scholarly journals Effects of topical doxycycline on inflammatory markers in periodontal disease

2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Ricardo Andreu ◽  
Sergio S del Riego
Keyword(s):  
Periodontal Disease ◽  
Inflammatory Markers

scholarly journals Salivary Pro-Inflammatory Markers and Smoking Status Influences the Treatment Effectiveness of Periodontal Disease Patients with Hypertension

2021 ◽  
Vol 18 (14) ◽  
pp. 7364
Author(s):  
Kun-Tsung Lee ◽  
Zhu-Ling Guo ◽  
Nai-Chia Teng ◽  
Kuei-Ling Christine Hsu ◽  
I-Hui Chen ◽  
...  
Keyword(s):  
Periodontal Disease ◽  
Recovery Rate ◽  
Inflammatory Markers ◽  
Treatment Effectiveness ◽  
Smoking Status ◽  
Periodontal Diseases ◽  
Probing Depth ◽  
Before And After ◽  
Therapeutic Procedures ◽  
History Of

Background: Hypertension and periodontal diseases share several risk factors. Inflammation biomarkers in saliva are related to hypertension and periodontal disease. The aim of this study was to explore the role of the salivary inflammatory biomarkers in the treatment effectiveness of patients with hypertension and periodontal disease. Methods: This observational study enrolled 160 subjects diagnosed with periodontitis, 40 of which had a history of hypertension. All subjects had completed scaling and root planning therapeutic procedures within four weeks. The clinical periodontal parameters (i.e., bleeding on probing, plaque control record (PCR), and probing depth (PD)) were evaluated before and after the treatment. Pro-inflammatory markers were determined using a commercial kit. Results: The recovery rate (PD 4–9 mm) in non-hypertensive subjects was significantly higher than in hypertensive subjects (60.47% vs. 52.60%, respectively; p = 0.04). All clinical parameters, excluding PCR, positively correlated with salivary IL-1β at baseline and after completing treatment. Our results showed that increased salivary IL-1β levels were positively associated with decreased PCR (β = −27.65 and p = 0.05) and PD recovery rate (β = −17.05 and p = 0.02) in hypertensive subjects. Conclusions: The present study sheds important light on the clinical use of salivary pro-inflammatory cytokines as valuable biomarkers for predicting the treatment effectiveness of patients suffering from hypertension and periodontitis.

Evaluation of Liver Chemistry Tests and Clinical Parameters in Patients with Periodontal Disease and Chronic Hepatitis C

2017 ◽  
Vol 68 (6) ◽  
pp. 1252-1254
Author(s):  
Dorin Nicolae Gheorghe ◽  
Darian Rusu ◽  
Elena Herascu ◽  
Dora Maria Popescu ◽  
Petra Surlin ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Periodontal Disease ◽  
Chronic Hepatitis C ◽  
Inflammatory Markers ◽  
Metabolic Markers ◽  
Periodontal Inflammation ◽  
Positive Correlations ◽  
Periodontal Medicine ◽  
Gingival Fluid

The concept of periodontal medicine has been created by taking into consideration the strong connection between the development of the periodontal disease and other general conditions. The presence in blood, saliva and gingival fluid of certain inflammatory markers that are common for the two conditions � periodontitis and chronic hepatitis C, that can generate the appearance of the periodontal inflammation, can be an explication for the probable interconnection of the two conditions. The purpose of this pilot study is to investigate whether chronic hepatitis C can be a worsening factor for the development of the periodontal disease, by setting correlations between the periodontal pathology and some metabolic markers of both hepatitis C and periodontitis patients in comparison to periodontitis-only ones. Positive correlations would justify the expansion of the study for a larger group of patients and the dosage of inflammatory markers for biologic fluids such as blood, saliva and gingival fluid.

scholarly journals Periodontal disease and atherosclerosis

2014 ◽  
Vol 13 (3) ◽  
pp. 208-216
Author(s):  
Jeferson Freitas Toregeani ◽  
Carlos Augusto Nassar ◽  
Krischina Aparecida Mendes Toregeani ◽  
Patrícia Oehlmeyer Nassar
Keyword(s):  
Periodontal Disease ◽  
Inflammatory Markers ◽  
Arterial Wall ◽  
Wall Thickening ◽  
Review Of Literature ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
High Prevalence ◽  
Using Data ◽  
Global Population

