scholarly journals The Role of Vitamin D Deficiency Prevention in Improving Obstetric, Perinatal and Long-Term Outcomes

2020 ◽  
pp. 35-40
Author(s):  
Iu.V. Davydova ◽  
◽  
A.Iu. Lymanska ◽  
Yu.P. Neroznak ◽  
◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Vitamin D3 ◽  
First Trimester ◽  
Soluble Form ◽  
High Dose ◽  
Fetoplacental Complex ◽  
History Of ◽  
Inflammatory Bowel

Much attention is paid to deficiencies prevention during pregnancy, since they negatively affect not only metabolic processes, including fetoplacental complex, but also the condition of the fetus, the newborn, and physical and mental development of the child in the future. Summarizing the recommendations for the use of vitamin D during pregnancy, it should be noted that the typical prophylactic dose is 400 IU/day starting from the first trimester. However, we should consider the use of corrective doses in the second and third trimesters when the fetal skeleton is growing and developing. A high dose of vitamin D (2000 IU/day) is recommended for women at high risk of developing hypertensive complications of pregnancy (a history of preeclampsia, in particular, arising before 28 weeks, arterial hypertension, chronic kidney disease), as well as pregnant women with comorbidity (systemic red lupus, rheumatoid arthritis, multiple sclerosis, cardiovascular disease, inflammatory bowel disease, oncological pathology). For women at risk of vitamin D deficiency, the recommended dose is less than 1000 IU/day. In case of confirmed vitamin D deficiency (<25-30 nmol/L), a correction dose of 2000-4000 IU/day is prescribed for 11 weeks to provide a cumulative dose of about 150,000 or 300,000 units in the second or third trimesters. Today, a sufficient number of vitamin D preparations are presented on the pharmaceutical market of Ukraine, among which one should pay attention to "Olidetrim" (Polpharma, Poland) in the form of oil solution in capsules ensuring its absorption and assimilation. Depending on the dosage, each capsule of the preparation contains 2000 IU or 4000 IU of vitamin D3 (cholecalciferol). In addition to the fat-soluble form, vitamin D preparation Aquadetrim® (Polpharma, Poland) is registered and successfully used in Ukraine. This is a unique form of vitamin D3 based on nanomycellae, which provides better absorption of vitamin D in the intestine. Key words: vitamin D, deficiency, pregnancy, fetus, prevention.

scholarly journals Vitamin D Supplementation Modulates T Cell–Mediated Immunity in Humans: Results from a Randomized Control Trial

2016 ◽  
Vol 101 (2) ◽  
pp. 533-538 ◽  
Author(s):  
Gauree Gupta Konijeti ◽  
Pankaj Arora ◽  
Matthew R. Boylan ◽  
Yanna Song ◽  
Shi Huang ◽  
...  
Keyword(s):  
Vitamin D ◽  
T Cell ◽  
Vitamin D Deficiency ◽  
T Cell Activation ◽  
Vitamin D3 ◽  
Cell Activation ◽  
Atp Release ◽  
High Dose ◽  
Cell Mediated Immunity ◽  
Ancillary Study

Abstract Context: Although studies have linked vitamin D deficiency with immune-mediated diseases, data demonstrating a direct effect on T-cell function are sparse. Objective: Our objective was to determine whether oral vitamin D3 influences T-cell activation in humans with vitamin D deficiency. Design: This was a single-center ancillary study within Vitamin D Therapy in Individuals at High Risk of Hypertension, a double-blind, multicenter, randomized controlled trial. Setting: This study was undertaken in a single academic medical center. Participants: Adults with vitamin D deficiency and untreated pre- or early stage I hypertension were included. Intervention: In Vitamin D Therapy in Individuals at High Risk of Hypertension, participants were randomized to either low- (400 IU daily) or high- (4000 IU daily) dose oral vitamin D3 for 6 months. In this ancillary study of 38 patients, we measured CD4+ T-cell activation estimated by intracellular ATP release after stimulation of whole blood with plant lectin phytohemagglutinin collected at baseline (pretreatment) and 2-month follow-up. Main Outcome Measure: Determining whether ATP level changes were significantly different between treatment groups was the main outcome measure. Results: Treatment with 4000 IU of vitamin D3 decreased intracellular CD4+ ATP release by 95.5 ng/ml (interquartile range, −219.5 to 105.8). In contrast, 400 IU of vitamin D3 decreased intracellular CD4+ ATP release by 0.5 ng/ml (interquartile range, −69.2 to 148.5). In a proportional odds model, high-dose vitamin D3 was more likely than low-dose vitamin D3 to decrease CD4+ ATP release (odds ratio, 3.43; 95% confidence interval, 1.06–1.11). Conclusions: In this ancillary study of a randomized controlled trial, we found that high-dose vitamin D3 significantly reduced CD4+ T-cell activation compared to low-dose vitamin D3, providing human evidence that vitamin D can influence cell-mediated immunity.

