Eosinophil microRNAs Play a Regulatory Role in Allergic Diseases Included in the Atopic March

(1) Background: The atopic march is defined by the increased prevalence of allergic diseases after atopic dermatitis onset. In fact, atopic dermatitis is believed to play an important role in allergen sensitization via the damaged skin barrier, leading to allergic diseases such as allergic asthma and allergic rhinitis. The eosinophil, a pro-inflammatory cell that contributes to epithelial damage, is one of the various cells recruited in the inflammatory reactions characterizing these diseases. Few studies were conducted on the transcriptome of this cell type and even less on their specific microRNA (miRNA) profile, which could modulate pathogenesis of allergic diseases and clinical manifestations post-transcriptionally. Actually, their implication in allergic diseases is not fully understood, but they are believed to play a role in inflammation-related patterns and epithelial cell proliferation. (2) Methods: Next-generation sequencing was performed on RNA samples from eosinophils of individuals with atopic dermatitis, atopy, allergic rhinitis and asthma to obtain differential counts of primary miRNA (pri-miRNA); these were also analyzed for asthma-related phenotypes such as forced expiratory volume in one second (FEV1), immunoglobulin E (IgE) and provocative concentration of methacholine inducing a 20% fall in forced expiratory volume in 1 s (PC20) levels, as well as FEV1 to forced vital capacity (FEV1/FVC) ratio. (3) Results: Eighteen miRNAs from eosinophils were identified to be significantly different between affected individuals and unaffected ones. Based on counts from these miRNAs, individuals were then clustered into groups using Ward’s method on Euclidian distances. Groups were found to be explained by asthma diagnosis, familial history of respiratory diseases and allergic rhinitis as well as neutrophil counts. (4) Conclusions: The 18 differential miRNA counts for the studying phenotypes allow a better understanding of the epigenetic mechanisms underlying the development of the allergic diseases included in the atopic march.

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Clinical manifestations of allergic rhinitis in children at Denpasar Hospital

Paediatrica Indonesiana ◽

10.14238/pi41.3.2001.160-5 ◽

2001 ◽

Vol 41 (3) ◽

pp. 160

Author(s):

Gary Adhianto ◽

Hendra S

Keyword(s):

Allergic Rhinitis ◽

Atopic Dermatitis ◽

Clinical Manifestations ◽

Signs And Symptoms ◽

Allergic Diseases ◽

Prick Test ◽

Pediatric Allergy ◽

The Family ◽

History Of ◽

Reported Data

This is a retrospective study by collecting data from the medical record of children diagnosed as allergic rhinitis at the Pediatric Allergy & Immunology out patient clinic at Denpasar Hospital between January 1996 and December 2000. Reported data including identifying patient, signs and symptoms, atopic history of the family, skin prick test (SPT) result and the environmental factors. Fifty-five from 297 children (18.5%) attending the Pediatric Allergy & Immunology out patient clinic were diagnosed as allergic rhinitis. Thirty nine were male and 16 female. The age ranged from 6 months to 15 years old. The majority of signs and symptom were sneezing and rhinorrhea (26%), itchy nose (23%), blocked nose (14%) and itchy eyes(12%).. Four children had history of atopic dermatitis, 1 food allergy, 10 asthma, 3 urticaria, 2 drug allaaaergy, 4 h-ad history of both atopic dermatitis and urticaria, 13 both asthma and urticaria, 2 both asthma and drug allergy and 6 children had no history of allergic diseases. Thirty three (60%) one of the parents and 12 (21.8%) both parents ever had allergic diseases. According to SPT, 27 (55.1%) of this children had positive reaction to inhalant allergen, 13 (26.5%) to food allergen and 13 (26.5%) had negative reaction.

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The AAA Risk Factors Scale: A New Model to Screen for the Risk of Asthma, Allergic Rhinitis and Atopic Dermatitis in Children

Medical Principles and Practice ◽

10.1159/000490704 ◽

2018 ◽

Vol 27 (5) ◽

pp. 472-480 ◽

Cited By ~ 5

Author(s):

Souheil Hallit ◽

Chantal Raherison ◽

Diana Malaeb ◽

Rabih Hallit ◽

Nelly Kheir ◽

...

