Association of family risk and lifestyle/comorbidities in ovarian cancer patients

Summary Objectives: to analyze factors that might indicate familial predisposition for ovarian cancer in patients diagnosed with this disease. Methods: in a prospective single center cohort study at the Institute of Cancer of the State of São Paulo (ICESP), 51 women diagnosed with ovarian cancer were included. Familial predisposition for ovarian cancer was defined as having a higher than 10% chance of having a BRCA1/2 mutation according to the Manchester scoring system, a validated method to assess the likelihood of mutation detection. Each patient was interviewed with a standardized questionnaire on established risk factors for ovarian cancer and other factors that might influence the risk to develop ovarian cancer. Logistic regression analyses were performed to estimate the impact of the evaluated factors on the likelihood of mutation detection, by calculating odds ratios and 95% confidence intervals. Results: seventeen out of 51 patients had a family history of breast and/or ovarian cancer, four patients had a history of breast or endometrial cancer, 11 were diagnosed before the age of 50, and 12 presented a risk of familial predisposition to ovarian cancer higher than 10%. Patients with comorbidities, such as hypertension, diabetes, hormonal disorders, dyslipidemia and psychiatric conditions, presented a lower chance of having a familial predisposition for ovarian cancer (OR: 0.22; 95% CI: 0.06-0.88; p=0.03). Conclusion: in this study, having comorbidities was associated with a lower risk of having a familial predisposition for ovarian cancer. Other factors associated with the risk of ovarian cancer did not have an impact on this predisposition.

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Willingness to receive future COVID-19 vaccines following the COVID-19 epidemic in Shanghai, China

BMC Public Health ◽

10.1186/s12889-021-11174-0 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Yehong Zhou ◽

Junjie Zhang ◽

Wenwen Wu ◽

Man Liang ◽

Qiang-Song Wu

Keyword(s):

Vaccine Safety ◽

Older Individuals ◽

Regression Analyses ◽

Pharmacological Interventions ◽

Cross Sectional Survey ◽

Cross Sectional ◽

Factors Associated ◽

History Of ◽

Potential Factors ◽

To Receive

Abstract Background There are no pharmacological interventions currently available to prevent the transmission of SARS-CoV-2 or to treat COVID-19. The development of vaccines against COVID-19 is essential to contain the pandemic. we conducted a cross-sectional survey of Shanghai residents to understand residents’ willingness to be vaccinated with any future COVID-19 vaccines and take measures to further improve vaccination coverage. Methods We conducted a cross-sectional survey using self-administered anonymous questionnaires from 1 July to 8 September 2020. The main outcome was willingness of participants, and any children or older individuals living with them, to receive future COVID-19 vaccines. Logistic regression analyses were used to explore potential factors associated with vaccination willingness. Results A total of 1071 participants were asked about their willingness to receive future COVID-19 vaccines, for themselves and at least 747 children and 375 older individuals (≥60 years old) living with them. The highest proportion of expected willingness to vaccinate was among participants (88.6%), followed by children (85.3%) and older individuals (84.0%). The main reasons for reluctance to vaccinate among 119 participants were doubts regarding vaccine safety (60.0%) and efficacy (28.8%). Participants with a self-reported history of influenza vaccination were more likely to accept COVID-19 vaccines for themselves [adjusted odds ratio (OR) = 1.83; 95% confidence interval (CI): 1.19–2.82], their children (adjusted OR = 2.08; 95%CI: 1.30–3.33), and older individuals in their household (adjusted OR = 2.12; 95%CI: 1.14–3.99). Participants with older individuals in their families were less willing to vaccinate themselves (adjusted OR = 0.59; 95%CI: 0.40–0.87) and their children (adjusted OR = 0.58; 95%CI: 0.38–0.89). Conclusions Participants were more reluctant to accept COVID-19 vaccines for older individuals living with them. The presence of older individuals in the home also affected willingness of participants and their children to be vaccinated.

