scholarly journals Incidence of colorectal cancer in young patients

2017 ◽  
Vol 44 (2) ◽  
pp. 208-215 ◽  
Author(s):  
FÁBIO GUILHERME C. M. DE CAMPOS ◽  
MARLENY NOVAES FIGUEIREDO ◽  
MARIANE MONTEIRO ◽  
SÉRGIO CARLOS NAHAS ◽  
IVAN CECCONELLO
Keyword(s):  
Colorectal Cancer ◽  
Young Adults ◽  
Opposite Effect ◽  
Young Patients ◽  
Educational Programs ◽  
Sporadic Colorectal Cancer ◽  
Clinical Prognosis ◽  
Great Volume ◽  
Apparent Increase ◽  
Sixth Decade

ABSTRACT Sporadic colorectal cancer (CRC) is traditionally diagnosed after de sixth decade of life, although a small percentage of cases are diagnosed in patients under 40 years of age, and incidence is increasing. There exists a great volume of controversy regarding clinical outcome of young patients diagnosed with colorectal cancer (CRC) when compared to elder counterparts. Our aims were to evaluate the rate of CRC in young patients, to review the pertaining literature and to discuss outcomes and clinical prognosis. A retrospective review involving patients with CRC was undertaken, focusing on age at diagnosis. The information extracted from this literature review showed a trend towards a decreased incidence in older people with an opposite effect among adolescents and young adults. Moreover, biological aggressiveness in young adults diagnosed with CRC has not been fully recognized, although it is usually diagnosed later and in association with adverse histological features. Besides that, these features don't affect outcome. These apparent increase in CRC incidence among young patients during the last decades raises the need for a greater suspicious when evaluating common symptoms in this group. Thus, educational programs should widespread information for both population and physicians to improve prevention and early diagnosis results.

scholarly journals Long-Term Outcome and Prognostic Factors of Sporadic Colorectal Cancer in Young Patients

Medicine ◽  
2016 ◽  
Vol 95 (19) ◽  
pp. e3641 ◽  
Author(s):  
Tae Jun Kim ◽  
Eun Ran Kim ◽  
Sung Noh Hong ◽  
Dong Kyung Chang ◽  
Young-Ho Kim
Keyword(s):  
Colorectal Cancer ◽  
Prognostic Factors ◽  
Young Patients ◽  
Sporadic Colorectal Cancer ◽  
Term Outcome ◽  
Long Term Outcome

Microsatelite instability in young patients with sporadic colorectal cancer

1998 ◽  
Vol 114 ◽  
pp. A581
Author(s):  
I. Claro ◽  
M. Cravo ◽  
L. Glória ◽  
C. Gaspar ◽  
P. Lage ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Young Patients ◽  
Sporadic Colorectal Cancer

Segmental versus extended resection for sporadic colorectal cancer in young patients

2014 ◽  
Vol 110 (3) ◽  
pp. 328-332 ◽  
Author(s):  
Coen L. Klos ◽  
Grace Montenegro ◽  
Nida Jamal ◽  
Paul E. Wise ◽  
James W. Fleshman ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Young Patients ◽  
Sporadic Colorectal Cancer ◽  
Extended Resection

scholarly journals Colorectal cancer in adolescents and young adults with Lynch syndrome: a Danish register-based study

BMJ Open ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. e053538
Author(s):  
Jon Ambæk Durhuus ◽  
Christina Therkildsen ◽  
Thomas Kallemose ◽  
Mef Nilbert
Keyword(s):  
Colorectal Cancer ◽  
Young Adults ◽  
Lynch Syndrome ◽  
Early Onset ◽  
Early Stage ◽  
Young Patients ◽  
Stage Distribution ◽  
Confounding Variables ◽  
Symptom Awareness ◽  
Cox Analysis

ObjectiveTo assess clinicopathological predictors and prognosis in early-onset colorectal cancer (CRC) in Lynch syndrome with comparison to patients diagnosed from age 40 and up.DesignNational, retrospective register-based case–control study.SettingDanish national hereditary CRC register.ParticipantsIndividuals with Lynch syndrome diagnosed with CRC from January 1950 to June 2020. The analysis was based on 215 early-onset CRCs diagnosed between 15 and 39 years of age and 574 CRCs diagnosed at age 40–88 years.Main outcome measuresClinical and histopathological characteristics and survival. Confounding variables were analysed by Cox analysis.Results27.2% of the tumours in the Danish Lynch syndrome cohort were diagnosed under age 40. Disease-predisposing alterations in MLH1 and MSH2 were overrepresented in the age 15–39 cohort compared with patients diagnosed over age 40. CRCs diagnosed under age 40 showed an adverse stage distribution with 36.2% stage III–IV tumours compared with 25.8% in the over age 40 group. However, young patients diagnosed with early-stage tumours did have a significantly better prognosis compared with early-stage tumours in the older age group.ConclusionsEarly-onset CRC in Lynch syndrome is primarily linked to alterations in MLH1 and MSH2 and displays an adverse stage distribution. These observations serve as a reminder of surveillance, symptom awareness and rapid diagnostic handling of CRC in young adults with Lynch syndrome.

