scholarly journals ROLE OF CYTOKINE-MEDIATED MECHANISMS IN DEVELOPMENT OF POST-TRAUMATIC MANDIBULAR OSTEOMYELITIS

2019 ◽  
Vol 21 (5) ◽  
pp. 953-958
Author(s):  
E. V. Paskova ◽  
E. V. Markelova ◽  
K. I. Shakhgeldyan ◽  
B. I. Geltser ◽  
A. B. Kriger
Keyword(s):  
Prognostic Significance ◽  
Mandibular Fracture ◽  
Interleukin 4 ◽  
Mandibular Fractures ◽  
Interleukin 17 ◽  
Posttraumatic Osteomyelitis ◽  
Post Traumatic ◽  
Binary Classifiers ◽  
Mixed Saliva

Osteomyelitis of the lower jaw is one of the urgent problems of modern medicine. There are many reasons for the evolvement of purulent necrotic processes of the jaw bones, including the role of disorders in the systems of innate and adaptive immunity. The aim of the study was to determine the content of TNFα, IL-17, IL-4 in serum and mixed saliva in patients with uncomplicated mandibular fractures and posttraumatic osteomyelitis to determine the possibility of using these indicators for early diagnosis of posttraumatic complications. The article presents the results of a study of tumor necrosis factor α (TNFα), interleukin-17 (IL-17) and interleukin-4 (IL-4) cytokines in serum and mixed saliva in patients with uncomplicated mandibular fracture and post-traumatic osteomyelitis at the first and tenth days of observation. By means of single-layer neural networks, binary classifiers were built, allowing patients to be stratified by the clinical form of the disease and to predict its course. The probability of uncomplicated mandibular fracture is described by the ratio P = 1/(1+e-z), where the index z is determined by the level of TNFα, IL-17, and IL-4 at the first and tenth day of observation. The simulation confirmed high prognostic significance of serum TNFα and IL-17 for early verification of posttraumatic osteomyelitis, which was confirmed by the OTC and ROC indices, which varied from 87 to 100% in different models. Models 4 and 5, where TNFα recorded on the tenth day of the study was used as predictors, and a combination of TNFα and IL-17 obtained on the first day of hospitalization, were the most accurate. Modeling the results of the study of immunological indicators in the mixed saliva showed that the predictive properties have only IL-4 and IL-17, was on the tenth day of hospitalization that distinguishes these binary classifiers from similar indexes, derive from the levels of cytokines in blood serum. The results of the study indicate the important role of disorders in the system of рro- and anti-inflammatory cytokines in pathogenesis of post-traumatic osteomyelitis.

scholarly journals Recovery of Post-Traumatic Temporomandibular Joint after Mandibular Fracture Immobilization: A Literature Review

2021 ◽  
Vol 11 (21) ◽  
pp. 10239
Author(s):  
Carmen Gabriela Stelea ◽  
Doriana Agop-Forna ◽  
Raluca Dragomir ◽  
Codrina Ancuţa ◽  
Roland Törok ◽  
...  
Keyword(s):  
Temporomandibular Joint ◽  
Real Life ◽  
Mandibular Fracture ◽  
Temporomandibular Joint Disorders ◽  
Treatment Modalities ◽  
Mandibular Fractures ◽  
Traumatic Injuries ◽  
Joint Fractures ◽  
Post Traumatic ◽  
Mandible Fractures

Considered as one of the most common traumatic injuries of the maxillofacial region, mandibular fractures remain among the complex causes of temporomandibular joint disorders (TMDs). Due to the complexity of the temporomandibular joint, the management of TMDs represents a challenge in real-life practice; although many treatment modalities have already been proposed, ranging from conservative options to open surgical procedures, a consensus is still lacking in many aspects. Furthermore, despite continuous improvement of the management of mandible fractures, the duration of immobilization and temporary disability is not reduced, and the incidence of complications remains high. The aim of the present study is to (i) review anatomophysiological components of temporomandibular joint; (ii) review concepts of temporomandibular joint fractures; and (iii) describe methods of the recovery of the temporomandibular joint after mandibular fracture immobilization.

scholarly journals Multiplex-Heterogeneous Network-Based Capturing Potential SNP “Switches” of Pathways Associating With Diverse Disease Characteristics of Asthma

