scholarly journals Profile of women with lymphedema after breast cancer treatment

2019 ◽  
Vol 23 (4) ◽  
Author(s):  
Thais de Oliveira Gozzo ◽  
Gabriela Aguado ◽  
Aniele Tomadon ◽  
Marislei Sanches Panobianco ◽  
Maria Antonieta Spinoso Prado

ABSTRACT Objective: To identify the profile of women with lymphedema after breast cancer treatment. Methods: This is a descriptive, retrospective and quantitative study with data from medical records of women with lymphedema who began treatment between 2010 and 2015 in a rehabilitation center. An instrument was used for data collection to characterize the participants and analysis was performed by means of descriptive statistics, the Chi-Square test and Fisher’s exact test. Results: 235 women with a mean age of 56.8 years were included, with an association between lymphedema and age (p = 0.016). It was observed that 76.6% of the sample had some comorbidity associated with breast cancer, especially hypertension (48.1%). They underwent radical surgery (60%), axillary lymphadenectomy (77.9%), sentinel lymph node biopsy (16.6%) and radiotherapy (74%). Treatments carried out for lymphedema were decongestant therapy and complementary treatments with 95.7% of adherence of women to therapies. Conclusion and implications for practice: Women with lymphedema presented risk factors such as radical surgery, axillary lymphadenectomy and radiotherapy, and good adherence to the required treatments of lymphedema. Knowing the profile of this population is crucial to the treatment choice.

2020 ◽  
Vol 4 (1) ◽  
Author(s):  
Tifanny Tantoso ◽  
Mega Sari Sitorus ◽  
Lita Feriyawati ◽  
Dian Dwi Wahyuni

Obesity is a worldwide problem that has been steadily increasing even in developing countries. Obesity has been linked to various types of cancer, one of which is breast cancer. Breast cancer has been classified into various types based on gene and hormone receptor expressions, which offered new insights to therapies and prognoses. We conducted a case-control study using 42 breast cancer patients and 43 healthy women, all of which are older than 55 years of age and have experienced menopause, and for case subjects, additional immunohistochemistry profiles have been provided. Data were collected by interviews and medical records. For data analysis, we used Pearson’s Chi-Square test and Fisher’s Exact test. Results showed that high BMI is significantly associated with breast cancer, and risk is elevated (p < 0.05, OR = 1.263, 95% CI = 1.007-1.583). No significant association with molecular subtypes was observed.


2018 ◽  
Vol 26 (0) ◽  
Author(s):  
Júlian Katrin Albuquerque de Oliveira ◽  
Eliana Ofélia Llapa-Rodriguez ◽  
Iza Maria Fraga Lobo ◽  
Luciana de Santana Lôbo Silva ◽  
Simone de Godoy ◽  
...  

ABSTRACT Objective: to evaluate the conformity of care practices of the nursing team during the administration of drugs through central vascular catheter. Method: a descriptive, prospective, observational study conducted in an Intensive Care Unit. The non-probabilistic intentional sample consisted of 3402 observations of drug administrations in patients with central vascular catheters. The previously validated collection instrument was constructed based on the Guideline for Prevention of Intravascular catheter-related infections. Data was collected through direct observations of nursing practices performed by the nursing team. The analysis used analytical, descriptive and inferential statistics (Chi-square test and Fisher’s exact test). Results: a total of 3402 procedures of drug administrations were observed. Female nursing technicians performed the highest number of actions. In none of the procedures did the professional perform all necessary actions. 0.2% of drug administrations were preceded by hand hygiene and 1.3% by disinfection of the multidose vial, ampoule or injectors. Conclusion: the practice evaluated was classified as undesirable. Failure to achieve the desired conformity was probably due to the low adherence of professionals to the practice of hand hygiene and disinfection of materials, injectors and connectors.


