scholarly journals The Basic Values of Intraocular Pressure Measured by Rebound Tonometry in Guinea Pig

2021 ◽  
Vol 78 (1) ◽  
pp. 38
Author(s):  
Diana Larisa ANCUȚA ◽  
Diana Mihaela ALEXANDRU ◽  
Maria CRIVINEANU ◽  
Răzvan BOTEZATU ◽  
Cristin COMAN
Keyword(s):  
Risk Factor ◽  
Intraocular Pressure ◽  
Guinea Pigs ◽  
Time Intervals ◽  
Human Patient ◽  
Mean Values ◽  
Rebound Tonometry ◽  
Elevated Intraocular Pressure ◽  
The Mean ◽  
The Right

Elevated intraocular pressure (IOP) is the most important risk factor associated with the progression of glaucoma and the research on animal models is constantly evolving. Rebound tonometry has been shown to be useful for the evaluation of IOP, not only for the human patient but also for the animal patient. The aim of the paper is to assess intraocular pressure in guinea pigs in order to establish reference values. IOP was measured for three days, at different time intervals, in 40 guinea pigs, using the iCare Tonovet TV01 tonometer. The mean values obtained in coloured guinea pigs were 13.82 mmHg ± 1.64 mmHg in the right eye, 14.11 mmHg ± 1.68 mmHg in the left eye, and in white guinea pigs 12.56 mmHg ± 0.95 mmHg in the right eye, 13.02 mmHg ± 1.29 mmHg for the left eye. The values obtained from this study it can be concluded that the strain of coloured, records the highest values in the morning, which remain linear during the day, and decrease in the evening compared to the white strain which has a constant evolution during the day, and in the evening increases.

scholarly journals Intraocular pressure measurement in sheep using an applanation tonometer

Revista CERES ◽  
2011 ◽  
Vol 58 (6) ◽  
pp. 685-689 ◽  
Author(s):  
João Antonio Tadeu Pigatto ◽  
Fabiana Quartiero Pereira ◽  
Luciane Albuquerque ◽  
Luis Felipe Dutra Corrêa ◽  
Bernardo Stefano Bercht ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Applanation Tonometry ◽  
Ovis Aries ◽  
Mean Values ◽  
Schirmer Tear Test ◽  
Healthy Sheep ◽  
Applanation Tonometer ◽  
The Mean ◽  
The Right ◽  
Ophthalmic Disease

The purpose of this study was to evaluate and establish the mean values of IOP in healthy adult sheep using an applanation tonometer. Information on age, sex, and breed was obtained for all animals included in this study. Twenty five healthy sheep (Ovis aries), of the same breed (Texel), male or female, with three years of age, received an ophthalmic examination in both eyes, including pupillary reflexes, Schirmer tear test, slit lamp biomicroscopy, and fluorescein staining. For all ophthalmic testing, animals were gently physically restrained, with no pressure in the jugular area and the eyelids were carefully open. IOP was measured by applanation tonometry (Tonopen XL). The same examiner performed the tonometry; measurements were taken three times for each eye, and their average was recorded as the IOP of the animal. Statistical analysis was performed using paired t-test and values of P < 0.05 were considered significant. The mean intraocular pressure in the whole group of 50 eyes was of 16.36 +/- 2.19 mm Hg. The mean (SD) IOP in the right eye was of 15.96 +/- 2.02 mm Hg, while the mean (SD) IOP in the left eye was of 16.76 +/- 2.32 mm Hg. Significant differences in IOP were not found between right and left eyes. The applanation tonometer was adequate for measuring the intraocular pressure in sheep. Reference data will assist in diagnosing testing for ophthalmic disease in sheep, as¹ well as promote further studies in this area.

scholarly journals Bilateral spontaneous crystalline lens dislocation to the anterior chamber: A case report

2013 ◽  
Vol 141 (11-12) ◽  
pp. 800-802 ◽  
Author(s):  
Milos Jovanovic
Keyword(s):  
Intraocular Pressure ◽  
Case Report ◽  
Anterior Chamber ◽  
Crystalline Lens ◽  
Time Intervals ◽  
Lens Dislocation ◽  
Elevated Intraocular Pressure ◽  
History Of ◽  
Sudden Decrease ◽  
The Right

Introduction. There are various reasons for the lens dislocation. Spontaneous dislocation of a clear lens is extremely rare, especially its dislocation to the anterior chamber. Case Outline. The author presents a case of spontaneous clear lens dislocation to the anterior chamber in both eyes in a patient without the history of any trauma. Dislocation occurred spontaneously, first in the left eye, along with a sudden decrease of vision. The ophthalmologist found a clear lens in the anterior chamber, without any sign of an elevated intraocular pressure, as should have been expected. The dislocated lens was removed surgically (intracapsular extraction) with the preventive basal iridectomy. Two years later, the same happened in the right eye: clear lens moved spontaneously to the anterior chamber, with a decrease of vision, but again without any rise of intraocular pressure and/or any pain. Intracapsular extraction of the lens with basal iridectomy was done again. Conclusion. The presented case demonstrates that spontaneous dislocation of the transparent lens to the eye anterior chamber can occur in both eyes at different time intervals. We suggest the removal of dislocated lens in the anterior chamber by the intracapsular extraction.

