scholarly journals A tüdő immunfiziológiája – útjelzők a terra incognita felé

2021 ◽  
Vol 162 (29) ◽  
pp. 1147-1155
Author(s):  
Péter Balogh
Keyword(s):  
Gas Exchange ◽  
Surface Area ◽  
Defense Mechanisms ◽  
Respiratory Epithelium ◽  
Critical Assessment ◽  
Therapeutic Interventions ◽  
Tissue Integrity ◽  
Daily Amount ◽  
Terra Incognita ◽  
Airway Infections

Összefoglaló. A tüdő a benne lévő légutak és a légzőhám felületének kiterjedtsége, valamint a folyamatos napi gázcsere mennyisége miatt az emlősszervezetnek a környezeti antigének számára legnagyobb mértékben kitett közvetlen behatolási kapuja. A különböző antigénekkel szemben számos fizikai-mechanikai tisztulási folyamat, valamint helyi és szisztémás immunológiai védelmi mechanizmus együttesen biztosítja a légutak átjárhatóságát és a megfelelő gázcseréhez a légzőhám és a tüdő interstitialis összetevőinek szöveti integritását. A tüdő – veleszületett és adaptív immunológiai – védelmét ellátó molekuláris és sejtes résztvevőkre, ezáltal a légutak alapvető életfontosságú működésének biztosítására vonatkozó ismereteink az utóbbi időben számos új megfigyeléssel bővültek, melyek felvetik a tüdő immunológiai szerveződésének egyedi szerkezeti és funkcionális specializációját. A jelen összefoglaló célja ezeknek az új eredményeknek a bemutatása, ezen keresztül a tüdőben zajló sokrétű immunológiai folyamatok főbb jellemzőinek és a bennük részt vevő sejtes és molekuláris összetevőknek az áttekintése. Ezek részletesebb megismerése elősegítheti a légúti (köztük a SARS-CoV-2 általi) fertőzések után fellépő, helyi és szisztémás immunpatológiai események pontosabb megértését és a lehetséges terápiás eljárások kritikai értelmezését. Orv Hetil. 2021; 162(29): 1147–1155. Summary. Due to the size of the surface area of airways and respiratory epithelium combined with the daily amount of continuous gas exchange, in mammalians the lung represents the most exposed organ serving as immediate entry port for airborne antigens. Together with several physicochemical clearance processes, both local and systemic immunological defense mechanisms ensure the passage of airways and the tissue integrity of respiratory epithelium and pulmonary interstitium necessary for the maintenance of gas exchange. Several recent observations concerning the molecular and cellular constituents of the pulmonary immunological defense have substantially broadened our knowledge of the maintenance of the vital functionality of airways, raising the unique specialization of the organization of pulmonary immune compartment. The purpose of the present review is to highlight the main findings on the complexity of pulmonary immunity, including the overview of the main characteristics of its cellular and molecular participants. Unrevealing these mechanisms may promote our understanding the local and systemic immunopathological processes occurring after airway infections (including SARS-CoV-2) and the critical assessment of potential therapeutic interventions. Orv Hetil. 2021; 162(29): 1147–1155.

Intrapulmonary blood flow redistribution during hypoxia increases gas exchange surface area

1982 ◽  
Vol 52 (6) ◽  
pp. 1575-1580 ◽  
Author(s):  
R. L. Capen ◽  
W. W. Wagner
Keyword(s):  
Carbon Monoxide ◽  
Blood Flow ◽  
Cardiac Output ◽  
Gas Exchange ◽  
Surface Area ◽  
Vascular Resistance ◽  
Diffusing Capacity ◽  
Capillary Recruitment ◽  
Blood Flow Redistribution ◽  
Exchange Surface