2021 ◽  
Vol 9 ◽  
Author(s):  
Ming-Yu Ran ◽  
Zhang Yuan ◽  
Chui-Ting Fan ◽  
Zhou Ke ◽  
Xin-Xing Wang ◽  
...  
Keyword(s):  
Airway Remodeling ◽  
Internal Communication ◽  
Interleukin 4 ◽  
Receptor Interaction ◽  
Interleukin 17 ◽  
Respiratory Disorder ◽  
Pathway Network ◽  
Disease Characteristics ◽  
Low Dimensional

Asthma is a complex heterogeneous respiratory disorder. In recent years nubbly regions of the role of genetic variants and transcriptome including mRNAs, microRNAs, and long non-coding RNAs in the pathogenesis of asthma have been separately excavated and reported. However, how to systematically integrate and decode this scattered information remains unclear. Further exploration would improve understanding of the internal communication of asthma. To excavate new insights into the pathogenesis of asthma, we ascertained three asthma characteristics according to reviews, airway inflammation, airway hyperresponsiveness, and airway remodeling. We manually created a contemporary catalog of corresponding risk transcriptome, including mRNAs, miRNAs, and lncRNAs. MIMP is a multiplex-heterogeneous networks-based approach, measuring the relevance of disease characteristics to the pathway by examining the similarity between the determined vectors of risk transcriptome and pathways in the same low-dimensional vector space. It was developed to enable a more concentrated and in-depth exploration of potential pathways. We integrated experimentally validated competing endogenous RNA regulatory information and the SNPs with significant pathways into the ceRNA-mediated SNP switching pathway network (CSSPN) to analyze ceRNA regulation of pathways and the role of SNP in these dysfunctions. We discovered 11 crucial ceRNA regulations concerning asthma disease feature pathway and propose a potential mechanism of ceRNA regulatory SNP → gene → pathway → disease feature effecting asthma pathogenesis, especially for MALAT1 (rs765499057/rs764699354/rs189435941) → hsa-miR-155 → IL13 (rs201185816/rs1000978586/rs202101165) → Interleukin-4 and Interleukin-13 signaling → inflammation/airway remodeling and MALAT1 (rs765499057/rs764699354/rs189435941) → hsa-miR-155 → IL17RB (rs948046241) → Interleukin-17 signaling (airway remodeling)/Cytokine-cytokine receptor interaction (inflammation). This study showed a systematic and propagable workflow for capturing the potential SNP “switch” of asthma through text and database mining and provides further information on the pathogenesis of asthma.

scholarly journals Assessment of the Role of the Mandibular First Molar Tooth in Mandibular Fracture Patterns of 29 Dogs

2019 ◽  
Vol 36 (1) ◽  
pp. 32-39 ◽  
Author(s):  
Ellen Scherer ◽  
Scott Hetzel ◽  
Christopher J. Snyder
Keyword(s):  
Mandibular Fracture ◽  
Fracture Repair ◽  
Molar Tooth ◽  
Mandibular Fractures ◽  
Fracture Classification ◽  
Imaging Evaluation ◽  
Structural Support ◽  
Fracture Patterns ◽  
Mandibular First Molar

Mandibular fractures at the level of the first molar tooth (M1) were assessed in 29 dogs. Patients included in this study demonstrated fractures involving the M1 tooth, tooth bud, or alveolus (if tooth was absent). Diagnostic imaging evaluation included intraoral dental radiography and/or computed tomography (CT) with 3D reconstruction. The distal root was involved in 55.2% of cases, mesial root involvement in 34.5% of cases, and the tooth was absent in 10.3% of cases. Fractures were described in the rostral-to-caudal direction. Fractures tended to occur in the caudoventral direction ( P = .057). Cases with CT imaging were also evaluated in the buccolingual direction. Fractures were found to occur significantly more frequently in the caudolingual direction ( P = .022). When classifying fracture patterns along M1 according to a previously published fracture classification system, it was noted that fractures occurred significantly more frequently in either the mesial ( P < .001) or distal ( P < .001) roots by coursing along the periodontal ligament space and communicating with the periapical region. Active or nonworsening periodontitis was described as radiographic or tomographic evidence of (>25%) bone loss in the vertical or horizontal direction. Periodontitis was associated with 7 (24.1%) cases. These results help frame the challenges associated with fracture repair at the M1 location. Treatment planning considerations should include limited structural support caudal to fractures involving the distal root, more frequent involvement of the distal root over the mesial root, risk for poor endodontic prognosis, and the predilection for unfavorable fracture patterns to occur.

