Comparison of muscle strength between hemodialysis patients and non-dialysis patients with chronic kidney disease

Introduction: Anemia is a common complication of chronic kidney disease (CKD) due to the insufficient production of erythropoietin by the kidneys. The administration of erythropoietin is one of the most common methods for the treatment of patients with anemia. Objectives: This study aimed to investigate the effect of the administration of synthetic erythropoietin on hemoglobin levels in dialysis patients using a systematic review and meta-analysis. Methods: In order to identify the related studies, the international databases of Web of Science, PubMed, Scopus, and Embase were searched from 2015 to 2020 using standard and valid keywords. The data were analyzed using STATA software (version 14), and a p-value of less than 0.05 was considered statistically significant. Results: In 12 reviewed articles with a sample size of 4,060 individuals, the standard effect size of the effect of synthetic erythropoietin on Hb in dialysis patients was reported as 2.08 (95% CI: 1.53-2.63), which was statistically significant; however, erythropoietin biosimilars did not show similar results. Conclusion: The administration of erythropoietin to hemodialysis patients increases Hb levels by more than 2 units.

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EFFICACY AND SAFETY OF IRON (III)–HYDROXIDE SUCROSE COMPLEX IN CORRECTION OF ANEMIA STAGE 5D CHRONIC KIDNEYDISEASE HEMODIALYSIS PATIENTS NOT TREATED BY ERYTHROPOIESIS–STIMULATING AGENTS (PROSPECTIVEANALYSIS)

Ukrainian Journal of Nephrology and Dialysis ◽

10.31450/ukrjnd.4(44).2014.07 ◽

2014 ◽

pp. 64-69

Author(s):

І. О. Dudar ◽

I. I. Gonchar ◽

І. М. Shifris ◽

Е. К. Krasjuk ◽

V. М. Savchuk ◽

...

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Iron Deficiency ◽

Adverse Events ◽

Transferrin Saturation ◽

Hemodialysis Patients ◽

Renal Anemia ◽

Efficacy And Safety ◽

Dialysis Patients ◽

Regular Hemodialysis

The aim of study was to evaluat the efficacy and safety ofSUFER® (iron (III) sucrose complex) in correction of anemia stage 5D chronic kidney disease hemodialysis patients. Methods. This study included thirty patients undergoing regular hemodialysis (mean age 48,81±3,24 years, mean duration of dialysis 30,43±9,25 months) with renal anemia and iron deficiency. All patients were treated with SUFER® intravenously 200 mg three times a week. Correction dose was determined according to the manufacturer’s recommendations. Results. Mean level offerritin was significantly increased from 125,15 ± 21,46 ng / ml to 375,56 ± 64,12 ng / ml (p <0,001), transferrin saturation – from 17,48 ± 2,71% to 38,21 ± 4,90 ng / ml (p <0,001). 23 (76.67%) patients achieved target levels offerritin and transferrin, 12 (40% ) adverse events. Conclusions. SUFER® is effective and safety drug in dialysis patients.

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Safety and Effectiveness of COVID-19 SPUTNIK V Vaccine in Dialysis Patients

10.1101/2021.10.21.21265349 ◽

2021 ◽

Author(s):

Guillermo Rosa-Diez ◽

Maria M Papaginovic-Leiva ◽

Fernando Lombi ◽

Maria S Crucelegui ◽

Ricardo D Martinez ◽

...

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Prospective Cohort ◽

Patient Population ◽

Analytical Study ◽

Buenos Aires ◽

Hemodialysis Patients ◽

Dialysis Patients ◽

Effectiveness Analysis ◽

High Level

Given the vulnerability of people with chronic kidney disease to COVID-19, nephrology societies have issued statements calling for prioritization of these patients for vaccination. It is not yet known whether COVID-19 vaccines confer the same high level of protection in patients with kidney disease. The aims of this study were to evaluate the safety measured by the events supposedly attributed to vaccines and the effectiveness evaluated by the presence of antibodies in dialysis patients immunized with the COVID-19 Sputnik V vaccine. Methods: multicenter, observational, and analytical study of a prospective cohort of hemodialysis patients in the Autonomous City of Buenos Aires with a vaccination plan. Patients older than 18 years on dialysis who received both components of the COVID-19 vaccine were included. Results: 491 patients included in the safety analysis. ESAVI with either the first or second component was detected in 186 (37.9% 95% CI 33.6%-42.34%). The effectiveness analysis measures of antibodies against SARS-Cov-2 were performed in 102 patients, 98% had positive IgG against SARS-Cov-2 antibodies 21 days after the second component. In patients with COVID-19 prior to vaccination, antibodies at day 21 after the first component reached almost the highest levels compared to those patients who did not have COVID-19, and the rise between the last measures was lower than patients without COVID-19. Conclusion: Dialysis patients constitute a vulnerable population for SARS-Cov-2 infection, beyond the recommendations that were implemented by dialysis units, full vaccination is a priority and necessary. The Sputnik V vaccine has been shown to be safe and effective in this patient population.

