scholarly journals Modern Outlooks on «Atopic March» Secondary Prevention Capabilities in Children with Atopic Dermatitis

2020 ◽  
Vol 19 (6) ◽  
pp. 514-519
Author(s):  
Nikolay N. Murashkin ◽  
Leyla S. Namazova-Baranova ◽  
Roman A. Ivanov ◽  
Dmitri V. Fedorov ◽  
Eduard T. Ambarchian ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Inflammatory Process ◽  
Inflammatory Diseases ◽  
Allergic Diseases ◽  
Disease Course ◽  
Therapeutic Approaches ◽  
Atopic March ◽  
Gradual Development ◽  
Severity Of The Disease

Atopic dermatitis (AD) is one of the most common inflammatory diseases of childhood, and it is the first one in gradual development of allergic diseases, also known as «atopic march». Sensitization establishment during the AD uncontrolled course is associated with the high risk of developing of serious allergic pathologies, increase in the severity of the disease course, and patients’ quality of life reduction. Thereby, it is crucial to achieve quick jugulation of the inflammatory process in case of severe AD with early onset of disease. This article shows modern therapeutic approaches to disease control in children.

scholarly journals Role of Emollients in Prevention of the Comorbid Allergic Diseases Development in Children with Atopic Dermatitis

2020 ◽  
Vol 17 (4) ◽  
pp. 334-339
Author(s):  
Nikolay N. Murashkin ◽  
Roman A. Ivanov ◽  
Dmitri V. Fedorov ◽  
Eduard T. Ambarchyan ◽  
Roman V. Epishev ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Inflammatory Diseases ◽  
Allergic Diseases ◽  
Main Role ◽  
Social Maladjustment ◽  
Active Components ◽  
Epidermal Barrier ◽  
New Class

Atopic dermatitis (AD) is one of the common multifactorial inflammatory diseases manifesting predominantly in childhood. There is significant number of cases of self-regression of the disease with aging. On the other hand, there is also another scenario ending with AD persistent course and/or development of comorbid allergic pathologies that can significantly worsen patient’s quality of life and finally lead to social maladjustment. The pathogenesis of such way includes epidermal barrier disturbance, transcutaneous sensibilisation and aberrant allergic (Th2) immune systemic response development. Main role in preventing of this pathological pathway is lying on the new class of moisturizers containing active components "emollients plus". They are considered as foundation for the therapy and prevention of the development of AD and other allergic diseases. This literature review provides relevant data on AD pathogenesis and development of comorbid allergic pathologies. This paper also covers data on the effect of emollients in restoration of the epidermal barrier and their use as preventive measures.

scholarly journals Prevention of Transcutaneous Sensitization to Cow Milk Proteins in Infants with Atopic Dermatitis: Cohort Study

2020 ◽  
Vol 19 (6) ◽  
pp. 538-544
Author(s):  
Nikolay N. Murashkin ◽  
Svetlana G. Makarova ◽  
Stepan G. Grigorev ◽  
Dmitri V. Fedorov ◽  
Roman A. Ivanov ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Maintenance Therapy ◽  
Milk Proteins ◽  
Allergic Diseases ◽  
Specific Ige ◽  
Dispersion Analysis ◽  
Cow Milk ◽  
Group 2 ◽  
Group 1

Background. Malformations in epidermal barrier in children with atopic dermatitis (AD) can cause transcutaneous sensitization with further development of allergic diseases that can worsen the AD course and significantly reduces patients’ quality of life.Objective. The aim of the study was to determine the effect of topical treatment and maintenance therapy with pimecrolimus 1% cream (PIM) and topical glucocorticosteroids (tGCS) in infants with AD on reducing the risk of developing transcutaneous sensitization (due to the levels of specific IgE to the cow milk protein over time) and on reducing the disease severity (by the EASI scale).Methods. The study included children aged from 1 to 4 months with early manifestations of moderate and severe AD. The severity of AD was estimated via the EASI scale at start of observation, then at 6, 9 and 12 months of life. The class and level of specific IgE to cow milk proteins (CMP) were determined by the ImmunoCAP method at the point of enrolment and at the ages of 6 and 12 months. Statistical analysis of studied indicators dynamics and their comparison in research groups was carried out using multifactorial dispersion analysis.Results. The study included 36 patients. All patients have received standard tGCS therapy in combination with emollients (wet wrap) for 10 days. The maintenance therapy was prescribed in postacute period. It included topical calcineurin inhibitor PIM 2 times/day for 3 months, then double application (morning/evening) 3 times/week up to the age of 1 year old (group 1). Other group had maintenance therapy — tGCS2 times/week for 3 months, and then at AD aggravation (group 2). Group 1 has shown lower level of sensitization to CMP at the age of 6 and 12 months and more significant decrease in AD severity according to EASI scale compared to group 2.Conclusion. The treatment with PIM is effective in therapy of AD and prevention of transcutaneous sensitization in infants.