The Role of Stress Sensitization in Progression of Post-Traumatic Distress Following Deployment

2012 ◽  
Author(s):  
Geert Smid ◽  
Rolf Kleber ◽  
Arthur Rademaker ◽  
Mirjam van Zuiden ◽  
Eric Vermetten
Keyword(s):  
Stress Sensitization ◽  
Post Traumatic ◽  
Traumatic Distress

Levels interleukine-4 and interleukin-17 (IL-4, IL-17) of blood in patients with habitual recurrent pregnancy loss, which occurred in a loop in vitro fertilization

2016 ◽  
pp. 137-139
Author(s):  
K.P. Golovatyuk ◽  
Keyword(s):  
In Vitro Fertilization ◽  
Conditioned Medium ◽  
Mononuclear Cells ◽  
Recurrent Miscarriage ◽  
Interleukin 4 ◽  
Control Group ◽  
Interleukin 17 ◽  
Vitro Fertilization ◽  
Blood Mononuclear Cells

The objective: was to investigate the levels of cytokines IL-4 and IL-17 in serum and conditioned medium cultures of blood mononuclear cells (MNC) and evaluation association between their products and miscarriage, which occurred in IVF cycles. Patients and methods. We observed 240 patients with recurrent miscarriage, came in IVF cycles, and 100 apparently healthy fertile women in the control group. The concentrations of IL-4 and IL-17 in serum and conditioned medium of MNC cultures were determined. Results. The levels of IL-4 in the serum and conditioned medium in spontaneous and stimulated mitogen secretion was not significantly different from those in the control group, whereas IL-17 levels were higher than those in the control group serum, in conditioned media of stimulated and non-stimulated MNCs. Conclusion. Disregulation of activity of circulating blood mononuclear cells in women with recurrent miscarriage that followed IVF, is accompanied by increased secretion of IL-17 and almost constant production of IL-4 on the back of high stimulation index of production of these cytokines. Key words: in vitro fertilization, miscarriage, interleukin-4, interleukin-17, serum stimulated and non-stimulated mononuclear blood.

EMDR as therapy for conditions other than PTSD: a systematic review.

2020 ◽  
Author(s):  
Charles Scelles ◽  
LUIS CARLO BULNES
Keyword(s):  
Mood Disorders ◽  
Obsessive Compulsive ◽  
Treatment As Usual ◽  
Compulsive Disorder ◽  
Adult Personality ◽  
Post Traumatic ◽  
Psychiatric Conditions ◽  
Research Criteria ◽  
Positive Effect

Eye Movement Desensitization and Reprocessing (EMDR) is a treatment for post-traumatic stressdisorder (PTSD). The technique is known to stimulate the capacity to reprocess maladaptive memoriesthat are thought to be central to this pathology. Here we investigate if EMDR therapy can be used in otherconditions than PTSD. We conducted a systematic literature search on PubMed, ScienceDirect, Scopus, and Web of Science. Wesearched for published empirical findings on EMDR, excluding those centred on trauma and PTSD,published up to 2020. The results were classified by psychiatric categories.   Ninety articles met our research criteria. A positive effect was reported in addictions, somatoformdisorders, sexual dysfunction, eating disorder, disorders of adult personality, mood disorders, reaction tosevere stress, anxiety disorders, performance anxiety, Obsessive-Compulsive Disorder (OCD), pain,neurodegenerative disorders, paedopsychiatry and sleep. The evidence was more consistent in pain, OCD,mood disorders, and reaction to severe stress.EMDR’s efficiency across numerous pathological situations, highlighted the central role of affectivememory in several psychiatric and non-psychiatric conditions. Furthermore, EMDR seems to besuccessful in usually uncooperative (e.g. Dementia) or unproductive cases (e.g. aphasia). Moreover, insome severe medical situations were psychologic distress was an obstacle, EMDR allowed thecontinuation of treatment-as-usual. Our review suggests that it is a safe and economical therapeuticoption, and its effect in non-pathological situations opens new avenues for translational research. Overallmore methodologically rigorous studies are needed.

Sign in / Sign up

Export Citation Format

Share Document