Keyword(s):

Risk Factors ◽

Allergic Rhinitis ◽

Atopic Dermatitis ◽

Allergic Disease ◽

Disease Risk ◽

Allergic Diseases ◽

Parental History ◽

Respiratory Problems ◽

History Of ◽

Or History

Objective: To create an allergic disease risk factors scale score that would screen for the risk assessment of asthma, allergic rhinitis and atopic dermatitis (AD) in children from 3 to 17 years. Methods: This case-control study, conducted between December 2015 and April 2016, enrolled 1,274 children. The allergic disease risk factors scale was created by combining environmental, exposure to toxics during pregnancy and breastfeeding and parental history of allergic diseases. Results: Playing on carpets, male gender, child’s respiratory problems or history of eczema before the age of 2 years, and humidity significantly increased the odds of allergies in the child. Maternal waterpipe smoking, maternal history of rhinitis, history of asthma in the mother or the father, along with the maternal drug intake or alcohol consumption during pregnancy significantly increased the odds of allergies in the child. There was a significant increase in allergy diseases per category of the allergic disease risk factors scale (p < 0.001 for trend). Scores ≤2.60 best represented control individuals, while scores > 5.31 best represented children with allergic diseases. Conclusion: Allergic diseases seem to be linked to several risk factors in our population of school children. Many environmental factors might be incriminated in these allergic diseases.

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Increasing Severity of Early-Onset Atopic Dermatitis, But Not Late-Onset, Associates with Development of Aeroallergen Sensitization and Allergic Rhinitis in Childhood

10.22541/au.162577238.82748980/v1 ◽

2021 ◽

Author(s):

Ann-Marie Malby Schoos ◽

Bo Chawes ◽

Klaus Bønnelykke ◽

Jakob Stokholm ◽

Morten Rasmussen ◽

...

Keyword(s):

Allergic Rhinitis ◽

Atopic Dermatitis ◽

Prospective Studies ◽

Early Onset ◽

Late Onset ◽

Skin Barrier ◽

Allergic Diseases ◽

Severe Atopic Dermatitis ◽

Early Exposure ◽

Time Points

Background: Early exposure to allergens through a defect skin barrier has been proposed as a mechanism for inducing sensitization and development of allergic diseases. We hypothesized that early-onset, severe atopic dermatitis (AD) is associated with development of aeroallergen sensitization and allergic rhinitis. Methods: We included 368 children from the Copenhagen Prospective Studies on Asthma in Childhood (COPSAC ) at-risk mother-child cohort. AD was diagnosed prospectively based on Hanifin&Rajka’s criteria and severity assessed using the Scoring Atopic Dermatitis (SCORAD) index. Early-onset AD was defined as debut ≤1 year, late-onset as debut from 1-6 years. Aeroallergen sensitization and allergic rhinitis were diagnosed at ages 6-7 and 12 years. Associations between early-onset and late-onset AD and allergy endpoints were calculated using general estimating equations (GEE) models to compute the overall odds ratios (OR) for both time points. Results: Early-onset AD (yes/no) and severity (SCORAD) were associated with development of aeroallergen sensitization during childhood; GEE OR=1.68 [1.08; 2.62], p=0.02 and 1.08 [1.03; 1.12], p<0.001, whereas late-onset was not; GEE OR=1.65 [0.92; 2.94], p=0.08 and 1.01 [0.97; 1.06], p=0.55. The same trend was seen for allergic rhinitis with significant association between early-onset AD and allergic rhinitis; GEE OR=1.56 [1.01; 2.41], p=0.04 and severity; GEE OR=1.09 [1.05; 1.13], p<0.001, whereas late-onset AD showed no association. The effects on sensitization and rhinitis of early-onset vs. late-onset AD severity were significantly different: p-interaction =0.03 and p-interaction <0.01. Conclusion: Increasing severity of early-onset AD, but not late-onset AD, associates with aeroallergen sensitization and allergic rhinitis later in childhood.