scholarly journals Phototherapy in Dermatology

Arkus ◽  
2021 ◽  
Vol 1 (1) ◽  
pp. 182-185
Author(s):  
Inda Astri Aryani ◽  
Maria Mayfinna Gozali ◽  
Indri Widyasari
Keyword(s):  
Atopic Dermatitis ◽  
Dose Adjustment ◽  
Inflammatory Process ◽  
Therapeutic Procedure ◽  
Minimal Erythema Dose ◽  
Skin Malignancy ◽  
Frequency Of Use ◽  
Narrowband Uvb ◽  
Epidermal Proliferation ◽  
Severity Of The Disease

Phototherapy is a therapeutic procedure in dermatology. Phototherapy uses certain ultraviolet wavelengths classified into 3 types,broadband UVB (BBUVB), narrowband UVB (NBUVB), and psoralen UVA (PUVA). The most widely used is NBUVB for treating psoriasis, atopic dermatitis and vitiligo. The mechanism of action of phototherapy is to reduce epidermal proliferation, suppress the immune system, reduce the inflammatory process, and induce repigmentation. Before starting phototherapy, the dose adjustment depends on skin type and minimal erythema dose (MED). Frequency of use is recommended based on the severity of the disease, continuously administered needed. Besides of this therapeutic effect, some contraindications and side effects that need to be considered in the use of phototherapy such as drug interactions, photoallergic and risk of skin malignancy.

scholarly journals Principles of complementary food introduction in atopic dermatitis

2021 ◽  
Vol 5 (6) ◽  
pp. 421-426
Author(s):  
A.S. Botkina ◽  
◽  
M.I. Dubrovskaya ◽  
Keyword(s):  
Atopic Dermatitis ◽  
Allergic Diseases ◽  
Elimination Diet ◽  
Complementary Food ◽  
Childhood Nutrition ◽  
Atopic March ◽  
Special Diet ◽  
Starting Point ◽  
Keywords Atopic Dermatitis ◽  
Early Childhood Nutrition

Atopic dermatitis (AD) is one of the most common inflammatory skin disorders. In most patients, AD is a starting point for developing other atopic diseases, e.g., food allergy, allergic diseases of the gastrointestinal tract, allergic rhinitis, and asthma known under the umbrella of "atopic march". In addition to genetic predisposition, various environmental factors are essential for the development of this dermatosis. In young children, food is the most relevant factor. This paper discusses principles of the selection of complementary food, techniques, and terms of its introduction. Prolonging of breastfeeding, the adequate introduction of complementary food, and personified nutrition program prevent the atopic march. The authors highlight that there is no special diet for atopic dermatitis. Meanwhile, food should be safe, low allergy, and balanced to provide a child with essential macro-and micronutrients. In addition, the paper addresses the utility and validity of an elimination diet which should be prescribed only in established food sensitization and used under the control o f a specialist. KEYWORDS: atopic dermatitis, atopic march, infancy, early childhood, nutrition, complementary foods, prevention. FOR CITATION: Botkina A.S., Dubrovskaya M.I. Principles of complementary food introduction in atopic dermatitis. Russian Medical Inquiry. 2021;5(6):421–426 (in Russ.). DOI: 10.32364/2587-6821-2021-5-6-421-426.

scholarly journals An overview of allergy and sinusitis

2017 ◽  
Vol 59 (3) ◽  
pp. 20-28
Author(s):  
Nicholus Magongwa ◽  
Natalie Schellack
Keyword(s):  
Quality Of Life ◽  
Atopic Dermatitis ◽  
Allergic Conjunctivitis ◽  
Allergic Diseases ◽  
Comorbid Conditions ◽  
Management Options ◽  
Current Management ◽  
Duration Of Therapy ◽  
The People

