scholarly journals Cardiometabolic risk factors and their relationship with the interleukin-6 receptor gene polymorphism (rs2228145) in patients with hypertrophic cardiomyopathy

2020 ◽  
Vol 25 (10) ◽  
pp. 4098
Author(s):  
T. G. Bezhanishvili ◽  
A. Ya. Gudkova ◽  
V. G. Davydova ◽  
S. E. Andreeva ◽  
A. N. Krutikov ◽  
...  
Keyword(s):  
Risk Factors ◽  
Hypertrophic Cardiomyopathy ◽  
Gene Polymorphism ◽  
Interleukin 6 ◽  
Cardiometabolic Risk ◽  
Receptor Gene ◽  
Disease Onset ◽  
Cardiometabolic Risk Factors ◽  
Control Group ◽  
Interleukin 6 Receptor

Aim. To analyze associations of interleukin-6 receptor gene (IL6R) polymorphism (rs2228145) with the clinical course characteristics of hypertrophic cardiomyopathy (HCM) in groups of patients with various cardiometabolic risk factorsMaterial and methods. The sample consisted of 123 patients with HCM. The age  of the included patients ranged from 18 to 91 years (59 [41; 66.5]), of whom 59 were men, 64 — women. Two age groups were identified: the first group included patients from 18 to 44 years old, the second — 45 years and older. The control group consisted of 200 people without cardiovascular diseases and other severe comorbidities.For genetic testing, DNA was isolated from peripheral blood lymphocytes. Genotyping of the IL6R gene polymorphism (rs2228145) was carried out by realtime polymerase chain reaction.Results. A significant prevalence of CC genotype of the IL6R gene polymorphism (rs2228145) was revealed in patients aged ³45 years compared with the control group, which occurred in 14,1% and 3,0% of cases, respectively (CC:AC+AA, odds ratio (OR), 0,885, 95% confidence interval (CI), 1,051-0,691, p=0,006), and insignificant prevalence of C allele in this group, which does not reach the level of significance (A:C, OR, 0,870, 95% CI, 0,427-1,02, p=0,06). The prevalence of CC genotype (15,1% vs 3,0%) and C allele (39,0% vs 29,0%) was revealed in patients with HCM in combination with hypertension (HTN) compared with the control group (CC:AS+AA, OR=0,174, 95% CI, 0,047-0,650), p=0,004); (A:C, OR=0,638, 95% CI, 0,406-1,002), p=0,05).Conclusion. The relationship between the IL6R gene polymorphism (rs2228145) and HTN in patients with HCM was confirmed. The presence of CC genotype and C allele of the rs2228145 IL6R gene polymorphism is significantly more common in patients with HCM with the disease onset ³45 years of age. The presence of CC genotype and C allele of the IL6R gene polymorphism (rs2228145) is associated with HTN in patients with HCM.

scholarly journals Interleukin-6 Receptor Gene Polymorphism Modulates Interleukin-6 Levels and the Metabolic Syndrome: GBCS-CVD

Obesity ◽  
2010 ◽  
Vol 18 (10) ◽  
pp. 1969-1974 ◽  
Author(s):  
Chao Qiang Jiang ◽  
Tai Hing Lam ◽  
Bin Liu ◽  
Jie Ming Lin ◽  
Xiao Jun Yue ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Gene Polymorphism ◽  
Interleukin 6 ◽  
Receptor Gene ◽  
The Metabolic Syndrome ◽  
Receptor Gene Polymorphism ◽  
Interleukin 6 Receptor

scholarly journals High Intensity Resistance Training Methods with and without Protein Supplementation to Fight Cardiometabolic Risk in Middle-Aged Males: A Randomized Controlled Trial

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Wolfgang Kemmler ◽  
Andreas Wittke ◽  
Michael Bebenek ◽  
Michael Fröhlich ◽  
Simon von Stengel
Keyword(s):  
Risk Factors ◽  
Resistance Training ◽  
High Intensity ◽  
Cardiometabolic Risk ◽  
High Volume ◽  
Protein Supplementation ◽  
Cardiometabolic Risk Factors ◽  
Control Group ◽  
High Intensity Training ◽  
Intensity Training

Time-effective protocols may potentially increase people’s compliance with exercise. The purpose of this paper was to compare the relative effects of 16 weeks of high intensity (resistance) training (HIT) with and without protein supplementation (HIT&P) and HVHIT (high volume/high intensity training) versus a nontraining control group on cardiometabolic risk factors. One hundred and twenty untrained males 30–50 years old were randomly assigned to 3 subgroups: (a) a HIT group; (b) a HIT&P group, and (c) a waiting-control group (phase I) that crossed over to (d) high volume/high intensity training (HVHIT) during the second study phase. HIT was defined as “single set to failure protocol” while HVHIT consistently applied two sets. Protein supplementation provided an overall intake of 1.5 g/kg/body mass. Primary study endpoint was the metabolic syndromeZ-Score (MetS-Z-Score). MetS-Z-Score significantly improved in all exercise groups (p≤0.001) with no significant difference between HIT, HIT&P, and HVHIT (p≥0.829). However, all the exercise groups differed significantly from the CG (p<0.001) which deteriorated significantly (p=0.039). In conclusion, all exercise protocols were similarly effective in improving cardiometabolic risk factors. Thus, HIT may be the best choice for people with low time budgets looking to improve their cardiometabolic health.

scholarly journals Reciprocal Association of Plasma IGF-1 and Interleukin-6 Levels With Cardiometabolic Risk Factors in Nondiabetic Subjects

