scholarly journals Transient global amnesia: clinical features and prognostic factors suggesting recurrence

2019 ◽  
Vol 77 (1) ◽  
pp. 3-9 ◽  
Author(s):  
Lucas Alessandro ◽  
Ismael L. Calandri ◽  
Marcos Fernández Suarez ◽  
María L. Heredia ◽  
Hernán Chaves ◽  
...  
Keyword(s):  
Clinical Features ◽  
Clinical Characteristics ◽  
Brain Mri ◽  
Transient Global Amnesia ◽  
Recurrence Risk ◽  
The Other ◽  
Multivariate Logistic Regression Model ◽  
Risk Of Recurrence ◽  
Increased Risk ◽  
Global Amnesia

ABSTRACT The risk of recurrence of new amnesia events in patients having previously experienced transient global amnesia (TGA) ranges between 2.9-23.8%. Objective: Our objective was to search for recurrence predictors in TGA patients. Methods: Retrospective analysis to identify recurrence predictors in a cohort of 203 TGA patients from a single center in Buenos Aires, Argentina, diagnosed between January 2011 and March 2017 Clinical features and complementary studies (laboratory results, jugular vein Doppler ultrasound and brain MRI) were analyzed. Comparison between patients with recurrent versus single episode TGA was performed, applying a multivariate logistic regression model. Results: Mean age at presentation was 65 years (20-84); 52% were female. Median time elapsed between symptom onset and ER visit was two hours, with the average episode duration lasting four hours. Mean follow-up was 22 months. Sixty-six percent of patients referred to an identifiable trigger. Jugular reflux was present in 66% of patients; and 22% showed images with hippocampus restriction on diffusion-weighted MRI. Eight percent of patients had TGA recurrence. Patients with recurrent TGA had a more frequent history of migraine than patients without recurrence (37.5% vs. 14%; p = 0.03). None of the other clinical characteristics and complementary studies were predictors of increased risk of recurrence. Conclusions: Patients with migraine may have a higher risk of recurrent TGA. None of the other clinical characteristics evaluated allowed us to predict an increased risk of recurrence. Although the complementary studies allowed us to guide the diagnosis, they did not appear to have a significant impact on the prediction of recurrence risk.

Transient global amnesia

2013 ◽  
Vol 23 (3) ◽  
pp. 189-195
Author(s):  
P Boovalingam ◽  
N Shah
Keyword(s):  
Medical Imaging ◽  
Retrograde Amnesia ◽  
19Th Century ◽  
Clinical Features ◽  
Transient Global Amnesia ◽  
Global Amnesia ◽  
The 19Th Century

SummaryTransient global amnesia (TGA) has been described since the 19th century. It is characterized by an episode of anterograde and retrograde amnesia lasting less than 24 hours. During this episode patients are conscious and able to interact normally, but are typically distressed and repeat questions without remembering explanations. Despite progress in medical imaging, no cause for the condition has been proven. Prognosis is excellent and management centres on recognition and reassurance. We describe the epidemiology, pathophysiology, clinical features and management.

Transient global amnesia: Clinical characteristics and prognosis

Neurology ◽  
1987 ◽  
Vol 37 (5) ◽  
pp. 733-733 ◽  
Author(s):  
J. W. Miller ◽  
R. C. Petersen ◽  
E. J. Metter ◽  
C. H. Millikan ◽  
T. Yanagihara
Keyword(s):  
Clinical Characteristics ◽  
Transient Global Amnesia ◽  
Global Amnesia

scholarly journals Differences in the clinical characteristics of chronic pulmonary aspergillosis according to spirometric impairment

PLoS ONE ◽  
2021 ◽  
Vol 16 (11) ◽  
pp. e0260274
Author(s):  
Myoung Kyu Lee ◽  
Sae Byol Kim ◽  
Beomsu Shin
Keyword(s):  
Clinical Features ◽  
Clinical Characteristics ◽  
Pulmonary Function Tests ◽  
Forced Expiratory Volume ◽  
The Other ◽  
Pulmonary Aspergillosis ◽  
Younger Age ◽  
Chronic Pulmonary Aspergillosis ◽  
Low Bmi ◽  
Wbc Count

The clinical features by declining lung function remain uncharacterized in chronic pulmonary aspergillosis (CPA) patients. We investigated the clinical characteristics of CPA patients based on spirometric impairments (restrictive spirometric pattern [RSP] and obstructive spirometric pattern [OSP]) and their severity. We retrospectively analyzed medical records of CPA patients who underwent pulmonary function tests from March 2017 to February 2020. We used Global Lung Initiative 2012 equations with lower limit of normal. The clinical characteristics of patients with RSP were compared to those with OSP. Additionally, RSP patients’ characteristics were analyzed according to forced vital capacity (FVC) tertile, and OSP patients’ characteristics were analyzed according to forced expiratory volume in 1 second (FEV1) tertile. Among the 112 patients with CPA (52 [46%] with RSP and 60 [54%] with OSP), body mass index (BMI) was significantly lower in patients with RSP than in those with OSP (17.6 kg/m2 versus 20.3 kg/m2; P = 0.003), and non-tuberculous mycobacterial disease was more frequently observed in patients with RSP than in those with OSP (28.8% versus 11.7%; P = 0.004). Additionally, for patients with RSP, younger age and bilateral pulmonary lesions were more frequently observed in the first tertile group than in the other groups (P for trend: 0.025 and 0.001, respectively). For patients with OSP, low BMI, paracavitary infiltrates, and elevated WBC count were more frequently observed in the first tertile group than in the other groups (P for trend: < 0.001, 0.011, and 0.041, respectively). Differences in the clinical features of CPA patients were identified according to heterogeneous spirometric patterns and their severity. Further studies are needed to investigate the clinical significance of these findings.