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Evaluating the impact of a history of breast cancer on outcomes in women with high-grade serous ovarian cancer

Gynecologic Oncology ◽

10.1016/j.ygyno.2018.04.482 ◽

2018 ◽

Vol 149 ◽

pp. 212

Author(s):

J. Gillen ◽

M. Rowland ◽

A.Y. Liu ◽

S. Vesely ◽

B. Powell ◽

...

Keyword(s):

Breast Cancer ◽

Ovarian Cancer ◽

High Grade ◽

Serous Ovarian Cancer ◽

History Of ◽

The Impact

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Factors associated with the incompliance with mammogram screening among individuals with a family history of breast cancer or ovarian cancer

Breast Cancer Research and Treatment ◽

10.1007/s10549-006-9298-5 ◽

2006 ◽

Vol 101 (3) ◽

pp. 317-324 ◽

Cited By ~ 10

Author(s):

Hongyu Wu ◽

Kangmin Zhu ◽

Ismail Jatoi ◽

Mona Shah ◽

Craig D. Shriver ◽

...

Keyword(s):

Breast Cancer ◽

Ovarian Cancer ◽

Family History ◽

Factors Associated ◽

History Of

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Evaluating the impact of a history of breast cancer on chemotherapy toxicities experienced in women with high grade serous ovarian cancer

Gynecologic Oncology ◽

10.1016/j.ygyno.2019.03.209 ◽

2019 ◽

Vol 154 (1) ◽

pp. e21

Author(s):

J. Gillen ◽

M. Enty ◽

M. Rowland ◽

J. Dvorak ◽

K. Ding ◽

...

Keyword(s):

Breast Cancer ◽

Ovarian Cancer ◽

High Grade ◽

Serous Ovarian Cancer ◽

History Of ◽

The Impact

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Admission to psychiatric hospital for mental illnesses 2 years prechildbirth and postchildbirth in Scotland: a health informatics approach to assessing mother and child outcomes

BMJ Open ◽

10.1136/bmjopen-2017-016908 ◽

2017 ◽

Vol 7 (9) ◽

pp. e016908 ◽

Cited By ~ 1

Author(s):

Julie Langan Martin ◽

Gary McLean ◽

Daniel Martin ◽

Roch Cantwell ◽

Daniel J Smith

Keyword(s):

Mental Illness ◽

Psychiatric Hospital ◽

Potential Risk ◽

Health Informatics ◽

Psychiatric Admission ◽

Affective Psychosis ◽

Factors Associated ◽

History Of ◽

Depressive Episodes ◽

The Impact

ObjectiveTo identify factors associated with: admission to a specialist mother and baby unit (MBU) and the impact of perinatal mental illness on early childhood development using a data linkage approach in the 2 years prechildbirth and postchildbirth.MethodsScottish maternity records (SMR02) were linked to psychiatric hospital admissions (SMR04). 3290 pregnancy-related psychiatric admissions for 1730 women were assessed. To investigate factors associated with MBU admission, the group of mothers admitted to an MBU were compared with those admitted to general psychiatric wards. To assess the impact of perinatal mental illness on early child development, a pragmatic indicator for ‘at potential risk of adversity’, defined as a child who was recorded as requiring intensive treatment at any time under the health plan indicators (HPI) and/or who had no record of completing three doses of the 5-in-1 vaccine by 12 months was generated. Logistic regression models were used to describe the association between each variable and the risk of admission between those with a history of prior psychiatric admission and those without.ResultsWomen admitted to an MBU were significantly more likely to be admitted with non-affective psychosis (OR=1.97, 95% CI 1.22 to 3.18), affective psychosis (OR=2.44, 95% CI 1.37 to 4.33) and non-psychotic depressive episodes (OR=1.93, 95% CI 1.42 to 2.63). They were less likely to come from deprived areas (OR=0.68 95% CI 0.49 to 0.93). Women with a previous history of psychiatric admission were significantly more likely to be located in the two most deprived quintiles. Almost one-third (29%) of children born to mothers with a pregnancy-related psychiatric admission were assessed as ‘at potential risk of adversity.’ConclusionsA health informatics approach has potential for improving understanding of social and clinical factors, which contribute to the outcomes of perinatal mental illness, as well as potential adverse developmental outcomes for offspring.

