HPV-testing in cervical screening

2016 ◽  
pp. 100-102
Author(s):  
O. Rykova ◽  

The article presents modern laboratory aspects of cervical screening, which include assessment of infection with human papillomavirus (HPV) high carcinogenic risk. Key words: cervical cancer, cervical screening, traditional cytology, liquid-based cytology, PAP-test, human papilloma virus.

2017 ◽  
pp. 82-84
Author(s):  
O.V. Rykovа ◽  
◽  
T.P. Bogomaz ◽  

The paper presents the principles of the conclusions Pap test in accordance with the terminology system Bethesda, 2014, and their correlation with other classifications cytological findings. Key words: cervical cancer, cervical screening, traditional cytology, liquid-based cytology, PAP-test, The Bethesda system.


2017 ◽  
pp. 62-64
Author(s):  
O.V. Rykovа ◽  
◽  
T.P. Bogomaz ◽  

The paper presents the principles of the conclusions Pap test in accordance with the terminology system Bethesda, 2014, and their correlation with other classifications cytological findings. Key words: cervical cancer, cervical screening, traditional cytology, liquid-based cytology, PAP-test, The Bethesda system.


2017 ◽  
pp. 132-136
Author(s):  
O.V. Rykovа ◽  
◽  
T.P. Bogomaz ◽  

The paper presents the principles of the conclusions Pap test in accordance with the terminology system Bethesda, 2014, and their correlation with other classifications cytological findings. Key words: cervical cancer, cervical screening, traditional cytology, liquid-based cytology, PAP-test, The Bethesda system.


Trials ◽  
2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Lisa P. Spees ◽  
Andrea C. Des Marais ◽  
Stephanie B. Wheeler ◽  
Michael G. Hudgens ◽  
Sarah Doughty ◽  
...  

Abstract Background Screening substantially reduces cervical cancer incidence and mortality. More than half of invasive cervical cancers are attributable to infrequent screening or not screening at all. The current study, My Body My Test (MBMT), evaluates the impact of mailed kits for self-collection of samples for human papillomavirus (HPV) testing on completion of cervical cancer screening in low-income, North Carolina women overdue for cervical cancer screening. Methods/design The study will enroll at least 510 US women aged 25–64 years who report no Pap test in the last 4 years and no HPV test in the last 6 years. We will randomize participants to an intervention or control arm. The intervention arm will receive kits to self-collect a sample at home and mail it for HPV testing. In both the intervention and control arms, participants will receive assistance in scheduling an appointment for screening in clinic. Study staff will deliver HPV self-collection results by phone and assist in scheduling participants for screening in clinic. The primary outcome is completion of cervical cancer screening. Specifically, completion of screening will be defined as screening in clinic or receipt of negative HPV self-collection results. Women with HPV-negative self-collection results will be considered screening-complete. All other participants will be considered screening-complete if they obtain co-testing or Pap test screening at a study-affiliated institution or other clinic. We will assess whether the self-collection intervention influences participants’ perceived risk of cervical cancer and whether perceived risk mediates the relationship between HPV self-collection results and subsequent screening in clinic. We also will estimate the incremental cost per woman screened of offering at-home HPV self-collection kits with scheduling assistance as compared to offering scheduling assistance alone. Discussion If mailed self-collection of samples for HPV testing is an effective strategy for increasing cervical cancer screening among women overdue for screening, this method has the potential to reduce cervical cancer incidence and mortality in medically underserved women at higher risk of developing cervical cancer. Trial registration ClinicalTrials.gov NCT02651883, Registered on 11 January 2016.


