Immunopathological findings in a cat with auricular chondritis

At clinical examination, a 5-year-old male domestic short-haired cat exhibited painful swelling and erythema of the pinnae of both ears. Microscopically, the lesions on both pinnae were composed of diffuse granulomatous chondritis with degeneration and necrosis of the pinnal cartilage. Numerous mast cells were also observed within and surrounding the inflammatory lesion. Immunohistochemistry showed a mixed inflammatory infiltrate characterised by the predominance of macrophages (CD68+, MAC 387+ and Lysozyme+), T lymphocytes (CD3+), some B lymphocytes (CD79α+) and neutrophils. Immunopathological characterisation of the lesion showed a granulomatous inflammation profile and suggests that the morphological changes and immunopathogenesis of auricular chondritis in cats presents a similarity with relapsing polychondritis in humans.

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Immunophenotype of the inflammatory response in the central and enteric nervous systems of cockatiels (Nymphicus hollandicus) experimentally infected with parrot bornavirus 2

Veterinary Pathology ◽

10.1177/03009858211069166 ◽

2022 ◽

pp. 030098582110691

Author(s):

Jeann Leal de Araújo ◽

Raquel R. Rech ◽

Aline Rodrigues-Hoffmann ◽

Paula R. Giaretta ◽

Cinthya Cirqueira ◽

...

Keyword(s):

Small Intestine ◽

T Lymphocytes ◽

B Lymphocytes ◽

Inflammatory Infiltrate ◽

Homogeneous Distribution ◽

Nymphicus Hollandicus ◽

Inflammatory Infiltrates ◽

Cellular Immune ◽

Proventricular Dilatation Disease ◽

The Brain

Proventricular dilatation disease is a lethal disease of psittacine birds. In this study, we characterized the local cellular immune response in the brain, proventriculus, and small intestine of 27 cockatiels ( Nymphicus hollandicus) experimentally infected with parrot bornavirus 2 (PaBV-2). Perivascular cuffs in the brain were composed of CD3+ T-lymphocytes and Iba1+ macrophages/microglia in most cockatiels (n = 26). In the ganglia of the proventriculus, CD3+ T-lymphocytes (n = 17) and Iba1+ macrophages (n = 13) prevailed. The ganglia of the small intestine had a more homogeneous distribution of these leukocytes, including PAX5+ B-lymphocytes (n = 9), CD3+ T-lymphocytes (n = 8), and Iba1+ macrophages (n = 8). Our results indicate that perivascular cuffs in the brain and the inflammatory infiltrate in the proventriculus of PaBV-2-infected cockatiels is predominately composed of T-lymphocytes, while the inflammatory infiltrates in the ganglia of the small intestine are characterized by a mixed infiltrate composed of T-lymphocytes, B-lymphocytes, and macrophages.

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Research onTrypanosoma cruziand Analysis of Inflammatory Infiltrate in Esophagus and Colon from Chronic Chagasic Patients with and without Mega

Journal of Tropical Medicine ◽

10.1155/2012/232646 ◽

2012 ◽

Vol 2012 ◽

pp. 1-6 ◽

Cited By ~ 12

Author(s):

Eliângela de Castro Côbo ◽

Thales Parenti Silveira ◽

Adilha Misson Micheletti ◽

Eduardo Crema ◽

Sheila Jorge Adad

Keyword(s):

T Lymphocytes ◽

B Lymphocytes ◽

Myenteric Plexus ◽

Inflammatory Process ◽

Inflammatory Infiltrate ◽

Inflammatory Infiltration

To compare parasitism and inflammatory process in esophagus and colon from chronic chagasic patients, immunohistochemistry was carried out to research forT. cruziand to evaluate the inflammatory infiltrate in the muscular and myenteric plexus in 39 esophagi (20 with and 19 without megaesophagus) and 50 colons (25 with and 25 without megacolon). The frequency ofT. cruziin megaesophagus was 20%, and in megacolon it was 4%. No amastigotes were found in organs without mega; considering the total of esophagi (with and without mega), the frequency ofT. cruziwould be 10% and 2% in the colon. Myositis and ganglionitis were more frequent and intense in organs with mega compared to those without mega, and in esophagus compared to colon. Qualitatively, inflammatory infiltration in esophagus and colon, with or without mega, was similar, consisting predominantly of T lymphocytes (CD3+), scarce macrophages (CD68+), and rare B lymphocytes (CD20+).

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A Focus of Differentiated Myeloid Sarcoma in a Ligation Specimen of the Fallopian Tube: No Evidence of Hematologic Abnormality in 18 Years of Follow-up Despite Absence of Treatment

International Journal of Surgical Pathology ◽

10.1177/1066896919864167 ◽

2019 ◽

Vol 28 (1) ◽

pp. 99-101

Author(s):

Eduardo Castro ◽

Linden Morales ◽

Riyam Zreik ◽

Ludvik R. Donner

Keyword(s):

Mast Cells ◽

T Lymphocytes ◽

B Lymphocytes ◽

Fallopian Tube ◽

Myeloid Cells ◽

The Body ◽

Myeloid Sarcoma ◽

Left Fallopian Tube ◽

The Right

A 0.2-cm intramural focus composed predominantly of myelocytes and metamyelocytes, many CD3+, CD43+ T-lymphocytes, scanty CD20+ B-lymphocytes, rare mast cells, but no eosinophils or myeloblasts was incidentally found in a ligation specimen of the left fallopian tube. The myeloid cells were positive for chloroacetate esterase, myeloperoxidase, myeloid marker BM2, and CD43, and they were negative for CD30, CD34, CD117, ERG, and TDT. The findings in the left fallopian tube were consistent with the diagnosis of differentiated myeloid sarcoma. The right fallopian tube was normal. No hematologic abnormalities were found elsewhere in the body. Curiously, the patient remains free of any hematologic abnormality for 18 years despite absence of treatment.