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Clinical manifestations of atopy in children up to two years of age

Vojnosanitetski pregled ◽

10.2298/vsp1108690i ◽

2011 ◽

Vol 68 (8) ◽

pp. 690-695 ◽

Cited By ~ 1

Author(s):

Nevenka Ilic ◽

Vesna Velickovic ◽

Dragoljub Djokic ◽

Nebojsa Rankovic ◽

Gordana Kostic ◽

...

Keyword(s):

Allergic Rhinitis ◽

Atopic Dermatitis ◽

Clinical Manifestations ◽

Allergic Diseases ◽

Developed Countries ◽

Specific Ige ◽

Food Allergies ◽

Atopic Diseases ◽

Ige Antibodies ◽

Total Ige

Background/Aim. Atopic diseases such as atopic dermatitis, allergic rhinitis and asthma have had increased prevalence during the past decade and nowadays occur in every third child in developed countries. The aim of the study was to determine frequency and type of atopic diseases at the age of two, as well as the importance the total IgE antibodies concentrations have in diagnosis and prognosis of the disease. Methods. The study involved 175 children up to two years of age. Allergy-like symptoms were found after surveying their parents and pediatric medical records. Using the fluorescence immunossay (FIA) method, total IgE antibodies concentrations and specific IgE antibodies (Phadiatop infant) were determined on an Immunocap 100 Dyagnostic System. Results. One or more allergy-like symptoms accounted for 57.7% of findings in children under the age of two, whilst in 19.4% the existence of IgE-related allergic diseases was found. Atopic diseases usually have clinical manifestations of atopic dermatitis (11.4%), IgE-bound wheezing/asthma (10.8%) and food allergies (7.4%), and to much lesser extent those of allergic rhinitis (3.4%) and urticaria (1.7%). The significantly higher total IgE antibodies concentrations were found in children with allergy-like symptoms (p < 0.0005) (cut-off 15.15 kU/L, sensitivity 76.5% specificity 71.6%). Conclusion. Almost 20% of two-year-old children have any of clinically manifested allergic diseases, with atopic dermatitis and IgE wheeze/asthma being predominant. The higher total IgE antibodies concentration is a good marker for sensitization in children with allergy-like symptoms.

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Significance of the epidermal barrier and sensitisation to household allergens to the development of atopic march for primary prevention

Bulletin of Siberian Medicine ◽

10.20538/1682-0363-2018-2-114-120 ◽

2018 ◽

Vol 17 (2) ◽

pp. 114-120

Author(s):

E. E. Varlamov ◽

A. N. Pampura ◽

A. N. Asmanov

Keyword(s):

Allergic Rhinitis ◽

Early Childhood ◽

Atopic Dermatitis ◽

Primary Prevention ◽

Bronchial Asthma ◽

Allergic Diseases ◽

The State ◽

Older Age ◽

Epidermal Barrier ◽

Atopic March

Atopic march is a variant flowing of atopia that begins in early childhood as atopic dermatitis, then developinto other allergic diseases (bronchial asthma, allergic rhinitis) at an older age. The state of the epidermal barrier and sensitization to inhaled allergens are considered as predictors for the development of atopic march. Data on the importance of these factors in the development of atopic march and information about possible approaches to prevention are presented in this article.

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Children with allergic diseases have an increased subsequent risk of migraine upon reaching school age

Journal of Investigative Medicine ◽

10.1136/jim-2018-000715 ◽

2018 ◽

Vol 66 (7) ◽

pp. 1064-1068 ◽

Cited By ~ 2

Author(s):

Chang-Ching Wei ◽

Cheng-Li Lin ◽

Te-Chun Shen ◽

An-Chyi Chen

Keyword(s):

