Unlisted Ingredients

PEDIATRICS ◽  
1993 ◽  
Vol 92 (5) ◽  
pp. 741-742
Author(s):  
NEIL L. KAO
Keyword(s):  
Adverse Drug Reactions ◽  
Etiologic Agent ◽  
Etiologic Factor ◽  
Potential Importance ◽  
Drug Reactions ◽  
Causative Agents

To the Editor.— Studies by Kumar et al1,2 demonstrate clearly the number and potential importance of unlisted ingredients. Reactions triggered by these excipients may in fact account for many reported adverse drug reactions, including reactions to antihistamines and corticosteroids, originally thought to be caused by the primary medications. When patients suspected of having a hypersensitivity disease are evaluated for the etiologic factor, excipients should be included among the suspected causative agents. For example, in a patient evaluated recently for the etiology of urticaria, we determined that his toothpaste was the etiologic agent.

scholarly journals A clinical study of cutaneous adverse drug reactions

2017 ◽  
Vol 6 (4) ◽  
pp. 919
Author(s):  
Riddhi Shah ◽  
Sakshi Agrawal ◽  
Neela Bhuptani
Keyword(s):  
Adverse Drug Reactions ◽  
Clinical Manifestations ◽  
Specific Treatment ◽  
Drug Reactions ◽  
Diagnostic Challenge ◽  
Female Ratio ◽  
Medical College ◽  
Causative Agents ◽  
Cutaneous Drug Reactions ◽  
Morbilliform Rash

Background: Adverse cutaneous drug reactions pose a diagnostic challenge due to a myriad of clinical manifestations and wide variety of causative agents. Present study aims to record various clinical patterns of adverse drug reactions, their causative agents and to study the pattern of morbidity and mortality in patients with severe cutaneous adverse drug reactions.Methods: 150 patients with adverse cutaneous drug reactions were included who came to Department of Dermatology, Venereology and Leprosy at PDU Govt. Medical College and Hospital, Rajkot, Gujarat from September 2009 to September 2011. Thorough history with all routine haematological and biochemical investigations, septic screening were done. HIV testing was done in severe reactions. Appropriate specific treatment was given with counselling regarding the offending drug.Results: The most common age group was 21-30 years (26.67%) with male to female ratio being 0.92:1. Morbilliform rash was the most common clinical type (42.67%) in both HIV reactive and non-reactive patients. Antimicrobials were the most common group (29.33%) and nevirapine was the most common offending drug (27.33%). Mortality rate was 2% (3 out of 150 cases) and all the patients were of toxic epidermal necrolysis.Conclusions: The pattern of cutaneous adverse drug reactions and the causative drugs are remarkably different in our study. Knowledge of the pattern and the causative agent helps in better management and reduced consequences in these patients particularly in severe adverse cutaneous drug reactions.

Cutaneous adverse drug reactions

2020 ◽  
pp. 347-358
Keyword(s):  
Toxic Epidermal Necrolysis ◽  
Adverse Drug Reactions ◽  
Clinical Manifestations ◽  
Stevens Johnson Syndrome ◽  
Drug Reactions ◽  
Practical Advice ◽  
Johnson Syndrome ◽  
Causative Agents

Cutaneous adverse drug reactions considers the principle types of unwanted responses to drugs seen on the skin. The most common exanthematous rash is examined as are serious eruptions such as Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) along with other reactions. The clinical manifestations are discussed along with likely causative agents. Practical advice about severity, worrying features, and management is given.

Use of Computer Drug-Drug Interaction Program for Detection of Adverse Drug Reactions and Related Therapeutic Problems

1979 ◽  
Vol 13 (12) ◽  
pp. 774-777 ◽  
Author(s):  
Jerry C. Hood ◽  
Jon R. Miller
Keyword(s):  
Drug Interaction ◽  
Adverse Drug Reactions ◽  
Basic Concept ◽  
Medical Center ◽  
Clinical Services ◽  
Potential Drug ◽  
Drug Reactions ◽  
Therapeutic Implications ◽  
Causative Agents ◽  
Clinically Significant

Pharmacies currently using computers to detect drug-drug interactions may not be fully utilizing the computers' programs. Potential drug-disease interactions and some potential adverse drug reactions not traditionally defined as interactions can be detected by extending the basic concept of cross-referencing. For example, certain clinically important ADRs are readily detected by cross-referencing drugs which are often used to treat the results of specific ADRs with certain causative agents. The potential therapeutic implications of such a system when restricted to clinically significant ADRs can be readily appreciated, especially in situations where the pharmacist's time in patient-care areas is limited. This concept is currently being practiced at Bayfront Medical Center, and has added a new dimension to the clinical services provided by the pharmacy. It seems likely that detection of therapeutic situations in this manner may be appropriate in other hospital settings.

