scholarly journals Evaluation of antioxidant, photoprotective and antinociceptive activities of Marcetia macrophylla extract: potential for formulation of sunscreens

2023 ◽  
Vol 83 ◽  
Author(s):  
S. C. C. Costa ◽  
P. K. F. Damasceno ◽  
R. G. G. Lima ◽  
M. B. Botura ◽  
C. R. C. Branco ◽  
...  
Keyword(s):  
Biological Activities ◽  
Spectroscopic Method ◽  
Pharmaceutical Preparations ◽  
Sun Protection ◽  
Array Detector ◽  
Protection Factor ◽  
Organoleptic Characteristics ◽  
Sun Protection Factor

Abstract The antioxidant, photoprotective and antinociceptive Marcetia macrophylla active extract was investigated as an active ingredient in a sunscreen cream formulation. Thus, the M. macrophylla extract showed IC50 of 3.43 mg/ml of the antioxidant (DPPH∙ scavenging test) and Sun Protection Factor of 20.25 (SPF/UV-B, at 250 µg/ml) and UV-A of 78.09% (photobleaching trans-resveratrol test). The antinociceptive activity was superior to all standards tested using the in vivo acetic acid-induced writhing test (99.14% at the dose of 200 mg/kg) and the high-performance liquid chromatography coupled with diode array detector and mass spectroscopy multi-stage (HPLC-DAD-MS/MS) enabled the structural characterization of the quercetin-3-O-hexoside, quercetin-3-O-pentoside and quercetin-3-O-desoxihexoside. The pharmaceutical formulation containing the Marcetia macrophylla crude active extract was prepared and the physicochemical tests (organoleptic characteristics, pH analysis and centrifugation), the in vitro UVB (sun protection factor, SPF) and UVA (β-carotene) using the spectroscopic method were investigated. The formulation showed satisfactory results concerning the physicochemical parameters evaluated and active against the UV test. Thus, M. macrophylla showed biological activities with potential use in pharmaceutical preparations.

Correlation of in vivo and in vitro measurements of sun protection factor

2020 ◽  
Vol 11 (2) ◽  
Author(s):  
M.-T. Sheu ◽  
C.-W. Lin ◽  
M.-C. Huang ◽  
C.-H. Shen ◽  
H.-O. Ho
Keyword(s):  
Sun Protection ◽  
Protection Factor ◽  
In Vitro Measurements ◽  
Sun Protection Factor

Evaluation of Sun Protection Factor of Cosmetic Formulations by a Simple Visual In Vitro Method Mimicking the In Vivo Method

2012 ◽  
Vol 101 (2) ◽  
pp. 726-732 ◽  
Author(s):  
Leonardo R. de Paula ◽  
André L.A. Parussulo ◽  
Koiti Araki ◽  
Henrique E. Toma
Keyword(s):  
Sun Protection ◽  
Protection Factor ◽  
In Vitro Method ◽  
Cosmetic Formulations ◽  
Sun Protection Factor

scholarly journals Aktivitas Perlindungan Tabir Surya Secara In Vitro Dari Ekstrak Etanol Kulit Buah, Kulit Biji dan Biji Pinang Yaki (Areca vestiaria Giseke)

Jurnal MIPA ◽  
2017 ◽  
Vol 6 (2) ◽  
pp. 46
Author(s):  
Irmawati Anggriani ◽  
Max R.J. Runtuwenen ◽  
Vanda S. Kamu
Keyword(s):  
Ethanol Extract ◽  
Sun Protection ◽  
Protection Factor ◽  
Rotary Evaporator ◽  
Three Samples ◽  
Maximum Protection ◽  
Sun Protection Factor ◽  
Protection Activity

