. HAART effectively reduced viral loads and increased CD4 counts in most of the patients whose medical record folders were reviewed. Socioeconomic factors, formal education and lack of health literacy had a significant effect on adherence to the HAART regimen, however; marital status of patients did not have any significant effect on adherence, CD4 counts and the haemoglobin concentration of patients. Based on results obtained from this study, HAART could be considered as effective in the adult population in the Ashanti region of Ghana provided there is a high level of adherence. Immunological and haematological markers for the assessment of effectiveness could also improve with high adherence recommended HAART regimen 

scholarly journals Examination of Haematotoxicity of Fixed-Dose Highly Active Antiretroviral Drug in Albino Wistar Rats

2012 ◽  
Vol 2012 ◽  
pp. 1-6
Author(s):  
Thomas Nubila ◽  
Ernest O. Ukaejiofo ◽  
Nkoyo I. Nubila ◽  
Godfrey I. Okorie
Keyword(s):  
Highly Active Antiretroviral Therapy ◽  
Wistar Rats ◽  
Venous Blood ◽  
Haemoglobin Concentration ◽  
Test Group ◽  
Mean Value ◽  
Fixed Dose ◽  
Control Group ◽  
Highly Active ◽  
Significant Difference

Highly active antiretroviral therapy (HAART) is considered toxic and has other life-threatening side effects. Our aim was to evaluate the haematotoxic effects of lamivudine, zidovudine, and nevirapine fixed-dose combinations in Albino Wistar rats. Fifty (50) three (3) months old male Albino Wistar rats weighing between 200 and 250 g were randomly assigned to five (5) groups (A, B, C, D, and E). Group A served as control. Two (2 mLs) of venous blood was aseptically collected on Days 5, 10, 15, 20, and 25 of treatment. Red blood cell (RBC) mean value recorded statistically significant increase () in groups B and C when compared with the control group on Day 5. However, there was a statistically significant decrease () in RBC, haemoglobin concentration (Hb), packed cell volume (PCV), and some red cell indices on Day 10. In addition there was no statistically significant difference () in all the parameters evaluated when the test group was compared with the control on Day 25. Furthermore, there was a time-related statistically significant increase () in the two major blood cells—RBC and platelet counts. From the result of this present study, it can be concluded that HAART when administered in fixed-dose combinations have no subacute haematotoxic effects.

Epidemiology ofMycoplasmaacquisition in male HIV-1 infected patients: a multistage cross-sectional survey in Jiangsu, China

2015 ◽  
Vol 143 (15) ◽  
pp. 3327-3334 ◽  
Author(s):  
L.-S. CHEN ◽  
J.-R. WU ◽  
B. WANG ◽  
T. YANG ◽  
R. YUAN ◽  
...  
Keyword(s):  
Risk Factors ◽  
Highly Active Antiretroviral Therapy ◽  
Protective Factor ◽  
Ureaplasma Urealyticum ◽  
Venous Blood ◽  
Mycoplasma Hominis ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Highly Active ◽  
Hiv Aids

SUMMARYMycoplasmainfections are most frequently associated with disease in the urogenital or respiratory tracts and, in most cases, mycoplasmas infect the host persistently. In HIV-infected individuals the prevalence and role of genital mycoplasmas has not been well studied. To investigate the six species ofMycoplasmaand the risk factors for infection in Jiangsu province, first-void urine and venous blood samples were collected and epidemiological questionnaires were administered after informed consent. A total of 1541 HIV/AIDS patients were recruited in this study. The overall infection rates of sixMycoplasmaspecies were:Ureaplasma urealyticum(26·7%),Mycoplasma hominis(25·3%),M. fermentans(5·1%),M. genitalium(20·1%),M. penetrans(1·6%) andM. pirum(15·4%). TheMycoplasmainfection rate in the unmarried group was lower than that of the married, divorced and widowed groups [adjusted odds ratio (aOR) 1·432, 95% confidence interval (CI) 1·077–1·904,P< 0·05]. The patients who refused highly active antiretroviral therapy (HAART) had a much higher risk ofMucoplasmainfection (aOR 1·357, 95% CI 1·097–1·679,P< 0·05). Otherwise, a high CD4+T cell count was a protective factor againstMycoplasmainfection (aOR 0·576, 95% CI 0·460–0·719,P< 0·05). Further research will be required to confirm a causal relationship and to identify risk factors forMycoplasmainfection in HIV/AIDS populations.

