scholarly journals S3504 Sporadic Colorectal Cancer in Young Adults: An Increasing Phenomenon

2021 ◽  
Vol 116 (1) ◽  
pp. S1441-S1441
Author(s):  
Vihitha Thota ◽  
Sudheer Konduru ◽  
Manaswitha Thota
Keyword(s):  
Colorectal Cancer ◽  
Young Adults ◽  
Sporadic Colorectal Cancer

scholarly journals Incidence of colorectal cancer in young patients

2017 ◽  
Vol 44 (2) ◽  
pp. 208-215 ◽  
Author(s):  
FÁBIO GUILHERME C. M. DE CAMPOS ◽  
MARLENY NOVAES FIGUEIREDO ◽  
MARIANE MONTEIRO ◽  
SÉRGIO CARLOS NAHAS ◽  
IVAN CECCONELLO
Keyword(s):  
Colorectal Cancer ◽  
Young Adults ◽  
Opposite Effect ◽  
Young Patients ◽  
Educational Programs ◽  
Sporadic Colorectal Cancer ◽  
Clinical Prognosis ◽  
Great Volume ◽  
Apparent Increase ◽  
Sixth Decade

ABSTRACT Sporadic colorectal cancer (CRC) is traditionally diagnosed after de sixth decade of life, although a small percentage of cases are diagnosed in patients under 40 years of age, and incidence is increasing. There exists a great volume of controversy regarding clinical outcome of young patients diagnosed with colorectal cancer (CRC) when compared to elder counterparts. Our aims were to evaluate the rate of CRC in young patients, to review the pertaining literature and to discuss outcomes and clinical prognosis. A retrospective review involving patients with CRC was undertaken, focusing on age at diagnosis. The information extracted from this literature review showed a trend towards a decreased incidence in older people with an opposite effect among adolescents and young adults. Moreover, biological aggressiveness in young adults diagnosed with CRC has not been fully recognized, although it is usually diagnosed later and in association with adverse histological features. Besides that, these features don't affect outcome. These apparent increase in CRC incidence among young patients during the last decades raises the need for a greater suspicious when evaluating common symptoms in this group. Thus, educational programs should widespread information for both population and physicians to improve prevention and early diagnosis results.

scholarly journals Sporadic colorectal cancer in adolescents and young adults: a scoping review of a growing healthcare concern

2020 ◽  
Vol 35 (8) ◽  
pp. 1413-1421
Author(s):  
Natasha Christodoulides ◽  
Mariam Lami ◽  
George Malietzis ◽  
Shahnawaz Rasheed ◽  
Paris Tekkis ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Young Adults ◽  
Scoping Review ◽  
Adolescents And Young Adults ◽  
Sporadic Colorectal Cancer

COLORECTAL CANCER MORTALITY IN YOUNG ADULTS IS RISING IN THE USA, CANADA, UK AND AUSTRALIA, BUT NOT IN EUROPE AND ASIA

2021 ◽  
Author(s):  
Claudia Santucci ◽  
Paolo Boffetta ◽  
Fabio Levi ◽  
Carlo La Vecchia ◽  
Eva Negri ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Young Adults ◽  
Cancer Mortality ◽  
The Usa ◽  
Colorectal Cancer Mortality

Clinicopathologic Features of Sporadic Colorectal Cancer with MLH1/MSH2 Loss of Expression - Reduced Likelihood of Metastases

2008 ◽  
Vol 24 (3) ◽  
pp. 175 ◽  
Author(s):  
Ji Won Park ◽  
Hee Jin Chang ◽  
Kyung Hae Jung ◽  
Dae Yong Kim ◽  
Dae Kyung Sohn ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Sporadic Colorectal Cancer ◽  
Clinicopathologic Features

Biomarkers for Early Detection of Colitis-associated Colorectal Cancer - Current Concepts, Future Trends

2020 ◽  
Vol 22 (1) ◽  
pp. 137-145
Author(s):  
Tomasz Mackiewicz ◽  
Aleksander Sowa ◽  
Jakub Fichna
Keyword(s):  
Colorectal Cancer ◽  
Early Detection ◽  
Cancer Development ◽  
Sporadic Colorectal Cancer ◽  
Future Trends ◽  
Significant Progress ◽  
Current Standard ◽  
Risk Of Cancer ◽  
Histological Testing ◽  
Made In

