scholarly journals COCs containing dienogest and 30 µg ethinylestradiol may carry a higher VTE risk compared to corresponding preparations with levonorgestrel: A meta-analysis of four large cohort studies

2020 ◽  
Vol 5 (1) ◽  
Author(s):  
Jürgen Dinger
Keyword(s):  
Cohort Studies ◽  
Meta Analysis ◽  
Large Cohort

Cardiovascular events associated with androgen deprivation therapy in patients with prostate cancer: A systematic review and meta-analysis.

2014 ◽  
Vol 32 (4_suppl) ◽  
pp. 40-40
Author(s):  
Arie Carneiro ◽  
Andre Deeke Sasse ◽  
Andrew Wagner ◽  
Bruno Toneto ◽  
Ary Serpa Neto ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cohort Studies ◽  
Cancer Patients ◽  
Androgen Deprivation Therapy ◽  
Cardiovascular Mortality ◽  
Cardiovascular Events ◽  
Meta Analysis ◽  
Androgen Deprivation ◽  
Cardiovascular Morbidity ◽  
Large Cohort

40 Background: A recently published meta-analysis of randomized clinical trials (RCT) showed that androgen deprivation therapy (ADT) did not significantly increase cardiovascular mortality in prostate cancer patients. However, cardiovascular morbidity, which can impact quality of life, was not evaluated. Objectives: To evaluate the risk of cardiovascular morbidity and mortality associated with long-term ADT in patients with prostate cancer. Methods: We conducted a literaturesearch from 1960 and June 2012. We selected RCT and large cohort studies that evaluated first-line endocrine therapy, ADT greater than 6 months, and follow up greater than 1 year. Results: Thirteen studies (137,658 patients) were included. Of four cohort studies, 126,898 patients were included and 10,760 patients were part of nine RCTs. Analysis of the RCTs showed no differences in development of acute myocardial infarction (AMI) (OR 1.23; 95% CI: 0.92 – 1.64; I2: 0%) or stroke (OR 1.02; 95% CI: 0.71 – 1.46; I2: 0%) among patients receiving ADT or not. The analysis of three randomized studies that reported other nonfatal cardiovascular events demonstrated a significant increase in such events in the group receiving ADT (OR 1.55; 95% CI: 1.09 – 2.20; I2: 0%). When large cohort studies were included in the analysis, an increased risk of AMI among men who had ADT was found ( OR 2.01, 95% CI:1.90 – 2.13; I2: 91.3%). Conclusions: ADT in prostate cancer patients for at least 6 months is not associated with cardiovascular mortality, acute myocardial infarct and stroke. However, patients receiving ADT had a significant increase in nonfatal cardiovascular events.

scholarly journals The Associations of Diuretics and Laxatives Use with Cardiovascular Mortality. An Individual Patient-Data Meta-analysis of Two Large Cohort Studies

2019 ◽  
Vol 33 (5) ◽  
pp. 567-579
Author(s):  
Liesa Katharina Hoppe ◽  
Dana Clarissa Muhlack ◽  
Wolfgang Koenig ◽  
Hermann Brenner ◽  
Ben Schöttker
Keyword(s):  
Cohort Studies ◽  
Cardiovascular Mortality ◽  
Individual Patient Data ◽  
Meta Analysis ◽  
Patient Data ◽  
Large Cohort
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