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The relationship between chronic kidney disease and restless legs syndrome and its effective factors. A case-control study.

Medical Journal of Tabriz University of Medical Sciences ◽

10.34172/mj.2021.072 ◽

2021 ◽

Vol 43 (5) ◽

pp. 469-476

Author(s):

Zahra Mousavi ◽

Mehrdad Ghaemmaghami ◽

Rasoul Alipour ◽

Sona Rahimpour

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Restless Legs Syndrome ◽

Case Control Study ◽

International Association ◽

Hemodialysis Patients ◽

Case Control ◽

Dialysis Patients ◽

Restless Legs ◽

Control Study

I Restless legs syndrome (RLS), is a neurological disorder in which persons feel uncomfortable, especially at night, in the limbs and needs to move their legs. This condition worsens with rest. The aim of this study was to evaluate the frequency of restless legs syndrome in patients with renal insufficiency. In this case-control study, 180 patients with chronic kidney disease (90 hemodialysis patients and 90 non-dialysis patients) who referred to the nephrology clinic and dialysis ward of Imam Reza Hospital in Tabriz, were investigated. Data collection was done through a questionnaire form which was based on the criteria of the International Association for the Study of Restless Legs Syndrome. Among 180 patients in studied, 92 (51.7%) cases were male and 88 (48.3%) cases were female. The mean age of patients was 60.4 ± 17.2. So, 90 non-dialysis patients and 90 hemodialysis patients were evaluated. Of all the hemodialysis patients studied, 33 (37%) patients had restless legs syndrome, and among the non-dialysis patients, only 16 (18%) patients had restless legs syndrome. The frequency of restless legs syndrome is significantly higher in patients undergoing hemodialysis (P=0.001). There was also a meaningful difference about the frequency of restless legs syndrome among the male (77%) patients than females (23%) (P=0.001). A significant percentage (27%) of patients with renal failure suffer from restless legs syndrome and the hemodialysis patients are more involved in this disease, which needs more importance. Also, based on our findings in this study, men have a high probability of a conflict of restless legs syndrome than women

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Is Serum Total Alkaline Phosphatase a Useful Tool for Chronic Kidney Disease – Mineral and Bone Disorder Assessment in Non-Dialysis Patients?

Medical Connections ◽

10.33311/medcon.2016.37.1.2 ◽

2016 ◽

Vol 37 (1/2016) ◽

Keyword(s):

Chronic Kidney Disease ◽

Alkaline Phosphatase ◽

Kidney Disease ◽

Dialysis Patients ◽

Total Alkaline Phosphatase ◽

Mineral And Bone Disorder ◽

Bone Disorder ◽

Total Alkaline

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Faculty Opinions recommendation of Plasma interleukin-6 is independently associated with mortality in both hemodialysis and pre-dialysis patients with chronic kidney disease.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.2728960.2391058 ◽

2010 ◽

Author(s):

William Mitch

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Interleukin 6 ◽

Dialysis Patients

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Investigation of the Impact of Endodontic Therapy on Survival among Dialysis Patients in Taiwan: A Nationwide Population-Based Cohort Study

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18010326 ◽

2021 ◽

Vol 18 (1) ◽

pp. 326

Author(s):

Chih-Chien Chiu ◽

Ya-Chieh Chang ◽

Ren-Yeong Huang ◽

Jenq-Shyong Chan ◽

Chi-Hsiang Chung ◽

...

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Renal Disease ◽

End Stage Renal Disease ◽

Root Canal ◽

Dialysis Patients ◽

Root Canal Therapy ◽

Risk Of Death ◽

Stage Renal Disease ◽

End Stage

Objectives Dental problems occur widely in patients with chronic kidney disease (CKD) and may increase comorbidities. Root canal therapy (RCT) is a common procedure for advanced decayed caries with pulp inflammation and root canals. However, end-stage renal disease (ESRD) patients are considered to have a higher risk of potentially life-threatening infections after treatment and might fail to receive satisfactory dental care such as RCT. We investigated whether appropriate intervention for dental problems had a potential impact among dialysis patients. Design Men and women who began maintenance dialysis (hemodialysis or peritoneal dialysis) between January 1, 2000, and December 31, 2015, in Taiwan (total 12,454 patients) were enrolled in this study. Participants were followed up from the first reported dialysis date to the date of death or end of dialysis by December 31, 2015. Setting Data collection was conducted in Taiwan. Results A total of 2633 and 9821 patients were classified into the RCT and non-RCT groups, respectively. From the data of Taiwan’s National Health Insurance, a total of 5,092,734 teeth received RCT from 2000 to 2015. Then, a total of 12,454 patients were followed within the 16 years, and 4030 patients passed away. The results showed that members of the non-RCT group (34.93%) had a higher mortality rate than those of the RCT group (22.79%; p = 0.001). The multivariate-adjusted hazard ratio for the risk of death was 0.69 (RCT vs. non-RCT; p = 0.001). Conclusions This study suggested that patients who had received RCT had a relatively lower risk of death among dialysis patients. Infectious diseases had a significant role in mortality among dialysis patients with non-RCT. Appropriate interventions for dental problems may increase survival among dialysis patients. Abbreviations: CKD = chronic kidney disease, ESRD = end-stage renal disease, RCT = root canal therapy.

