scholarly journals HIV infection, bone metabolism, and fractures

2014 ◽  
Vol 58 (5) ◽  
pp. 478-483 ◽  
Author(s):  
Robert Güerri-Fernández ◽  
Judit Villar-García ◽  
Adolfo Díez-Pérez ◽  
Daniel Prieto-Alhambra
Keyword(s):  
Vitamin D ◽  
Antiretroviral Therapy ◽  
Bone Mass ◽  
Hiv Infection ◽  
Bone Metabolism ◽  
European Society ◽  
Bone Fragility ◽  
Low Bone Mass ◽  
Bone Changes ◽  
Affect Bone Metabolism

With the advent of high active antiretroviral therapy there was a significant improvement on HIV subjects survival. Thus, bone changes related to HIV became an important aspect of these individuals. HIV affects bone remodeling causing bone fragility. In addition, antiretroviral therapy may also negatively affect bone metabolism. Several studies describe an increased incidence of fractures in these patients when compared with controls without the disease. The European Society of AIDS (EACS), and other societies, have included guidance on management of osteoporosis in HIV-infected patients emphasizing the identification of patients with low bone mass. Supplementation of calcium and vitamin D and the use of alendronate in these individuals should be recommended on a case base.

scholarly journals Direct effects of physical training on markers of bone metabolism and serum sclerostin concentrations in older adults with low bone mass

2016 ◽  
Vol 17 (1) ◽  
Author(s):  
Gabriella Császárné Gombos ◽  
Viktória Bajsz ◽  
Emese Pék ◽  
Béla Schmidt ◽  
Eszter Sió ◽  
...  
Keyword(s):  
Older Adults ◽  
Bone Mass ◽  
Bone Metabolism ◽  
Physical Training ◽  
Direct Effects ◽  
Low Bone Mass

Low bone mass in human immunodeficiency virus–infected climacteric women receiving antiretroviral therapy

2015 ◽  
Vol 22 (2) ◽  
pp. 224-230 ◽  
Author(s):  
Debora C. Gomes ◽  
Ana L.R. Valadares ◽  
Monica J. de Moraes ◽  
Bianca B. Lagrutta ◽  
Aarão M. Pinto-Neto ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Antiretroviral Therapy ◽  
Bone Mass ◽  
Low Bone Mass ◽  
Immunodeficiency Virus

Vitamin K status is associated with childhood bone mineral content

2008 ◽  
Vol 100 (4) ◽  
pp. 852-858 ◽  
Author(s):  
Marieke J. H. van Summeren ◽  
Silvia C. C. M. van Coeverden ◽  
Leon J. Schurgers ◽  
Lavienja A. J. L. M. Braam ◽  
Florence Noirt ◽  
...  
Keyword(s):  
Vitamin D ◽  
Bone Mass ◽  
Bone Mineral Content ◽  
Bone Metabolism ◽  
Vitamin K ◽  
Bone Health ◽  
Mineral Content ◽  
Vitamin D Status ◽  
Time Points ◽  
Total Body

In adult bone, vitamin K contributes to bone health, probably through its role as co-factor in the carboxylation of osteocalcin. In children, the significance of vitamin K in bone-mass acquisition is less well known. The objective of this longitudinal study was to determine whether biochemical indicators of vitamin K status are related to (gains in) bone mineral content (BMC) and markers of bone metabolism in peripubertal children. In 307 healthy children (mean age 11·2 years), BMC of the total body, lumbar spine and femoral neck was determined at baseline and 2 years later. Vitamin K status (ratio of undercarboxylated (ucOC) to carboxylated (cOC) fractions of osteocalcin; UCR) was also measured at both time points. Markers of bone metabolism, sex steroids, vitamin D status and growth hormones were measured at baseline only. Large variations in the levels of the UCR were found at both time-points, indicating a substantial interindividual difference in vitamin K status. Improvement of vitamin K status over 2 years (n281 children) was associated with a marked increase in total body BMC (r− 49·1,P < 0·001). The UCR was associated with pubertal stage, markers of bone metabolism, sex hormones and vitamin D status. A better vitamin K status was associated with more pronounced increase in bone mass in healthy peripubertal children. In order to determine the significance of these findings for childhood bone health, additional paediatric studies are needed.