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High levels ofbcl-2 protein in circulating t lymphocytes, but not b lymphocytes, of patients with systemic lupus erythematosus

Arthritis & Rheumatism ◽

10.1002/art.1780371004 ◽

1994 ◽

Vol 37 (10) ◽

pp. 1423-1430 ◽

Cited By ~ 70

Author(s):

Martin Aringer ◽

Winfried Wintersberger ◽

Carl W. Steiner ◽

Hans Kiener ◽

Elisabeth Presterl ◽

...

Keyword(s):

Systemic Lupus Erythematosus ◽

T Lymphocytes ◽

B Lymphocytes ◽

Lupus Erythematosus ◽

Systemic Lupus

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Pseudo-Placentational Endometrial Hyperplasia in the Bitch: Case Series

Animals ◽

10.3390/ani11030718 ◽

2021 ◽

Vol 11 (3) ◽

pp. 718

Author(s):

Gabriele Marino ◽

Alessandra Sfacteria ◽

Giuseppe Catone ◽

Antonina Zanghì ◽

Fabiana Pecchia ◽

...

Keyword(s):

Mast Cells ◽

Endometrial Hyperplasia ◽

Inflammatory Infiltrate ◽

Case Series ◽

Pregnant Female ◽

Large Database ◽

Tissue Architecture ◽

Classical Form ◽

Spongy Layer ◽

Proliferative Lesion

Canine pseudo-placentational endometrial hyperplasia differs from the classical form of cystic endometrial hyperplasia for the well-organized tissue architecture resembling the canine placenta. After the discovery, it has been inconstantly reported. The present work reports the clinicopathological details of six spontaneous cases retrieved retrospectively from a large database. The lesion was found in young non-pregnant female dogs (median 2.0 years) at the end of dioestrus. It could be imaged by ultrasound and was always grossly detectable as single or multiple uterine enlargements of 2–3 cm in diameter with a villous whitish tissue growing on the mucosa and occluding the lumen. Histology confirmed the tissue architecture of the canine placenta with a basal glandular layer, a connective band, a spongy layer and a tortuous and compact labyrinth, often poorly recognizable. The pseudo-placentational hyperplasia is a non-inflammatory proliferative lesion although numerous mast cells inhabit the connective band, and a superimposed inflammatory infiltrate was seen in a case. Canine pseudo-placentational endometrial hyperplasia has very peculiar features, and it is a model for canine placentation and may help to better understand the cystic endometrial hyperplasia/pyometra complex.

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T lymphocyte-dependent B lymphocyte proliferative response to antigen. I Genetic restriction of the stimulation of B lymphocyte proliferation.

Journal of Experimental Medicine ◽

10.1084/jem.153.4.871 ◽

1981 ◽

Vol 153 (4) ◽

pp. 871-882 ◽

Cited By ~ 20

Author(s):

H Y Tse ◽

J J Mond ◽

W E Paul

Keyword(s):

T Lymphocytes ◽

B Lymphocytes ◽

T Lymphocyte ◽

Lymphocyte Proliferation ◽

B Lymphocyte ◽

Antigen Specificity ◽

Apparent Lack ◽

The Face ◽

Stimulation Of

For the purpose of examining more closely the interaction between T and B lymphocytes, we have developed an in vitro T lymphocyte-dependent B lymphocyte proliferation assay. Proliferation of B lymphocytes in response to antigen was found to depend on the presence of primed T lymphocytes; the B lymphocytes could be derived from nonprimed animals. It appears that these B cells were nonspecifically recruited to proliferate. This nonspecific recruitment, however, was found to be Ir-gene restricted in that B lymphocytes from B10.S mice, which are genetic nonresponders to the polymer Glu60-Ala30-Tyr10 (GAT), could not be stimulated by GAT-primed (responder X nonresponder) F1 T cells. The apparent lack of antigen specificity in the face of Ir gene-restricted T-B interaction may have important implications in our understanding of the recognition unit(s) on T lymphocytes.

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Parotid Duct Sialolithiasis in a Dog

Journal of the American Animal Hospital Association ◽

10.5326/0430045 ◽

2007 ◽

Vol 43 (1) ◽

pp. 45-51 ◽

Cited By ~ 20

Author(s):

Brian J. Trumpatori ◽

Kyleigh Geissler ◽

Kyle G. Mathews

Keyword(s):

Computed Tomography ◽

Inflammatory Infiltrate ◽

Surgical Excision ◽

Histological Evaluation ◽

Parotid Duct ◽

Facial Swelling ◽

History Of ◽

Mixed Inflammatory Infiltrate ◽

Glandular Atrophy ◽

English Bulldog

Computed tomography was used to evaluate a 7-year-old English bulldog with a history of facial swelling and to aid in the diagnosis of parotid duct sialolithiasis. Removal of the sialolith with repair of the duct was not possible because of ductal fibrosis. Histological evaluation revealed glandular atrophy and fibrosis with lymphoplasmacytic inflammation. The parotid duct was ulcerated and fibrotic, with a mixed inflammatory infiltrate. Surgical excision of the parotid duct and salivary gland was curative.

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