scholarly journals Vitamin D sebagai Terapi Potensial Anak Gizi Buruk

2019 ◽  
Vol 1 (1) ◽  
pp. 61-70
Author(s):  
Lisa Dwi Aryani ◽  
Muhammad Aldy Riyandry
Keyword(s):  
Vitamin D ◽  
Literature Review ◽  
Vitamin D Deficiency ◽  
Vitamin D3 ◽  
Child Nutrition ◽  
Infant Health ◽  
Well Being ◽  
High Dose ◽  
Z Score ◽  
The Impact

Masalah malnutrisi (gizi buruk) masih menjadi isu kesehatan global. Gizi buruk merupakan penyebab kematian tertinggi anak di negara berkembang. Malnutrisi adalah keadaan kekurangan energi dan protein berat akibat ketidakseimbangan antara ambilan makanan dengan kebutuhan gizi. Keadaan malnutrisi energi-protein sering dikaitkan dengan temuan kasus defisiensi vitamin D. Berdasarkan studi epidemiologi >50% anak malnutrisi berat juga mengalami defisiensi vitamin D. Pengoreksian melalui diet terapeutik sebagai standar pengobatan hanya mengandung vitamin D dalam jumlah sedang sehingga tidak cukup adekuat untuk mencukupi kebutuhan anak. Pemberian tambahan vitamin D3 dosis tinggi sebanyak 200.000 IU (5 mg) diduga mampu mengoreksi keadaan gizi buruk dengan meningkatkan berat badan dan nilai z-score anak. Literature review ini bertujuan untuk menjelaskan pengaruh pemberian vitamin D dalam memperbaiki tampilan klinis anak gizi buruk. Metode yang digunakan dalam artikel ini adalah penelusuran artikel melalui database NCBI dan Google Scholar. Tahun penerbitan sumber pustaka adalah dari tahun 2004 hingga 2019 dengan 29 sumber pustaka. Tema dalam artikel yang dikumpulkan yaitu terkait gambaran pengaruh pemberian vitamin D dalam meningkatkan berat badananak gizi buruk. Hasil dari sintesa 24 artikel yang telah ditemukan terdapat pengaruh pemberian vitamin D (cholecalciferol) terhadap kenaikan berat badan sebagai hasil kumulatif lemak di jaringan adiposa sehingga cukup potensial sebagai terapi gizi buruk.   Kata kunci: Vitamin D, gizi buruk, berat badan, cholecalciferol   VITAMIN D AS POTENTIAL THERAPY FOR MALNUTRITION CHILD   ABSTRACT Malnutrition (malnutrition) is still a global health problem. Malnutrition is the highest cause of deaths children in developing countries. Malnutrition is the impact of lack of energy and protein due to an imbalance between food intake and nutritional needs. The symptoms are marasmus, kwashiorkor or marasmik-kwashiorkor. Energy-protein malnutrition is often related to the case finding of vitamin D deficiency, which is caused by epidemiological studies>50% of severely malnourished children also have vitamin D deficiency. Correcting malnutrition with a therapeutic diet as a standard is sufficient to meet the child's needs. An additional 200,000 IU (5 mg) of high-dose vitamin D3 supplements can replace malnutrition by increasing the child's weight and z-score. This review summarizes the role of vitamin D as a potential therapy in improving infant health and well-being and malnutrition. The method taken by the article was made using the literature review method, involving 29 books, national or international journals. The results of a review of 24  articles that show the difference between vitamin D (cholecalciferol) and weight gain as a result of cumulative fat in adipose tissue through increased intracellular calcium, is quite potentially used as a supplementary therapy for child nutrition.   Keywords: vitamin D, malnutrition, weight, cholecalciferol

scholarly journals Single high-dose oral vitamin D3 (stoss) therapy — A solution to vitamin D deficiency in children with cystic fibrosis?