Therapeutic Effects of Hab Shabyar on Open-Angle Glaucoma: A Double-Blinded, Randomized, Placebo-Controlled Trial

2019 ◽  
Vol 8 ◽  
pp. 1218
Author(s):  
Ebrahim Khalil BaniHabib ◽  
Ali Mostafai ◽  
Seyyed Mohammad Bagher Fazljou ◽  
Ghadir Mohammdi
Keyword(s):  
Placebo Group ◽  
Intraocular Pressure ◽  
Open Angle Glaucoma ◽  
Controlled Trial ◽  
Intervention Group ◽  
Therapeutic Effects ◽  
Open Angle ◽  
The Mean ◽  
The Right ◽  
Double Blinded

Background: Open-angle glaucoma (OAG) is one of the leading causes of blindness worldwide. This study evaluates the therapeutic effects of hab shabyar in patients with open-angle glaucoma. Materials and Methods: In this clinical randomized controlled trial, 50 patients with OAG were randomized into two groups. The intervention group was received a drop of timolol plus 500 mg of hab shabyar every 12 hours. The placebo group was received a drop of timolol every 12 hours plus 500 mg of wheat germ as a placebo. The intraocular pressure in patients with OAG was measured in each group and compared at before the intervention (t1), one month (t2), and two months (t3) after the intervention. Results: The mean decrease in intraocular pressure for the right eye at three times in the intervention group was statistically significant, but the mean decrease in the placebo group was not significant. Similar results were obtained for the left eye at t1 when compared to t3. The patients in the intervention group expressed more satisfaction than the patients in the placebo group (P≤0.001). Conclusion: Our study demonstrated that consumption of timolol plus hab shabyar instead of consuming of timolol alone was probably more effective for reducing intraocular pressure in patients with OAG.[GMJ.2019;In press:e1218]

scholarly journals Minimally Invasive Surgery for Intraocular Lens Removal and Intrascleral Intraocular Lens Fixation with Trabeculectomy in a Patient with Dislocated Intraocular Lens and Elevated Intraocular Pressure

2021 ◽  
pp. 538-542
Author(s):  
Yuko Mano ◽  
Kei Mizobuchi ◽  
Tomoyuki Watanabe ◽  
Akira Watanabe ◽  
Tadashi Nakano
Keyword(s):  
Intraocular Pressure ◽  
Intraocular Lens ◽  
Combined Therapy ◽  
Swept Source ◽  
Needle Technique ◽  
Elevated Intraocular Pressure ◽  
Anterior Segments ◽  
The Right ◽  
End Stage

A 88-year-old female who was being treated for end-stage pseudoexfoliation syndrome was referred to our hospital for treatment of dislocated intraocular lens (IOL) and the elevated intraocular pressure (IOP) and in the right eye (RE). At the first visit to our hospital, best-corrected visual acuity (BCVA) was 0.2 in the RE and 0.02 in the left eye (LE). IOP was 47 mm Hg in the RE and 21 mm Hg in the LE. Slit-lamp examination showed no abnormalities in anterior segments and dislocated IOL in the RE. Fundus photograph showed optic disc pallor in both eyes. We performed the combined therapy of flanged intrascleral IOL fixation with the double-needle technique and trabeculectomy. Throughout the follow-up period, BCVA slightly improved from 0.2 to 0.4 in the RE. The angle of tilt of the IOL was 6.6, 7.9, and 8.7° as measured by swept-source optical coherence tomography at 1, 4, and 6 months after the surgery, respectively. The IOP remained less than 10 mm Hg without having to administer any other glaucoma medications. Furthermore, any complications associated with the surgery were not confirmed.

scholarly journals Association Between Osteoarticular Scores and Acute Phase Reactant Levels in Rheumatoid Arthritis