Changes in the relative expression of circulating microRNAs linked to bone metabolism in HIV-infected Individuals with low bone mass

2020 ◽  
Author(s):  
Maria Yavropoulou ◽  
Artemis Kolynou ◽  
Polyzois Makras ◽  
Lemonia Skoura ◽  
Sideris Nanoudis ◽  
...  
Keyword(s):  
Bone Mass ◽  
Bone Metabolism ◽  
Low Bone Mass ◽  
Circulating Micrornas ◽  
Relative Expression

scholarly journals Bone density, fractures and the associated factors in iranian children and adolescent with Osteogenesis Imperfecta

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Pooran Mohsenzade ◽  
Anis Amirhakimi ◽  
Naser Honar ◽  
Forough Saki ◽  
Gholam Hossein Ranjbar Omrani ◽  
...  
Keyword(s):  
Vitamin D ◽  
Bone Mass ◽  
Osteogenesis Imperfecta ◽  
Vitamin D Deficiency ◽  
Sun Exposure ◽  
Chronological Age ◽  
Low Bone Mass ◽  
Mineral Density ◽  
Southern Iran ◽  
Lumbar Area

Abstract Backround Osteogenesis imperfecta(OI) is a frequent bone fragility disorder in children. The purpose of this study was to assess the BMD and Vitamin D level in children with OI in southern Iran. Method This case-control study was conducted on 23 children, clinically diagnosed as osteogenesis imperfecta and 23 age- and gender-matched healthy controls. Demographic and anthropometric data, biochemical parameters, puberty, sun exposure and physical activity were assessed. Bone mineral density (BMD) was measured by Dual-energy X-ray absorptiometry (DXA). Data analysis was done by SPSS22. Results Forty-three point four percent of OI patients and fifty-six point five percent of control group had vitamin D deficiency (P = 0.376). Thirteen OI patients (56%) had low bone mass for chronological age in lumbar area (P < 0.001). Fracture episodes during treatment was significantly influenced by time of Pamidronate start, courses of Pamidronate injection, puberty and sun exposure (P values = 0.015, 0.030, 0.044 and 0.032, respectively). Fracture episodes during treatment had significantly increased in patients who had received Pamidronate more than 3 years compared with those received less than 3 years(P values = 0.047). Conclusions This study showed that vitamin D deficiency is prevalent amongst OI children in southern Iran. More than half of the OI children had low bone mass for chronological age in lumbar area, despite receiving bisphosphonate therapy. The present results revealed that early initiation of Pamidronate and number of Pamidronate courses are associated with lower fracture rate. However, treatment period more than 3 years can have adverse effect on fracture rates.

scholarly journals Genetic Determinants of Osteoporosis: Common Bases to Cardiovascular Diseases?

2010 ◽  
Vol 2010 ◽  
pp. 1-16 ◽  
Author(s):  
Francesca Marini ◽  
Maria Luisa Brandi
Keyword(s):  
Health Care ◽  
Cardiovascular Diseases ◽  
Bone Mass ◽  
Bone Fragility ◽  
Low Bone Mass ◽  
Genetic Determinants ◽  
Age Related ◽  
Care Costs ◽  
Consequent Increase ◽  
Genetic Bases

Osteoporosis is the most common and serious age-related skeletal disorder, characterized by a low bone mass and bone microarchitectural deterioration, with a consequent increase in bone fragility and susceptibility to spontaneous fractures, and it represents a major worldwide health care problem with important implications for health care costs, morbidity and mortality. Today is well accepted that osteoporosis is a multifactorial disorder caused by the interaction between environment and genes that singularly exert modest effects on bone mass and other aspects of bone strength and fracture risk. The individuation of genetic factors responsible for osteoporosis predisposition and development is fundamental for the disease prevention and for the setting of novel therapies, before fracture occurrence. In the last decades the interest of the Scientific Community has been concentrated in the understanding the genetic bases of this disease but with controversial and/or inconclusive results. This review tries to summarize data on the most representative osteoporosis candidate genes. Moreover, since recently osteoporosis and cardiovascular diseases have shown to share common physiopathological mechanisms, this review also provides information on the current understanding of osteoporosis and cardiovascular diseases common genetic bases.