2013 ◽  
Vol 12 (2) ◽  
pp. 177-182 ◽  
Author(s):  
Darren Shepherd ◽  
Yvonne Belessis ◽  
Tamarah Katz ◽  
John Morton ◽  
Penny Field ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Vitamin D3 ◽  
High Dose ◽  
Oral Vitamin ◽  
Single High Dose ◽  
Dose Oral

scholarly journals HIGH DOSE VITAMIN D3 VS PLACEBO IN CRITICALLY ILL PATIENTS WITH VITAMIN D DEFICIENCY

CHEST Journal ◽  
2021 ◽  
Vol 160 (4) ◽  
pp. A1005
Author(s):  
Metri Haddaden ◽  
Ibrahim Haddad ◽  
Mohammad Darweesh ◽  
David Weisman
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Critically Ill ◽  
Vitamin D3 ◽  
Critically Ill Patients ◽  
High Dose ◽  
High Dose Vitamin

scholarly journals Effect of Vitamin D3 on Untreated Graves' Disease with Vitamin D Deficiency

2014 ◽  
Vol 7 ◽  
pp. CCRep.S13157 ◽  
Author(s):  
Omar N. Alhuzaim ◽  
Naji Aljohani
Keyword(s):  
Vitamin D ◽  
Thyroid Gland ◽  
Vitamin D Deficiency ◽  
Vitamin D3 ◽  
Graves Disease ◽  
Bone Homeostasis ◽  
Heterogeneous Distribution ◽  
Satisfactory Outcome ◽  
Vitamin D Levels ◽  
History Of

Objective Besides its classical role in calcium and bone homeostasis, vitamin D is considered a potent immunomodulator that can affect the pathogenesis of several autoimmune diseases. Our aim is to evaluate the effect of vitamin D correction to a patient with new onset Graves' disease (GD) with an underlying vitamin D deficiency. Method We describe the effect of vitamin D3 on untreated Graves' disease with vitamin D deficiency. Results A healthy Saudi woman in her 40s sought consultation with a three-month history of palpitation. She denied any history of heat intolerance, weight loss, menstrual irregularity or sweating. She has a history of chronic muscle aches and pains. Physical examination revealed a mild diffusely enlarged and non-tender thyroid gland with no bruit. She had no signs of Graves' ophthalmopathy. In laboratory examinations, the initial thyroid function test, which was done in an outside hospital, revealed a TSH, 0.01 mIU/L; FT4, 22.5 pmol/L and FT3, 6.5 pmol/L. Vitamin D 25-OH level was done in our hospital and showed a result of 26.0 nmol/L with a TSH, 0.013 mIU/L; FT4, 16.7 pmol/L; and FT3, 3.8 pmol/L. TSH receptor antibody was positive. TC-99 m thyroid scintigraphy demonstrated an enlarged thyroid gland with increased radiotracer trapping and heterogeneous distribution. The patient was given only oral cholecalciferol 4000 IU per day since November 2012 (prescribed by an outside hospital) then from May 2013 onwards she was given 50,000 IU per month. Follow-up laboratory exams revealed improved vitamin D levels as well as TSH and FT4. She eventually improved both clinically and biochemically with a satisfactory outcome. Conclusion Vitamin D deficiency may exacerbate the onset and/or development of GD and correction of the deficiency may be able to reverse it. However, further prospective clinical studies will be needed to define the role of vitamin D treatment in GD.

Vitamina D e rachitismo carenziale

2020 ◽  
Vol 39 (7) ◽  
pp. 426-429
Author(s):  
Anna Agrusti ◽  
Sarah Contorno ◽  
Irene Bruno ◽  
Giulia Gortani ◽  
Egidio Barbi
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Vitamin D3 ◽  
Vitamin D Supplementation ◽  
High Dose ◽  
The Sun ◽  
Phosphorus Metabolism ◽  
Calcium Phosphorus ◽  
Vitamin D3 Supplementation ◽  
First Year Of Life

Mouhamed, a 7-year-old boy of African origin, presented with progressive fatigue and difficulty in walking. He was never treated with vitamin D supplementation. The evaluation of his calcium-phosphorus metabolism revealed a myopathy related to severe rickets. Therefore, he was treated with high-dose vitamin D3 and myopathy and fatigue progressively resolved. Vitamin D plays a crucial role in the calcium-phosphorus metabolism, by acting on enterocytes, osteoclasts and renal tubule. Vitamin D deficiency is defined when the 25OHD value is less than 20 ng/ml. In order to guarantee the assumption of the minimum daily dose of vitamin D, it is recommended to start vitamin D3 supplementation in all newborns and infants in their first year of life, regardless of the feeding modality. Exposure to the sun is essential for the activation of vitamin D, so dark-skinned children and mothers or those little exposed to the sun should start vitamin D3 supplementation. Vitamin D3 should also be supplemented in children with cerebral palsy and in patients treated with anti-epileptic drugs. Other conditions at risk of vitamin D deficiency are inflammatory bowel disease, celiac disease, cystic fibrosis, obesity, liver failure, cholestasis and vegetarian or vegan diets. Classic signs of rickets are the rickety rosary, the widening of the wrist and the arching of the tibia. Severe hypocalcaemia secondary to vitamin D deficiency can occur with dilated cardiomyopathy or convulsions, especially in dark-skinned infants. Vitamin D deficiency should be considered in children with progressive myopathy or muscular weakness, especially in dark-skinned ones or in those poorly exposed to the sun for cultural or religious reasons.

