Multiplexed Electrical Detection of Single Viruses

2004 ◽  
Vol 828 ◽  
Author(s):  
Gengfeng Zheng ◽  
Fernando Patolsky ◽  
Charles M. Lieber
Keyword(s):  
Influenza A ◽  
Large Scale ◽  
Field Effect Transistors ◽  
Simultaneous Detection ◽  
Optical Measurements ◽  
Electrical Detection ◽  
Virus Particles ◽  
Large Scale Integration ◽  
Conductance Changes ◽  
Scale Integration

ABSTRACTWe report direct, real-time electrical detection of single virus particles with high selectivity using nanowire field effect transistors. Measurements made with nanowire arrays modified with antibodies for influenza A showed discrete conductance changes characteristic of binding and unbinding in the presence of influenza A but not paramyxovirus or adenovirus. Moreover, simultaneous electrical and optical measurements using fluorescently-labelled influenza A demonstrate conclusively that the conductance changes correspond to binding/unbinding of single viruses at the surface of nanowire devices. In addition, studies of nanowire devices modified with antibodies specific for either influenza or adenovirus show that multiple viruses can be selectively detected in parallel. The possibility of large scale integration of these nanowire devices suggests potential for simultaneous detection of a large number of distinct viral threats at the single virus level.

First Principle Study of Tunnel Currents through CeO2, Y2O3, TiO2 and Al2O3 Dielectrics in MOSFETs for Ultra Large Scale Integration

2012 ◽  
Vol 584 ◽  
pp. 428-432 ◽  
Author(s):  
Mayank Chakraverty ◽  
Harish M. Kittur
Keyword(s):  
Density Functional ◽  
Large Scale ◽  
Gate Dielectric ◽  
Field Effect Transistors ◽  
Atomic Scale ◽  
Gate Leakage ◽  
High Tunnel ◽  
Large Scale Integration ◽  
High Dielectric ◽  
Scale Integration

High gate leakage current, as a central problem, has decelerated the downscaling of minimum feature size of the field effect transistors In this paper, a combination of density functional theory and non equilibrium Green’s function formalism has been applied to the atomic scale calculation of the tunnel currents through CeO2, Y2O3, TiO2 and Al2O3 dielectrics in MOSFETs. The tunnel currents for different bias voltages applied to Si/Insulator/Si systems have been obtained along with tunnel conductance v/s bias voltage plots for each system. The results are in agreement to the use of high dielectric constant materials as gate dielectric so as to enable further downscaling of MOSFETs with reduced gate leakage currents thereby enabling ultra large scale integration. When used as dielectric, TiO2 exhibits extremely low tunnel currents followed by Y2O3 while CeO2 and Al2O3 exhibit high tunnel currents through them at certain bias voltages.

An innovative large scale integration of silicon nanowire-based field effect transistors

2018 ◽  
Vol 143 ◽  
pp. 97-102 ◽  
Author(s):  
M. Legallais ◽  
T.T.T. Nguyen ◽  
M. Mouis ◽  
B. Salem ◽  
E. Robin ◽  
...  
Keyword(s):  
Field Effect ◽  
Large Scale ◽  
Field Effect Transistors ◽  
Silicon Nanowire ◽  
Large Scale Integration ◽  
Scale Integration

The large-scale integration of high-performance silicon nanowire field effect transistors

2009 ◽  
Vol 20 (41) ◽  
pp. 415202 ◽  
Author(s):  
Qiliang Li ◽  
Xiaoxiao Zhu ◽  
Yang Yang ◽  
Dimitris E Ioannou ◽  
Hao D Xiong ◽  
...  
Keyword(s):  
Field Effect ◽  
High Performance ◽  
Large Scale ◽  
Field Effect Transistors ◽  
Silicon Nanowire ◽  
Large Scale Integration ◽  
Scale Integration

Normally‐on and normally‐off camel diode gate GaAs field effect transistors for large scale integration

1982 ◽  
Vol 53 (8) ◽  
pp. 5951-5958 ◽  
Author(s):  
R. E. Thorne ◽  
S. L. Su ◽  
W. Kopp ◽  
R. Fischer ◽  
T. J. Drummond ◽  
...  
Keyword(s):  
Field Effect ◽  
Large Scale ◽  
Field Effect Transistors ◽  
Large Scale Integration ◽  
Camel Diode ◽  
Scale Integration

Plant hormones, plant growth regulators

2014 ◽  
Vol 155 (26) ◽  
pp. 1011-1018 ◽  
Author(s):  
György Végvári ◽  
Edina Vidéki
Keyword(s):  
Nervous System ◽  
Growth And Development ◽  
Large Scale ◽  
Essential Role ◽  
Higher Plants ◽  
Structure And Function ◽  
Wide Sense ◽  
Large Scale Integration ◽  
Scale Integration ◽  
And Function

Plants seem to be rather defenceless, they are unable to do motion, have no nervous system or immune system unlike animals. Besides this, plants do have hormones, though these substances are produced not in glands. In view of their complexity they lagged behind animals, however, plant organisms show large scale integration in their structure and function. In higher plants, such as in animals, the intercellular communication is fulfilled through chemical messengers. These specific compounds in plants are called phytohormones, or in a wide sense, bioregulators. Even a small quantity of these endogenous organic compounds are able to regulate the operation, growth and development of higher plants, and keep the connection between cells, tissues and synergy beween organs. Since they do not have nervous and immume systems, phytohormones play essential role in plants’ life. Orv. Hetil., 2014, 155(26), 1011–1018.

Behavior Models of Voltage Differencing Inverting Buffered Amplifier and Applications in Circuit Analysis

2019 ◽  
Vol 12 (4) ◽  
pp. 298-303
Author(s):  
YongAn LI
Keyword(s):  
Large Scale ◽  
Vlsi Design ◽  
Circuit Analysis ◽  
Second Order ◽  
Very Large Scale Integration ◽  
Behavioral Models ◽  
Order Filter ◽  
Large Scale Integration ◽  
Scale Integration ◽  
Behavior Models

Background: The symbolic nodal analysis acts as a pivotal part of the very large scale integration (VLSI) design. Methods: In this work, based on the terminal relations for the pathological elements and the voltage differencing inverting buffered amplifier (VDIBA), twelve alternative pathological models for the VDIBA are presented. Moreover, the proposed models are applied to the VDIBA-based second-order filter and oscillator so as to simplify the circuit analysis. Results: The result shows that the behavioral models for the VDIBA are systematic, effective and powerful in the symbolic nodal circuit analysis.</P>

Sign in / Sign up

Export Citation Format

Share Document