2005 ◽  
Vol 11 (5) ◽  
pp. 370-371 ◽  
Author(s):  
Atilla Soran ◽  
Cengiz Aydin ◽  
Ali Harlak ◽  
Victor G. Vogel ◽  
Ronald Johnson

2021 ◽  
Vol 8 (2) ◽  
pp. 106-112
Author(s):  
Seden Akan ◽  
◽  
Husamettin Oktay ◽  

ntroduction The aim of this study was to evaluate cases of impacted maxillary canines (IMC) using cone beam tomography (CBCT) and panoramic images in an attempt to assess if panoramic radiographs can provide information compatible with CBCT results regarding canine position and root resorption. Methodology Fifty-six impacted maxillary canines from 48 patients were radiographically evaluated. The positions of the canine teeth were classified by Sector localization on panoramic radiographs and the same teeth were also analyzed by KPG on CBCT. Root resorptions in maxillary lateral incisors were also evaluated on CBCT. The relationships between panoramic and CBCT findings were compared by Chi-square test and Fischer’s exact test. Results Statistically significant correlations were found between panoramic Sectors and KPG indexes (p<0.001). KPG index values of 1, 3 and 4 corresponded to the panoramic Sectors 1, 4 and 5, respectively; but KPG index 2 matched the panoramic Sectors 3 and more often 2. Mid-alveolar impaction generally coincided with score 1 for both KPG index and panoramic Sector. In palatally IMC, this score value was generally 2 or 3 for the KPG index and 4 for the panoramic Sector (p≤0.001). Root resorptions in maxillary lateral incisors showed significant differences according to Sector localization and KPG index (p<0.05), namely they coincided with 2 and 3 in Sector evaluation and 2, 3 and 4 in KPG index. Conclusions Sector location on OPG is found to be related to KPG index on CBCT, and it can help evaluate mainly certain positions of impacted canines; thus, unnecessary CBCT scans are not requested.


PeerJ ◽  
2021 ◽  
Vol 9 ◽  
pp. e12506
Author(s):  
Yue Zhong ◽  
Zhenjie Zhuang ◽  
Peiju Mo ◽  
Mandi Lin ◽  
Jiaqian Gong ◽  
...  

Background Spindle and kinetochore associated complex subunit 3 (SKA3) plays an important role in tumorigenesis and the progression of various tumors. But the relationship between SKA3 and early breast cancer remains unclear. The study aimed to explore the prognostic significance of SKA3 in breast cancer. Methods In the study, SKA3 expression was initially assessed using the Oncomine database and The Cancer Genome Atlas database (TCGA). Then, we presented validation results for RT-qPCR (quantitative reverse transcription PCR) and ELISA (enzyme-linked immunosorbent assay). The relationship between clinical characteristics and SKA3 expression was assessed by Chi-square test and Fisher’s exact test. Kaplan–Meier method and Cox regression analysis were conducted to evaluate the prognostic value of SKA3. Gene set enrichment analysis (GSEA) was performed to screen biological pathways using the TCGA dataset. Besides, single sample gene set enrichment analysis (ssGSEA) was utilized to identify immune infiltration cells about SKA3. Results SKA3 mRNA was expressed at high levels in breast cancer tissues compared with normal tissues. Chi-square test and Fisher’s exact test showed SKA3 expression was related to age, tumor (T) classification, node (N) classification, tumor-node-metastasis (TNM) stage, estrogen receptor (ER), progesterone receptor (PR), molecular subtype, and race. RT-qPCR results showed that SKA3 expression was overexpressed in ER, PR status, and molecular subtype in Chinese people. Kaplan–Meier curves implicated that high SKA3 expression was related to a poor prognosis in female early breast cancer patients. Cox regression models showed that high SKA3 expression could be used as an independent risk factor for female early breast cancer. Four signaling pathways were enriched in the high SKA3 expression group, including mTORC1 signaling pathway, MYC targets v1, mitotic spindle, estrogen response early. Besides, the SKA3 expression level was associate with infiltrating levels of activated CD4 T cells and eosinophils in breast cancer. Conclusion High SKA3 expression correlates with poor prognosis and immune infiltrates in breast cancer. SKA3 may become a biomarker for the prognosis of breast cancer.