scholarly journals S3504 Sporadic Colorectal Cancer in Young Adults: An Increasing Phenomenon

2021 ◽  
Vol 116 (1) ◽  
pp. S1441-S1441
Author(s):  
Vihitha Thota ◽  
Sudheer Konduru ◽  
Manaswitha Thota
Keyword(s):  
Colorectal Cancer ◽  
Young Adults ◽  
Sporadic Colorectal Cancer

A population-based study of young-onset colorectal cancer patients: Effect of knowledge gaps among patients and providers on stage at diagnosis and quality of life.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. 4095-4095
Author(s):  
Ronit Yarden ◽  
Kim Lynn Newcomer ◽  
Danielle Peterson ◽  
Keyword(s):  
Quality Of Life ◽  
Colorectal Cancer ◽  
Social Media ◽  
Young Adults ◽  
Online Survey ◽  
Young Patients ◽  
Young Onset ◽  
Number Of Patients ◽  
Incidence And Mortality

4095 Background: Colorectal cancer (CRC) is one of the leading cause of cancer-related death in the US. Despite a decrease in overall incidence and mortality, there has been an alarming increase in CRC diagnosis among young adults (20-49 years old) and causes remain unknown. To explore the unique challenges and unmet needs of the young-adult patients many still establishing their life-long goals, the Colorectal Cancer Alliance launched a comprehensive survey for young-onset CRC patients and survivors via social media to track the self-reported pre-diagnosis awareness, path to diagnosis, and post-diagnosis quality of life experiences of this often overlooked group. Methods: A cross-sectional study, conducted in the form of an online survey, was launched via multiple channels of social media. The questionnaire was based on established instruments including PROMIS, EORTC-QOL-30, and EORTC-CR-29 and EORTC-SHC-22. Results: The survey was completed by 885 patients and survivors. The median age at diagnosis was 42 +/-7, significantly lower than the recommended screening age. Only 6% of respondents were diagnosed with Lynch syndrome although 29% reported some family history. Most respondents (63%) indicated they were not aware that CRC can affect people younger than 50, which may explain why the majority of patients waited more than 3 months and 23% waited over 12 months after noticing their symptoms to visit their doctor. The majority, 75%, of all patients visited 2+ doctors and 11% of those patients visited 10+ doctors before their doctor suspected colorectal cancer. A significant number of patients felt their doctors were dismissive of their symptoms. 77% of patients were diagnosed with advanced disease and were subjected to aggressive therapies that substantially affected their quality of life including neuropathy, anxiety, clinical depression, sexual morbidity, unemployment, and financial toxicity. Many young patients indicated that their doctors did not inform them about fertility preservation. Conclusions: Our survey indicates that medical professionals and young adults need to be aware of the increasing incidence of young-onset CRC, and the importance of timely screening when signs and symptoms are present, regardless of age.

scholarly journals Sporadic colorectal cancer in adolescents and young adults: a scoping review of a growing healthcare concern

2020 ◽  
Vol 35 (8) ◽  
pp. 1413-1421
Author(s):  
Natasha Christodoulides ◽  
Mariam Lami ◽  
George Malietzis ◽  
Shahnawaz Rasheed ◽  
Paris Tekkis ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Young Adults ◽  
Scoping Review ◽  
Adolescents And Young Adults ◽  
Sporadic Colorectal Cancer

scholarly journals Clinical and phenotypic variants of hereditary and sporadic colorectal cancer in young patients

2021 ◽  
Vol 60 (2) ◽  
pp. 9-21
Author(s):  
G. A. Afonin ◽  
N. A. Baltayev ◽  
D. R. Kaidarova ◽  
А. К. Ababakriyev ◽  
P. B. Kalmenova
Keyword(s):  
Colorectal Cancer ◽  
Young People ◽  
Young Patients ◽  
Response To Therapy ◽  
Sporadic Colorectal Cancer ◽  
Upward Trend ◽  
Primary Tumors ◽  
The Republic ◽  
Group 2 ◽  
Group 1