Clinical pattern and causative agents of adverse cutaneous drug reactions in a tertiary care hospital SKIMS Soura Srinagar.

JMS SKIMS ◽  
2017 ◽  
Vol 20 (2) ◽  
pp. 73-76 ◽  
Author(s):  
Surjeet Singh ◽  
Zahoor A Wafai ◽  
Ajaz Koul
Keyword(s):  
Adverse Drug Reactions ◽  
Tertiary Care ◽  
Maculopapular Rash ◽  
Care Hospital ◽  
Drug Reactions ◽  
Drug Eruptions ◽  
Fixed Drug ◽  
Pharmacovigilance Center ◽  
Causative Agents ◽  
Cutaneous Drug Reactions

Background: Adverse drug reactions are the most frequent side effects of drugs. Most of them being benign but can prove fatal sometimes. Aim: To study the different clinical spectrum of cutaneous adverse drug reactions and to determine causative drugs. Methods: It was a prospective hospital based study carried out for a period of 3 years. It was part of continuous adverse drug reaction monitoring carried out by our pharmacovigilance center at SKIMS. Results: Out of 1225 total adverse drug reactions 685 were enrolled as cutaneous ADR’s. Most common types observed were maculopapular rash (43.9%), fixed drug eruptions (36.2%) and urticaria (15.1%). The drugs most incriminated for various cutaneous ADR’s were antimicrobials (48.7%), anticonvulsants (22%), and NSAIDS (17.9%). Antimicrobials were also responsible for maximum of (58.3%) of severe cutaneous ADR’s like TEN and SJS. Conclusion: Pattern of cutaneous ADR’s and their causative drugs are similar to those observed in other regions with small variations, as reported by similar studies. However, due to emergence of newer drugs and differing trends in use of drugs, both pattern of cutaneous ADR’s as well as drugs causing them are changing every year. Further studies of similar nature with more expertise are required for safe use of drugs in future. JMS 2017;20(2):73-76  

scholarly journals A study on cutaneous adverse drug reactions in a tertiary care center in Rajnandgaon, Chattisgarh

2019 ◽  
Vol 5 (4) ◽  
pp. 839
Author(s):  
Pooja Pandey ◽  
Prabhat Pandey ◽  
Sharad Manore ◽  
Darshan Sandesara
Keyword(s):  
Adverse Drug Reactions ◽  
Care Center ◽  
Tertiary Care ◽  
Age Groups ◽  
Drug Reactions ◽  
Presenting Symptoms ◽  
Causative Agents ◽  
Life Threatening ◽  
Cutaneous Reactions ◽  
The Common

<p class="abstract"><strong>Background:</strong> Cutaneous reactions are one of the most common types of adverse drug reactions which may vary from mildly discomforting to those that are life-threatening.</p><p class="abstract"><strong>Methods:</strong> This prospective, observational study was done in the department of dermatology. Patients with suspected drug rash, of either sex or all age groups were included in the study.<strong></strong></p><p class="abstract"><strong>Results:</strong> A total of 114 patients were enrolled in the study. The most common presenting symptoms of cutaneous adverse drug reactions (CADRs) were itching, burning sensation and pigmentation with 61.31%, 13.87% and 10.22% respectively. A total of 21 different CADRs were observed. The common causative agents were of anti-microbial, nervous system and musculoskeletal class in both outdoor and indoor patients with 51 (37.22%), 21 (15.32%) and 25 (18.24%) respectively.</p><p class="abstract"><strong>Conclusions:</strong> The most common CADR observed in the study was antimicrobials and NSAIDs were the most common causative drugs.</p><p class="abstract"> </p>

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