We have previously shown that airway hypoxia causes pulmonary capillary recruitment and raises diffusing capacity for carbon monoxide. This study was designed to determine whether these events were caused by an increase in pulmonary vascular resistance, which redistributed blood flow toward the top of the lung, or by an increase in cardiac output. We measured capillary recruitment at the top of the dog lung by in vivo microscopy, gas exchange surface area of the whole lung by diffusing capacity for carbon monoxide, and blood flow distribution by radioactive microspheres. During airway hypoxia recruitment occurred, diffusing capacity increased, and blood flow was redistributed upward. When a vasodilator was infused while holding hypoxia constant, these effects were reversed; i. e., capillary “derecruitment” occurred, diffusing capacity decreased, and blood flow was redistributed back toward the bottom of the lung. The vasodilator was infused at a rate that left hypoxic cardiac output unchanged. These data show that widespread capillary recruitment during hypoxia is caused by increased vascular resistance and the resulting upward blood flow redistribution.

scholarly journals Differential Regulation of the Immune Response in the Spleen and Liver of Mice Infected withLeishmania donovani

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Rashmi Bankoti ◽  
Simona Stäger
Keyword(s):  
Immune Response ◽  
Immune Responses ◽  
Host Defense ◽  
Defense Mechanisms ◽  
Leishmania Donovani ◽  
Differential Regulation ◽  
Therapeutic Interventions ◽  
Adaptive Immune Responses ◽  
Adaptive Immune ◽  
Novel Therapeutic

Immunity to pathogens requires generation of effective innate and adaptive immune responses.Leishmania donovanievades these host defense mechanisms to survive and persist in the host. A better understanding and identification of mechanisms thatL. donovaniemploys for its survival is critical for developing novel therapeutic interventions that specifically target the parasite. This paper will highlight some of the mechanisms that the parasite utilizes for its persistence and also discuss how the immune response is regulated.

scholarly journals Stereological monitoring of mouse lung alveolarization from the early postnatal period to adulthood

2017 ◽  
Vol 312 (6) ◽  
pp. L882-L895 ◽  
Author(s):  
Agnieszka Pozarska ◽  
José Alberto Rodríguez-Castillo ◽  
David E. Surate Solaligue ◽  
Aglaia Ntokou ◽  
Philipp Rath ◽  
...  
Keyword(s):  
Gas Exchange ◽  
Surface Area ◽  
Lung Development ◽  
Laboratory Mouse ◽  
Mouse Lung ◽  
Postnatal Life ◽  
Lung Maturation ◽  
Septal Wall ◽  
Mouse Lungs ◽  
Exchange Surface

Postnatal lung maturation generates a large number of small alveoli, with concomitant thinning of alveolar septal walls, generating a large gas exchange surface area but minimizing the distance traversed by the gases. This demand for a large and thin gas exchange surface area is not met in disorders of lung development, such as bronchopulmonary dysplasia (BPD) histopathologically characterized by fewer, larger alveoli and thickened alveolar septal walls. Diseases such as BPD are often modeled in the laboratory mouse to better understand disease pathogenesis or to develop new interventional approaches. To date, there have been no stereology-based longitudinal studies on postnatal mouse lung development that report dynamic changes in alveoli number or alveolar septal wall thickness during lung maturation. To this end, changes in lung structure were quantified over the first 22 mo of postnatal life of C57BL/6J mice. Alveolar density peaked at postnatal day (P)39 and remained unchanged at 9 mo (P274) but was reduced by 22 mo (P669). Alveoli continued to be generated, initially at an accelerated rate between P5 and P14, and at a slower rate thereafter. Between P274 and P669, loss of alveoli was noted, without any reduction in lung volume. A progressive thinning of the alveolar septal wall was noted between P5 and P28. Pronounced sex differences were observed in alveoli number in adult (but not juvenile) mice, when comparing male and female mouse lungs. This sex difference was attributed exclusively to the larger volume of male mouse lungs.

Strategies to Reduce Surface Area Requirements for Carbon Dioxide Removal for an Intravenacaval Gas Exchange Device

ASAIO Journal ◽  
1995 ◽  
Vol 41 (3) ◽  
pp. M567-M572 ◽  
Author(s):  
Weike Tao ◽  
Akhil Bidani ◽  
Victor J. Cardenas ◽  
S C Niranjan ◽  
Joseph B. Zwischenberger
Keyword(s):  
Carbon Dioxide ◽  
Gas Exchange ◽  
Surface Area ◽  
Carbon Dioxide Removal

Recent advances in late lung development and the pathogenesis of bronchopulmonary dysplasia