Allergic diseases affect many people across the globe. They are considered to significantly disturb the quality of life of the people who are affected, creating personal and economic predicaments. Some of the most commonly diagnosed allergic diseases include atopic dermatitis, rhinitis, allergic conjunctivitis and sinusitis. Some conditions, such as eosinophilic esophagitis, are on the rise and are being diagnosed across all continents except for Africa. The use of antihistamines has been the mainstay of therapy for most allergic conditions, except for other conditions that require corticosteroids, or in severe allergic conditions such as anaphylaxis where antihistamines are ineffective as main therapy. It is important to consider first versus second-generation options when treating allergic diseases, also bearing in mind the duration of therapy and any comorbid conditions that a patient might have. This article provides an overview of these conditions and their current management options.

scholarly journals Significance of the epidermal barrier and sensitisation to household allergens to the development of atopic march for primary prevention

2018 ◽  
Vol 17 (2) ◽  
pp. 114-120
Author(s):  
E. E. Varlamov ◽  
A. N. Pampura ◽  
A. N. Asmanov
Keyword(s):  
Allergic Rhinitis ◽  
Early Childhood ◽  
Atopic Dermatitis ◽  
Primary Prevention ◽  
Bronchial Asthma ◽  
Allergic Diseases ◽  
The State ◽  
Older Age ◽  
Epidermal Barrier ◽  
Atopic March

Atopic march is a variant flowing of atopia that begins in early childhood as atopic dermatitis, then developinto other allergic diseases (bronchial asthma, allergic rhinitis) at an older age. The state of the epidermal barrier and sensitization to inhaled allergens are considered as predictors for the development of atopic march. Data on the importance of these factors in the development of atopic march and information about possible approaches to prevention are presented in this article.

scholarly journals Emotional distress and quality of life in allergic diseases

2020 ◽  
Vol 73 (2) ◽  
pp. 370-373
Author(s):  
Marcin Jarosz ◽  
Sadia Syed ◽  
Michał Błachut ◽  
Karina Badura Brzoza
Keyword(s):  
Quality Of Life ◽  
Atopic Dermatitis ◽  
Anxiety Disorders ◽  
Mood Disorders ◽  
Emotional Disorders ◽  
Behavioral Disorders ◽  
Bronchial Asthma ◽  
Allergic Diseases ◽  
Increased Risk

Emotional disorders accompany many somatic diseases, especially ones with severe or chronic course, and such are allergic diseases. Long-term course of the disease, the need for chronic treatment and repeated exacerbations as well as symptoms of depression or anxiety have a significant impact on the quality of life of patients, constituting a serious burden both from the point of view of the individual and the society. The data evaluating emotional disturbances and their impact on the quality of life in three atopic diseases: bronchial asthma, atopic dermatitis and seasonal rhinitis were analysed. Mood disorders as well as mental and behavioral disorders due to alcohol abuse are the most common psychiatric disorders observed in patients with bronchial asthma. There are data indicating a relationship between the occurrence of allergic rhinitis and mood disorders, anxiety disorders and suicidal tendencies. Atopic dermatitis is associated with an increased risk of depressive and anxiety disorders and sleep disorders, and in children with more prevalence of behavioral disorders. Most studies highlighted the relationship between emotional disorders and quality of life in the above-mentioned patient groups. In addition to physical ailments, patients suffering from allergic diseases also report emotional problems that can adversely affect the course of the disease, the treatment process, and reduce quality of life. Therefore, these patients require a holistic approach with a more accurate assessment of emotional disorders.

scholarly journals FEATURES OF THE CYTOKINE PROFILE IN INFANTS WITH MULTIPLE FOOD PROTEIN INTOLERANCE

2012 ◽  
Vol 9 (5) ◽  
pp. 76-80
Author(s):  
E E Varlamov ◽  
T V Vinogradova ◽  
A A Chuslyaeva ◽  
A N Pampura
Keyword(s):  
Atopic Dermatitis ◽  
Food Allergy ◽  
Amino Acid ◽  
Inflammatory Process ◽  
Allergic Diseases ◽  
Cytokine Profile ◽  
Food Protein ◽  
Additional Indication ◽  
Protein Intolerance