Penelitian ini bertujuan untuk menguji aktivitas perlindungan tabir surya dari ekstrak etanol kulit buah, kulit biji dan biji pinang yaki secara in vitro. Tahap pendahuluan penelitian ini yaitu menguji nilai SPF (Sun Protection Factor) yang dilakukan secara invitro dengan menggunakan metode spektrofotometri UV-Vis. Serbuk kulit buah, kulit biji dan biji dimeserasi dengan pelarut etanol kemudian dipekatkan dengan rotary evaporator sehingga menghasilkan ekstrak pekat. Ekstrak etanol kulit buah, kulit biji dan biji pinang yaki memiliki nilai SPF yang berbeda yaitu 12,05 , 3,45 , dan 1,00. Dari nilai SPF ketiga sampel tersebut, kulit buah yang memiliki nilai SPF tertinggi dan termasuk dalam kategori Proteksi Maksimum sehingga kulit buah pinang yaki dapat dilakukan uji lanjut tentang aktivitas perlindungan tabir surya secara in vivo.The purpose of this study were to test the sunscreen protection activity of ethanol extract of the skin of Pinang Yaki fruit, shell skin and seed by using in vitro method. The preliminary stage of this research was to test the value of SPF (Sun Protection Factor) by invitro using UV-Vis spectrophotometry method. Skin of Pinang Yaki Fruit, shell skin and seed were maceration with ethanol then concentrated with a rotary evaporator to produce a concentrated extract. Skin of Pinang fruit, shell skin and seed have different SPF values of 12.05, 3.45, and 1.00. From the SPF values of the three samples, the skin of the fruit has the highest SPF value and is included in the Maximum Protection category so that the skin of Pinang Yaki fruit could be tested futher for  sunscreen protection activity by in vivo method.

scholarly journals A Randomized Study to Determine the Sun Protection Factor of Natural Pterostilbene from Pterocarpus Marsupium

Cosmetics ◽  
2020 ◽  
Vol 7 (1) ◽  
pp. 16 ◽  
Author(s):  
Muhammed Majeed ◽  
Shaheen Majeed ◽  
Renuka Jain ◽  
Lakshmi Mundkur ◽  
H. R. Rajalakshmi ◽  
...  
Keyword(s):  
Skin Irritation ◽  
Radical Scavenging ◽  
Sun Protection ◽  
The Sun ◽  
Protection Factor ◽  
Pterocarpus Marsupium ◽  
Sun Protection Factor ◽  
Harmful Effects

Ultraviolet (UV) rays and its harmful effects have always been a concern to skin health. Sunscreen and sunblock prevent the harmful effects of UV radiation on the skin. Sun Protection Factor (SPF) is an indication of the sun-protective capacity of an ingredient. There is an ever increasing interest in the cosmetic industry for developing novel functional ingredients from natural sources. The purpose of this study was to determine in-vitro and in vivo SPF of natural 90% pterostilbene extracted from the dried heartwood of Pterocarpus marsupium (Indian Kino). The SPF of purified pterostilbene and a formulation containing 0.4% pterostilbene was determined In Vitro using a UV spectrophotometer. Pterostilbene had an SPF of 21.73 ± 0.06, while the cream formulation had an SPF of 8.84 ± 0.01. The in vivo SPF of the 0.4% pterostilbene cream in humans was found to be 6.2 ± 1.30. Primary skin irritation tests in human subjects showed the formulation was safe and had no irritation potential. Pterostilbene was also found to have significant antioxidant activity as determined by free radical scavenging assays in vitro. These results suggest that natural pterostilbene is an antioxidant and shows SPF value both in-vitro and in the human clinical study and thus could be used as an ingredient in topical sun-protective formulations.

In Vitro Evaluation of Sun Protection Factor of Plant Extracts By Ultraviolet Spectroscopy Method

2021 ◽  
Vol 1 (30) ◽  
pp. 58-62
Author(s):  
Geeta Bhandari Garima Negi
Keyword(s):  
Chronic Exposure ◽  
Sun Protection ◽  
Skin Protection ◽  
Murraya Koenigii ◽  
Protection Factor ◽  
Safe Alternative ◽  
Sun Protection Factor ◽  
Acute And Chronic Exposure ◽  
Sunscreen Products

Abstract-Acute and chronic exposure to nonphysiological doses of ultraviolet radiation leads to variety of changes of skin ranging from sun-burn, erythema to skin cancer. For skin protection from deleterious effects of sunlight, sunscreen products are used in various forms having chemical and physical filters. However, synthetic sunscreen formulations are reported to cause adverse effects. Thus the present study was planned to evaluate the sun protection factor (SPF) of leaves extract of Murraya koenigii for their application as herbal sunscreens. The results suggested that the occurrence of active compounds responsible for ultraviolet absorption can be extracted for use in sunscreens preparations as better, cheaper and safe alternative to harmful chemical sunscreens. Keywords: UV radiations, SPF, Murraya koenigii

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