2016 ◽  
Vol 2 (3_suppl) ◽  
pp. 72s-73s
Author(s):  
Sean Parkinson ◽  
Ian Bambury ◽  
Carole Rattray

Abstract 51 Background: Cervical cancer is the second most common cancer in Jamaica with an incidence of 17.4/100,000. (1). Cervical cancer is acquired sexually, with the human papilloma virus (HPV) being the most important causative agent (2,3). HPV infection is associated with the development of other cancers such as anogenital, vaginal, vulvar and anal cancers in women, and penile and anal cancers in men.(2) It is also responsible for genital warts and oropharyngeal cancer in both men and women. Two vaccines were approved for the prevention of cervical cancer by the Food and Drug Administration (FDA) and are available in Jamaica (4,5). This study assessed the knowledge and attitudes in a male cohort towards HPV and HPV vaccine. Methods: This was a cross-sectional study in which two hundred male students were recruited. Information for this study was gathered from responses given in a self-administered questionnaire. Data was analyzed using the statistical package for social sciences (SPSS) version 20. Results: The mean age of the respondents was 22.6 years. 50.5% stated that they had heard of HPV. Of those who knew of the HPV, only 37.6% vs 39.6% of respondents reported that sexual intercourse was a requirement for HPV transmission, while 22.8% did not know. 43% reported knowing that HPV causes genital warts and 42% knew of an association with cervical cancer. 16.5% of the respondents knew of the HPV vaccine. Only 21.2% knew that the HPV vaccine protects against cervical cancer while the remaining 78.8% either said that it didn't provide protection or did not know. 15.3% knew that the vaccine is approved for both males and females while 84.7% did not know. Conclusion: There was significant knowledge deficit in the awareness of HPV and the HPV vaccine in our male university students. Gibson, T.N., et al., Age-specific incidence of cancer in Kingston and St. Andrew, Jamaica, 2003-2007. West Indian Med J, 2010. 59(5): p. 456-64. Centers for Disease Control and Prevention. Basic information about HPV –associated cancers. Available at: http://www.cdc.gov/cancer/hpv/basic_info . 2013. Bosch, F.X. and S. de Sanjose, Chapter 1: Human papillomavirus and cervical cancer-- burden and assessment of causality. J Natl Cancer Inst Monogr, 2003(31): p. 3-13. FDA licensure of bivalent Human Papillomavirus vaccine (HPV2,Cervarix) for use in females and updated vaccination recommendations from the Advisory Committee on Immunization Practices (ACIP) .Centers For Disease Control and Prevention (CDC). MMWR Morb Mort Wkly Rep, 2010(59): p. 626-9. FDA, “FDA Approves New Vaccine Indication for Gardasil to Prevent Genital Warts in Men and Boys,” Bethesda, Md, USA. 2009. AUTHORS' DISCLOSURES OF POTENTIAL CONFLICTS OF INTEREST: No COIs from the authors.


BMJ Open ◽  
2019 ◽  
Vol 9 (2) ◽  
pp. e026887 ◽  
Author(s):  
Sovannara Thay ◽  
Andrew Goldstein ◽  
Lena Sophia Goldstein ◽  
Vaishnavi Govind ◽  
Kruy Lim ◽  
...  