scholarly journals Neopterin and Biochemical Parameters as Indicators of Predicting HIV Disease Progression and Treatment Response: A Cross-sectional Study in Ghana

2019 ◽  
pp. 1-10
Author(s):  
Louis Boafo Kwantwi ◽  
Christian Obirikorang ◽  
Margaret Agyei Frempong ◽  
Dan Yedu Quansah
Keyword(s):  
Disease Progression ◽  
Highly Active Antiretroviral Therapy ◽  
Biochemical Parameters ◽  
Cross Sectional Study ◽  
Hiv Disease ◽  
Sectional Study ◽  
Cross Sectional ◽  
Highly Active ◽  
Hiv Seropositive ◽  
Therapy Treatment

Background: Surrogate markers have been identified to play significant role in the pathogenesis and prognosis of HIV infection. However, there is limited data on the utility of neopterin estimation in HIV infection. Therefore, the study sought to measure and ascertains the trends of serum neopterin and other biochemical parameters as indicators of predicting HIV disease progression and treatment response among HIV seropositive individuals. Methods: A cross-sectional study with 298 HIV seropositive individuals consisting of 165 HIV on highly active antiretroviral treatment and 136 naïve highly active antiretroviral patients. Venous blood was drawn for the assay of neopterin and the other biochemical parameters. Results: Neopterin was significantly lower (P<0.0001) in patients in the highly active antiretroviral therapy than those in the naïve highly active antiretroviral therapy group. Serum neopterin increased as the disease progresses and decreased as the duration of the therapy treatment increased (p=0.0001). At a cut of point of 54.5 nmol/L, neopterin gave a sensitivity of 97.5%, specificity of 95.9% and an area under the curve of 0.99. Conclusion: Neopterin has shown to be to be good marker in predicting HIV disease progression especially in patients with CD4 counts less than 200mm-3 and a useful indicator of patient’s response to therapy treatment.

scholarly journals Influence of Spirituality and Religion on Adherence to Highly Active Antiretroviral Therapy in Adult HIV/AIDS Patients in Calabar, Nigeria

2017 ◽  
Vol 03 ◽  
pp. 48
Author(s):  
Agam Ebaji Ayuk ◽  
Ndifreke Udonwa ◽  
Abraham Gyuse ◽  
◽  
◽  
...  
Keyword(s):  
Chronic Illness ◽  
Antiretroviral Therapy ◽  
Religious Coping ◽  
Highly Active Antiretroviral Therapy ◽  
Aids Patients ◽  
Strict Adherence ◽  
Highly Active ◽  
Spirituality And Religion ◽  
Positive Religious Coping ◽  
Hiv Aids

The emergence of a chronic medical illness such as Human Immune Deficiency Virus and Acquired Immunodeficiency Syndrome (HIV/AIDS) may be the time when people turn to the Sacred through spirituality and religion. HIV is a chronic illness that requires strict adherence to medication regimens that may be influenced by spirituality/religion. This study was aimed at finding the association between spirituality/religion and adherence to highly active antiretroviral therapy (HAART) in adult HIV/AIDS patients. This is a cross-sectional descriptive study of 370 patients. Adherence was measured using an adapted adult AIDS clinical trial group (AACTG) and visual analogue scale (VAS) tools. Spirituality was assessed using Functional Assessment of Chronic Illness Therapy-Spirituality Expanded (FACIT-Sp-Ex) scale, religiosity with Duke University Religion index (DUREL), and religious coping with Brief Religious Coping (RCOPE) scale. Adherence rates were 86.2 and 43.8% using AACTG and VAS tools, respectively. Statistical significant correlation was found between spirituality and adherence to HAART (r = 0.265; p = 0.00). Also, significant correlation was found between positive religious coping and adherence (r = 0.15, p = 0.003). Odds ratio indicated that female respondents were 1.6 times more likely to be adherent, compared with males. Similarly, every unit rise in spirituality score yielded a 1.3 times increased likelihood of adherence to HAART on multiple logistic regression of adherence to HAART with relevant predictors. Both spirituality and positive religious coping have positive influence on optimal adherence. Therefore, the training of health care personnel to assess and provide spiritual care and involvement of chaplains/religious leaders is advocated for improved adherence.

scholarly journals A cross-sectional study on caregivers’ perspective of the quality of life and adherence of paediatric HIV patients to Highly Active Antiretroviral Therapy 