Allergic Rhinitis ◽

Atopic Dermatitis ◽

Allergic Disease ◽

Allergic Conjunctivitis ◽

Cumulative Effect ◽

Allergic Diseases ◽

School Age ◽

Increasing Trend ◽

History Of ◽

Subsequent Risk

The association between migraine and allergy has remained a subject of debate for more than a century. To systemically investigate the interaction between children with antecedent allergic diseases and their future risks of migraine on reaching school age, we recruited 16,130 children aged 7–18 with migraine diagnosed between 2000 and 2008, and 64,520 matched controls without a history of migraine. The ORs of migraine were calculated for the association with allergic diseases diagnosed before migraine diagnosis. The allergic diseases included atopic dermatitis, allergic conjunctivitis, allergic rhinitis (AR), and asthma. Children with preceding allergic diseases had a greater subsequent risk of migraine than the controls. Among the four evaluated diseases, AR had the highest adjusted OR (aOR) of 2.17 (95% CI 2.09 to 2.26). Children with all four allergic diseases had the highest aOR of 3.59 (95% CI 2.91 to 4.44). Further, an increasing trend of aORs was observed with more allergic disease-associated medical consulting. Our study indicates that children with allergic diseases are at increased subsequent risk of migraine when they reach school age, and the risk shows a cumulative effect of more allergic diseases and more allergy-related healthcare.

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Association among Thyroid Dysfunction, Asthma, Allergic Rhinitis and Eczema in Children with Alopecia Areata

Open Access Macedonian Journal of Medical Sciences ◽

10.3889/oamjms.2017.050 ◽

2017 ◽

Vol 5 (3) ◽

pp. 305-309 ◽

Cited By ~ 1

Author(s):

Javad Ghaffari ◽

Ghasem Rahmatpour Rokni ◽

Armaghan Kazeminejad ◽

Hosein Abedi

Keyword(s):

Allergic Rhinitis ◽

Atopic Dermatitis ◽

Alopecia Areata ◽

Allergic Diseases ◽

Control Group ◽

Case Group ◽

Control Groups ◽

Significant Difference ◽

History Of ◽

And Control

BACKGROUND: Alopecia areata is a non-scarring hair loss, which typically starts quickly. Atopy is one of the possible predisposing risk factors for this condition.AIM: This study aimed to evaluate the prevalence of thyroid disease, atopic dermatitis and allergic diseases in children with alopecia areata and compare the results with healthy individuals.METHODS: This case-control study was conducted on 50 patients with alopecia areata, diagnosed by a dermatologist, and 150 healthy individuals as the control group. Participants filled the questionnaires, and necessary tests were performed.RESULTS: In this study, the mean age of the participants was 2.55 Â± 14.26 and 3.19 Â± 11.92 in the case and control groups, respectively. Prevalence of asthma was 22% in the case group and 12.5% in control group (P = 0.109). Also, allergic rhinitis and eczema were observed in 20% and 22% of the subjects of the case group, whereas they were reported to be 8% and 10% in the control group (PV = 0.03 and 0.175, respectively). Moreover, 28% and 8% of the participants in the case and control groups had a family history of atopy and allergic disorders, respectively (P = 0.046). A significant difference was observed between the two groups regarding gender, type of delivery and contact with animals.CONCLUSIONS: According to the results of this study, a significant association was observed between the prevalence of alopecia areata and atopic conditions, such as allergic rhinitis and history of atopic dermatitis.

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A case of atopic dermatitis with a severe resistant course in adult patient with atopic march

Rossiiskii Allergologicheskii ZHurnal ◽

10.36691/rja1369 ◽

2020 ◽

Vol 17 (2) ◽

pp. 69-73

Author(s):

Galiya M. Tusupbekova ◽

Aigul A. Syzdykova ◽

Botagoz M. Davletova

Keyword(s):

Atopic Dermatitis ◽

Adult Patient ◽

Clinical Symptoms ◽

Clinical Manifestations ◽

Allergic Diseases ◽

Atopic Disease ◽

Significant Others ◽

Natural Course ◽

Atopic March ◽

Typical Sequence

Introduction. The atopic march is the natural course of development of atopy symptoms. It is characterized by a typical sequence of development of clinical symptoms of atopic disease, when some symptoms become more significant, others are recede. Timely allergological diagnostics with the identification of causal allergens allows to preventor suspend the atopic march. Purpose of the study was to demonstrate the stages of the atopic march formation and clinical manifestations of atopy, the importance of on timely detection of causal allergens, the capability of modern diagnostics and treatment of severe resistant forms of allergic diseases.