ObjectivesLogistical and economic issues make traditional cytology-based cervical cancer screening challenging in developing countries. Alternative, cost-effective, screening strategies must be developed to screen millions of women in resource-poor countries such as Cambodia.DesignA prospective cohort study during which all women underwent four cervical cancer screening methods: (1) self-sampled human papilloma virus (HPV) testing (careHPV system), (2) clinician-collected HPV testing, (3) visualization with acetic acid (VIA) and (4) digital colposcopy (DC) with the Enhanced Visual Assessment System (EVA).SettingA referral hospital in Phnom Penh, Cambodia.ParticipantsTwo hundred and fifty Cambodian women (129 HIV+, 121 HIV-). Subjects were recruited from the National Center for HIV/AIDS Dermatology and sexually transmitted disease (STD) cohort, the Sihanouk Hospital Center of Hope’s Rural Outreach Teams and the Pochentong Medical Center.ResultsFifty six of the 250 (22.4%) patients tested positive for high-risk HPV (hrHPV+). Thirty seven of the 129 HIV+ women were hrHPV+ (28.6%) whereas 19/121 HIV- women were hrHPV+ (15.7%) p=0.0154. Self-sampling HPV specimens identified 50/56 (89%) whereas physician-collected specimens identified 45/56 (80%) p=0.174. 95.2% of the patients felt comfortable obtaining HPV self-samples. Thirty seven of 250 women were VIA+. Thirty of 37 VIA+ women underwent confirmatory biopsies for cervical intraepithelial neoplasia (CIN) (26 CIN1, 4 CIN2+). The rate of confirmed dysplasia in the HIV+ group was 20/129 (15.5%) compared with 10/121 (8.26%) in HIV- women p=0.0291. The contemporaneous physician impressions of the DC images accurately differentiated between CIN1 and CIN2+ lesions in all 30 women having confirmatory biopsies.ConclusionsThe results of this study suggest potential modifications of the current cervical screening strategy that is currently being employed in Cambodia. The first step in this new strategy would be self-swabbing for hrHPV. Subsequently, hrHPV+ patients would have DC and immediate treatment based on colposcopic findings: cryotherapy for suspected CIN1 and loop electrosurgical excision procedure (LEEP) for suspected CIN2+.


2002 ◽  
Vol 6 (22) ◽  
Author(s):  
◽  

Following two conferences which took place in the United States (US) last year, the American Medical Association has recently published two consensus statements concerning screening for and management of cervical cancer (1-3). It is recommended that human papilloma virus (HPV) testing become an integral part of both screening and clinical management of cervical cytological abnormalities.


Author(s):  
Aisha Nasser Al Saadi ◽  
Aisha Hamed Al Muqbali ◽  
Eihab Dawi

Objectives: This study aimed to assess knowledge of cervical cancer and its prevention among Omani women aged 20 to 65 years. Method: This analytic cross-sectional study took place at primary healthcare institutions, in the Al Buraimi governorate, Oman, between November 2018 I believe that in response to comment #5 too much information may have been removed from the Results section, therefore we return the first two paragraphs that were removed to the Results section and make them more concise during the copy editing stage.  and February 2019. The study was carried out on the basis of a predesigned, validated, and self-administered 55 question questionnaire. Results: Data from seven hundred and ninety-one completed questionnaires were included in the final analysis, which represents a response rate of 79.1% of the total. The results of the study indicated that 86.7 percent of surveyed women had previously heard of cervical cancer, and 13.0 per cent assumed the possibility of this disease to affect them in the future. The results showed that women had low awareness of the association between Human Papilloma Virus (HPV) and cervical cancer (24.7%). Participants considered HPV infection and initiation of sexual intercourse at an age younger than 17 years as the lowest risks associated with cervical cancer. The results also indicated that 63.8% of women were unaware of a vaccination 'against HPV related cervical cancer' and many of respondents were unaware of Pap test. Women aged over 30 years, those married, and those with a high level of education were more likely to be aware of cervical cancer. Conclusion: General knowledge of cervical cancer among women aged 20 to 65 years is insufficient. Young women aged 20-30 are largely unaware. Thus, concerted efforts are needed to promote awareness among women in Oman. Keywords: Cervical cancer, risk factor, Human Papilloma Virus, vaccine, Pap test.


2021 ◽  
pp. 543-564
Author(s):  
Aggie Jokhan ◽  
Joyce Aburam ◽  
Emma Sinfield ◽  
Debra Holloway

This chapter begins with an overview of the NHS cervical screening programme, then describes ways of taking samples for liquid-based cytology. The colposcopy procedure is detailed, and indications for referral are listed. Subsequent treatment and follow-up are explained, and the role of the nurse in cervical screening in primary care is covered. The human papilloma virus, testing, and vaccines are included, along with the clinical features and management of cervical polyps, and cervical ectropion are explained.


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