2020 ◽  
Author(s):  
Michael Lahai ◽  
Peter Bai. James ◽  
Noel N. Wannang ◽  
Haja R. Wurie ◽  
Sorie Conteh ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Antiretroviral Therapy ◽  
Highly Active Antiretroviral Therapy ◽  
Nuclear Family ◽  
Strong Association ◽  
Hiv Positive ◽  
Cross Sectional ◽  
Highly Active ◽  
Health Domains

Abstract Background: Poor compliance to highly active antiretroviral therapy (HAART) can result in the poor quality of life in children living with HIV/AIDS because of low plasma drug concentration and the possibility of drug resistance. This study evaluates the response of caregivers for determination of adherence and the four quality of life domains in children (aged 14 years and under) on HAART.Methods: We conducted a cross-sectional study of 188 children, each accompanied by their caregivers at Ola During Children's Hospital and Makeni Government Hospital between September and November 2016. Adherence to HAART and Quality of life was assessed using the WHO Quality of life summary questionnaire (WHOQOL-BREF). We obtained ethical approval from the Sierra Leone Ethics and Scientific Review Committee. Results: The study revealed 5.9% adherence amongst paediatric patients, and a strong association of adherent patients(p=0.019*) to the physical health domain (mean=64.61 SD=8.1).Caregiver HIV status showed a strong association with the physical (mean=58.3, SD=11.7 and p=0.024*), and psychological health domains (mean=68.2, SD=14.7 and p=0.001). Caregiver type (mother/father/sibling) accompanying child to hospital also showed strong associated with the physical (mean=58.0, SD=10.6, p <0.001), psychological (mean 68.2 SD=14.81 p <0.001) and environmental health domains (mean=59.7, SD=13.47, p <0.001). Further regression analysis showed a strong association with physical health domain for HIV positive caregivers (p=0.014) and adherent paediatric patients (p=0.005). Nuclear family also showed a strong association with psychological (p<0.001) and environmental (p=0.001) health domains. Conclusion: This study showed a strong association between the quality of life domains and the involvement of nuclear family caregiver, HIV-positive caregiver and adherence to HAART. Our study suggests that the involvement of any member of the nuclear family, HIV positive parents and patient adherence to therapy can improve the quality of life of paediatric HIV/AIDS patients on highly active antiretroviral therapy in the two hospitals.

scholarly journals Highly active antiretroviral therapy and left ventricular diastolic function in children with human immunodeficiency virus infection

2019 ◽  
Vol 59 (3) ◽  
pp. 139-43
Author(s):  
Ni Made Ayu Agustini ◽  
Eka Gunawijaya ◽  
Ni Putu Venny Kartika Yantie ◽  
Ketut Dewi Kumara Wati ◽  
Komang Ayu Witarini ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Diastolic Dysfunction ◽  
Diastolic Function ◽  
Highly Active Antiretroviral Therapy ◽  
Left Ventricular Diastolic Function ◽  
Left Ventricular ◽  
Doppler Imaging ◽  
Cross Sectional ◽  
Ventricular Diastolic Function ◽  
Highly Active

Background In the past, cardiovascular involvement did not seem to be a common complication of HIV, but in recent years it has been described more frequently. With the advent of highly active antiretroviral therapy (HAART), the symptoms of cardiac disease has changed, as the number of HIV-infected patients with abnormal diastolic parameters has increased significantly, often presenting as symptomatic rather than asymptomatic. Objective To analyze for a possible correlation between HAART duration and left ventricular diastolic function in HIV-infected children. Methods This cross-sectional study was conducted from December 2016 to December 2017 at the Cardiology and Allergy-Immunology Division/Department of Child Health, Universitas Udayana Medical School/Sanglah Hospital, Denpasar, Bali. Subjects with HAART were collected using a consecutive sampling method. The following data were recorded for each subject: age, sex, current stage of HIV, CD4+ level, as well as HAART regimen and duration of use. Transthoracic echocardiography was performed for tissue doppler imaging (TDI) of diastolic function. Spearman’s test was used to analyze the strength of correlation based on normality test results. Results This study involved 53 subjects, 21 of whom had impaired diastolic function. There was no correlation between HAART duration and diastolic function in children with HIV infection (r= -0.03; P=0.82). Conclusion Diastolic dysfunction is found in children under HAART treatment, but there is no correlation between HAART treatment duration and diastolic dysfunction.

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