scholarly journals Evaluation of 41Calcium as a New Approach to Assess Changes in Bone Metabolism: Effect of a Bisphosphonate Intervention in Postmenopausal Women With Low Bone Mass

2007 ◽  
Vol 22 (10) ◽  
pp. 1518-1525 ◽  
Author(s):  
Eberhard Denk ◽  
Darren Hillegonds ◽  
Richard F Hurrell ◽  
John Vogel ◽  
Karin Fattinger ◽  
...  
Keyword(s):  
Bone Mass ◽  
Bone Metabolism ◽  
Postmenopausal Women ◽  
Low Bone Mass ◽  
New Approach

scholarly journals High prevalence of low bone mass and associated factors in Korean HIV-positive male patients undergoing antiretroviral therapy

2014 ◽  
Vol 17 (1) ◽  
pp. 18773 ◽  
Author(s):  
Pyoeng Gyun Choe ◽  
Hyung Jin Choi ◽  
Nak-Hyun Kim ◽  
Wan Beom Park ◽  
Kyoung-Ho Song ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Bone Mass ◽  
Associated Factors ◽  
Hiv Positive ◽  
Low Bone Mass ◽  
High Prevalence ◽  
Male Patients

scholarly journals Characterization of Bone Metabolism in Hungarian Psoriatic Arthritis Patients: A Case–Control Study.

2020 ◽  
Author(s):  
Zsofia Petho ◽  
Edit Kalina ◽  
Zoltan Pap ◽  
Katalin Hodosi ◽  
Rebeka Falcsik ◽  
...  
Keyword(s):  
Psoriatic Arthritis ◽  
Bone Mass ◽  
Fracture Risk ◽  
Disease Activity ◽  
Bone Metabolism ◽  
Osteoporotic Fracture ◽  
Independent Predictor ◽  
Low Bone Mass ◽  
Major Osteoporotic Fracture ◽  
Volumetric Bmd

Abstract Background: Skeletal manifestations are predominant in psoriatic arthritis (PsA). The aim of this cross-sectional, case-controlled study is the complex assessment of areal and volumetric bone mineral density (BMD), fracture risk, vitamin D status and bone turnover markers, and its association with disease-related variables.Methods: Lumbar spine (L1-L4) and femur neck (FN) areal, and distal radius (DR) volumetric BMD, 10-year probability of major and hip osteoporotic fracture as assessed by the fracture risk assessment (FRAX) tool, markers of bone metabolism and disease activity were assessed.Results: Upon comparison of the disease and age- and sex-matched control groups, there was a statistically significant difference in FN areal (0.955±0.145 g/cm2 vs. 1.034±0.148 g/cm2; p=0.001) and DR total volumetric (285.7±61.8 mg/cm3 vs. 369.6±23.6 mg/cm3; p<0.001) BMD, 10 year probability for major osteoporotic (5.0% (0.7%-32%) vs. 3.5% (0%-17.5%); p=0.003) and hip (1.1% (0%-16%) vs. 0.5% (0%-6.1%); p=0.002) fracture and 25-hydroxyvitamin D status (53 (10-120) nmol/L vs. 67 (10-137; p<0.001) nmol/L). As compared to areal assessment, volumetric BMD measurements identified a significantly higher number of patients with low bone mass (T-Score £ -1.00) (34% vs. 88%, p<0.001). Upon multiple linear regression analysis, disease activity score, as determined by DAS28 assessment, was an independent predictor of 10-year probability for major osteoporotic fracture (B (95%CI) = 1.351 (0.379–2.323); p = 0.007).Conclusion: In the studied PsA cohort, disease activity was an independent predictor of 10-year probability for a major osteoporotic fracture, and complemented assessment of volumetric and areal BMD assured better efficacy at identifying those with low bone mass.

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