: Colitis-associated colorectal cancer (CAC) remains a critical complication of ulcerative colitis (UC) with mortality of approximately 15%, which makes early CAC diagnosis crucial. The current standard of surveillance, with repetitive colonoscopies and histological testing of biopsied mucosa samples is burdensome and expensive, and therefore less invasive methods and reliable biomarkers are needed. Significant progress has been made thanks to continuous extensive research in this field, however no clinically relevant biomarker has been established so far. This review of the current literature presents the genetic and molecular differences between CAC and sporadic colorectal cancer and covers progress made in the early detection of CAC carcinogenesis. It focuses on biomarkers under development, which can be easily tested in samples of body fluids or breath and, once made clinically available, will help to differentiate between progressors (UC patients who will develop dysplasia) from non-progressors and enable early intervention to decrease the risk of cancer development.

scholarly journals Tracking the Antibody Immunome in Sporadic Colorectal Cancer by Using Antigen Self-Assembled Protein Arrays

Cancers ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 2718
Author(s):  
María González-González ◽  
José María Sayagués ◽  
Luis Muñoz-Bellvís ◽  
Carlos Eduardo Pedreira ◽  
Marcello L. R. de Campos ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Clinical Utility ◽  
Genetic Alterations ◽  
Western World ◽  
Sporadic Colorectal Cancer ◽  
Protein Arrays ◽  
Humoral Immune ◽  
Cellular Processes ◽  
Healthy Donors ◽  
Associated Proteins

Sporadic Colorectal Cancer (sCRC) is the third leading cause of cancer death in the Western world, and the sCRC patients presenting with synchronic metastasis have the poorest prognosis. Genetic alterations accumulated in sCRC tumor cells translate into mutated proteins and/or abnormal protein expression levels, which contribute to the development of sCRC. Then, the tumor-associated proteins (TAAs) might induce the production of auto-antibodies (aAb) via humoral immune response. Here, Nucleic Acid Programmable Protein Arrays (NAPPArray) are employed to identify aAb in plasma samples from a set of 50 sCRC patients compared to seven healthy donors. Our goal was to establish a systematic workflow based on NAPPArray to define differential aAb profiles between healthy individuals and sCRC patients as well as between non-metastatic (n = 38) and metastatic (n = 12) sCRC, in order to gain insight into the role of the humoral immune system in controlling the development and progression of sCRC. Our results showed aAb profile based on 141 TAA including TAAs associated with biological cellular processes altered in genesis and progress of sCRC (e.g., FSCN1, VTI2 and RPS28) that discriminated healthy donors vs. sCRC patients. In addition, the potential capacity of discrimination (between non-metastatic vs. metastatic sCRC) of 7 TAAs (USP5, ML4, MARCKSL1, CKMT1B, HMOX2, VTI2, TP53) have been analyzed individually in an independent cohort of sCRC patients, where two of them (VTI2 and TP53) were validated (AUC ~75%). In turn, these findings provided novel insights into the immunome of sCRC, in combination with transcriptomics profiles and protein antigenicity characterizations, wich might lead to the identification of novel sCRC biomarkers that might be of clinical utility for early diagnosis of the tumor. These results explore the immunomic analysis as potent source for biomarkers with diagnostic and prognostic value in CRC. Additional prospective studies in larger series of patients are required to confirm the clinical utility of these novel sCRC immunomic biomarkers.

S2054 A Novel Mouse Model of Sporadic Colorectal Cancer

2008 ◽  
Vol 134 (4) ◽  
pp. A-305-A-306
Author(s):  
Kenneth Hung ◽  
Larissa Georgeon Richard ◽  
Alexandra Kunin ◽  
Umar Mahmood ◽  
Raju Kucherlapati
Keyword(s):  
Colorectal Cancer ◽  
Mouse Model ◽  
Sporadic Colorectal Cancer
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