Immunology in Clinical Medicine, ed. 2, by J. L. Turk, M.D., D.Sc. (Lond.), M.R.C.P., M.R.C. Path. New York: Appleton-Century-Crofts, 1972, 259 pp., $9.75

PEDIATRICS ◽  
1974 ◽  
Vol 53 (4) ◽  
pp. 591-591
Author(s):  
Paul G. Quie

This second edition (1972) of Dr. Turk's book "Immunology in Clinical Medicine," first published in 1969, is a welcome guide for clinicians in the tangled pathways of immunologic information. As in the first edition, Dr. Turk has provided his readers with concepts of immunology underlying disease processes. The author is ever mindful that his reader is concerned with patients, and the information about immunologic concepts is intended to provide helpful understanding of the pathophysiology of immunologic diseases.

2020 ◽  
Author(s):  
Jason R. Bobe ◽  
Jessica K. De Freitas ◽  
Benjamin S. Glicksberg

AbstractBackgroundN-of-1 trials are single patient, multiple crossover, comparative effectiveness experiments. Despite their rating as “level 1” evidence, they are not routinely used in clinical medicine to evaluate the effectiveness of treatments.ObjectiveWe explored the potential for implementing a mobile app-based n-of-1 trial platform for collaborative use by clinicians and patients to support data-driven decisions around the treatment of insomnia.MethodsA survey assessing awareness and utilization of n-of-1 trials was administered to healthcare professionals that frequently treat patients with insomnia at the Icahn School of Medicine at Mount Sinai in New York City. 1M electronic health records were analyzed to evaluate evidence for a comorbid relationship between insomnia and dementia or Alzheimer’s disease among a patient population that may benefit from n-of-1 trials for the selection of optimal sleep treatments.ResultsA total of 45 healthcare professionals completed the survey and were included in the analysis. We found that 64% of healthcare professionals surveyed had not heard of n-of-1 trials. After a brief description of these methods, 75% of healthcare professionals reported that they are likely or highly likely to use an app-based n-of-1 trial at least once in the next year if the service were free and easy to offer to their patients.ConclusionsAn app-based n-of-1 trials platform might be a valuable tool for clinicians and patients to identify the best treatments for insomnia. Educational interventions that raise awareness and provide training are also likely necessary. The electronic health record (EHR) may help identify eligible patients.


Author(s):  
JOSEPH J. FINS

Abstract The COVID-19 Pandemic a stress test for clinical medicine and medical ethics, with a confluence over questions of the proportionality of resuscitation. Drawing upon his experience as a clinical ethicist during the surge in New York City during the Spring of 2020, the author considers how attitudes regarding resuscitation have evolved since the inception of do-not-resuscitate (DNR) orders decades ago. Sharing a personal narrative about a DNR quandry he encountered as a medical intern, the author considers the balance of patient rights versus clinical discretion, warning about the risk of resurgent physician paternalism dressed up in the guise of a public health crisis.


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