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Does the lunar regolith contain secrets of the Solar System? Using the Moon as a cosmic witness plate

Proceedings of the International Astronomical Union ◽

10.1017/s1743921309993140 ◽

2009 ◽

Vol 5 (S264) ◽

pp. 475-477 ◽

Cited By ~ 1

Author(s):

David S. McKay ◽

Louise Riofrio ◽

Bonnie L. Cooper

Keyword(s):

Solar System ◽

Lunar Regolith ◽

Lunar Soil ◽

The Moon ◽

System A ◽

The Earth ◽

Radiation History ◽

History Of ◽

Time Capsule ◽

The Impact

AbstractThe lunar regolith (soil) has recorded a history of the early Moon, the Earth, and the entire solar system. A major goal of the developing lunar exploration program should be to find and play back existing fragments of that tape. By playing back the lunar tape, we can uncover a record of planetary bombardment, as well as solar and stellar variability. The Moon can tell us much about our place in the solar system and in the Universe. The lunar regolith has likely recorded the original meteoritic bombardment of Earth and Moon, a violent cataclysm that may have peaked around 4 GY, and the less intense bombardment occurring since that time. Decrease in bombardment allowed life to develop on Earth. This impact history is preserved as megaregolith layers, ejecta layers, impact melt rocks, and ancient impact breccias. The impact history for the Earth and Moon possibly had profound effects on the origin and development of life. Life may have arrived via meteorite transport from a more quiet body, such as Mars. The solar system may have experienced bursts of severe radiation from the Sun, other stars or from unknown sources. The lunar regolith has also recorded a radiation history in the form of implanted and trapped solar wind and solar flare materials and radiation damage. The Moon can be considered as a giant tape recorder containing the history of the solar system. Lunar soil generated by small impacts will be found sandwiched between layers of basalt or pyroclastic deposits. This filling constitutes a buried time capsule that is likely to contain well-preserved ancient regolith. Study of such samples will show us how the solar system has evolved and changed over time. The lunar recording can provide detailed snapshots of specific portions of solar and stellar variability.

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Gender Differences in Factors Associated with Clinically Meaningful Weight Loss among Adults Who Were Overweight or Obese: A Population-Based Cohort Study

Obesity Facts ◽

10.1159/000512294 ◽

2020 ◽

pp. 1-13

Author(s):

Ji-Bin Li ◽

Zhi-Yu Qiu ◽

Zhen Liu ◽

Qian Zhou ◽

Li-Fen Feng ◽

...

Keyword(s):

Physical Activity ◽

Gender Differences ◽

Weight Loss ◽

Chronic Diseases ◽

Study Entry ◽

Factors Associated ◽

History Of ◽

Males And Females ◽

The Impact

Objectives: The impact of heterogeneity on gender difference for achieving clinically meaningful weight loss (cmWL) remains unclear. Here, we explored the potential gender differences in factors associated with cmWL. Methods: A total of 60,668 participants with body mass index (BMI) ≥25 kg/m2 at study entry and available BMI values at follow-up were included in this study. cmWL was defined as a weight loss of ≥5% from the study entry to follow-up. The associations of social-demographic factors, personal history of chronic diseases, lifestyle behaviors, and history of BMI with cmWL were evaluated using logistic regression models. Results: During a median follow-up of 9.13 years, 26.6% of the participants had a cmWL (30.8% for females vs. 23.1% in males; p < 0.001). Participants with older age, obesity at study entry, being more physical activity compared to 10 years ago, being relapsed smokers or consistent current smokers, having a history of chronic diseases (i.e., diabetes, osteoporosis, and stroke), cancer diagnosis during the study period, and more than 10-year follow-up were more likely to achieve cmWL in both males and females (all p < 0.05). The new smoking quitters and participants with less active in physical activity compared to 10 years ago were less likely to achieve cmWL in both males and females (all p < 0.05). Specifically, males with a history of emphysema were more likely to reach cmWL, and for females, those being overweight at 20 years old and current drinkers were more likely to reach cmWL (p < 0.05). Sensitivity analyses demonstrated similar results. Conclusion: Age, BMI status, physical activity, smoking status, family income, and health status were independent factors in males and females for weight management. However, further well-designed prospective studies are warranted to confirm our findings.