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Reliability and validity of the Persian version of 5-D itching scale among patients with chronic kidney disease

BMC Nephrology ◽

10.1186/s12882-020-02220-x ◽

2021 ◽

Vol 22 (1) ◽

Author(s):

Amin Kordi Yoosefinejad ◽

Fatemeh Karjalian ◽

Marzieh Momennasab ◽

Shahrokh Ezzatzadegan Jahromi

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Psychometric Properties ◽

Internal Consistency ◽

Reliability And Validity ◽

Hemodialysis Patients ◽

Life Questionnaire ◽

Retest Reliability ◽

Persian Version ◽

Test Retest Reliability

Abstract Background Hemodialysis is considered a major therapeutic method for patients with chronic kidney disease. Pruritus is a common complaint of hemodialysis patients. The 5-D pruritus scale is amongst the most common tools to evaluate several dimensions of itch. Psychometric properties of the 5-D scale have not been evaluated in Persian speaking population with hemodialysis; hence, the objective of this study was to assess reliability and validity of the Persian version of the scale. Methods Ninety hemodialysis patients (men: 50, women: 40, mean age: 54.4 years) participated in this cross-sectional study. The final Persian version of 5-D scale was given to the participants. Tests Compared: One-third of the participants completed the scale twice within 3–7 days apart to evaluate test- retest reliability. Other psychometric properties including internal consistency, absolute reliability, convergent, discriminative and construct validity, floor/ceiling effects were also evaluated. Results The Persian 5-D scale has strong test-retest reliability (ICC= 0.98) and internal consistency (Cronbach’s alpha= 0.99). Standard error of measurement and minimal detectable change were 0.33 and 0.91, respectively. Regarding convergent validity, the scale had moderate correlation with numeric rating scale (r =0.67) and quality of life questionnaire related to itch (r = 0.59). Exploratory factor analysis revealed two factors within the scale. No floor or ceiling effect was found for the scale. Conclusion The Persian version of 5-D the itching scale is a brief instrument with acceptable reliability and validity. Therefore, the scale could be used by experts, nurses, and other health service providers to evaluate pruritus among Persian speaking hemodialysis patients.

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Oxidative Stress in Non-Dialysis-Dependent Chronic Kidney Disease Patients

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18157806 ◽

2021 ◽

Vol 18 (15) ◽

pp. 7806

Author(s):

Patricia Tomás-Simó ◽

Luis D’Marco ◽

María Romero-Parra ◽

Mari Carmen Tormos-Muñoz ◽

Guillermo Sáez ◽

...

Keyword(s):

Oxidative Stress ◽

Chronic Kidney Disease ◽

Kidney Disease ◽

Reduced Glutathione ◽

Genetic Material ◽

Future Research ◽

Control Group ◽

Dialysis Patients ◽

Early Stages ◽

Molecular Lines

Background: Cardiovascular complications are the leading cause of morbidity and mortality at any stage of chronic kidney disease (CKD). Moreover, the high rate of cardiovascular mortality observed in these patients is associated with an accelerated atherosclerosis process that likely starts at the early stages of CKD. Thus, traditional and non-traditional or uremic-related factors represent a link between CKD and cardiovascular risk. Among non-conventional risk factors, particular focus has been placed on anaemia, mineral and bone disorders, inflammation, malnutrition and oxidative stress and, in this regard, connections have been reported between oxidative stress and cardiovascular disease in dialysis patients. Methods: We evaluated the oxidation process in different molecular lines (proteins, lipids and genetic material) in 155 non-dialysis patients at different stages of CKD and 45 healthy controls. To assess oxidative stress status, we analyzed oxidized glutathione (GSSG), reduced glutathione (GSH) and the oxidized/reduced glutathione ratio (GSSG/GSH) and other oxidation indicators, including malondialdehyde (MDA) and 8-oxo-2’-deoxyguanosine (8-oxo-dG). Results: An active grade of oxidative stress was found from the early stages of CKD onwards, which affected all of the molecular lines studied. We observed a heightened oxidative state (indicated by a higher level of oxidized molecules together with decreased levels of antioxidant molecules) as kidney function declined. Furthermore, oxidative stress-related alterations were significantly greater in CKD patients than in the control group. Conclusions: CKD patients exhibit significantly higher oxidative stress than healthy individuals, and these alterations intensify as eGFR declines, showing significant differences between CKD stages. Thus, future research is warranted to provide clearer results in this area.

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