2013 ◽  
Vol 305 (12) ◽  
pp. L893-L905 ◽  
Author(s):  
Alicia Madurga ◽  
Ivana Mižíková ◽  
Jordi Ruiz-Camp ◽  
Rory E. Morty
Keyword(s):  
Gas Exchange ◽  
Surface Area ◽  
Bronchopulmonary Dysplasia ◽  
Lung Development ◽  
Oxygen Toxicity ◽  
Structural Development ◽  
Vascular Structure ◽  
Recent Developments ◽  
Immature Lung ◽  
Prematurely Born Infants

In contrast to early lung development, a process exemplified by the branching of the developing airways, the later development of the immature lung remains very poorly understood. A key event in late lung development is secondary septation, in which secondary septa arise from primary septa, creating a greater number of alveoli of a smaller size, which dramatically expands the surface area over which gas exchange can take place. Secondary septation, together with architectural changes to the vascular structure of the lung that minimize the distance between the inspired air and the blood, are the objectives of late lung development. The process of late lung development is disturbed in bronchopulmonary dysplasia (BPD), a disease of prematurely born infants in which the structural development of the alveoli is blunted as a consequence of inflammation, volutrauma, and oxygen toxicity. This review aims to highlight notable recent developments in our understanding of late lung development and the pathogenesis of BPD.

scholarly journals Η προσκόλληση και οι μηχανισμοί άμυνας σε άτομα διεγνωσμένα με οριακή διαταραχή προσωπικότητας

2020 ◽  
Vol 20 (1) ◽  
pp. 1
Author(s):  
Αντώνιος Καλαματιανός ◽  
Λίσσυ Κανελλοπούλου
Keyword(s):  
Defense Mechanisms ◽  
Theoretical Background ◽  
Borderline Personality ◽  
Insecure Attachment ◽  
Therapeutic Interventions ◽  
Defense Style ◽  
Defense Style Questionnaire ◽  
The Past ◽  
Outpatient Departments ◽  
Attachment Model

The interest with regard to the Borderline Personality Disorder (BPD) has increased in the past few years, because the number of people with the aforementioned diagnosis who use mental health services has risen. The study aimed at examining the defense mechanisms in people with BPD diagnosis in relation to the attachment type they adopt. Thesample consisted of 36 adult subjects diagnosed with BPD who attended psychiatric outpatient departments and 36 people who attended the ophthalmologic outpatient care at a general hospital. The adult attachment questionnaire CA-MIR and the Defense Style Questionnaire-40 were administered to the participants. In general, results are in accordance with the theoretical background, because it was demonstrated that diagnosed subjects scored higher in the insecure attachment types, that is, the ambivalent, the detached and the non-resolved, whereas the non-diagnosed scored higher in the autonomous attachment. Moreover, diagnosed subjects used more than the non-diagnosed participants the neurotic and the immature defenses,but they did not differ with respect to mature defenses. Finally, correlations between attachment and defenses were found with the exception of the mature that correlated with no attachment model. These findings may contribute to the identification of factors that participate in BPD and in the configuration of more efficient therapeutic interventions.

Fluid Flow and Particle Dispersion in Acini During Asynchronous Ventilation

2008 ◽  
Author(s):  
Sudhaker Chhabra ◽  
Ajay K. Prasad
Keyword(s):  
Carbon Dioxide ◽  
Fluid Flow ◽  
Gas Exchange ◽  
Surface Area ◽  
Opposite Direction ◽  
Respiratory System ◽  
Human Lung ◽  
Alveolar Epithelium ◽  
Particle Dispersion ◽  
Conducting Airways

The human lung comprises 24 generations of dichotomously branching tubes known as bronchi [1]. Functionally, these generations can be categorized as: (1) conducting airways which are non-alveolated and comprise the first 16 generations, and (2) the acini which consist of flexible, alveolated airways and are responsible for gas exchange. The alveoli are the most important units of the human respiratory system and provide large surface area (about 70–80 m2) for efficient gas exchange; oxygen diffuses into the blood through the alveolar epithelium, whereas carbon dioxide diffuses in the opposite direction from the blood to the lung.

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