2021 ◽  
Vol 6 ◽  
pp. 6-10
Author(s):  
Ajay Bapna ◽  
Nidhi Patni ◽  
Sanjeev Patni

Objectives: Breast cancer is increasing in India due to aging population, better awareness among general public, willingness to seek treatment of cancers, and easier access to cancers centers. We present our single-center data over a 2-year period and discuss cost implications taking the example of metronomic chemotherapy maintenance and predictive markers in early breast cancer. Material and Methods: Prospectively collected data of all consecutive patients with breast cancer registered between September 2017 and August 2019 were evaluated. Clinical features, stage, receptor status, and other features were tabulated. Statistical analysis was using SAS version 9.4 – Chi-square test and Fisher’s exact test were performed. P ≤ 0.05 was considered as statistically significant. Results: For the 484 consecutive patients, the median age was 50 years. This included EBC (201, 42%), LABC (141, 29%), and MBC (142, 29%). ER expression was seen in 52% of cases (253/484), PR in 47% (229/484), and Her2 was positive in 47% (229/484). Finally, 83 patients (17%) were identified as TNBC. HR-positive Her2-negative EBC constituted 111/484 patients (23%). Discussion: If our 83 TNBC patients were given metronomic maintenance chemotherapy, their 3-year overall survival (OS) is projected to increase from 54% to 100% at a cost of INR 8191/- per patient (equivalent to USD 109/-). If our 111 HR-positive Her2-negative EBC patients were evaluated for risk by biomarker test validated in Indian patients, 76 of these would be spared the toxicity of adjuvant CT. This would also result in saving on the cost of chemotherapy medication of INR 4,035,296/- in India (equivalent to USD 53,699/- if treated in USD). In addition, they would also have better quality of life (QoL). Conclusion: It is possible to identify patients with low risk early breast cancer using Can assist and save them from unnecessary cost and/or toxicity.


2022 ◽  
Vol 3 (1) ◽  
Author(s):  
Fernanda Cristina Barbosa Pereira Queiroz ◽  
Christian Luiz Da Silva ◽  
Nilton Cézar Lima ◽  
Jamerson Viegas Queiroz ◽  
Carmem Kistemacher Barche ◽  
...  

A pandemia COVID-19 intensificou a diversidade de tecnologias de aprendizagem na educação superior, de maneira impositiva, desmistificou usos remotos, à fronteira da totalidade do ensino à distância a todos cursos superiores, em atendimento aos protocolos sanitários. Todavia, os eixos de aprendizagem (Ensino-Pesquisa-Extensão), tiveram que se adequar ao emprego das tecnologias educacionais. Sob essa abordagem, emergem questões, buscando examinar impactos que os docentes vivenciaram na pandemia para assegurar continuidade de tais eixos. Os dados contaram com 560, respostas válidas, de docentes da educação superior, distribuídos em todas regiões do Brasil. O estudo de abordagem quantitativa contou com o método da estatística não paramétrica, teste qui-quadrado, teste exato de Fischer e U de Mann Whitney. Resultados demonstraram que a adaptação e adoção de novas estratégias aos eixos de aprendizagem foram superadas pelos docentes sem identificações de impactos notórios que gerassem barreiras ou impeditivos. Entretanto, as relações familiares e sociais, assim como a saúde mental e física dos docentes, despertaram como impactos percebidos. Estudos foram sugeridos empregando expectativas diversas, sob contextos que analisem a exclusão digital e a saúde mental como interseccionalidade e enfoque de discussão em período pandêmico e pós-pandemia em países em desenvolvimento.   The pandemic COVID-19 intensified the diversity of learning technologies in higher education, in an imposing way, demystified remote uses, to the border of the totality of distance learning to all higher education courses, in attendance to sanitary protocols. However, the learning axes (Teaching-Research-Extension) had to adapt to the use of educational technologies. Under this approach, questions emerge, seeking to examine the impacts that the teachers experienced in the pandemic to ensure the continuity of these axes. The data counted on 560 valid answers from teachers of higher education, distributed in all regions of Brazil. The quantitative approach study relied on the non-parametric statistical method, chi-square test, Fischer's exact test, and Mann Whitney's U test. Results showed that the adaptation and adoption of new strategies to the learning axes were overcome by the teachers without the identification of notorious impacts that would generate barriers or impediments. However, family and social relationships, as well as the mental and physical health of the faculty members aroused as perceived impacts. Studies were suggested employing diverse expectations under contexts that analyze digital exclusion and mental health as intersectionality and focus of discussion in pandemic and post-pandemic period in developing countries.


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