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Homologous recombination deficiency and platinum rechallenge in platinum-resistant ovarian cancer patients.

Journal of Clinical Oncology ◽

10.1200/jco.2017.35.15_suppl.5576 ◽

2017 ◽

Vol 35 (15_suppl) ◽

pp. 5576-5576 ◽

Cited By ~ 1

Author(s):

Alexandre Andre B. A. Da Costa ◽

Marcela Marinelli Salvadori ◽

Camila Vieira Valadares ◽

Carlos Stecca ◽

Louise Brot ◽

...

Keyword(s):

Ovarian Cancer ◽

Overall Survival ◽

Homologous Recombination ◽

Cancer Patients ◽

Response Rate ◽

Homologous Recombination Deficiency ◽

Platinum Resistant ◽

Platinum Based Chemotherapy ◽

History Of ◽

The Impact

5576 Background: Ovarian carcinomas show homologous recombination deficiency (HRD) in up to 50% of cases and in 15 to 20% of cases occur due to germline BRCA1 or BRCA2 mutations. BRCA mutated tumors are more sensitive to PARP inhibitors and platinum based chemotherapy. The objective of this study was to characterize a cohort of ovarian cancer patients regarding HRD and to evaluate the impact of these scores in prolonged platinum sensitivity. Methods: Thirty one ovarian cancer patients with platinum resistant recurrence reexposed to platinum based chemotherapy were selected. Paraffin embedded tumor samples from 14 patients were analyzed using ONCOSCAN assay (Affymetrix) to evaluate HRD scores. The association of the scores with response rate to platinum rechallenge, overall survival and clinical pathologic factors was evaluated. Results: From the cohort of 31 patients, 15 samples from 14 patients were analyzed for genomic alterations. Median scores were 19.5 for TAI, 12.5 for cnLOH+L, 26.0 for LST and 6.3 for HRD. High scores were found in 10 out of 14 (for cnLOH+L score) and 9 out of 14 (for LST score) patients. Seven of the 14 patients analyzed analyzed for genomic alterations had response, which suggested homologous recombination deficiency. No significant differences were observed between response rates for high versus low scores. Numerically, cnLOH+L, LST and HDR scores were higher in patients with response to treatment compared to those without response. Median overall survival was 13.4 months from the beginning of platinum rechallenge and no difference in survival according to scores was observed. Among the clinical pathologic factors, family history of breast or ovarian cancer or personal history of breast cancer was associated to higher response rate to platinum rechallenge. Conclusions: In conclusion,HRD scores showed to be potential markers of response to platinum rechallenge in the platinum resistant setting. Further studies are necessary to clarify the best cutoffs for each score, the impact of tumor heterogeneity and the analysis of tumor samples in the moment of treatment. Positive family history of cancer is a clinical factor predictvie of platinum rechallenge response.

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Ovarian Cancer and Comorbidity: Is Poor Survival Explained by Choice of Primary Treatment or System Delay?

International Journal of Gynecological Cancer ◽

10.1097/igc.0000000000001001 ◽

2017 ◽

Vol 27 (6) ◽

pp. 1123-1133 ◽

Cited By ~ 4

Author(s):

Mette Calundann Noer ◽

Cecilie Dyg Sperling ◽

Bent Ottesen ◽

Sofie Leisby Antonsen ◽

Ib Jarle Christensen ◽

...

