scholarly journals Serum levels of retinol binding protein 4 in women with different levels of adiposity and glucose tolerance

2014 ◽  
Vol 58 (7) ◽  
pp. 709-714 ◽  
Author(s):  
Eleonora Beltrame Comucci ◽  
Ana Carolina Junqueira Vasques ◽  
Bruno Geloneze ◽  
Antonio Ramos Calixto ◽  
José Carlos Pareja ◽  
...  

Objective Retinol-binding protein 4 (RBP4) is an adipokine responsible for vitamin A (retinol) transportation. Studies associated RBP4 increased levels with severity of type 2 diabetes mellitus (T2DM) and insulin resistance (IR). The study aimed to quantify RBP4 serum standards in women with a wide range of body mass index (BMI) and glucose tolerance level. Subjects and methods: Cross-sectional study was performed with 139 women divided into three groups: Group 1 (lean-control, n = 45) and Group 2 (obese, n = 53) with normal glucose tolerance and group 3 (obese with T2DM, n = 41), called G1, G2 and G3. Were assessed clinical, biochemical, anthropometric and body composition parameters. Results According to data analysis, we obtained in G1 higher RBP4 levels (104.8 ± 76.8 ng/mL) when compared to G2 (87.9 ± 38 ng/mL) and G3 (72.2 ± 15.6 ng/mL) levels. Also, were found: in G1 positive correlations of RBP4 with BMI (r = 0.253), glycated hemoglobin (r = 0.378) and fasting insulin (r = 0.336); in G2 with glycated hemoglobin (r = 0.489); in G3 with glycated hemoglobin (r = 0.330), fasting glucose (r = 0.463), HOMA-IR (r = 0.481). Conclusions Although RBP4 have shown lower levels in diabetic and obese, a strong correlation with HOMA-IR index highlights that, in our study, there is growing IR when there is an increasing in RBP4 levels.

2015 ◽  
Vol 22 (2) ◽  
pp. L1-L4 ◽  
Author(s):  
Matthew V Abola ◽  
Cheryl L Thompson ◽  
Zhengyi Chen ◽  
Amitabh Chak ◽  
Nathan A Berger ◽  
...  

Medicine ◽  
2020 ◽  
Vol 99 (31) ◽  
pp. e21254
Author(s):  
Xiaoping Hu ◽  
Wenjun Huang ◽  
Feng Wang ◽  
Yifei Dai ◽  
Xiaocong Hu ◽  
...  

Diabetes Care ◽  
2008 ◽  
Vol 31 (4) ◽  
pp. e24-e24
Author(s):  
M. Ziegelmeier ◽  
A. Bachmann ◽  
J. Seeger ◽  
U. Lossner ◽  
M. Bluher ◽  
...  

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