2009 ◽  
Vol 28 (2) ◽  
pp. 116-121 ◽  
Author(s):  
Irena Kafeđiska ◽  
Dejan Spasovski ◽  
Todor Gruev ◽  
Mane Grličkov ◽  
Kočo Cakalaroski ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Acute Phase ◽  
Acute Phase Reactant ◽  
Control Group ◽  
Time Intervals ◽  
Acute Phase Reactants ◽  
Mean Values ◽  
Cell Counts ◽  
Phase Reactant ◽  
The Mean

Association Between Osteoarticular Scores and Acute Phase Reactant Levels in Rheumatoid Arthritis The aim of this prospective control study was a quantitative evaluation of the activity of rheumatoid arthritis (RA) in certain time intervals, using articular indexes (set of 28 sensitive and 28 swollen joints), laboratory parameters (Hb, Hct, Er, Le and Plt) and acute phase reactants (ESR, RF, CRP); to determine which of the acute phase reactants is the most useful biochemical marker for the evaluation of disease activity in RA; to quantify the therapeutical and laboratory differences in certain time intervals in the group with and without immunomodulatory therapy with Methotrexate. Sixty patients with RA were included, 27 of who were treated with non-steroid antiinflammatory drugs (NSAIDs) and Methotrexate (MTX). The control group consisted of 33 patients treated only with NSAIDs because of irregular controls. In the first group of patients the disease activity was estimated at four time intervals, and in the control group of patients at three time intervals following the scores of the articular indexes, blood cell counts, ESR and CRP in every patient. In the first group of patients decreased activity of RA was found upon every following control with a consecutive decrease in mean values of the scores of articular indexes with statistically significant differences at the four time intervals. Considering laboratory parameters, there were statistically significant differences in the mean values of Hb, Er, Plt, ESR, (p=0.0462, p=0.0076, p= 0.0058, p= 0.0003). Mean values of CRP did not show statistically significant differences, but the number of patients who were CRP negative increased (there were great standard deviations). In the group of patients treated only with NSAIDs, there were statistically significant differences in the mean values of the scores of articular indexes with an increse at every following control (in favour of progression of the disease). There were no statistically significant differences considering blood cell counts, ESR and CRP (in favour of permanently active disease). In conclusion, CRP is the most useful marker for the prospective follow-up of patients with RA.

scholarly journals Retinomotor movements in the Antarctic fish Trematomus newnesi Boulenger submitted to different environmental light conditions

2007 ◽  
Vol 24 (2) ◽  
pp. 457-462 ◽  
Author(s):  
Lucélia Donatti ◽  
Edith Fanta
Keyword(s):  
Pigment Epithelium ◽  
Antarctic Fish ◽  
Constant Darkness ◽  
Time Intervals ◽  
Mean Values ◽  
Environmental Light ◽  
The Mean ◽  
The Difference ◽  
The One ◽  
The Antarctic

The Antarctic fish Trematomus newnesi (Boulenger, 1902) occurs from benthic to pelagic habitats, in seasonally and daily varied photic conditions that induce retinomotor movements. Fish were experimentally kept under constant darkness or light, and 12Light/12Dark for seven days. The retinomotor movement of the pigment epithelium was established through the pigment index, while that of the cones was calculated as the length of the myoid. The retinomotor movement of the pigment epithelium in T.newnesi,revealed that the adaptation to constant light occurred in the one hour of exposure, remaining constant for the next seven days. However, the adaptation to constant darkness, was slower. The difference between the mean values of the pigment indices in the time intervals of sampling was significant in the first hours of the experiment, and only after six hours they were not significant any more. The myoid of cones became elongated in darkness and contracted in light. In the experiments where T.newnesiwas exposed initially to 12 hours light followed by 12 hours darkness 12 was evidenced that the speed and intensity of the retinomotor movements was higher when darkness changed into light, than when light changed into darkness.

Measuring the Biaxial Stress-Strain Characteristics of Human Sclera

2007 ◽  
Author(s):  
C. G. Olesen ◽  
I. Tertinegg ◽  
A. Eilaghi ◽  
G. W. Brodland ◽  
C. Horst ◽  
...  
Keyword(s):  
Risk Factor ◽  
Intraocular Pressure ◽  
Optic Nerve ◽  
Ganglion Cell ◽  
Mechanical Strain ◽  
Biaxial Stress ◽  
Retinal Ganglion ◽  
Irreversible Loss ◽  
Elevated Intraocular Pressure ◽  
Primary Risk Factor

Glaucoma is a common ocular disease that causes irreversible loss of vision. Elevated intraocular pressure (IOP) is the primary risk factor for developing glaucoma. It is believed that increased IOP causes mechanical strain on the glial cells that support the retinal ganglion cell axons and thereby causes ganglion cell apoptosis [1,2]. This damage occurs in the optic nerve head (ONH) region of the eye, and is important for understanding ONH biomechanics.

