Synthesis and Characterization of Magnetic Polymeric Nanospheres for Biomedical Applications

2002 ◽  
Vol 750 ◽  
Author(s):  
D. K. Kim ◽  
M. Mikhaylova ◽  
M. Toprak ◽  
A. Guyou ◽  
Y. K. Jeong ◽  
...  

ABSTRACTEntrapment of proteins in biodegradable nanospheres has been widely investigated as a technique to produce sustained release formulations for protein or anti-cancer drugs administration. Amphiphilic PLLA-mPEG diblock copolymer was prepared by ring opening polymerization (ROP) to form polymeric nanoparticles with a core-shell structure. The main encapsulation technique done is a water-in-oil-in-water (w/o/w) solvent evaporation technique. Here, protein was encapsulated using a newly developed water-in-oil emulsion-solvent diffusion technique. This technique leads to the formation of an emulsion combined with the immediate precipitation of the PLLA-mPEG. This phenomenon is caused by the diffusion of the polymer solvent to an external organic phase.

Langmuir ◽  
2017 ◽  
Vol 33 (49) ◽  
pp. 14087-14092 ◽  
Author(s):  
Kazuki Akamatsu ◽  
Koki Minezaki ◽  
Masumi Yamada ◽  
Minoru Seki ◽  
Shin-ichi Nakao

2017 ◽  
Vol 31 (2) ◽  
pp. 1468-1477 ◽  
Author(s):  
Di Shu ◽  
Yong Chi ◽  
Jieli Liu ◽  
Qunxing Huang

2022 ◽  
Vol 19 ◽  
Author(s):  
Diaa Al-Domi ◽  
Ayat Bozeya ◽  
Mohamed Al-Fandi

Aim: To develop a new nano-delivery system for insulin buccal administration. Background: Biodegradable polymeric nanoparticles (PNPs) had viewed countless breakthroughs in drug delivery systems. The main objective of PNPs application in delivering and carrying different promising drugs is to make sure that the drugs being delivered to their action sites. As a result maximizing the desired effect and overcoming their limitations and drawbacks. Objectives: The main goals of this study were to produce an insulin consumable nano-delivery system for buccal administration and enhance the mucoadhesive effect in sustaining insulin release. Methods: Water in oil in water (W-O-W) microemulsion solvent evaporation technique was used for the preparation of nanoparticles consisting from positively charged poly (D, L-lactide-co-glycolide) coated with chitosan and loaded with insulin. Later, a consumable buccal film was prepared by the spin coating method and loaded with the previously prepared nanoparticles. Results: The newly prepared nanoparticle was assessed in terms of size, charge and surface morphology using a Scanning Electron Microscope (SEM), zeta potential, Atomic Force Microscope (AFM), and Fourier Transform Infra-red (FTIR) spectroscopy. An in-vitro investigation of the insulin release, from nanoparticles and buccal film, demonstrated controlled as well as sustained delivery over 6 hrs. The cumulative insulin release decreased to about (28.9%) with buccal film in comparing with the nanoparticle (50 %). Conclusion: The buccal film added another barrier for insulin release. Therefore, the release was sustained.


2019 ◽  
Vol 7 (9) ◽  
pp. 4941-4949 ◽  
Author(s):  
Weifeng Zhang ◽  
Xiangyu Li ◽  
Ruixiang Qu ◽  
Yanan Liu ◽  
Yen Wei ◽  
...  

A PANI–SiNP-decorated Janus membrane was fabricated for highly efficient stabilized oil-in-water and water-in-oil emulsion separation, meeting industrial purification standards.


2020 ◽  
Vol 8 (46) ◽  
pp. 24388-24392
Author(s):  
Guangyan Chen ◽  
Yanan Wang ◽  
Yujia Wang ◽  
Hanzhong Xiao ◽  
Xin Huang ◽  
...  

Tuning the wettability of materials is of significance in developing efficient separation materials.


2010 ◽  
Vol 02 (10) ◽  
pp. 1061-1065 ◽  
Author(s):  
Jesada Karnchanajindanun ◽  
Mangkorn Srisa-ard ◽  
Prasong Srihanam ◽  
Yodthong Baimark

Fuel ◽  
2011 ◽  
Vol 90 (6) ◽  
pp. 2113-2117 ◽  
Author(s):  
Kyeongseok Oh ◽  
Milind D. Deo

1983 ◽  
Vol 1983 (1) ◽  
pp. 331-337 ◽  
Author(s):  
Donald Mackay ◽  
Warren Stiver ◽  
Peter A. Tebeau

ABSTRACT When crude oil or a petroleum product is to be produced or transported in the marine environment, there is always a risk of spills. To assess the nature of the risk and the likely behavior of the spilled oil, it is desirable to test the oil for those properties which will determine its environmental behavior and effects. Further, the properties should be expressed in the form of parameters in equations which are suitable for direct incorporation into oil spill models. Suitable tests for properties such as chemical composition, density, viscosity or rheology, volatility, aqueous solubility, and interfacial properties are suggested and equations suggested for these properties as a function of temperature and extent of weathering. Tests which can be used to predict the rates of environmental processes such as evaporation, water-in-oil emulsion formation, natural and chemically-induced dispersion and spreading are also reviewed and test inadequacies identified. A reasonably complete test protocol can be established now but some problems remain, especially with regard to characterization of an oil's natural dispersability.


2013 ◽  
Vol 34 (4) ◽  
pp. 560-565 ◽  
Author(s):  
Byeong-Gyu Park ◽  
In-Ji Park ◽  
Jong-Sub Han ◽  
Sang-Min Lee ◽  
Chon-Gu Lee ◽  
...  

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