Diabetes Care ◽  
2008 ◽  
Vol 31 (9) ◽  
pp. 1886-1888 ◽  
Author(s):  
E. Succurro ◽  
F. Andreozzi ◽  
A. Sciaqua ◽  
M. L. Hribal ◽  
F. Perticone ◽  
...  
Keyword(s):  
Risk Factors ◽  
Interleukin 6 ◽  
Cardiometabolic Risk ◽  
Cardiometabolic Risk Factors

scholarly journals Carotid Arterial Stiffness and Cardiometabolic Profiles in Women with Fibromyalgia

Biomedicines ◽  
2021 ◽  
Vol 9 (12) ◽  
pp. 1786
Author(s):  
Yunkyung Kim ◽  
Geun-Tae Kim ◽  
Jihun Kang
Keyword(s):  
Risk Factors ◽  
Arterial Stiffness ◽  
Central Obesity ◽  
Cardiometabolic Risk ◽  
Statistical Significance ◽  
Cardiometabolic Risk Factors ◽  
Control Group ◽  
Increased Risk ◽  
Carotid Arterial ◽  
High Triglyceride

Background: The present study aimed to evaluate the association between FM and cardiometabolic risk factors and carotid arterial stiffness in FM patients. Methods: The cardiometabolic risk profile was defined based on the Adult Treatment Panel III panel. Carotid intimal media thickness (cIMT) and arterial stiffness were assessed using high-resolution ultrasonography. Multivariate logistic analysis was performed to estimate the association between FM and cardiometabolic risk factors. We used a general linear regression to compare the cIMT and carotid beta-index between the participants with and without FM. Pearson’s coefficient was calculated to evaluate the potential correlation between cardiometabolic risk profiles, cIMT, and arterial stiffening in FM. Results: FM participants showed a higher risk of central obesity (odds ratio [OR] = 3.21, 95% confidence interval [CI] 1.49, 6.91), high triglyceride (OR = 4.73, 95% CI 2.29, 9.79), and impaired fasting glucose (IFG) (OR = 4.27, 95% CI 2.07, 8.81) compared to the control group. The FM group exhibited higher beta-index values than the control group (p = 0.003). Although IFG and triglyceride glucose index showed a tendency to correlate with the beta-index, statistical significance was not observed. Conclusions: FM was associated with an increased risk of central obesity, high triglyceride levels, and IFG. Furthermore, advanced arterial stiffness of the carotid artery was observed in FM, which might be correlated with insulin resistance.

C3 gene polymorphism and cardiometabolic risk factors in chronic Chagas disease

Immunobiology ◽  
2016 ◽  
Vol 221 (10) ◽  
pp. 1184
Author(s):  
Fabiana Antunes de Andrade ◽  
Kárita Cláudia Freitas Lidani ◽  
Vanessa Picceli ◽  
Cesar Maistro Guimarães ◽  
Thaisa Lucas Sandri ◽  
...  
Keyword(s):  
Risk Factors ◽  
Gene Polymorphism ◽  
Chagas Disease ◽  
Cardiometabolic Risk ◽  
Cardiometabolic Risk Factors ◽  
C3 Gene ◽  
Chronic Chagas Disease

scholarly journals Sustained Weight Loss and Improvements in Cardiometabolic Risk Factors in a Worksite-based Behavioral Program (FS18-04-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Sai Krupa Das ◽  
Taylor Vail ◽  
Rachel Silver ◽  
Meghan Chin ◽  
Caroline Blanchard ◽  
...  
Keyword(s):  
Risk Factors ◽  
Weight Loss ◽  
Body Fat ◽  
Cardiometabolic Risk ◽  
Controlled Trial ◽  
Intervention Group ◽  
Cardiometabolic Risk Factors ◽  
Control Group ◽  
Average Weight ◽  
Funding Sources

Abstract Objectives To evaluate the effectiveness of a novel low-burden behavioral intervention (BI) for weight loss on changes in body weight and cardiometabolic risk factors when implemented with or without meal replacements (MR). Methods Twelve worksites (≥300 employees each) in the Greater Boston area participated in a cluster-randomized controlled trial, with 8 worksites (n = 259 participants) allocated to the intervention group (IG) and 4 worksites (n = 76) to a wait-listed control group (CG). IG participants were further randomized to receive the BI, which emphasizes hunger and craving management via diet composition, for 18 months without or with MR (BI + MR). Weight and cardiometabolic variables were measured at baseline and 6 months for all groups, and also at 12 and 18 months in the IGs. Linear mixed models compared 6-month changes in % weight loss, body mass index (BMI), body fat, and cardiometabolic risk factors for all groups. Similar analyses were conducted for the BI and BI + MR groups at 12 and 18 months. Estimated means and standard deviations were calculated. Statistical models were adjusted for age, sex, baseline measurement, and worksite. Results The study population was 83% female. The Mean ± SD for age and BMI were 47.9 ± 10.4 years and 32.9 ± 5.5 kg/m2, respectively. At 6 months, average weight loss was 9.2 ± 7.2% for BI and 8.3 ± 7.0% for BI + MR. Weight loss was significantly greater in both IGs than the CG (both P < 0.001), but not significant between IGs (P = 0.35). Similar results were observed for BMI and % body fat (both P < 0.01). BI and BI + MR had significant reductions in glucose and triglycerides (P < 0.05) compared to the CG. Changes in total cholesterol and LDL were significantly greater in BI + MR compared to BI alone (P < 0.05). Clinically significant reductions in weight and cardiometabolic risk factors were sustained in the IGs at 12 and 18 months. Conclusions To our knowledge, weight loss in this study was greater than previous scalable worksite-based interventions. Weight loss did not significantly differ between the BI and BI + MR groups, and MR use was associated with additional reductions in total and LDL cholesterol. These results demonstrate the feasibility of novel approaches to achieve clinically impactful weight management in worksite settings. Funding Sources Nutrient Foods LLC.

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