Effect of manual eyelid manipulation on intraocular pressure measurement by rebound tonometry

2018 ◽  
Vol 102 (11) ◽  
pp. 1515-1519 ◽  
Author(s):  
Sung Uk Baek ◽  
Ahnul Ha ◽  
Young Kook Kim ◽  
Jin Wook Jeoung ◽  
Ki Ho Park
Keyword(s):  
Intraocular Pressure ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Mean Value ◽  
Applanation Tonometry ◽  
Palpebral Fissure ◽  
Altman Plot ◽  
Bland Altman Plot ◽  
Rebound Tonometry ◽  
The Mean

Background/aimsTo investigate the effect of eyelid manipulation on the measurement of intraocular pressure (IOP) using two different tonometries (rebound tonometry (RT) vs Goldmann applanation tonometry (GAT)).Methods103 patients with primary open-angle glaucoma were prospectively enrolled. For all of the patients, IOP measurements were performed in three different ways: (1) RT with lid manipulation (LM), (2) RT without LM and (3) GAT. The order of the three measurements was randomly selected. Additionally, the palpebral fissure height (PFH; elliptical space between upper and lower eyelids) was measured.ResultsThe mean value of IOP measured by GAT was 13.97±2.80 mm Hg, which was not significantly different from that by RT without LM (13.75±2.44 mm Hg; P=0.096), but which was significantly lower than that by RT with LM (15.21±2.91 mm Hg; P<0.001). On a Bland-Altman plot, RT with LM was overestimated relative to GAT (mean: −1.5) and RT without LM (mean: −1.2). Among the high IOPs (>20 mm Hg), interestingly, those measured by RT without LM were significantly lower than those measured by GAT (P<0.001). In the subgroup analysis of PFH, the smaller the PFH, the more exaggerated the IOP difference between GAT (P=0.014) and RT with LM (P<0.001).ConclusionRT-measured IOP was significantly exaggerated when manipulation was applied to the eyelid. This overall trend was more pronounced when PFH was small. GAT-measured IOP, meanwhile, showed a good correlation with IOP measured using RT without LM.

The analysis of temperature fluctuations by pulse-counting techniques

1959 ◽  
Vol 6 (2) ◽  
pp. 261-271 ◽  
Author(s):  
A. A. Townsend
Keyword(s):  
Time Derivative ◽  
Temperature Fluctuations ◽  
Mean Value ◽  
Time Intervals ◽  
Mean Values ◽  
Average Value ◽  
Electrical Pulses ◽  
The Mean ◽  
The Stability ◽  
Better Than

To determine experimentally the mean value of a randomly fluctuating quantity, it may be necessary to measure the average value over a considerable interval of time. This problem arose in a recent study of the temperature fluctuations over a heated horizontal plate, and a system was used that depended on the counting of electrical pulses generated at a rate proportional to the quantity being measured. The advantage of this technique is that mean values may be measured over time intervals of almost unlimited length with little added difficulty for the experimenter. Circuits are described which measure: (a) the mean square of a fluctuating quantity and of its time-derivative, (b) the statistical distribution of the fluctuations, (c) the mean frequency of the fluctuation assuming a particular value, and (d) the mean product of two fluctuating quantities. Over the range of use, the stability and linearity of the calibrations is better than 1%, more than sufficient for work on natural convection. In its present form, the equipment responds uniformly to all frequencies below 100 c/s, but it would not be difficult to extend this range of response to higher frequencies.

A Study of the Variation of Size within two Species of Aphides

1940 ◽  
Vol 31 (1) ◽  
pp. 45-56
Author(s):  
G. H. L. Dicker ◽  
S. C. Pearce
Keyword(s):  
The Body ◽  
Standard Errors ◽  
Mean Values ◽  
The Mean ◽  
The Asymmetry ◽  
The Right ◽  
Different Parts

At least 30 specimens of each form of Macrosiphum rubiellum, Theobald, and Aphis idaei, van der Goot, were collected, mounted and their principal organs measured.Correlations were calculated between different parts on the right side and the conclusion reached that the ratios of lengths of organs were unstable characteristics of the species examined. High correlations were obtained between the same part on different sides of the body.The mean values and standard errors are tabulated and a method given for assigning limits of variation within a species. The standard errors obtained were of the order of 7 per cent. of the mean.The asymmetry, kurtosis and skewness of the distributions were calculated to test the effect of possible non-normality on the foregoing work.

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