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Factors Associated with Atopic Dermatitis and Allergic Rhinitis among Residents of Two Municipal Areas in South Korea

Medicina ◽

10.3390/medicina55050131 ◽

2019 ◽

Vol 55 (5) ◽

pp. 131 ◽

Cited By ~ 1

Author(s):

Dilaram Acharya ◽

Bishnu Bahadur Bajgain ◽

Seok-Ju Yoo

Keyword(s):

Risk Factors ◽

Allergic Rhinitis ◽

Atopic Dermatitis ◽

Family History ◽

Allergic Disease ◽

Multivariate Logistic Regression Analysis ◽

Allergic Diseases ◽

Factors Associated ◽

History Of ◽

Significant Factors

Background and Objectives: The growing burden and deleterious health consequences of allergic diseases, especially of allergic rhinitis (AR) and atopic dermatitis (AD), in developed countries remains an important public health issue. The current study aimed to assess the prevalence and to identify the risk factors of atopic dermatitis and allergic rhinitis among residents of Pohang-Si and Yeongdeok-Gun, two municipal areas in South Korea. Materials and Methods: A cross-sectional study was conducted in both municipal areas between 12 November and 13 December 2017. A total of 302 subjects were recruited from 100 households (25 apartments and 25 houses in each municipality), by system extraction according to district code numbers. Data were collected using International Study of Asthma and Allergies in Childhood (ISAAC) Standard Questionnaires for children and a health questionnaire for adults. Risk factors were identified by multivariate logistic regression analysis. Results: Of the 302 study participants, 12.9% and 25.5% had AD and AR, respectively. The significant factors associated with AD by multivariate logistic regression analysis were age ≥19 years (aOR (adjusted odds ratio) 6.9; 95% CI (confidence interval) (2.9–16.37)), residence in Pohang-Si (aOR 2.5; 95% CI (1.18–5.53)), and family history of allergic disease (aOR 2.3; 95% CI (1.09–4.9)). Similarly, the significant factors associated with AR were male gender (aOR 2.3; 95% CI (1.24–4.42)), age ≥19 years (aOR 4.4; 95% CI (2.28–8.48)), residence in Pohang-Si (aOR 2.8; 95% CI (1.51–5.37)), and family history of allergic disease (aOR 6.7; 95% CI (3.50–12.82)). Conclusion: The present study shows that age ≥19 years, residence in Pohang-Si, and family history of allergic disease are risk factors for AD and AR, and that, additionally, male gender is a risk factor of AR. Understanding the risk factors of allergic diseases can aid the design and implementation of evidence-specific strategies to reduce the long-standing problems associated with allergic disease.

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Atopic Dermatitis—Beyond the Skin

Diagnostics ◽

10.3390/diagnostics11091553 ◽

2021 ◽

Vol 11 (9) ◽

pp. 1553

Author(s):

Mădălina Mocanu ◽

Dan Vâță ◽

Anisia-Iuliana Alexa ◽

Laura Trandafir ◽

Adriana-Ionela Patrașcu ◽

...

Keyword(s):

Atopic Dermatitis ◽

Immunoglobulin E ◽

Negative Impact ◽

Systemic Disease ◽

Clinical Manifestations ◽

Allergic Diseases ◽

Serum Levels ◽

Chronic Inflammatory Disease ◽

Food Allergies ◽

Disease Category

Atopic dermatitis is a chronic inflammatory disease that can arise during the first months of life or at maturity and have a significant negative impact on the quality of life. The main pathogenic mechanism is the breakdown of cutaneous barrier integrity, which is associated with systemic inflammatory immunologic disorders. Atopic dermatitis involves numerous immunologic, allergic, respiratory, and ophthalmologic comorbidities that develop through similar intricate pathogenic phenomena. The atopic march represents the evolution in time of various allergic diseases, of which food allergies often cause the first manifestations of atopy, even from a very young age. Chronic inflammation translated through specific markers, next to increased immunoglobulin E (IgE) serum levels and heterogenous clinical manifestations, argue for the inclusion of atopic dermatitis in the systemic disease category.

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