Vitamin D3 supplementation improves glycemic control in type 2 diabetic patients: Results from an Italian clinical trial

2020 ◽  
pp. 1-10
Author(s):  
Giuseppe Derosa ◽  
Angela D’Angelo ◽  
Chiara Martinotti ◽  
Maria Chiara Valentino ◽  
Sergio Di Matteo ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Metabolic Control ◽  
Vitamin D3 ◽  
Therapy Group ◽  
Hypoglycemic Agents ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

Abstract. Background: to evaluate the effects of Vitamin D3 on glyco-metabolic control in type 2 diabetic patients with Vitamin D deficiency. Methods: one hundred and seventeen patients were randomized to placebo and 122 patients to Vitamin D3. We evaluated anthropometric parameters, glyco-metabolic control, and parathormone (PTH) value at baseline, after 3, and 6 months. Results: a significant reduction of fasting, and post-prandial glucose was recorded in Vitamin D3 group after 6 months. A significant HbA1c decrease was observed in Vitamin D3 (from 7.6% or 60 mmol/mol to 7.1% or 54 mmol) at 6 months compared to baseline, and to placebo (p < 0.05 for both). At the end of the study period, we noticed a change in the amount in doses of oral or subcutaneous hypoglycemic agents and insulin, respectively. The use of metformin, acarbose, and pioglitazone was significantly lower (p = 0.037, p = 0.048, and p = 0.042, respectively) than at the beginning of the study in the Vitamin D3 therapy group. The units of Lispro, Aspart, and Glargine insulin were lower in the Vitamin D3 group at the end of the study (p = 0.031, p = 0.037, and p = 0.035, respectively) than in the placebo group. Conclusions: in type 2 diabetic patients with Vitamin D deficiency, the restoration of value in the Vitamin D standard has led not only to an improvement in the glyco-metabolic compensation, but also to a reduced posology of some oral hypoglycemic agents and some types of insulin used.

Vitamin D3 and women's health

GYNECOLOGY ◽  
2019 ◽  
Vol 21 (1) ◽  
pp. 44-51
Author(s):  
Iuliia E Dobrokhotova ◽  
Ekaterina I Borovkova ◽  
Sofya A Zalesskaya ◽  
Victoria S Skalnaya ◽  
Ivan M Borovkov ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Vitamin D3 ◽  
Negative Impact ◽  
Perinatal Outcomes ◽  
Hypovitaminosis D ◽  
Malignant Neoplasms ◽  
Cellular Functions ◽  
Prophylactic Drug ◽  
Drug Doses

Background. Vitamin D is an essential component that regulates calcium homeostasis and many other cellular functions. Hypovitaminosis D is associated with a risk of osteopenia, obesity, type 1 and type 2 diabetes, malignant neoplasms and immune disorders. Inadequate vitamin D intake during pregnancy increases a risk of pre-eclampsia, preterm birth, low birth weight as well as it has a negative impact on both children’s and adolescents’ health. It is important for the clinician to be known administrating of vitamin D prophylactic and therapeutic regimens according to serum 25(OH)D levels. Aim. To determine causes and effects of vitamin D deficiency and to elaborate ways of their correction. Materials and methods. To write this review a search for domestic and foreign publications in Russian and international search systems (PubMed, eLibrary, etc.) for the last 2-15 years was conducted. The review includes articles from peer-reviewed literature. Results. The article shows that vitamin D has a significant impact on both the cardiovascular, endocrine, digestive, respiratory and other systems functioning and perinatal outcomes that necessitates vitamin D deficiency correction. It provides schemes for effective therapeutic and prophylactic drug doses calculating depending on vitamin D3 blood serum concentration. Conclusion. Preference should be given to cholecalciferol (vitamin D3) due to its better absorption properties and more efficient conversion to active vitamin metabolites (class IIC).

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