scholarly journals Transient Global Amnesia as a Possible First Manifestation of COVID-19

2020 ◽  
Vol 11 (1) ◽  
pp. 84-86
Author(s):  
Haitham M. Hussein
Keyword(s):  
Nervous System ◽  
Respiratory Failure ◽  
Brain Mri ◽  
Transient Global Amnesia ◽  
Respiratory Illness ◽  
X Ray ◽  
Unexplained Fever ◽  
Chest X Ray ◽  
Hypoxic Respiratory Failure ◽  
Global Amnesia

Evidence of involvement of the nervous system in COVID-19 disease is accumulating. We describe a case of a 53-year-old man presented with classic syndrome of transient global amnesia with symptoms lasting less than 24 hours and mild transient unexplained fever. Workup including brain MRI, electroencephalogram, and chest X ray was negative and the patient was discharged. The day after discharge, the patient started to experience the classic respiratory and systemic COVID-19 illness and was eventually readmitted with hypoxic respiratory failure and positive COVID-19 test a week after the first hospital discharge. The case highlights the importance of neurological syndromes as presenting prodrome to the respiratory illness of COVID-19.

Telomere length and recurrence risk after curative resection in women with adenocarcinoma of the lung: A prospective cohort study.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. 1532-1532
Author(s):  
Eric S. Kim ◽  
Yuanqing Ye ◽  
Ara A. Vaporciyan ◽  
Jinliang Xing ◽  
Maosheng Huang ◽  
...  
Keyword(s):  
Prospective Study ◽  
Telomere Length ◽  
Curative Resection ◽  
Early Stage ◽  
Recurrence Risk ◽  
Cancer Center ◽  
Risk Of Recurrence ◽  
Early Stage Nsclc ◽  
Increased Risk ◽  
Telomere Biology

1532 Background: We hypothesized that telomere length in peripheral blood would have significant predictive value for risk of recurrence after curative resection in non-small cell lung cancer (NSCLC). Methods: This prospective study included 473 patients with histologically confirmed early stage NSCLC who underwent curative resection at MD Anderson Cancer Center between 1995 and 2008. Relative telomere length (RTL) of peripheral leukocytes was measured by real-time PCR. The risk of recurrence was estimated as hazard ratios (HRs) and 95% confidence intervals (CIs) using a multivariable Cox proportional hazard regression model. Results: Median duration of follow-up was 61 months and 151 patients (32%) had developed recurrence at time of analysis. Patients who developed recurrence had significantly longer mean RTL compared to those without recurrence (1.13 vs 1.07, P=0.046). A subgroup analysis indicates that women had longer RTL compared to males (1.12 vs 1.06, P=0.025), and the patients with adenocarcinoma demonstrated longer RTL compared to those with other histologic types (1.11 vs 1.05, P=0.042). To determine if longer RTL in women and adenocarcinoma subgroup would predict risk of recurrence, multivariate Cox analysis adjusting for age, gender, stage, pack year and treatment regimens was performed. Longer telomeres were significantly associated with higher risk of developing recurrence in female (HR=2.25; 95% CI, 1.02-4.96, P=0.044) and adenocarcinoma subgroups (HR=2.19; 95% CI, 1.05-4.55, P=0.036). The increased risk of recurrence due to long RTL was more apparent in females with adenocarcinoma (HR=2.67; 95% CI, 1.19-6.03, P=0.018). Conclusions: This is the first prospective study to suggest that long RTL is associated with recurrence in early stage NSCLC after curative resection. Women and adenocarcinoma appear to be special subgroups in which telomere biology may play an important role. (Supported by NCI CA 111646, CA 55769, and CA 70907.)