Relevance: In the Republic of Kazakhstan, colorectal cancer (CRC) ranks third in the structure of oncological pathology. In 2008-2019, the CRC incidence in the Republic was growing each year. There is an upward trend in CRC incidence among young people. Cohort studies show that, in young patients, CRC is characterized by distal localization of the tumor process, advanced stages of the disease, an aggressive course, and low tumor differentiation. The known association of phenotypic signs with clinical characteristics of the disease, such as the response to therapy and survival rates, urges addressing this problem. The phenotypic and molecular genetic aspects of CRC in young people have not been systematically studied in Kazakhstan. The purpose of the study was to compare the phenotypic features of hereditary and sporadic colorectal cancer in young patients and patients over 65 years. Results: The study involved 185 patients aged 17 to 50 years (Group 1) and 112 patients aged 65 to 85 (Group 2). In Group 1, a locally advanced process (stage III) was 14.8% more often than in Group 2; stage IV was 1.23 times more common in men; and multiple primary tumors were 3.1% more often, with a prevailing metachronous course. In Groups 1 & 2, most tumors were localized in the rectum; 84.8% and 78.6% of tumors, respectively, occurred in the left half of the colon. The frequency of right-sided tumors increased with age modified by gender (in Group 2). Hereditary burdened anamnesis was detected in 14.6% patients before 50 (6.57% more than in Group 2); family history of CRC – in 4.8% patients. The latter is consistent with published data. The studied syndromic variants met the diagnostic criteria for familial adenomatous polyposis, Lynch syndrome, Peutz-Jeghers syndrome, and familial type X colorectal cancer. Conclusion: The increase in CRC incidence at the age of 50-70 years is explained by the effectiveness of screening. However, the upward trend for the age below 50 needs a detailed study of etiological (dietary, environmental, behavioral, hereditary) factors. Effective early diagnostics requires considering the phenotypic characteristics and hereditary history associated with a high risk of CRC onset.

Young-onset colorectal cancer patients disproportionately diagnosed with advanced disease: Patient self-reported journey of symptom duration and misdiagnosis.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. 3567-3567
Author(s):  
Ronit Yarden ◽  
Kim Lynn Newcomer ◽  
Keyword(s):  
Quality Of Life ◽  
Colorectal Cancer ◽  
Young Adults ◽  
Advanced Disease ◽  
Disease Patient ◽  
Young Patients ◽  
Symptom Duration ◽  
Young Onset ◽  
Incidence And Mortality

3567 Background: Colorectal cancer (CRC) is the second leading cause of cancer-related death among males and females in the US. Despite a decrease in overall incidence and mortality, there has been an alarming increase of CRC diagnosis among young adults (20-49 years old). The Colorectal Cancer Alliance launched a comprehensive survey for young-onset CRC patients and survivors via social media to track the self-reported clinical, psychosocial, financial and quality of life experiences of this often overlooked, group. Methods: The survey was completed by 1195 living patients and survivors. The majority of participants (57%) were diagnosed between the ages of 40 and 49, 33% of patients/survivors were diagnosed between the ages 30-39 and about 10% were diagnosed before the age of 30. Only 8% of the respondents were diagnosed with Lynch syndrome although about 28% reported some family history. Results: Our survey revealed a higher proportion of the young-onset patients and survivors (71%), diagnosed with advanced stage tumors, compared with ACS report for overall CRC patients (60%). The late stage diagnosis subjected young patients to aggressive therapies and a substantial decrease in quality of life including neuropathy, anxiety, clinical depression, and sexual dysfunctions. Most respondents (63%) waited 3-12 months before visiting a doctor, with higher proportion of females waited more than 12 months compared with males (22% vs. 15% p = 0.02). Moreover, even when visited their doctors, most patients indicated that they were initially misdiagnosed. The majority of the respondents (67%) saw at least 2 physicians, and some more than 4 physicians, prior to their diagnosis. Patients that saw 3 or more physicians prior to diagnosis were more likely to be diagnosed with advanced disease. Interestingly, half of the patients that were seen by one physician also claimed they were initially misdiagnosed. Conclusions: Our survey indicates that medical professionals and young adults need to be aware of the increasing incidence of young-onset CRC, and the importance of timely screening when signs and symptoms are present, regardless of age. Yet, 50% of physicians did not explain to the patients’ family members about their elevated risk of the disease and their need for screening.

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