Keyword(s):

Ovarian Cancer ◽

Primary Treatment ◽

Regression Analyses ◽

System Delay ◽

Debulking Surgery ◽

Primary Debulking Surgery ◽

Choice Of Treatment ◽

Severe Comorbidity ◽

Comorbidity Index ◽

The Impact

ObjectivesComorbidity influences survival in ovarian cancer, but the causal relations between prognosis and comorbidity are not well characterized. The aim of this study was to investigate the associations between comorbidity, system delay, the choice of primary treatment, and survival in Danish ovarian cancer patients.MethodsThis population-based study was conducted on data from 5317 ovarian cancer patients registered in the Danish Gynecological Cancer Database. Comorbidity was classified according to the Charlson Comorbidity Index and the Ovarian Cancer Comorbidity Index. Pearson χ2 test and multivariate logistic regression analyses were used to investigate the association between comorbidity and primary outcome measures: primary treatment (“primary debulking surgery” vs “no primary surgery”) and system delay (more vs less than required by the National Cancer Patient Pathways [NCPPs]). Cox regression analyses, including hypothesized mediators stepwise, were used to investigate if the impact of comorbidity on overall survival is mediated by the choice of treatment or system delay.ResultsA total of 3945 patients (74.2%) underwent primary debulking surgery, whereas 1160 (21.8%) received neoadjuvant chemotherapy. When adjusting for confounders, comorbidity was not significantly associated to the choice of treatment. Surgically treated patients with moderate/severe comorbidity were more often experiencing system delay longer than required by the NCPP. No association between comorbidity and system delay was observed for patients treated with neoadjuvant chemotherapy. Survival analyses demonstrated that system delay longer than NCPP requirement positively impacts survival (hazard ratio, 0.90 [95% confidence interval, 0.82–0.98]), whereas primary treatment modality has no significant impact on survival.ConclusionsPatients with moderate/severe comorbidity experience often a longer system delay than patients with no or mild comorbidity. Age, stage, and comorbidity are factors influencing the choice of treatment, with stage being the most important factor and comorbidity of lesser importance. The impact of comorbidity on survival does not seem to be mediated by the choice of treatment or system delay.

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Factors associated with referral and completion of genetic counseling in women with epithelial ovarian cancer

International Journal of Gynecological Cancer ◽

10.1136/ijgc-2019-001168 ◽

2020 ◽

Vol 30 (9) ◽

pp. 1397-1403

Author(s):

Stephanie Alimena ◽

Lauren Scarpetti ◽

Erica L Blouch ◽

Linda Rodgers ◽

Kristen Shannon ◽

...

Keyword(s):

Ovarian Cancer ◽

Genetic Counseling ◽

Family History ◽

Epithelial Ovarian Cancer ◽

Older Women ◽

General Hospital ◽

Massachusetts General Hospital ◽

Insurance Status ◽

Factors Associated ◽

History Of

ObjectiveThe National Comprehensive Cancer Network recommends that all women diagnosed with epithelial ovarian cancer undergo genetic testing, as the diagnosis of pathogenic variants may inform cancer survival and impact treatment options. The objective of this study was to assess factors associated with referral to genetic counseling in women with epithelial ovarian cancer.MethodsA retrospective cohort study identified women with epithelial ovarian cancer from 2012 to 2017 at Massachusetts General Hospital and North Shore Medical Center, a community hospital affiliated with Massachusetts General Hospital. Multivariate logistic regression evaluated how race, age, stage, year of diagnosis, insurance status, family history of breast or ovarian cancer, and language relates to the receipt of genetic counseling.ResultsOf the total 276 women included, 73.9% were referred for genetic screening, of which 90.7% attended a genetic counseling visit. Older women were less likely to undergo genetic counseling (age ≥70 years: OR 0.26, 95% CI 0.07–0.94, p=0.04). Women who died within 365 days of initial oncology consult rarely reached a genetic counselor (OR 0.05, 95% CI 0.01–0.24, p<0.001). Women with a family history of breast or ovarian cancer were more likely to undergo counseling (OR 3.27, 95% CI 1.74–6.15, p<0.001). There was no difference in receipt of genetic counseling by race, stage, year of diagnosis, insurance status, or language.ConclusionOlder women with epithelial ovarian cancer and those who died within 1 year of initiation of care were less likely to undergo recommended genetic counseling. Race, insurance status, and language were not identified as predictive factors, although we were limited in this assessment by small sample size.

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