Risk of Prostate Cancer Recurrence in Men Treated With Radiation Alone or in Conjunction With Combined or Less Than Combined Androgen Suppression Therapy

2008 ◽  
Vol 26 (18) ◽  
pp. 2979-2983 ◽  
Author(s):  
Anthony V. D'Amico ◽  
Ming-Hui Chen ◽  
Andrew A. Renshaw ◽  
Brittany Loffredo ◽  
Philip W. Kantoff
Keyword(s):  
Prostate Cancer ◽  
Prognostic Factors ◽  
Cox Regression ◽  
Specific Antigen ◽  
Liver Function Tests ◽  
Recurrence Risk ◽  
Risk Of Recurrence ◽  
Increased Risk ◽  
Psa Recurrence ◽  
Androgen Suppression

PurposeWe determined the risk of recurrence in men enrolled on a randomized trial for prostate cancer who were treated with radiation therapy (RT) alone or in conjunction with combined or less than combined androgen suppression therapy (AST).Patients and MethodsBetween 1995 and 2001, 206 men with localized but unfavorable-risk adenocarcinoma of the prostate were randomly assigned to receive RT or RT and AST, which was defined as 6 months of both a luteinizing hormone-releasing hormone agonist and an antiandrogen. A post–random assignment hypothesis that was generated by multivariable Cox regression analyses was used to evaluate whether the risk of prostate-specific antigen (PSA) recurrence was significantly associated with months of antiandrogen use; regression analysis adjusted for known prognostic factors, comorbidity score, and medications that can elevate liver function tests sufficiently to necessitate discontinuation of the antiandrogen.ResultsAfter a median follow-up of 8.2 years (interquartile range,7.0 to 9.5 years), 81 men sustained PSA recurrence. An increasing PSA level (P < .001); Gleason score of 8, 9, or 10 (P < .001); and clinical category T2 disease (P = .005) were significantly associated with an increased risk of recurrence. However, recurrence risk was significantly decreased (adjusted hazard ratio, 0.81; 95% CI, 0.72 to 0.92; P = .001) with each additional month of antiandrogen use after analysis was adjusted for these known prognostic factors.ConclusionMen with localized but unfavorable-risk prostate cancer who were treated with RT and 6 months of planned combined AST appear to have an increased risk of recurrence when treated with less than as compared with 6 months of the antiandrogen.

scholarly journals How to forget a “traumatic” experience: a case report of transient global amnesia after nasopharyngeal swab for Coronavirus disease 19

BMC Neurology ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Sabrina Ravaglia ◽  
Antonio Zito ◽  
Lara Ahmad ◽  
Isabella Canavero
Keyword(s):  
Short Term Memory ◽  
Brain Mri ◽  
Memory Loss ◽  
Transient Global Amnesia ◽  
Clinical Syndrome ◽  
Traumatic Experience ◽  
Nasopharyngeal Swab ◽  
Medical Procedures ◽  
Diffusion Weight Image ◽  
Global Amnesia

Abstract Background Transient global amnesia (TGA) is a clinical syndrome characterized by a temporary short-term memory loss with inability to retain new memories, usually lasting 2 to 8 h. TGA may be related to several medical procedures, including angiography, general anesthesia, gastroscopy. Case presentation We report a 58-year-old woman who experiencing TGA one hour after the execution of her first-time nasopharyngeal swab for COVID-19. Brain MRI showed a typical punctate Diffusion Weight Image (DWI) hippocampal lesion. Conclusions This is the first report of TGA after the execution of nasopharyngeal swab for COVID-19. This association lengthen the list of medical procedures associated with TGA, and we discuss the possible plausible mechanisms by which a nasopharyngeal swab could trigger TGA.

Clinical features, risk factors, and prognosis in transient global amnesia: a follow-up study

2005 ◽  
Vol 12 (5) ◽  
pp. 350-356 ◽  
Author(s):  
L. Pantoni ◽  
E. Bertini ◽  
M. Lamassa ◽  
G. Pracucci ◽  
D. Inzitari
Keyword(s):  
Risk Factors ◽  
Clinical Features ◽  
Transient Global Amnesia ◽  
Follow Up Study ◽  
Global Amnesia

scholarly journals Increased biological antioxidant potential in the cerebrospinal fluid of transient global amnesia patients

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Takayuki Kawai ◽  
Ryuji Sakakibara ◽  
Yosuke Aiba ◽  
Fuyuki Tateno ◽  
Tsuyoshi Ogata ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cerebrospinal Fluid ◽  
Brain Mri ◽  
Antioxidant Properties ◽  
Transient Global Amnesia ◽  
Pathological Process ◽  
Antioxidant Potential ◽  
Control Subjects ◽  
Total Antioxidant ◽  
Global Amnesia

AbstractOxidative stress may accompany the pathological process in transient global amnesia (TGA). We measured the biological antioxidant potential (BAP) in the cerebrospinal fluid (CSF) of TGA patients. We enrolled 13 TGA patients (7 men, 6 women; mean age 65.0 years [48–70 years]) and 24 control subjects (12 men, 12 women; mean age 38.2 years [17–65 years]; age did not correlate with csfBAP in this group). We performed brain MRI in all TGA patients, and CA1 lesions were noted by MRI in 5 subjects. We measured csfBAP, total antioxidant properties, in all TGA patients and controls. csfBAP levels were higher in TGA patients than in controls (p = 0.024, 0.028). csfBAP levels in TGA patients did not differ between MRI-positive and -negative subgroups. Elevated csfBAP levels were observed in TGA patients, suggesting that oxidative stress may have a role in the pathogenesis of TGA.

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