Introduction. Types of the course of allergic diseases may be related to cytokine profile. Determination of the spectrum of cytokines to evaluate the mechanisms of allergic inflammatory process that improves the efficiency of management of patients with allergic diseases was performed. Background. To establish the features of cytokine profile in children with multiple food protein intolerance. Methods. 39 children with atopic dermatitis and food allergy were included in the openlabel study, 18 of whom had multiple food protein intolerance. All patients were examined with enzyme immunoassay (ELISA) to determine the concentration of IL-4, IL-5, IL-13, IL-17, IL-22, eotaxin, eotaxin2, TGF-β. Results. In children with multiple food protein intolerance the concentration of TGF-β was increased in comparison with the group of children without multiple food intolerances Me 14,04 [11,3; 18,0] against 10,3 [4,8; 12, 8] pg/ml, respectively, p = 0,038. The level of other cytokines had no difference. Conclusion. Increased concentration of TGF-β in patients with multiple food protein intolerance may be an additional indication for the amino acid formulas.

scholarly journals Eosinophil microRNAs Play a Regulatory Role in Allergic Diseases Included in the Atopic March

2020 ◽  
Vol 21 (23) ◽  
pp. 9011
Author(s):  
Émile Bélanger ◽  
Anne-Marie Madore ◽  
Anne-Marie Boucher-Lafleur ◽  
Marie-Michelle Simon ◽  
Tony Kwan ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Immunoglobulin E ◽  
Clinical Manifestations ◽  
Skin Barrier ◽  
Allergic Diseases ◽  
Forced Expiratory Volume ◽  
Inflammatory Reactions ◽  
Atopic March ◽  
History Of

(1) Background: The atopic march is defined by the increased prevalence of allergic diseases after atopic dermatitis onset. In fact, atopic dermatitis is believed to play an important role in allergen sensitization via the damaged skin barrier, leading to allergic diseases such as allergic asthma and allergic rhinitis. The eosinophil, a pro-inflammatory cell that contributes to epithelial damage, is one of the various cells recruited in the inflammatory reactions characterizing these diseases. Few studies were conducted on the transcriptome of this cell type and even less on their specific microRNA (miRNA) profile, which could modulate pathogenesis of allergic diseases and clinical manifestations post-transcriptionally. Actually, their implication in allergic diseases is not fully understood, but they are believed to play a role in inflammation-related patterns and epithelial cell proliferation. (2) Methods: Next-generation sequencing was performed on RNA samples from eosinophils of individuals with atopic dermatitis, atopy, allergic rhinitis and asthma to obtain differential counts of primary miRNA (pri-miRNA); these were also analyzed for asthma-related phenotypes such as forced expiratory volume in one second (FEV1), immunoglobulin E (IgE) and provocative concentration of methacholine inducing a 20% fall in forced expiratory volume in 1 s (PC20) levels, as well as FEV1 to forced vital capacity (FEV1/FVC) ratio. (3) Results: Eighteen miRNAs from eosinophils were identified to be significantly different between affected individuals and unaffected ones. Based on counts from these miRNAs, individuals were then clustered into groups using Ward’s method on Euclidian distances. Groups were found to be explained by asthma diagnosis, familial history of respiratory diseases and allergic rhinitis as well as neutrophil counts. (4) Conclusions: The 18 differential miRNA counts for the studying phenotypes allow a better understanding of the epigenetic mechanisms underlying the development of the allergic diseases included in the atopic march.

scholarly journals A case of atopic dermatitis with a severe resistant course in adult patient with atopic march

2020 ◽  
Vol 17 (2) ◽  
pp. 69-73
Author(s):  
Galiya M. Tusupbekova ◽  
Aigul A. Syzdykova ◽  
Botagoz M. Davletova
Keyword(s):  
Atopic Dermatitis ◽  
Adult Patient ◽  
Clinical Symptoms ◽  
Clinical Manifestations ◽  
Allergic Diseases ◽  
Atopic Disease ◽  
Significant Others ◽  
Natural Course ◽  
Atopic March ◽  
Typical Sequence

Introduction. The atopic march is the natural course of development of atopy symptoms. It is characterized by a typical sequence of development of clinical symptoms of atopic disease, when some symptoms become more significant, others are recede. Timely allergological diagnostics with the identification of causal allergens allows to preventor suspend the atopic march. Purpose of the study was to demonstrate the stages of the atopic march formation and clinical manifestations of atopy, the importance of on timely detection of causal allergens, the capability of modern diagnostics and treatment of severe resistant forms of allergic diseases.

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