Atherosclerotic disease (AD) is one of the most important causes of morbidity and mortality in the world. It expresses inflammatory markers such as C-reactive protein (CRP) and can provoke arterial wall thickening, which can be evaluated using Doppler ultrasound. Risk factors associated with AD include diabetes mellitus, systemic arterial hypertension, dyslipidemia and smoking. More recently, periodontal disease (PD) has been identified as a factor related to AD. Periodontal disease has a high prevalence in the global population and the inflammatory process and bacterial activity at the periodontium appear to increase the risk of AD. Encouraging good oral hygiene can reduce expression of inflammatory markers of AD. A review of literature on PD, AD and inflammatory markers and the interrelationships between the two diseases was conducted using data published in articles indexed on the PUBMED, SCIELO and BIREME databases.

scholarly journals Gender-Specific Associations of Serum Antibody toPorphyromonas gingivalisand Inflammatory Markers

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Michiko Furuta ◽  
Yoshihiro Shimazaki ◽  
Shunichi Tanaka ◽  
Kenji Takeuchi ◽  
Yukie Shibata ◽  
...  
Keyword(s):  
Periodontal Disease ◽  
Antibody Titer ◽  
Inflammatory Markers ◽  
Serum Antibody ◽  
C Reactive Protein ◽  
Periodontal Health ◽  
Reactive Protein ◽  
Retrospective Study Design ◽  
Gender Specific ◽  
Serum Antibody Titer

It remains unclear whether serum antibody titer againstPorphyromonas gingivalis(Pg) and inflammatory components lead to periodontal deterioration in each gender, as periodontal and systemic status is influenced by gender. The present study investigates the gender-specific probable effects of titer againstPgand inflammatory markers on periodontal health status in a longitudinal study. A retrospective study design was used. At two time points over an 8-year period (in 2003 and 2011), 411 individuals (295 males with a mean age of 57.6 ± 11.2 years and 116 females with a mean age of 59.2 ± 10.3 years) were surveyed. Periodontal status, serum antibody titer againstPg, and high-sensitive C-reactive protein (hsCRP) were evaluated. Poisson regression analyses revealed that the elevated titer againstPgand hsCRP significantly predicted the persistence of periodontal disease 8 years later in females with periodontal disease in 2003. Elevated hsCRP was significantly associated with the incidence of periodontal disease 8 years later in females who were periodontally healthy in 2003. Males had a weaker association among titer againstPg, inflammatory markers, and periodontal disease. These findings suggest that immune response toPginfection in addition to inflammatory components affects periodontal deterioration in females.

scholarly journals Gingival crevicular fluid in the diagnosis of periodontal and systemic diseases

2009 ◽  
Vol 137 (5-6) ◽  
pp. 298-303 ◽  
Author(s):  
Sasa Cakic
Keyword(s):  
Diabetes Mellitus ◽  
Periodontal Disease ◽  
Inflammatory Markers ◽  
Host Response ◽  
Gingival Crevicular Fluid ◽  
Periodontal Pocket ◽  
Systemic Diseases ◽  
Noninvasive Methods ◽  
First Case ◽  
Crevicular Fluid

Gingival crevicular fluid (GCF) can be found in the physiologic space (gingival sulcus), as well as in the pathological space (gingival pocket or periodontal pocket) between the gums and teeth. In the first case it is a transudate, in the second an exudate. The constituents of GCF originate from serum, gingival tissues, and from both bacterial and host response cells present in the aforementioned spaces and the surrounding tissues. The collection and analysis of GCF are the noninvasive methods for the evaluation of host response in periodontal disease. These analyses mainly focus on inflammatory markers, such as prostaglandin E2, neutrophil elastase and ?-glucuronidase, and on the marker of cellular necrosis - aspartat aminotransferase. Further, the analysis of inflammatory markers in the GCF may assist in defining how certain systemic diseases (e.g., diabetes mellitus) can modify periodontal disease, and how peridontal disease can influence certain systemic disorders (atherosclerosis, preterm delivery, diabetes mellitus and some chronic respiratory diseases). Major factors which influence the results obtained from the analyses of GCF are not only the methods of these analyses, but the method of GCF collection as well. As saliva collection is less technique-sensitive than GCF collection, some constituents of saliva which originate from the GCF can be analyzed as more amenable to chairside utilization.

scholarly journals Lipid Peroxidation Is Associated with the Severity of Periodontal Disease and Local Inflammatory Markers in Patients with Type 2 Diabetes

2012 ◽  
Vol 97 (8) ◽  
pp. E1353-E1362 ◽  
Author(s):  
Alliny S. Bastos ◽  
Dana T. Graves ◽  
Ana Paula de Melo Loureiro ◽  
Carlos Rossa Júnior ◽  
Dulcinéia Saes Parra Abdalla ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Lipid Peroxidation ◽  
Periodontal Disease ◽  
Inflammatory Markers
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